Could a gentle brain zap quiet voices in schizophrenia?

NCT ID NCT06155695

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small, early study tested a new approach called Auditory Control Enhancement (ACE) for people with schizophrenia who hear voices (auditory hallucinations) that don't respond to medication. ACE combines a mild brain stimulation technique called tDCS with cognitive training. The study aimed to see if the method is safe, acceptable, and whether it changes brain activity in areas linked to hearing and attention. Only 12 people were enrolled, and the study was terminated early, so the results are very preliminary.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS)
What this could lead to
If it works, this could point toward a new, noninvasive treatment for auditory hallucinations in schizophrenia.
What could go wrong
This was a very small, early feasibility study (12 people) that was terminated, so results are limited. It is not yet known if the approach is effective or safe for wider use.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Western Psychiatric Hospital of UPMC

    Pittsburgh, Pennsylvania, 15213, United States

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