Alzheimer's drug trial halted early – what we know

NCT ID NCT03919162

Terminated Disease control Sponsor: Vivoryon Therapeutics N.V. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called varoglutamstat (PQ912) in people with early Alzheimer's disease. The goal was to see if it is safe and if it could slow memory and thinking problems. The trial was stopped early, so we have less information than planned. About 112 people took part, receiving either the drug or a placebo for at least 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: varoglutamstat (PQ912)
What this could lead to: If it works, this could slow cognitive decline in early Alzheimer's disease.
What could go wrong: The trial was terminated early, so results are limited. It is still in early phases, and many Alzheimer's drugs fail to show benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE

Contacts and locations

Locations

Abington Neurological Associates

Abington, Pennsylvania, 19001, United States
Banner Sun Health Research Institute

Sun City, Arizona, 85351, United States
Barrow Neurological Institute

Phoenix, Arizona, 85013, United States
Cedars-Sinai Center

Los Angeles, California, 90048, United States
Emory University

Atlanta, Georgia, 30329, United States
Georgetown University Medical Center

Washington D.C., District of Columbia, 20057, United States
Lowcountry Center for Veterans Research (LCVR)

Charleston, South Carolina, 29403, United States
NYU Langone Health Tisch Hospital

New York, New York, 10016, United States
Northern Light Acadia Hospital

Bangor, Maine, 04401, United States
Northwestern University Feinberg School of Medicine

Chicago, Illinois, 60611, United States
OHSU Neurology Clinic

Portland, Oregon, 97239, United States
Ohio State University

Columbus, Ohio, 43210, United States
PCND Neurology

Poway, California, 92064, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
SUNY Upstate Medical University

Syracuse, New York, 13210, United States
The Neuron Clinic

Chula Vista, California, 91910, United States
The University of Iowa Carver College of Medicine

Iowa City, Iowa, 52242, United States
The University of Kentucky Sanders-Brown Center on Aging

Lexington, Kentucky, 40504, United States
UCSD Alzheimer's Disease Research Center

La Jolla, California, 92037, United States
USF Health Byrd Alzheimer's Center and Research Institute

Tampa, Florida, 33613, United States
UT Health San Antonio

San Antonio, Texas, 78229, United States
University of California

Irvine, California, 92868, United States

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