Cognitive disorder

This study tested the long-term safety of AXS-05, a combination of dextromethorphan and bupropion, for treating agitation in people with Alzheimer's disease. It enrolled 139 participants who had completed earlier studies. The trial was terminated early, so the full safety picture…

This study looked at the long-term safety and effects of ALZ-801, a tablet taken twice daily, in 163 people with early Alzheimer's disease who have the APOE4/4 gene. Participants had already completed a previous phase 3 study. The goal was to see if the drug could slow cognitive …

This pilot study tested deep brain stimulation (DBS) in 15 people with treatment-resistant schizophrenia who still had severe hallucinations despite medication. The device was placed in a brain area linked to schizophrenia to try to calm symptoms. The study was terminated early, …

This study tested an experimental drug called SHR-1707 in people with mild memory problems or mild Alzheimer's disease. The goal was to see if it could safely reduce harmful protein clumps in the brain. The trial was stopped early, and it is not expected to cure the disease.

This study looked at the long-term safety of an experimental drug called TB006 (oloctinebart) in people with Alzheimer's disease. It included 119 participants who had either completed a previous TB006 study or were new to the drug. The study was terminated early, so the full safe…

This early-stage study tested a new drug, ADEL-Y01, in healthy volunteers and people with mild Alzheimer's or mild cognitive impairment. The goal was to check safety and how the drug moves through the body. The trial was stopped early, so results are limited.

This study looked at the long-term safety of a medicine called iclepertin in adults with schizophrenia who had already finished earlier studies. About 1,356 participants took iclepertin tablets once a day for one year, along with their usual schizophrenia medications. The main go…

This study tested a drug called PrimeC in people with mild to moderate Alzheimer's disease. The goal was to see if it is safe and if it helps with thinking and daily activities. The study was stopped early and only 8 people took part, so results are very limited.

This study tested an experimental antibody called JNJ-63733657 in 523 people with early Alzheimer's disease. The antibody aims to clear tau protein clumps in the brain, which are linked to cognitive decline. Participants received either the antibody or a placebo by IV infusion. T…

This early study tested a weekly injection of allopregnanolone, a natural brain steroid, in 6 people with early Alzheimer's or mild cognitive impairment. The goal was to find a safe dose and check for side effects. The trial was terminated early, so we have limited information on…

This study gave Alzheimer's patients who had already completed earlier XPro1595 trials an extra 55 to 74 weeks of the drug to check long-term safety and effects on memory and brain health. Only 11 people took part, and the trial was terminated early, so the findings are limited. …

This study was a long-term extension of an earlier trial, testing the safety and tolerability of AL002 in 197 people with early Alzheimer's disease. Participants received the drug by IV infusion. The trial was terminated, meaning it stopped before completion, so the full safety a…

This early-stage study tested a drug called ION269 in adults with Down syndrome who also showed signs of Alzheimer's disease. The goal was to check if the drug was safe and tolerable when injected into the spinal fluid. Only one person took part, and the study was stopped early, …

This study tested a dental health education program for people with schizophrenia to see if it could improve their oral hygiene and quality of life. Participants were randomly assigned to either the education program or standard monitoring. The study lasted 12 months and included…

This study tested a combination of long-acting injectable antipsychotic medication and cognitive/functional skills training in people with early schizophrenia. The goal was to see if this approach helps patients achieve stable symptom remission and improve daily functioning. Only…

This study was designed to let people who had already taken latozinemab in an earlier study continue receiving the drug. Only 17 people took part, and the study was stopped early. The goal was to track safety and how long people stayed on treatment, not to test if the drug could …

This phase 3 study tested a drug called AL001 in 119 people who carry a mutation in the progranulin gene, putting them at high risk for or already diagnosed with frontotemporal dementia. The goal was to see if AL001 could slow the worsening of memory, behavior, and language probl…

This study aimed to check the long-term safety and effects of a daily pill called SPG302 in people with mild-to-moderate Alzheimer's disease. It included 12 participants who had already been in a previous SPG302 study. The study was terminated early, so results are limited.

This study tested a drug called varoglutamstat (PQ912) in people with early Alzheimer's disease. The goal was to see if it is safe and if it could slow memory and thinking problems. The trial was stopped early, so we have less information than planned. About 112 people took part,…

This study tested an experimental drug called REM0046127 in people with mild to moderate Alzheimer's disease. The goal was to see if it was safe and how it affected brain chemicals and brain wave activity. The trial was stopped early and included only 14 participants instead of t…

This study tested an experimental drug called IMG-007 in 13 adults with moderate-to-severe atopic dermatitis (eczema) who did not get enough relief from topical treatments. The main goal was to check the drug's safety, and researchers also looked at how the body processes it and …

This early-stage trial tested a gene therapy called SBT101 for adrenomyeloneuropathy (AMN), a rare nerve disease that causes walking difficulties. Eight adults received either the therapy or a sham procedure. The study was terminated early, so we have limited data on safety and e…

This study tested cariprazine (VRAYLAR), an approved schizophrenia drug in the U.S., for people with acute schizophrenia in Japan and Taiwan. Participants received either cariprazine or a placebo for 6 weeks, then could continue on cariprazine for 18 more weeks. The trial was ter…

This study tested a drug called AVP-786 to see if it could safely reduce agitation in people with Alzheimer's dementia over the long term. It was an extension of earlier studies, enrolling over 1,100 participants who had already completed a prior trial. However, the study was ter…

This study aimed to see how two antipsychotic drugs, aripiprazole and ziprasidone, affect heart risk in people with schizophrenia, schizoaffective disorder, or bipolar disorder. Researchers measured blood fats and heart electrical changes in 48 adults over 12 months. The trial wa…

This study tested whether giving lithium carbonate before carotid artery surgery could reduce brain damage and confusion after the operation. The trial planned to include 107 adults undergoing elective carotid surgery, but it was terminated early. The goal was to see if lithium c…

This study tested a drug called simufilam in over 1,000 people with mild-to-moderate Alzheimer's disease. Participants took either 50 mg, 100 mg, or a placebo twice daily for 76 weeks. The goal was to see if simufilam could slow memory loss and help with daily activities. However…

This early pilot study tested whether a combination of injectable naltrexone and oral bupropion could help people with schizophrenia who smoke cigarettes. Only 2 participants were enrolled before the study was terminated. The main goals were to see if the treatment was feasible a…

This study explored whether a special eye scan (hyperspectral retinal imaging) can detect beta-amyloid, a protein linked to Alzheimer's disease, in the retina. Researchers aimed to see if this non-invasive test could distinguish people with Alzheimer's from healthy individuals. T…

This study tested a wearable device that sits on the neck to detect swallowing problems in people with conditions like stroke, Parkinson's, multiple sclerosis, Alzheimer's, or dementia. The device was compared to a standard X-ray test. Unfortunately, the device did not meet the a…

This study tested whether a wearable EEG device can help doctors diagnose Alzheimer's disease and mild cognitive impairment. Researchers compared brain wave data from the EEG with standard memory and thinking tests in 148 participants. The goal was to see if the EEG could improve…

This study tested whether adding vaccine discussions to routine behavioral health visits could reduce hesitancy and increase COVID-19 and flu shots among Latinx adults with mental illness. Clinicians used motivational interviewing and could offer a warm handoff to a nurse for vac…

This study tests whether adding MK-1167 to standard Alzheimer's treatment can improve memory and thinking in people with mild to moderate Alzheimer's dementia. About 350 participants will receive either MK-1167 or a placebo for 24 weeks. Researchers will measure changes in cognit…

This study tested whether a single 200 mg dose of American Ginseng (Cereboost) could improve attention and brain function in healthy young adults aged 18-40. Participants completed cognitive tests and gave blood samples over 6 hours. However, the trial was terminated early and on…

This study tested whether a non-invasive brain stimulation technique called TMS could help reduce negative symptoms of schizophrenia, like low motivation and reduced facial expression. The trial enrolled 47 adults with schizophrenia or schizoaffective disorder and compared active…

This study tests a mobile telehealth app called Brain CareNotes designed to help unpaid Hispanic caregivers manage challenging behaviors in people with Alzheimer's or related dementias. The app offers coaching and tools to handle symptoms like agitation or wandering. Researchers …

This study looked at whether a drug called K0706 is safe and tolerable for people with Dementia with Lewy Bodies (DLB). Researchers planned to give 45 participants either a low dose, high dose, or placebo for 12 weeks, then check for side effects and measure changes in brain and …

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce severe agitation in older adults with dementia. The trial aimed to enroll many participants but was stopped early after only 5 people joined. Because it ended so soon, we cannot draw reli…

This study tested a drug called AVP-786 to see if it could safely reduce disinhibition—impulsive or inappropriate behavior—in people with neurodegenerative disorders like Alzheimer's or frontotemporal dementia. The trial planned to include many participants but was terminated ear…

This study tested a personalized touchscreen device (My PATI) to help people with Alzheimer's or related dementias communicate their care preferences. The goal was to improve quality of life for both patients and their caregivers. The study was terminated early, so results are li…

This study aimed to see if taking omega-3 supplements before and after major heart surgery could lower the chance of confusion (delirium) in patients aged 65 and older. The trial was planned for many participants but was stopped early after enrolling only one person. Because it e…

This pilot study aimed to compare trazodone and quetiapine for treating delirium in ICU patients. It enrolled only 10 adults in the surgical ICU who had delirium with symptoms like agitation or hallucinations. The study was terminated early, so the results are very limited and ca…

This study looked at whether adding cognitive remediation therapy (a type of brain training) to supported education (help returning to school) improves academic functioning in young adults with psychotic disorders. Only 9 people enrolled before the study was stopped early. The go…

This study tested a drug called CVL-871 to see if it is safe and can help reduce apathy (lack of motivation or interest) in people with dementia. The trial included 41 participants with mild to moderate dementia and clinically significant apathy. The main goal was to check for si…

This pilot study tested whether combining repetitive transcranial magnetic stimulation (rTMS) with computerized cognitive training could help adults with schizophrenia who have thinking and memory problems. Twelve participants received either active or sham rTMS followed by cogni…

This study tested whether a gentle, non-invasive brain stimulation technique (tDCS) done at home, along with computer-based brain games, could improve thinking and language skills in people with primary progressive aphasia, mild cognitive impairment, or dementia. Participants use…

This study looked at whether oxytocin, a natural brain chemical that helps with social bonding, could improve social functioning in veterans with schizophrenia. Researchers planned to give oxytocin and use brain scans to see who might benefit. The study was stopped early, so resu…

This study aimed to see if a simple eye scan could predict which people with early schizophrenia would benefit from a drug called sodium nitroprusside. The drug was given to reduce psychosis symptoms like delusions and hallucinations. Only one person enrolled before the study was…

This study tested whether giving methadone to ICU patients on breathing machines could help them get off the ventilator faster. Patients who needed strong painkillers were given either methadone or a placebo. The trial was stopped early and only included 9 people, so no firm conc…

This study tested a home system that uses aromatherapy, music, and brain-training games to help older adults with mild memory issues stay safe and independent. Only 4 people took part before the study was stopped early. The goal was to see if seniors would use and enjoy these non…

This study tested a behavioral program using bright light therapy and sleep coaching to improve sleep and thinking in older adults with mild cognitive impairment or mild Alzheimer's. Only 15 people were enrolled before the study was stopped early. The goal was to see if the progr…

This pilot study tested a special helmet and abdominal panel that shines near-infrared light and uses a static magnetic field on people with mild-to-moderate Alzheimer's disease. The goal was to see if it could safely improve memory and thinking. The study planned to enroll 60 pa…

This study tested a digital health app called medidux™ in 196 people with HER2-positive breast cancer. The app was used for up to 16 weeks during chemotherapy to help track and manage side effects. The goal was to see if using the app reduced the number of severe side effects. Ho…

This study tested whether a robotic seal named PARO could help elderly people with moderate to severe memory problems feel calmer during daily care like bathing. The robot was used for a few minutes before and during care, twice a week for 16 weeks. The goal was to see if it redu…

This study tested whether combining a computer-based speed-of-processing training with a gentle electrical brain stimulation (alpha-tACS) could improve how quickly people with mild cognitive impairment process visual information. The trial planned to enroll 40 adults aged 65 and …

This study looked at whether giving elderly patients a combination of acetaminophen and ibuprofen (Maxigesic) during and after minimally invasive lung surgery could reduce the risk of postoperative delirium (sudden confusion). The trial planned to compare the drug group to a plac…

This study aimed to see if a short test called BEARNI could detect alcohol-related cognitive impairments (like memory and thinking problems) in people with alcoholic cirrhosis. The researchers planned to enroll patients with cirrhosis, but the study was stopped early after only o…

This study aimed to understand why people with autism or schizophrenia sometimes struggle to recognize emotions on faces. Researchers used brain wave recordings (EEG) and eye-tracking to see how participants processed facial expressions. The study included people with autism, sch…

This study looked at how noninvasive brain stimulation techniques like rTMS, tDCS, and ECT change BDNF levels in people with depression or schizophrenia. Researchers took blood samples before and after stimulation to measure BDNF, a protein linked to brain health. The study was t…

This study tested whether a visual consent form with pictures helps patients with cancer or Alzheimer's understand research better than standard text. Researchers planned to enroll 266 adults across three U.S. sites. The trial was terminated early, so results may be limited.

This study tested a French version of a questionnaire that measures how much patients know about lithium, a drug used for bipolar and schizoaffective disorders. Researchers wanted to see if higher knowledge scores matched safe lithium levels in the blood. The study included 22 ho…

This pilot study measured brain activity (EEG) in 6 healthy volunteers while they performed computer tasks that test attention and memory. The goal was to develop better ways to measure thinking skills that could be used in future Alzheimer's drug trials. The study was terminated…

This study looked at how early Alzheimer's disease affects a person's ability to make decisions. Researchers tested 100 people with Alzheimer's and healthy volunteers using memory and thinking tasks, plus a special decision-making test. The goal was to understand which brain func…

This early-stage study aimed to see if taking memantine, an Alzheimer's drug, for 15 days would change certain brain and cognitive markers in healthy young men aged 18-30. The goal was to validate a test battery for future Alzheimer's drug development. However, the study was term…

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This pilot study tested a decision aid designed to help older adults with early dementia or depression think about safer ways to store firearms at home. Only 5 people took part, and the study was ended early. The goal was to see if the tool was practical and acceptable, and wheth…

This study tested whether a non-invasive brain stimulation technique called deep rTMS could change brain activity and reduce smoking in people with schizophrenia. Researchers used brain scans to measure changes in brain connections and smoking behavior. The study was small and en…

This small, early study tested a new approach called Auditory Control Enhancement (ACE) for people with schizophrenia who hear voices (auditory hallucinations) that don't respond to medication. ACE combines a mild brain stimulation technique called tDCS with cognitive training. T…

This study tested a smartphone-based program to help veterans with serious mental illness (like PTSD, bipolar disorder, or schizophrenia) better recognize and describe their emotions. The goal was to see if improving emotion awareness could lower suicide risk. Only 11 veterans to…

This study explored whether a non-invasive technique called transcranial magnetic stimulation (TMS) could improve memory in healthy older adults and those with mild memory problems due to Alzheimer's. Researchers used TMS to stimulate brain networks linked to memory and measured …

This study tested whether a robot that moves on its own could patrol nursing home rooms and detect when a resident with Alzheimer's has fallen. The robot was designed to turn on lights, alert staff, and let them see and talk to the resident through its camera and screen. The stud…

This study aimed to compare the effects of clozapine versus other antipsychotic medications on inflammation in people with treatment-resistant schizophrenia. Researchers measured inflammatory markers like interleukin-6 in a small group of participants. The study was terminated ea…

This study looked at whether caregivers' negative beliefs about antipsychotic medications make it harder for people with schizophrenia to stick to their treatment. About 50 patients and their main caregivers answered questionnaires about medication beliefs and adherence. The goal…

This study aimed to see if introducing formal home help (like a paid aide) improves the quality of life for people caring for elderly relatives with memory or thinking problems. Researchers planned to follow 12 caregivers for 90 days, measuring changes in their well-being, stress…

This study followed 65 adult men with a rare inherited nerve disease called AMN (a form of spastic paraplegia) to understand how their symptoms change over time. Researchers collected data on walking ability and quality of life. The goal was to fill gaps in knowledge about the di…

This study tested whether anti-inflammatory drugs could help people with early Alzheimer's or mild cognitive impairment. It was stopped early, so only one drug was studied in 34 participants. The main goal was to measure changes in thinking and memory, but the early termination l…

This study looked at whether a digital platform called Horyzons could be used in clinics that help young people with early psychosis. The platform offers therapy content and a safe social network. Researchers wanted to understand what helps or hinders its use in real-world care. …