Could an arthritis drug spark motivation in schizophrenia?
NCT ID NCT05823532
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether infliximab, an anti-inflammatory drug used for arthritis, can improve motivation and brain activity in people with schizophrenia who have high inflammation. Sixty adults with schizophrenia will receive either infliximab or a placebo, and researchers will measure changes in brain scans and motivation tasks. The goal is to see if reducing inflammation helps with the lack of motivation that many patients experience.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Infliximab
What this could lead to
If it works, this could point toward a new way to treat motivational problems in schizophrenia by reducing inflammation.
What could go wrong
This is a small early-phase study with only 60 people, so results may not apply widely. Infliximab can have serious side effects like infections.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Emory University Hospital
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Grady Memorial Hospital
RECRUITINGAtlanta, Georgia, 30303, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••