Can a common schizophrenia drug curb violent acts? new trial aims to find out

NCT ID NCT05208190

Recruiting now Disease control Sponsor: New York State Psychiatric Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether clozapine, a medication for schizophrenia, can reduce violent acts better than other antipsychotic drugs. Researchers will enroll 280 people with schizophrenia or schizoaffective disorder who have been violent in the past six months. Participants will receive either clozapine or their usual antipsychotic treatment for 24 weeks, and researchers will track violent behavior and other symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Clozapine (a medication also known as Clozaril)
What this could lead to: If it works, this could provide a clearer treatment option to reduce violence in people with schizophrenia, improving safety and quality of life.
What could go wrong: This is a Phase 4 trial, but results may not apply to everyone. Clozapine has known serious side effects, including blood disorders, and the open-label design may introduce bias.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Psychotic Disorders schizoaffective disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOAFFECTIVE DISORDER SCHIZOPHRENIA

Contacts and locations

Locations

Augusta University Research Institute, Inc.
RECRUITING

Augusta, Georgia, 30912, United States
Manhattan Psychiatric Center
RECRUITING

New York, New York, 10035, United States
NYU Langone Medical Center
RECRUITING

New York, New York, 10016, United States
New York State Psychiatric Institute
RECRUITING

New York, New York, 10032, United States
University of California, Los Angeles
RECRUITING

Los Angeles, California, 90024, United States
University of Maryland School of Medicine
RECRUITING

Baltimore, Maryland, 21201, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States

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