Can two antipsychotics together tame schizophrenia better?
NCT ID NCT05169268
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 6 people with schizophrenia who were already taking a combination of two long-acting injectable medications: Abilify Maintena and Rexulti. Researchers tracked their symptoms and side effects over 6 months to see how well the combo worked in everyday life. The goal was to see if this approach could improve control of psychotic and mood symptoms while being tolerable.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
aripiprazole (Abilify Maintena) and brexpiprazole (Rexulti)
What this could lead to
If successful, this could show that combining these two medications helps control schizophrenia symptoms with fewer side effects in everyday life.
What could go wrong
This was a very small study (only 6 people) and was not a controlled trial, so results may not apply broadly. The combination may still cause side effects or not work for everyone.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Queen Mary Hospital
Hong Kong, 000000, Hong Kong