Could a gentle brain zap quiet voices in schizophrenia?
NCT ID NCT06155695
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This small, early study tested a new approach called Auditory Control Enhancement (ACE) for people with schizophrenia who hear voices (auditory hallucinations) that don't respond to medication. ACE combines a mild brain stimulation technique called tDCS with cognitive training. The study aimed to see if the method is safe, acceptable, and whether it changes brain activity in areas linked to hearing and attention. Only 12 people were enrolled, and the study was terminated early, so the results are very preliminary.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- transcranial direct current stimulation (tDCS)
- What this could lead to
- If it works, this could point toward a new, noninvasive treatment for auditory hallucinations in schizophrenia.
- What could go wrong
- This was a very small, early feasibility study (12 people) that was terminated, so results are limited. It is not yet known if the approach is effective or safe for wider use.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Western Psychiatric Hospital of UPMC
Pittsburgh, Pennsylvania, 15213, United States
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Other studies related to the condition(s) this trial covers.
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- Can a gentle brain current silence voices that medication Can't?