Tiny study compares trazodone and quetiapine for ICU delirium – but was cut short

NCT ID NCT05307003

Terminated Symptom relief Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This pilot study aimed to compare trazodone and quetiapine for treating delirium in ICU patients. It enrolled only 10 adults in the surgical ICU who had delirium with symptoms like agitation or hallucinations. The study was terminated early, so the results are very limited and cannot provide clear answers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Trazodone and quetiapine
What this could lead to: If successful, this could suggest a better option for managing ICU delirium with fewer side effects.
What could go wrong: This was a very small pilot study (only 10 participants) that was terminated early, so the findings are not reliable or generalizable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Confusion delirium psychiatric disorder Sepsis-Associated Encephalopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DELIRIUM DELIRIUM CONFUSIONAL STATE DELIRIUM IN OLD AGE DELIRIUM OF MIXED ORIGIN DELIRIUM, SEPSIS ASSOCIATED MORALITY PSYCH TREATMENT SIDE EFFECTS

Contacts and locations

Locations

Keck Hospital of the University of Southern California

Los Angeles, California, 90033, United States

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