Could a gut supplement boost brain health in schizophrenia?

NCT ID NCT05527210

Ongoing Disease control Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study tests whether a prebiotic supplement (Prebiotin®) can reduce inflammation and improve thinking in people with schizophrenia or schizoaffective disorder. Sixty adults aged 18-60 who are stable on antipsychotics will take the prebiotic or a placebo for 12 weeks. Researchers will measure changes in blood butyrate levels, cognitive test scores, and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Prebiotin® (a prebiotic dietary supplement)
What this could lead to: If it works, this could point toward a simple, safe way to improve thinking and reduce inflammation in people with schizophrenia.
What could go wrong: This is a small, early-stage trial with only 60 participants. The prebiotic may not change inflammation or cognition, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Psychotic Disorders schizoaffective disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOAFFECTIVE DISORDER SCHIZOPHRENIA

Contacts and locations

Locations

Maryland Psyciatric Research Center

Catonsville, Maryland, 21228, United States

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