Cognitive disorder

This early-stage study tests a vaccine called AV-1959D in 48 people with early Alzheimer's disease. The vaccine aims to train the immune system to target harmful amyloid plaques in the brain. The main goal is to check if the vaccine is safe and tolerable.

This phase 2 trial tests whether allopregnanolone, a natural hormone, can safely help repair the brain in people with early Alzheimer's disease. About 100 volunteers aged 55 to 80 will receive weekly infusions of the drug or a placebo for several months. Researchers will measure …

This Phase 2 study tests an experimental drug called BIIB080 in people with mild cognitive impairment or mild dementia due to Alzheimer's disease. The drug is injected into the fluid around the spinal cord every 12 or 24 weeks. Researchers want to see if it can slow the worsening…

This early-stage trial tests a single injection of ARO-ATXN2 in 36 adults with spinocerebellar ataxia type 2, a rare genetic disorder that affects movement and coordination. The main goal is to see if the drug is safe and how the body processes it. Participants are randomly assig…

This 12-week study is for people who completed a previous trial of the ketogenic diet for first-episode bipolar disorder. Researchers want to see if the diet can improve symptoms like depression, mania, and psychosis, as well as brain energy metabolism and insulin resistance. Abo…

This phase 3 trial tests whether the drug troriluzole can slow the progression of spinocerebellar ataxia, a rare genetic disorder that affects coordination and balance. About 300 adults with different types of SCA are randomly assigned to take either troriluzole or a placebo dail…

This early-stage trial tests whether a single infusion of donated mesenchymal stem cells is safe for children with cerebral adrenoleukodystrophy (cALD), a rare and life-threatening brain disease. The stem cells are given as a temporary bridge to buy time before a more definitive …

This study tests different dosing schedules of the drug donanemab in about 1,175 people with early symptomatic Alzheimer's disease. The goal is to find a regimen that lowers brain amyloid plaques while reducing the risk of a side effect called ARIA-E (brain swelling or small blee…

This clinical trial is testing whether dimethyl fumarate, a drug already used for multiple sclerosis, can improve balance and walking in adults with adrenomyeloneuropathy (AMN), a rare nerve disease. Forty participants will take either the drug or a placebo daily for 36 months, w…

This phase 2 trial tests whether leuprolide (Eligard), a drug that lowers certain hormones, can slow memory and thinking decline in 180 women with mild Alzheimer's or mild cognitive impairment. All participants are already taking donepezil. The study compares leuprolide injection…

This study tests an experimental drug called RO7126209 (Trontinemab) in people with early to moderate Alzheimer's disease. The drug is given by IV infusion and aims to reduce amyloid plaques in the brain, a hallmark of Alzheimer's. About 241 participants will receive either the d…

This study tests whether the drug rapamycin is safe and tolerable for older adults with mild memory problems or early Alzheimer's disease. About 40 participants will take rapamycin for 12 months while researchers monitor side effects and changes in memory and thinking. The goal i…

This study looks at whether the drug troriluzole can slow the progression of spinocerebellar ataxia (SCA), a rare genetic disease that affects movement and balance. Researchers will compare 909 patients who took troriluzole for up to three years with similar patients who did not …

This study tests whether daily phone reminders can help people with schizophrenia or schizoaffective disorder remember to take their medication. 104 participants will receive repeated cues on their mobile phones for 30 days. The goal is to see if this improves medication adherenc…

This study tests whether benfotiamine, a form of vitamin B1, can safely slow memory and thinking decline in people with early Alzheimer's. About 406 adults aged 50-89 with mild symptoms will take the drug or a placebo for up to 72 weeks. Researchers will measure changes in cognit…

This study tests an investigational drug called lecanemab in people aged 55-80 who have early signs of Alzheimer's-related brain changes but no memory problems yet. The goal is to see if the drug can slow cognitive decline and reduce amyloid buildup over about 4 years. Around 140…

This phase 2 study tests a vaccine called JNJ-64042056 in 55 people with very early signs of Alzheimer's (no symptoms yet but tau buildup in the brain). The vaccine is designed to train the immune system to attack tau protein, which forms tangles in Alzheimer's. Participants rece…

This study follows 629 older adults for 3 years to see if using hearing aids and getting hearing rehab can slow down memory loss and lower the risk of dementia. Participants were already in an earlier trial and now continue with hearing care or a delayed treatment. The goal is to…

This study is testing the long-term safety of a daily pill called OLZ/SAM (olanzapine plus samidorphan) in 236 teenagers with schizophrenia or bipolar I disorder. Participants have already completed a previous study with the same drug. The goal is to see if the drug is safe and t…

This study looks at whether adding pistachios to the daily diet for 6 months can improve memory, thinking speed, and other brain functions in adults aged 65 to 80. It also checks for changes in blood pressure and overall life satisfaction. About 97 participants who are already in…

This early-stage trial tests a drug called NIO752 in 38 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. The drug is given as one or two injections into the spinal fluid to see if it can lower levels of tau protein, a key marker of Alzheimer's damage.…

This phase 3 study tests whether donanemab, an antibody given through an IV, can safely slow cognitive decline in 1500 people with early Alzheimer's. Participants receive either the drug or a placebo for up to 93 weeks. The main goal is to measure changes in thinking and daily fu…

This early-stage study tests the safety of acamprosate, a drug used for alcohol dependence, in 30 adults with ALS who have a specific mutation in the C9orf72 gene. Participants take the pill three times daily for 24 weeks and undergo regular checkups, breathing tests, and spinal …

This study tests a drug called ACP-204 for treating psychosis (hallucinations or delusions) in people with Lewy body dementia. It is a 52-week open-label extension, meaning all 126 participants will receive the drug. The main goal is to check for side effects over the long term. …

This study looks at whether adding topiramate (a seizure medication) to clozapine can help with weight loss and improve symptoms in people with treatment-resistant schizophrenia or schizoaffective disorder. About 50 overweight or obese adults aged 17-59 who are already on clozapi…

This study tests a program called PICU Up! that helps critically ill children in the intensive care unit start moving earlier than usual. The program combines sleep support, delirium prevention, and less sedation to encourage safe mobility. Researchers will see if this approach r…

This expanded access program offers the experimental drug zervimesine (CT1812) to people aged 50 to 86 with mild-to-moderate dementia with Lewy bodies. Participants take one 100 mg pill daily for up to a year. The goal is to provide access to the drug and collect long-term safety…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with schizophrenia who are overweight or obese and did not lose weight on metformin. About 92 participants will receive either semaglutide or a placebo. The main goal is to see if sema…

This Phase 1 study tests the safety of OLX-07010, a drug designed to stop tau proteins from clumping in the brain—a hallmark of Alzheimer's disease. Researchers will give single or multiple doses to 88 healthy adults and elderly volunteers to see how the body handles the drug and…

This phase 2 trial tests whether a combination of intravenous immunoglobulin (IVIG) and rituximab can help people with psychosis caused by antibodies attacking the brain. 70 participants with acute psychosis and specific antibodies receive either the immunotherapy or a placebo. T…

This study aimed to test a drug called BAC in people with Alzheimer's disease or vascular dementia. The goal was to see if it could improve thinking and memory, and to check for side effects. However, the trial was withdrawn before any participants were enrolled, so no results ar…

This study tests an experimental daily pill (RO7269162) in 256 people who either have brain plaques but no symptoms, or have mild memory problems due to Alzheimer's. Participants take the pill or a placebo for about 1.5 years, with regular check-ups to monitor safety and brain ch…

This study tests whether a daily pill called buntanetap can help people with early Alzheimer's disease think more clearly and handle daily tasks better. About 760 adults aged 55-85 will take either the drug or a placebo for 18 months. Researchers will check memory, thinking, and …

This study aimed to test whether electronic cigarettes could help people with schizophrenia quit or reduce smoking. It planned to enroll smokers with schizophrenia from Sicily and compare e-cigarettes with nicotine, without nicotine, and a nicotine-free inhaler. However, the tria…

This early-stage study tests a gene therapy called AB-1001 in 5 adults with early Huntington's disease. The treatment is injected directly into the brain to potentially slow the disease. The main goal is to check safety, but researchers will also look at brain changes on MRI and …

This early-stage trial tests a gene therapy called PBFT02 for frontotemporal dementia (FTD) in people with specific genetic mutations. The therapy delivers a working copy of the GRN gene directly into the brain. The study involves 30 adults and primarily checks for safety and sid…

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This pilot study is testing whether adults with serious mental health issues like psychosis, anxiety, or depression can receive hospital-level care in their own homes. Researchers will see how many people are eligible and willing to try this approach. The goal is to offer a safe,…

This study tests whether adding a new recovery-focused psychotherapy program (RECOVERYTRSGR or RECOVERYTRSBDGR) to standard medication can improve thinking, symptoms, and daily function in people with treatment-resistant schizophrenia or bipolar disorder. About 84 adults aged 18–…

This study tests whether intensive home-based psychiatric treatment can help children and teens with mental health disorders as an alternative to being in the hospital. Over 3 months, participants receive 3 to 7 home visits per week from a team of doctors, therapists, and other s…

This study tests a single-dose gene therapy called LY3884963 in 35 people with frontotemporal dementia caused by GRN gene mutations. The therapy aims to raise levels of a missing protein (progranulin) in the brain. Participants receive the treatment via injection into the fluid a…

This phase 2 trial tests whether rituximab, an anti-inflammatory drug used for conditions like multiple sclerosis, can improve symptoms in adults with schizophrenia spectrum disorders. About 123 participants aged 18-55 will receive rituximab or a placebo added to their usual trea…

This study tests whether a combination of dasatinib and quercetin, two drugs that clear out aging cells, can safely slow down accelerated aging in older adults with treatment-resistant depression or schizophrenia. Forty participants aged 50 and older will take the drugs and be mo…

This study tests whether a daily 10 mg pill called Xanamem can safely slow memory and function loss in people with mild or moderate Alzheimer's dementia. About 247 participants will receive either Xanamem or a placebo for 36 weeks, with an option to continue the drug for up to 10…

This study tests whether regular warm-water baths can improve blood sugar control and brain energy use in healthy adults aged 65 and older who are at risk for Alzheimer's disease. Over 10 weeks, 60 participants will soak in warm water three times a week. Researchers will measure …

This study tests a new drug called PRI-002 in 304 people with mild memory problems or early Alzheimer's. The drug aims to break apart harmful protein clumps in the brain that are linked to Alzheimer's. Researchers want to see if it is safe and can slow down memory and thinking de…

This study tests a drug called SHP611, given as a spinal injection, in 36 children with late infantile metachromatic leukodystrophy (MLD), a rare and severe brain disease. The main goal is to see if the treatment helps children keep their ability to walk and move for as long as p…

This study tests whether blood plasma from young, healthy, and very fit donors is safe and can help people with early Alzheimer's disease. Sixty patients aged 50-75 will receive monthly transfusions of either this 'exercise plasma' or a saltwater placebo over a year. Researchers …

This study tests whether a home-based program combining cognitive exercises (like puzzles) with mild brain stimulation can improve thinking and memory in older adults with mild cognitive impairment or late-life depression. About 40 participants will use the program at home with h…

This study tests whether deep brain stimulation (DBS) can improve thinking and memory in people with early Alzheimer's disease. Two participants will have electrodes implanted in a brain area that produces a key chemical for memory. The goal is to see if daily, one-hour stimulati…

This study tests a custom-made drug called an antisense oligonucleotide (ASO) designed for one person with dentatorubral-pallidoluysian atrophy (DRPLA), a rare genetic disorder that affects movement and brain function. The drug aims to reduce the harmful effects of the mutated AT…

This study tests a custom-made genetic medicine (called an antisense oligonucleotide) designed for one person with dentatorubral-pallidoluysian atrophy (DRPLA), a rare inherited brain disorder. The treatment aims to reduce seizures and improve quality of life. Only one participan…

This study tests whether lecanemab can slow memory and thinking decline in people with early Alzheimer's disease. About 1,900 participants received either the drug or a placebo for 18 months, followed by an open-label extension where everyone can get lecanemab. The main goal is t…

This Phase II trial tests whether high-dose vitamin D (4,000 IU daily) can correct deficiency and slow cognitive decline better than standard doses in 180 older adults aged 65-90. Participants include those with normal thinking, mild impairment, or early Alzheimer's. The study la…

This phase 2 trial is testing whether a combination of two drugs, dasatinib and quercetin, is safe and feasible for people with early-stage Alzheimer's or mild cognitive impairment. The drugs aim to clear aging 'senescent' cells that may contribute to brain damage. 48 participant…

This study tests whether offering financial rewards can help people with schizophrenia, bipolar disorder, or substance use disorder stick to their long-acting injectable medication after being forced into the hospital. About 1,000 participants will be randomly assigned to receive…

This study tests whether ATI-045 can safely reduce eczema symptoms like redness, itching, and skin patches in people with moderate-to-severe disease. About 110 adults who haven't had success with topical treatments will receive either the drug or a placebo. The main goal is to se…

This Phase 3 trial tests whether butylphthalide soft capsules can improve thinking, memory, and daily living skills in people with mild to moderate vascular dementia. About 707 participants are randomly assigned to receive either the drug or a placebo for 52 weeks. The study aims…

This study tests whether adding sodium benzoate (a common food preservative) to brain stimulation therapy can improve thinking and memory in people with early Alzheimer's or mild cognitive impairment. 140 participants will receive two weeks of brain stimulation and then 24 weeks …

This study tests a peer-facilitated program (Peer-RESIM) for adults who have had a first episode of psychosis. The program includes 10 sessions over 4 months, led by trained peer support workers, to help participants improve self-care and recovery. Researchers will compare this t…

This study tests a 10-session program called AIM-AT, which uses acceptance-based techniques to help people with recent-onset psychosis better understand their illness and stick to their medication. The trial involves 126 participants in Hong Kong and tracks their medication adher…

This study looks at how often older adults (62+) who are worried about memory loss should take dance or music classes to boost brain health and physical fitness. Over 6 months, 165 participants will attend 1, 2, or 3 group classes per week. Researchers will measure changes in mem…

This phase 2 trial tests whether glycerol phenylbutyrate (GPB) can slow corticobasal syndrome (CBS), a rare and fast-progressing brain disease. 32 adults with CBS will receive either GPB or a placebo for 26 weeks. The main goal is to see if GPB lowers levels of a nerve damage mar…

This early-phase study tests a lab-made protein (recombinant human serum albumin) in 30 people with mild to moderate Alzheimer's. Participants receive one of three doses to check safety and any effect on thinking skills. The goal is to see if this treatment can help control the d…

This study was designed to test whether a program called Lifestyle MIND can help people with serious mental illness (like schizophrenia or bipolar disorder) prevent or manage type 2 diabetes. The program includes group exercise and health classes twice a week for 10 weeks. Howeve…

This study tests lecanemab, an antibody that targets amyloid plaques in the brain, in 40 people who carry a gene mutation that causes early-onset Alzheimer's. Participants previously received another anti-amyloid drug and will now receive lecanemab to see if it can fully clear am…

This study tests whether adding daratumumab back to pomalidomide and dexamethasone can improve complete remission rates in 15 adults with relapsed or refractory AL amyloidosis who have already received daratumumab. Participants receive the three-drug combination to control the di…

This study tests whether a smartphone app that coaches older adults to eat more protein can help them maintain muscle mass and strength. Researchers will enroll 140 participants who are open to changing their diet and using an app. The app provides personalized nutritional coachi…

This study tests a surgical procedure that aims to improve the brain's waste-clearing system in people with Alzheimer's disease. The surgery involves relieving pressure on lymphatic vessels in the neck and connecting a lymph node to a vein to help drain harmful proteins. Research…

This study tests an experimental drug called ION363 in people with a rare, inherited form of ALS caused by FUS gene mutations. The goal is to see if the drug can slow the disease and help people live longer. About 89 participants will receive the drug via spinal injection. This i…

This study tests whether olive pomace oil, a type of olive oil, can lower brain inflammation in people with early-stage Alzheimer's. Researchers will give 40 Alzheimer's patients and 40 healthy adults meals containing either pomace oil or a different oil, then measure blood marke…

This phase 2 trial is testing whether adding a new drug called E2814 to the existing Alzheimer's drug lecanemab can better slow the disease in people with early Alzheimer's. The study involves 105 participants and will measure changes in tau protein levels in spinal fluid and bra…

This study tests whether experimental drugs can slow down memory and thinking problems in people who have a gene mutation that causes Alzheimer's disease. About 490 adults aged 18-80 with this genetic risk are taking either a study drug or a placebo. The goal is to see if the dru…

This study tests whether two drugs, E2814 and lecanemab, can slow the progression of Alzheimer's in people who carry a gene mutation that causes the disease. About 197 participants will receive either the drugs or a placebo over 2 to 4 years. Researchers will measure changes in t…

This phase II trial tests whether cannabidiol (CBD) capsules, added to standard antipsychotic medication, can help people with early schizophrenia recover better and stay on treatment longer. 180 participants receive either CBD or placebo for 26 weeks. The goal is to see if CBD i…

This study compares cannabidiol (CBD) to the standard antipsychotic risperidone in 64 adults with schizophrenia or related psychotic disorders who have used cannabis. The goal is to see if CBD can reduce psychotic symptoms and help people stop or cut down cannabis use. Participan…

This study tests a new medicine called ONO-2020 in 240 people with mild to moderate Alzheimer's disease. The goal is to see if it can safely improve memory and thinking skills. Participants will receive either the drug or a placebo for 26 weeks, and researchers will track side ef…

This program monitors 4000 people with schizophrenia who receive Zyprexa Relprevv, a long-acting injection. The goal is to track and reduce the risk of a rare but serious reaction called post-injection delirium/sedation syndrome (PDSS). Researchers will record how often PDSS happ…

This study tests a family-focused therapy for 220 youth aged 13-25 who show early signs of psychosis risk. The therapy aims to reduce symptoms and prevent the development of full psychosis over 18 months. Participants receive either the family therapy or a comparison treatment, w…

This study tests a program that uses a smartphone app, an activity tracker, phone coaching, and rewards to help adults in rural Kentucky eat more fruits and vegetables, cut down on fat, get more exercise, and spend less time on screens. About 279 participants will use the app and…

This study tests whether using focused ultrasound to temporarily open the blood-brain barrier can safely help standard antibody therapy reach the brain in people with mild Alzheimer's or mild cognitive impairment. About 15 participants will receive the combined treatment. The goa…

This study tests an experimental drug called DNL593 in healthy volunteers and people with frontotemporal dementia (FTD), a rare brain disease that causes personality changes and memory loss. The trial aims to check if the drug is safe, how the body processes it, and whether it mi…

This study tests a stem cell transplant method for people with inherited metabolic disorders and severe osteopetrosis. The goal is to get the donor cells to take hold while keeping side effects low. Participants receive chemotherapy drugs before the transplant to prepare their bo…

This study tests whether giving tranexamic acid before major gastrointestinal surgery can lower the chance of delirium (sudden confusion) after the operation. Delirium is common in older or sicker patients and may be caused by inflammation harming the brain. The trial includes 82…

This study tests a new drug called PMN310 in people with early Alzheimer's disease. The goal is to see if it is safe and if it can reduce signs of the disease in the brain. About 144 participants will receive multiple doses of the drug or a placebo. This is an early-phase trial, …

This large trial tests whether a program led by village doctors can help control high blood pressure in rural China. Over 33,000 participants will receive training, discounted medications, and a simple treatment protocol. The study aims to see if this approach improves blood pres…

This study tests whether nicorandil, a drug currently used for heart conditions, can help people with a type of dementia called hippocampal sclerosis of aging. This condition is often mistaken for Alzheimer's but has no approved treatments. The trial includes 64 older adults and …

This study tests whether a drug made from Ginkgo Biloba extract (Egb761) can lower a key Alzheimer's protein in the blood and improve thinking skills. Fifty adults with mild memory problems will take the drug twice daily for 6 months. The goal is to see if it can reduce brain dis…

This pilot study tests whether lamivudine, an antiviral drug used for HIV, can lower levels of brain-damage-related proteins in the blood of people with mild cognitive impairment (MCI) who also have early signs of Alzheimer's disease. Twenty-three participants will take lamivudin…

This study tests whether a computerized brain-training program can improve thinking skills in older adults (60+) who have type 2 diabetes and are at high risk for dementia. 120 participants will be randomly assigned to either adaptive cognitive training or a placebo version, both…

This study tests whether metformin, a widely used diabetes drug, is safe for people with a specific genetic form of ALS (C9orf72). Over 24 weeks, 41 participants will take metformin to see if it reduces toxic proteins linked to the disease. The goal is to determine if metformin c…

This Phase 3 study tests an injected drug called remternetug against a placebo in 1,400 people with early Alzheimer's who are at risk for worsening memory and thinking. The goal is to see if the drug can delay or prevent meaningful decline in daily function. Participants may be i…

This study tests whether treating severe gum disease can slow down Alzheimer's disease. Researchers will give 26 people with both conditions deep dental cleaning, extractions if needed, and oral hygiene training. Over 24 months, they will track memory, thinking skills, and brain …

This study is testing a new medicine called VY7523 in 52 people with early Alzheimer's disease. The goal is to see if the drug is safe and how it works in the brain. Some participants will get the drug, others a placebo, and the study lasts up to 12 months for the highest dose gr…

This study tests an experimental drug called GSK4527226 in 367 people with early Alzheimer's (mild memory problems or mild dementia). Participants receive either a low dose, high dose, or placebo through an IV. The goal is to see if the drug can slow down declines in memory and d…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study uses special brain scans (PET imaging) to measure amyloid buildup—a protein linked to Alzheimer's—in healthy older adults, people with mild memory problems, and those with dementia. Participants receive scans every 2-3 years for up to 20 years to see how amyloid change…

This large study tests whether a simple iPad-based cognitive test, called MyCog, can help primary care doctors detect early dementia and cognitive impairment in underserved communities. Over 57,000 older adults from 24 clinics will take the test during routine visits. The goal is…

This study explores whether a self-administered digital test called eSAGE, combined with information from electronic health records and machine learning, can help detect early signs of cognitive impairment, including dementia and Alzheimer's disease. Researchers will analyze data…

This study tests a new radioactive tracer called Fluselenamyl for PET scans to detect beta-amyloid plaques in the brain, a hallmark of Alzheimer's disease. Researchers will check its safety and how well it works in 60 healthy volunteers and people with mild cognitive impairment o…

This study aimed to see if a special fMRI scan (fMRI-SAM) could help detect Alzheimer's disease early. Researchers planned to compare brain activity in 25 people with Alzheimer's, 25 with mild memory problems (MCI), and 60 healthy adults. The goal was to find differences that mig…

This early-phase study tests whether a single injection of pramlintide, a diabetes drug, can temporarily increase levels of Alzheimer's-related proteins in the blood, potentially revealing early signs of the disease. Researchers will measure changes in beta-amyloid and tau protei…

This study compares a new ultra-high resolution PET/CT scanner, the NeuroEXPLORER, with standard clinical PET/CT scanners for imaging the head and neck. Researchers aim to see if the new device provides more detailed images to improve diagnosis of conditions like dementia, Parkin…

This study is developing a web-based app that analyzes how you speak and remember things to quickly detect early cognitive problems like dementia or Alzheimer's. Researchers will enroll 500 people (healthy adults over 45 and those already diagnosed with mild cognitive impairment …

Stanford University is developing a mobile app that uses video of a simple physical test (the Short Physical Performance Battery) to assess physical and cognitive function in older adults. The study will collect video data from 30 healthy volunteers to train the app's AI. The goa…

This study is looking for better ways to diagnose Parkinson's disease using samples that are easy to collect, like blood, skin, and nasal swabs. Researchers will compare these samples from 340 people, including those with Parkinson's, Alzheimer's, and healthy volunteers. The goal…

This study uses a special brain scan called DaTscan to look at how certain brain diseases affect the brain. Researchers will scan 500 adults with conditions like Parkinson's disease, dementia, mild cognitive impairment, or REM sleep behavior disorder. The goal is to see if DaTsca…

This study explores whether eye-tracking technology in a virtual reality headset can help identify schizophrenia, bipolar disorder, and depression. Researchers will compare eye movement patterns of 120 participants (including healthy controls) to find specific markers for each co…

This study is testing whether a blood test can identify people who have Alzheimer's-related brain changes, even if they have no memory problems. Researchers will enroll 2000 adults aged 50-80, some with risk factors like family history. The goal is to see if the blood test can ac…

This large study is testing a simple, low-cost digital screening tool called ToolboxDetect to help primary care doctors identify early signs of cognitive decline or dementia in adults aged 65 and older. Over 41,000 participants from diverse backgrounds will take a short computer …

This study tests a new app called RACS that helps primary care doctors screen older adults for early cognitive decline. The app includes risk questions, a symbol matching task, and voice tasks. Researchers will enroll 500 adults aged 60 and older to see if the tool is easy to use…

Researchers at Mayo Clinic are testing whether measuring brain stiffness with a special MRI scan (magnetic resonance elastography) can serve as a new biomarker for Alzheimer's disease. The study will enroll 450 adults, including healthy volunteers, people with mild cognitive impa…

This study compares two ways to sedate ICU patients who need a breathing machine: inhaled sedation (using isoflurane gas) versus standard intravenous (IV) sedation. The goal is to see if the inhaled approach reduces the chance of delirium—a state of confusion that often occurs in…

This study tests an 8-week group program called My Healthy Brain for adults aged 50 and older who have memory concerns but not dementia. The program teaches about lifestyle factors like exercise, sleep, and diet that may help prevent dementia. Researchers want to see if the progr…

This study tests whether metformin, a drug used for diabetes, can prevent Alzheimer's dementia in people with mild cognitive impairment (MCI). Over 18 months, 326 overweight adults aged 55-90 with MCI will receive either metformin or a placebo. Researchers will track memory, brai…

This study tests whether sulforaphane, a compound found in broccoli, can prevent psychosis in 300 people at high risk. Participants take either sulforaphane or a placebo daily for a year, then are followed for another year. The main goal is to see if fewer people in the sulforaph…

This study involves 60 young people at high risk for psychosis. They receive a stepped series of psychological treatments, starting with the least intensive options like group support, and moving to more intensive therapy if needed. The goal is to prevent the development of psych…

This study tests whether following the MIND diet for 2 to 3 years can slow cognitive decline and reduce dementia risk in people aged 55 and older who have had an ischemic stroke. The MIND diet combines elements of the Mediterranean and DASH diets, with extra emphasis on leafy gre…

This study tests whether a pharmacist-led program to stop certain medications (anticholinergics) can lower dementia risk in older adults. 344 participants aged 65+ who take these drugs will be followed for 2 years, comparing cognitive changes and quality of life between those who…

This 7-year study tests whether a combination of mild electrical brain stimulation (tDCS) and computer-based memory exercises can slow mental decline and prevent Alzheimer's dementia. It involves 375 older adults with mild cognitive impairment or depression (both risk factors for…

This study tests whether a combination of aerobic exercise, cognitive training, and turmeric (with black pepper) can prevent memory decline in adults aged 55-70 who have insulin resistance and self-reported memory concerns. Participants will follow a 24-week program, repeated aft…

This study tests a plant-based supplement called PhytoSERM in 100 women aged 45-60 who are in or just past menopause. The goal is to see if it can prevent changes in brain activity and thinking skills that often happen during this time. Participants take either the supplement or …

This study tests if a drug called dalargin can prevent serious organ problems like kidney injury, lung failure, or heart damage after major abdominal surgery. About 200 adults having high-risk surgery will get either dalargin or a placebo for 3 days. The goal is to see if dalargi…

This study tests whether donanemab, a monthly infusion, can delay or prevent memory and thinking problems in people who have early signs of Alzheimer's disease but no symptoms yet. About 3000 participants with a positive blood test for Alzheimer's-related proteins are being follo…

This study looks at whether memantine, a drug already used for Alzheimer's symptoms, might help prevent the disease in people at high risk. Researchers are testing it in 32 adults aged 50 to 65 who have a family history of dementia and carry the ApoE4 gene. The main goal is to se…

This study tests an online program called Luci that helps people aged 50 to 75 adopt healthier habits to lower their risk of dementia. The program provides educational materials, tips, and a personal coach to guide participants in improving physical activity, diet, and mental eng…

This trial investigates whether combining two types of brain stimulation—intermittent theta burst stimulation (iTBS) and high-definition transcranial direct current stimulation (HD-tDCS)—can reduce negative symptoms of schizophrenia, such as lack of motivation, social withdrawal,…

This study looks at whether pramipexole, a drug used for restless leg syndrome, can ease leg symptoms in women with X-linked adrenoleukodystrophy (ALD). About 24 women will take the drug or a placebo for two months. The goal is to see if it improves sleep, walking, and quality of…

This study tests a simple, drug-free approach to help people with moderate-to-severe dementia who struggle with eating. The experimental group receives a salivary gland massage combined with aromatherapy before meals for 20 days, while the control group gets a palm massage. Resea…

This study tests whether a structured conversation between people with dementia or mild cognitive impairment and their care partners can reduce difficult symptoms like agitation and depression. The idea is that when care partners better understand the person's everyday preference…

This study tests whether an 8-week internet-based mindfulness program (iMBSR) can improve brain health in adults aged 50 and older who have subjective cognitive decline, a potential early sign of Alzheimer's disease. Sixty participants will be randomly assigned to either the mind…

This study tests whether a device that plays brief, soft sounds during deep sleep can enhance brain wave activity in people with mild cognitive impairment due to Alzheimer's disease. Participants use the device at home each night for three months, with an optional three-month ext…

This study tests whether a special therapy using sights, sounds, touch, and other senses can help people with moderate Alzheimer's think clearer, feel calmer, and behave better. It also looks at whether this therapy reduces stress for their caregivers. Twenty-four people aged 65 …

This study tests a web-based support program called Hospital GamePlan4Care for caregivers of veterans with dementia who are discharged from skilled nursing facilities to home. Fifty-five caregivers will receive either the program (website, emails, and phone coaching) or basic hea…

This pilot study tests a mobile app called Brain CareNotes designed to reduce the burden on unpaid caregivers of people with Alzheimer's or related dementias who live in rural areas. About 60 caregivers will use either the Brain CareNotes app or a basic education app for six mont…

This study tests a behavioral program called SWITCH that teaches people with serious mental illness (like depression, schizophrenia, or bipolar disorder) to set goals, use rewards, and build habits to do more activities outside the home. 52 participants will attend weekly online …

This study tests whether a safe, painless brain stimulation technique called tDCS can improve verbal learning in people with Alzheimer's disease. Researchers will compare active stimulation to a sham (fake) version in 90 participants with typical or language-based Alzheimer's. Th…

This study tests whether a wearable light device can help improve sleep and daily rhythms in people with Alzheimer's who have sleep problems. Researchers will also use activity trackers and blood tests to better understand the disease. About 162 participants will try the light th…

This study tests whether adding cognitive training to balance and gait exercises helps people with Parkinson's disease improve their balance, walking, and thinking. Fourteen participants will undergo 12 sessions of combined training. The goal is to see if this approach eases move…

This study planned to test whether automated music therapy could help manage agitation and sleep problems in people with severe Alzheimer's living in nursing homes. An actigraph would detect sleep issues and trigger music sessions automatically. The trial was withdrawn before any…

This study looks at how well two drugs, haloperidol and lorazepam, can control severe agitation and confusion (delirium) in people with advanced cancer who are in palliative care. About 110 patients will be enrolled to compare different drug approaches. The goal is to improve com…

This study looks at whether special video games (serious games) that combine physical and mental exercises are a good value for managing Alzheimer's disease. About 136 people with mild to moderate Alzheimer's will either play these games with a therapist or receive usual care. Re…

This study tests a telemedicine program called FOCUS that helps advanced cancer patients manage common symptoms like trouble sleeping, worry, tiredness, and low mood. The program uses counseling techniques delivered through a phone app. Researchers will enroll 120 adults with adv…

This study tests two 18-month talk therapy programs—Cognitive Enhancement Therapy and Enriched Supportive Therapy—for people with schizophrenia who have lasting negative symptoms like low motivation and social withdrawal. About 90 outpatients aged 18-60 will participate. The goal…

This study tests whether virtual reality (VR) brain exercises can help people with schizophrenia or bipolar disorder think more clearly and function better in daily life. 80 adults will either receive VR training twice a week for 12 weeks or continue their usual care. Researchers…

This study tests whether combining music-based movement cues (patterned sensory enhancement) with mild brain stimulation can improve arm and hand function in people with corticobasal syndrome, a rare brain disorder. Twenty participants will be split into two groups: one receiving…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This study compares how honey versus table sugar, each paired with almonds, affects blood sugar levels, hunger, and fullness in 58 healthy premenopausal women. Participants will eat snacks containing honey or sugar with or without almonds, and their glucose will be tracked with a…

This study tests a new way to match dementia caregivers with each other for emotional support using a computer algorithm. Researchers want to see if matching based on personal preferences leads to better satisfaction and less stress than random matching. About 355 caregivers of p…

This study tests whether using a device that delivers light and sound stimulation for 60 minutes each day is safe and practical for people with mild Alzheimer's. Fifteen participants will use the device at home for 6 to 9 months. The main goals are to see if people can stick with…

This study tests whether a team of doctors, nurses, social workers, and community health workers providing palliative care at home can improve symptom control and reduce hospital visits for people with advanced dementia. About 153 patients and their family caregivers are taking p…

This study tests whether a more targeted form of transcranial magnetic stimulation (TMS) can help people with schizophrenia whose symptoms don't improve with medication. The treatment uses each patient's own brain wave frequency (alpha rhythm) and MRI scans to precisely stimulate…

This pilot study tests a live music therapy program called AMUSED for older adults with severe dementia living in care facilities. Participants attend small group sessions twice a week for 12 weeks, either with music therapy or a reading activity. Researchers want to see if music…

This study tests an experimental oral medication, ML-007C-MA, in 307 adults hospitalized with schizophrenia who are having a sudden worsening of psychosis. The goal is to see if the drug reduces symptoms like hallucinations and delusions better than a placebo. Participants take t…

This study looks at two medicines given before surgery to prevent delirium (confusion and agitation) in children aged 3 months to 9 years. One is a nose spray (dexmedetomidine), the other is a syrup (midazolam). The goal is to see which works better and is easier for kids to take…

This pilot study is testing a type of talk therapy called Metacognitive Interpersonal Therapy (MIT-ED) for adults with various eating disorders, including those who are underweight. The therapy aims to help people understand and manage the negative thoughts and feelings that driv…

This study tests a home-based exercise program for older adults with mild cognitive impairment or dementia. Participants play a specially designed game while a therapist supervises them remotely via telemedicine. The goal is to see if this approach can improve balance and thinkin…

This pilot study is testing whether taking 24 grams of whey protein daily for three months can improve brain antioxidant levels, physical function, and thinking skills in pre-frail adults aged 65 to 85. Twenty participants will be randomly assigned to receive either whey protein …

This study tests a special guide (Swedish Palliative Care Guide) to help nursing home staff provide better care for older adults, including those with dementia. The goal is to make sure residents and their families feel informed and secure about future care. About 400 people livi…

This study tests whether a virtual reality program that teaches mindfulness, self-compassion, and understanding others can help people with mood, anxiety, or psychotic disorders feel more at ease in social situations. Researchers are enrolling 174 college students and healthcare …

This pilot study tests whether a daily 15-minute massage plus guided relaxation with music can prevent delirium in critically ill patients. About 120 adults in the ICU will be randomly assigned to receive the relaxation intervention or standard care for up to five days. The main …

This small pilot study tests whether adding brain-wave feedback (EEG) to virtual reality therapy helps people with schizophrenia better tolerate and reduce distressing auditory hallucinations. Thirty adults with schizophrenia who hear voices will receive either VR therapy alone o…

This study tests whether an oral oil containing THC and CBD can reduce agitation in people with dementia who are eligible for hospice care. About 120 participants will receive either the active drug or a placebo for 12 weeks. The main goal is to see if agitation scores improve af…

This study tests whether a 20-week program of exercise alone or exercise combined with cognitive training can improve thinking and memory in breast cancer survivors. 108 women who have finished primary treatment will be assigned to one of three groups: dual-task training, exercis…

This study aimed to see if trazodone works better than quetiapine or a placebo for treating confusion (delirium) in adult surgical ICU patients. It planned to measure how long delirium lasts, sleep quality, and side effects. However, the study was withdrawn before enrolling any p…

This study tests a headset that delivers flashing lights and clicking sounds at 40 times per second (40 Hz) for one hour daily. Researchers want to see if this stimulation improves visual processing and thinking in 20 people aged 60+ with Alzheimer's disease. Participants will ha…

This study tests an online Emergency Preparedness Toolkit for caregivers of people with dementia. The toolkit helps caregivers find a backup caregiver so they can focus on their own health needs during an emergency. About 68 caregivers aged 55 and older who live with their partne…

This study tests a coaching program called CuRB-IT for family caregivers of people with dementia. The program includes 9 video sessions over 12 weeks to help caregivers manage care-resistant behaviors (like refusing help) and improve their own coping skills. About 266 caregivers …

This study planned to test a type of brain stimulation called intermittent theta burst stimulation on the precuneus area in people with resistant schizophrenia who had experienced childhood trauma. The goal was to see if it could reduce symptoms better than a placebo. However, th…

This study tests whether inhaling rosemary essential oil can improve memory, attention, and other thinking skills in healthy adults. 63 participants will either sniff rosemary oil or a placebo for 14 days and take brain tests before and after. The goal is to see if this natural r…

This study aimed to see if high-dose DHA (an omega-3 fatty acid) could reduce involuntary movements in people with tardive dyskinesia, a side effect of long-term antipsychotic medication. It planned to enroll 40 adults aged 30-75 with schizophrenia and tardive dyskinesia, giving …

This study tests an online program called SAGE LEAF that teaches positive emotion skills to family caregivers of people with dementia. Over 6 weeks, participants learn techniques like gratitude and mindfulness through short lessons and daily practice. The goal is to see if the pr…

This pilot study tested whether a non-invasive brain stimulation technique called tDCS could improve cognitive and motor functions in older adults with mild Alzheimer's disease living in supportive housing. Eleven participants received either real or sham stimulation over 10 sess…

This study tests whether D-serine, a natural brain chemical, can improve learning and memory in people with schizophrenia. Participants take D-serine or a placebo for 16 weeks while doing auditory training exercises. The goal is to see if D-serine helps the brain adapt and learn …

This study tests a 6-week online program called Learning Skills Together for family caregivers of people with Alzheimer's or related dementias. The program includes weekly group discussions and a workbook covering topics like communication, medication management, and home safety.…

This study tests whether watching 10-minute 360° nature videos twice a week for 12 weeks can improve quality of life, mood, and agitation in nursing home residents with dementia. Sixty residents will be randomly assigned to either the virtual nature program or their usual care. R…

This study tests a new, non-invasive brain stimulation technique called Temporal Interference Stimulation (TIS) in 40 people with early-stage Alzheimer's. Participants receive either real or sham stimulation for 2 weeks. Researchers will check if it improves thinking and memory r…

This study tests whether a non-invasive brain stimulation technique called paired associative stimulation (PAS) can improve memory and thinking in 150 older adults with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. Participants receive daily sessio…

This study tests whether special lights placed over doorways can help reduce nighttime falls in assisted living residents with Alzheimer's or related dementias. The lights are low-intensity and outline the bathroom or entry door, providing visual cues to improve balance. Research…

This study tests whether an accelerated schedule of transcranial magnetic stimulation (TMS) is safe and effective for treating symptoms of psychotic disorders like schizophrenia. About 20 adults aged 18-65 with schizophrenia, schizoaffective disorder, or at high risk for psychosi…

This study tests whether giving caffeine to adults aged 70 and older after major surgery can lower their risk of postoperative delirium—a state of sudden confusion. Researchers will compare low-dose and high-dose caffeine against a placebo in 250 participants. The goal is to see …

This study tests whether a non-invasive brain stimulation technique called tDCS can improve memory, attention, and thinking in older adults who have noticed their thinking is slipping. Twenty participants will receive either real or sham stimulation over several weeks. Researcher…

This study tests a structured care pathway for treating agitation and aggression in people with Alzheimer's disease. The pathway combines personalized activities with medication guidelines to reduce symptoms and avoid using too many drugs. Researchers will compare this approach t…

This study tests a new drug called NS-136 to see if it can ease schizophrenia symptoms. About 150 adults with schizophrenia will take either a low dose, a high dose, or a placebo pill daily for 5 weeks. Researchers will measure changes in symptom scores to check if the drug works…

This study tests whether shining near-infrared light on the head (a device called NirsCure) can safely help people with mild-to-moderate Alzheimer's disease. 38 participants will either get real light or a sham treatment for 16 weeks, then everyone can get the real light for up t…

This study tests a mobile app called iPREPARED that helps patients and their caregivers prepare for a hospital stay. The app provides videos and tips to prevent or reduce delirium, a sudden confused state common in older adults. Researchers want to see if the app is easy to use a…

This study tests an 8-week program that helps people with mild dementia and their caregivers identify and use their strengths. The program includes workshops and a biography activity led by trained volunteers. Researchers will measure changes in thinking skills and caregiver conf…

This study looks at whether a ketogenic diet (high-fat, low-carb) is practical and safe for people with early-stage Alzheimer's disease over one year. The diet may provide an alternative energy source for the brain and reduce inflammation. Researchers will track diet adherence, b…

This study tests a tablet-based app called the Digital Memory Notebook (DMN) to help older adults with mild memory problems or early Alzheimer's manage everyday tasks like appointments and medications. Twenty participants will learn to use the app over six weekly sessions, then c…

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This pilot study tests whether low-intensity focused ultrasound, guided by MRI, can safely and feasibly target a deep brain region (the thalamus) in people with treatment-resistant schizophrenia. Only 3 participants were planned, and the study is currently suspended. The goal is …

This small, early-stage study tested a high-CBD, low-THC liquid spray for 8 weeks in 12 older adults with mild cognitive impairment or mild-to-moderate Alzheimer's who also had significant anxiety or agitation. The goal was to see if the treatment could reduce these behavioral sy…

This study tests whether a non-invasive brain stimulation technique called theta-burst stimulation (TBS) can improve cognitive function in people diagnosed with young-onset Alzheimer's disease (before age 65). Seventy participants will receive TBS to a specific brain area, and re…

This study tests a 12-week program called PERSEVERE for 502 family caregivers of people with Lewy body dementia (LBD). Caregivers are matched with a trained peer mentor who guides them through lessons on LBD and provides support. The goal is to see if this reduces caregiver strai…

This study tests if learning memory techniques (like mnemonics) can improve thinking and memory in adults over 50 who have mild memory concerns. 80 participants will either take memory training or just get information. The goal is to see if training helps and if benefits last up …

This study tests whether giving haloperidol alone or with chlorpromazine can safely calm severe agitation and confusion (delirium) in 70 advanced cancer patients in a palliative care unit. The main goal is to see if the drugs improve sedation scores within 24 hours. It is a phase…

This study tests a website tool called WeCareToFeedDysphagia to see if it reduces stress and burden for people caring for older adults with Alzheimer's disease or related dementias who also have trouble swallowing. About 800 caregivers will be split into two groups: one gets acce…

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This study looks at whether a gentle brain stimulation technique (tDCS) combined with a special exercise program can reduce symptoms of spinocerebellar ataxia, a disease that affects coordination and balance. Fifteen adults who can walk (with or without help) will receive either …

This study tests whether teaching older adults with early-stage dementia how to use aromatherapy through augmented reality (AR) can improve their mood and behavior. 300 participants in Taiwan will either receive AR-based aromatherapy education or standard activities. The goal is …

This study looks at whether online community support and telemedicine can improve quality of life for people with Parkinson's disease, Lewy body dementia, and related conditions, as well as their caregivers. About 632 participants will receive palliative care training for their d…

This study compares two exercise programs for adults aged 65 and older living in residential care. One group does short, frequent 'exercise snacks' twice a day, while the other does longer, structured sessions a few times a week. Over 12 weeks, researchers will measure changes in…

This study tests whether daily exposure to a flickering gamma light is safe and tolerable for people with Parkinson's disease who experience freezing of gait—a sudden inability to step forward. Researchers will monitor side effects and see if the light therapy reduces freezing ep…

This study tests a set of virtual reality exergames in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. 25 participants will try games like virtual cooking an…

This study tests whether coaching for people with dementia and their caregivers can improve care and reduce future emergency room visits. About 19,200 participants aged 66 and older with Alzheimer's or related dementias will receive different combinations of support after an ER v…

This study tests whether monthly nurse-led coaching sessions over a year can help people with mild cognitive impairment or dementia and their caregivers. Researchers will track symptoms, quality of life, and how well care plans are documented. The goal is to improve supportive ca…

This study compares two approaches to help stroke survivors with mild to moderate thinking problems. Both groups use a web-based computer game that trains how quickly they process information. One group also gets in-lab training on everyday activities, while the other focuses on …

This pilot study tests whether a telehealth program called HOBSCOTCH-PACS can help people with long COVID manage memory and thinking problems. Ten participants will attend nine virtual coaching sessions and complete questionnaires about their quality of life and cognitive functio…

This study tests whether a type of talk therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) can improve sleep and daily functioning in veterans who have both psychosis and insomnia. About 152 veterans are taking part. The goal is to see if better sleep leads to bette…

This study tests whether wearing a special helmet that shines near-infrared light on the head can help brain cells work better and protect themselves. About 100 people with early to mid-stage dementia will wear the helmet regularly for 8 weeks. Researchers will check memory, thin…

This study looks at whether adding lorazepam to haloperidol can better reduce delirium (sudden confusion and agitation) in people with advanced cancer who are in a palliative care unit. About 93 participants will receive either haloperidol alone or with lorazepam, and their level…

This study tests whether virtual reality (VR) reminiscence therapy can reduce behavioral problems and improve quality of life in 50 nursing home residents with mild to moderate Alzheimer's disease. Participants will use VR to explore familiar heritage sites, aiming to trigger pos…

This study from Yale University will test whether listening to live music can reduce anxiety and improve brain activity in people with early Alzheimer's disease, dementia, or mild cognitive impairment, along with their caregivers. Sixty pairs (patient and caregiver) will attend b…

This study tests a group version of the Feeling Safe Programme, a type of cognitive behavioral therapy for people with schizophrenia or schizoaffective disorder. The goal is to reduce distressing symptoms like paranoia and hallucinations and improve quality of life. Fifty partici…

This study tests whether playing a child's favorite music before and during ear tube surgery can reduce confusion and agitation when they wake up. Researchers will enroll 160 children ages 3 to 9. The goal is to see if personalized music makes recovery smoother and less distressi…

This study tests whether adding group mindfulness-based therapy to usual treatment helps people with serious mental illnesses like schizophrenia, bipolar disorder, or major depression. Researchers will randomly assign 160 patients to either usual care alone or usual care plus min…

This study looks at whether weekly choir singing can reduce loneliness in people with dementia and their family caregivers. About 100 people will join dementia-friendly choirs for 12 weeks, with breaks and follow-ups. Researchers will measure loneliness, mood, and caregiver burde…

This phase 2 study tests whether SPG302, a small synthetic molecule, can safely reduce schizophrenia symptoms in adults. 32 participants will receive either the drug or a placebo. Researchers will measure symptom severity, brain activity, and eye tracking to see if the drug works…

This study is testing a device called MemorEM, which is a cap that sends low-level electromagnetic waves to the head. The goal is to get feedback from 1,000 patients with neurological diseases like Alzheimer's or Parkinson's, and their caregivers, on how easy the device is to use…

This study looked at whether sunlight exposure therapy could improve sleep problems in people with Alzheimer's disease. Sixty participants with mild Alzheimer's and sleep issues received a health education plan on sun exposure and were followed for 14 days. The goal was to see if…

This study tests a 15-session creative writing program called REWRITALIZE for people with serious mental illnesses like schizophrenia, bipolar disorder, or severe depression. About 300 adults will either join the writing groups plus their usual care, or stay on a waiting list wit…

This study tests a special therapy program delivered over the internet for people with mild cognitive impairment or dementia who also feel anxious. The program uses cognitive behavioral therapy (CBT) techniques to help manage worry and fear. Researchers will measure changes in an…

This study tests whether berberine, a natural compound, can safely improve negative symptoms of schizophrenia—like low motivation and emotion—that current medications often miss. Researchers will give berberine or a placebo to 120 Han Chinese adults with stable schizophrenia and …

This study tests whether wearing bright light glasses can improve sleep, thinking, and physical strength in older veterans. The glasses emit a special blue light that may help reset the body's internal clock. Researchers will measure sleep quality, balance, and coordination in 43…

This study tests a group therapy called Awareness, Courage, and Love (ACL) for older adults with psychiatric disorders who feel lonely. The therapy focuses on mindfulness, sharing feelings, and building connections. Researchers want to see if the program is practical and helpful …

This study tests a program called FACE-Rare, designed to support family caregivers of children with rare, life-limiting diseases. The program includes three sessions to help families prepare for future medical decisions and improve their quality of life. Researchers will compare …

This study aimed to see if a dissolvable film placed under the tongue could quickly calm agitation in people with bipolar disorder or schizophrenia who come to the emergency room. The drug, BXCL501, is already approved for this use, but the study wanted to test it in the ER setti…

This early-stage study tests whether two drugs, dasatinib and quercetin, are safe and practical for people with mild cognitive impairment or Alzheimer's disease. The drugs aim to clear aging cells that may contribute to brain decline. Twenty participants aged 55 and older will be…

This study looks at whether acupuncture can help people with schizophrenia feel better by reducing side effects from their medication and improving psychiatric symptoms. About 100 participants will receive acupuncture twice a week for four weeks. Researchers will measure anxiety,…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can improve memory and mood in adults aged 60-80 who have subjective cognitive decline (worries about memory) and depression. Eighty-six participants will receive either real or sham e…

This study tests whether a mild electrical current applied to the scalp (tDCS) before computer-based cognitive training can improve thinking skills like memory and attention in people with schizophrenia. 120 adults aged 18-65 will receive either real or fake tDCS for 20 minutes, …

This study tests whether partnered dance aerobic exercise can reduce 'OFF-time' (when Parkinson's medication stops working well) and improve thinking skills. Researchers will enroll 82 people with Parkinson's who experience OFF-time. Participants will take dance classes twice a w…

This study tests whether two different essential oil blends can reduce agitation (sundowning) and improve sleep in 35 people with dementia living in long-term care. Participants receive a stimulating morning blend and a relaxing afternoon blend, then a calming all-day blend, each…

This small study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can improve thinking and memory in people with early-stage Alzheimer's disease. Six participants will receive either real TBS or a sham (fake) treatment to see if the re…

This study tests a new, non-invasive treatment using low-intensity ultrasound to stimulate a deep brain area (the hippocampus) in older adults with mild memory and sleep problems. The goal is to see if it safely improves sleep quality and thinking skills. Twenty participants aged…

This pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease. Ten participants will work one-on-one with a coach in nine virtual sessions to learn problem-solving strategies and memory a…

This study tests a 12-session personalized program for adults 65 and older who have fallen at least once in the past year. The program focuses on balance, safe walking, home adjustments, and activities that matter to each person. Researchers will measure improvements in balance, …

This study tests a new, non-invasive treatment called transcranial photobiomodulation (t-PBM) for people with mild cognitive impairment or early Alzheimer's disease. 196 participants aged 65-85 will receive either real or fake light therapy to the forehead for 8 weeks. The goal i…

This study tests whether a probiotic called PS23 can improve thinking and quality of life in people aged 50-85 who feel their memory is slipping but don't have dementia. Forty participants will take one capsule daily for 12 weeks, and researchers will measure changes in computer-…

This study tests a therapy called imagery rescripting in 8 people with early psychosis. Participants imagine a different, more positive outcome to their traumatic memories. The goal is to see if this improves core beliefs, wellbeing, and self-esteem. It is a very small, early-pha…

This study explores whether a simple music activity—tapping along to rhythms together—can improve social attention and feelings of closeness in people with frontotemporal dementia or Alzheimer's disease, and their caregivers. Eighty patient-caregiver pairs will participate in a c…

This study tests whether a gentle electrical brain stimulation technique called tDCS, combined with cognitive training on a tablet, can reduce apathy in older adults with mild cognitive impairment. Apathy is a lack of motivation and interest that can affect daily life. The trial …

This study tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can improve movement in people with degenerative ataxia, a rare condition that damages the cerebellum and impairs balance and coordination. Sixteen participan…

This early-phase study tests whether a noninvasive technique called transcranial focused ultrasound (tFUS) can improve memory in people with mild neurocognitive disorder and in healthy older adults. Using MRI guidance, the device sends sound waves to specific brain areas. The tri…

This study tests whether a 12-week mobile app program can improve thinking skills and motivation in people with early psychosis. About 400 participants already receiving coordinated specialty care will either use the app or continue standard care. Researchers will track changes i…

This pilot study tests a home-based program called HOBSCOTCH, designed to help people with multiple sclerosis manage memory and thinking problems. Eleven participants will attend virtual coaching sessions and complete questionnaires about their quality of life and cognitive funct…

This study tests two types of speech therapy for people with primary progressive aphasia, a brain disorder that slowly destroys language skills. Sixty participants will work on word retrieval or script practice with a clinician and at home. Researchers will measure changes in com…

This study tests whether a ketogenic diet—low in carbs, high in fat—can reduce symptoms in people with schizophrenia or schizoaffective disorder. Fifty adults will be randomly assigned to either the ketogenic diet or a regular diet for several weeks. Researchers will measure chan…

This study follows 25 people with spinocerebellar ataxia type 7 (SCA7) for up to 5 years to learn how the disease changes vision, coordination, and thinking. Participants will have yearly eye exams, brain scans, and neurological tests. No treatment is given; the goal is to gather…

This study looks at whether a special recovery program can help older adults (65+) who experienced confusion (delirium) after emergency surgery. Participants will have virtual visits with a care coordinator and complete physical, cognitive, and psychological assessments over 18 m…

This study follows 125 people with Parkinson's disease or related conditions over two years. Researchers use special brain scans to measure changes in a chemical called acetylcholine, which is linked to walking problems, falls, and thinking skills. The goal is to understand how t…

This study investigates cognitive problems in intensive care patients with acute respiratory distress syndrome (ARDS) who develop delirium (sudden confusion). Researchers use a non-invasive EEG cap and auditory tests to measure brain activity at the bedside. The goal is to identi…

This study aimed to see if Alzheimer's disease affects the nerves in the gut, similar to what happens in Parkinson's disease. Researchers planned to take extra colon biopsies during routine colonoscopies from people with Alzheimer's, Parkinson's, and healthy individuals to compar…

This study looks at whether intensive computer-based brain exercises can improve memory, attention, and problem-solving in people who have had a brain injury. Thirty adults aged 25-65 with mild cognitive problems will train on a computer for 45-60 minutes a day, five days a week,…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study is creating a learning healthcare system for OnTrackNY, a program that helps young people (ages 16-30) who have recently experienced psychosis. Researchers will collect data and feedback from participants, families, and clinicians to continuously improve care. The goal…

This study investigates factors that may influence cognitive skills—like memory, attention, and problem-solving—in women diagnosed with fibromyalgia. Researchers will assess thinking abilities using a detailed cognitive test and measure how fibromyalgia affects daily life. The go…

This study looks at how adults at risk for Alzheimer's disease react after learning their amyloid and tau biomarker test results. Researchers will track changes in distress, stigma, quality of life, and future planning over time. The goal is to understand the psychological and be…

This study tests whether an AI tool that uses electronic medical records can help predict and reduce delirium (sudden confusion) in older adults after major surgery. About 60 people aged 65 and older will take part. The goal is to see if giving doctors a delirium risk alert can l…

This study tracks a protein called neurofilament light chain in the blood of 342 people who carry genetic mutations linked to frontotemporal dementia (FTD). Participants provide blood samples every three months for three years, often from home. The goal is to see if this biomarke…

This study uses MRI scans to look at the brains of children and adults with conditions like ADHD, autism, schizophrenia, and endocrine disorders, as well as healthy volunteers. Researchers aim to compare brain anatomy and function across different groups and ages. The goal is to …

This study follows 1,500 volunteers with normal memory, mild cognitive impairment, or Alzheimer's over several years. Researchers use brain scans, memory tests, and blood samples to track how the disease progresses. The goal is to find better ways to diagnose and treat Alzheimer'…

This study is observing 217 people with ALS and related conditions like frontotemporal dementia and hereditary spastic paraplegia. Researchers aim to connect each person's genetic makeup with their symptoms and find biological markers in blood and spinal fluid. No new treatments …

This study looks at people with ALS and similar diseases like frontotemporal dementia and hereditary spastic paraplegia. Researchers want to understand how genes affect the disease and find biological markers (biomarkers) to help develop future treatments. About 708 participants,…

This study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study enrolls people with ALS and related disorders, as well as healthy volunteers, to track biological markers (biomarkers) in urine, blood, and spinal fluid. The goal is to better understand how these markers change over time, which could help design more effective future …

This study tests a 10-week program called 'Grow to Recovery' for people with mental illness. The program is co-led by a peer (someone who also has a mental illness) and a professional. Researchers want to see if it helps participants feel more hopeful and capable. 138 people are …

This study uses a special PET scan to look at tau protein buildup in the brains of African Americans who are either cognitively normal or have dementia. Researchers hope to learn how these brain changes differ across racial groups. The study involves 240 participants and uses a t…

This study uses brain scans and behavioral data from 267 adults (80 with autism, 79 with schizophrenia, and 108 healthy controls) to explore shared brain activity patterns related to social thinking. No new treatments are given; researchers analyze existing data to understand how…

This study tests a new radioactive compound called F 18 T807 that lights up tau tangles in the brain during a PET scan. Researchers want to see if the amount of tau relates to memory and thinking problems in people with a rare, inherited form of Alzheimer's disease. About 130 adu…

This study uses a radioactive tracer called [18F]MK-6240 to take detailed pictures of tau protein clumps in the brain, a hallmark of Alzheimer's disease. Researchers will scan 200 people from families with a rare genetic form of Alzheimer's to see how tau buildup changes over tim…

This study follows 600 mentally ill offenders in Italy and California over three years to compare two very different treatment systems. Italy uses community-based care, while California relies on long-term hospital stays. Researchers will track violence, recovery, and functioning…

This study is trying to find ways to diagnose chronic traumatic encephalopathy (CTE) in living people. Right now, CTE can only be confirmed after death. Researchers will study 350 former college and professional football players, using memory tests and other biomarkers. The goal …

This study aimed to see if personalized computer-based brain exercises could improve thinking skills in adults with HIV who have mild memory or attention problems. Researchers planned to enroll 120 people aged 40 and older, giving half of them training focused on their weakest me…

This study follows 640 adults with normal cognition, mild cognitive impairment, or Alzheimer's disease to track brain changes over time. Researchers use advanced brain scans and genetic tests to understand how Alzheimer's develops. The goal is to find better ways to diagnose and …

This study looks at how gut bacteria change when young people (ages 12-35) with psychosis start taking antipsychotic medication. Researchers want to see if these changes are linked to weight gain and other metabolic problems. Participants provide stool and blood samples over 12 w…

This study uses special PET/CT scans to measure inflammation in the brains of people with Alzheimer's disease or Lewy body dementia. Researchers want to see if brain inflammation is linked to memory decline and other dementia symptoms. The study also tests a new radioactive trace…

This study looks at how stress influences long-term mood and thinking in 75 older adults with depression. Participants receive standard antidepressant treatment while researchers track their depression severity, memory, and brain activity using MRI scans. The goal is to understan…

This study looks at whether improving sleep through cognitive behavioral therapy (CBT-I) can reduce neuropsychiatric symptoms like anxiety, depression, and agitation in 150 older adults with mild cognitive impairment or early Alzheimer's. Participants are randomly assigned to CBT…

This study looks at whether adults aged 65 and older with memory concerns can collect a small blood sample at home to check for Alzheimer's disease risk. Participants will use a simple device to draw blood, mail it to a lab, and get results from a doctor over video. The goal is t…

This study explores whether smartphone sensors can detect early changes in behavior that might signal cognitive decline. About 100 adults aged 65 and older living in assisted living facilities will have an app on their phones that tracks movement, typing patterns, and app usage f…

This Stanford study is testing whether non-intrusive sensors placed in the home can automatically track neuropsychiatric symptoms like mood changes and agitation in older adults. Researchers will enroll 25 participants with or at risk of mild cognitive impairment or dementia, alo…

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with clinical information to build machine learning models that might one d…

This study enrolls 500 adults with a sleep condition called REM sleep behavior disorder (RBD), which often leads to Parkinson's disease or related brain disorders. Researchers will track symptoms like thinking, movement, and smell to develop a rating scale. The goal is to prepare…

This study explores whether playing quiet sounds during a nap can help normalize brain activity and improve memory in people with schizophrenia. Researchers will compare memory and sleep patterns in 70 participants (healthy controls and schizophrenia patients) under two condition…

This study looks at how thinking, memory, and movement change in older adults with conditions like dementia or Parkinson's disease. Researchers will use tests, brain scans, and lab samples to find clues for earlier diagnosis and better care. About 260 people, including healthy vo…

This study looks at how certain genes influence the activity of immune cells in the brain, called microglia, in people with Alzheimer's disease. Researchers will use a special PET scan to measure these cells in about 107 older adults, some with mild memory problems or Alzheimer's…

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study uses a special brain scan called PIB PET to look at different types of dementia in people with Parkinson's disease. The goal is to find out who might develop dementia and what causes it. Researchers will study 320 participants to better understand these brain changes.

This study is testing a new way to analyze MRI brain scans, called Cortical Disarray Measurement (CDM), to see if it can help diagnose Alzheimer's disease more accurately. Researchers will follow 400 people with mild memory or thinking problems over time, comparing CDM results wi…

This study looks at whether restoring chewing ability through dental procedures can improve memory and thinking in adults aged 65-80. Eighty participants with chewing problems will be randomly assigned to receive dental rehabilitation either immediately or after a waiting period.…

This study tests three new imaging agents (18F-RO948, 18F-MK6240, and 18F-GTP1) to see how well they detect tau protein buildup in the brains of people with Alzheimer's disease compared to healthy older adults. About 38 participants aged 50-100 will receive PET scans to compare t…

This study was designed to see if a smartphone app called iBlink can measure how well the brain learns new movements in people with spinocerebellar ataxia, a rare and serious movement disorder. Researchers planned to compare aerobic exercise with balance training to see which bet…

This study looks at whether a web-based education program can boost brain health knowledge in older adults (60+) before elective non-cardiac surgery. Researchers will measure changes in knowledge scores after patients complete the online module. The goal is to help patients and f…

This study uses advanced MRI scans and genetic tests to track how neurodegenerative diseases like frontotemporal dementia and ALS spread across the brain's network. Researchers will follow 645 participants, including patients, family members, and healthy controls, for up to 2 yea…

This study looks at health records and insurance claims from nearly 7,000 adults in the U.S. who take KarXT for schizophrenia. Researchers want to understand who gets the drug, how it's used, and how often people need hospital visits. The goal is to see how the medication works i…

This study looks at a small part of the brain called the locus coeruleus, which may be one of the first areas damaged in Alzheimer's disease. Researchers will use brain scans, eye tracking, and a mild nerve stimulation device to measure how this area affects attention and memory …

This study uses brain imaging techniques like MRI and EEG to explore how brain lesions cause cognitive deficits such as reading or visual perception problems. Researchers will study 1,500 patients and healthy volunteers using a detailed single-case approach. The goal is to better…

This study aimed to understand how blood pressure changes when standing up affect thinking abilities and brain blood flow in people with Parkinson's disease. Researchers planned to compare participants with and without orthostatic hypotension (low blood pressure upon standing) us…

This study at Yale University looks at how THC, the active ingredient in cannabis, affects short-term and long-term memory. Researchers will give 80 adults who have used cannabis before either a low dose of THC or a placebo and then test their memory. The goal is to better unders…

This study planned to use a gentle brain stimulation technique called tDCS to see if it could help people with schizophrenia who have negative symptoms (like lack of motivation or emotion). Researchers wanted to use brain scans to understand how it works. However, the study was w…

This study looks at how things like social support, income, and health habits are linked to mental health and brain diseases such as depression, Alzheimer's, and Parkinson's. Researchers will collect surveys, blood samples, and optional brain scans from over 1,300 adults in Europ…

This study follows 100 people aged 60-85 with mild memory or movement problems to see if losing smell, hearing, or balance speeds up cognitive decline. Researchers will test these senses and track thinking skills and quality of life for 5 years. The goal is to understand which se…

This study aims to validate Turkish versions of two short knowledge scales about dementia and urinary incontinence for older adults living in the community. Researchers will enroll 230 people aged 55 and older to test how well the scales work. No treatments or interventions are i…

This study was designed to test whether scheduled video calls with a nurse could help family members who make medical decisions for hospitalized older adults with Alzheimer's or similar cognitive issues. The goal was to improve communication and reduce anxiety and depression. How…

Researchers at Stanford are creating a database to better understand why some older adults experience memory or thinking problems after surgery with anesthesia. They will collect information from 250 patients aged 65 and older, including blood samples, brain wave recordings, and …

This study follows 400 people with advanced dementia and their caregivers in Singapore to understand the care, costs, and challenges at the end of life. Researchers survey caregivers every 4 months and review medical bills to track quality of life, caregiver burden, and healthcar…

This study aims to translate and test a cognitive assessment tool called the ECCA (Electroconvulsive Therapy Cognitive Assessment) into Turkish. The ECCA is designed to measure memory, attention, and other thinking skills that can be affected by electroconvulsive therapy (ECT), a…

This study is creating a simple test to check if people with Alzheimer's or similar conditions can understand and agree to medical decisions. Researchers will work with 100-150 participants to compare the new test with existing methods and look at brain scans and blood markers. T…

This study uses special PET scans to look for signs of inflammation in the brains of people with Alzheimer's disease or mild cognitive impairment, compared to healthy volunteers. Nine participants will receive an investigational radioactive tracer called [18F]NOS, and some may al…

This study adapts a program called Youth-Nominated Support Team (YST) for suicidal adolescents who are at high risk for psychosis. The goal is to see if having a personally chosen support team helps these teens feel more connected, hopeful, and engaged in treatment. About 70 part…

This study explores how non-invasive brain stimulation can help understand and treat agitation in people with Alzheimer's and mixed dementia. Researchers will use transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to study brain activity, and test whether tr…

This study is building an online platform called DBS MatchMaker to connect doctors around the world who treat rare movement disorders with deep brain stimulation (DBS). The goal is to help doctors share knowledge and find the best ways to treat patients. Up to 500 people of all a…

This study follows over 6,600 elderly patients (aged 60+) who had major surgery to see if lighter anesthesia helps them live longer. The original trial found no difference in survival at one year, but this follow-up checks for effects beyond that, including on cancer recurrence a…

This study tests a brain stimulation technique called paired associative stimulation (PAS) using transcranial magnetic stimulation (TMS) in 72 adults with schizophrenia. The goal is to see if daily sessions over two weeks can improve working memory, as measured by a letter-matchi…

This study looks at whether stopping overnight neurological checks in stroke patients can help prevent delirium, a common and serious complication. Researchers will compare patients who continue standard overnight checks with those who have them stopped, measuring rates of deliri…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study uses special brain scans (PET imaging) to measure two key proteins, amyloid and tau, in people with different forms of Alzheimer's disease. Researchers want to see how these protein levels change over one year. The study involves 60 adults with typical or atypical Alzh…

This study is creating a registry of 452 adults with a family history of Alzheimer's or early memory problems. Researchers will track their health, blood markers, and thinking skills over time to see if personalized care plans can help prevent or treat the disease. The goal is to…

This study looks at how age-related sleep changes and sleep apnea might increase the risk of Alzheimer's disease. Researchers will use brain scans and overnight sleep tests in 158 healthy adults aged 55-75 to measure amyloid buildup and sleep patterns over two years. The goal is …

This study aims to create more sensitive cognitive tests for Huntington's disease by combining brain imaging (PET and MRI) with blood markers. Researchers will study 90 participants—healthy controls, pre-symptomatic gene carriers, and early-stage patients—to understand how brain …

This study tests a program to help older adults (65+) safely reduce unnecessary medications that may cause harm. Researchers will use a risk-prediction tool to identify high-risk participants and then guide their doctors to deprescribe. The goal is to see if this approach is prac…

This study tests whether personalized digital coaching helps people stick to brain-healthy habits like exercise, diet, and sleep. 120 adults at risk for cognitive decline will be assigned to generic education, a digital platform, or the platform plus health coaching. The goal is …

This study was designed to test a wearable sensor system that tracks how people walk on different surfaces like grass, pavement, and stairs. It aimed to include healthy volunteers and people with conditions such as Parkinson's disease, dementia, stroke, multiple sclerosis, or low…

This study from Mayo Clinic is creating a large collection of blood, urine, stool, spinal fluid, and skin samples from 1000 people with ataxia and related genetic diseases, plus their healthy family members. The goal is to better understand the genetic and physical features of th…

This study looks at data from 1 million adults worldwide to see if eating nuts is linked to a lower risk of diseases like diabetes, heart disease, cancer, and dementia. Researchers will combine information from many past studies to get clearer answers. The goal is to understand i…

This study tests a 4-month program that combines memory strategies with fun leisure activities like music or Spanish lessons, plus brain games. It involves 144 adults who feel their memory is getting worse but still test in the normal range. The goal is to see if this approach ca…

This study follows 135 people with Lewy body dementia over up to 5 years, using special PET scans to measure brain changes linked to memory and thinking decline. Researchers hope to find imaging markers that show how the disease progresses. Participants will have regular tests an…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This pilot study tests whether keeping blood pressure higher than usual during and after major surgery can reduce serious complications like heart attack, kidney injury, and confusion. About 80 adults aged 45 and older who take blood pressure medication and are having long surger…

This study translates a scale that measures how thinking difficulties affect daily life in people with Parkinson's disease into Turkish. Researchers will test the translated version in 60 Turkish-speaking Parkinson's patients to see if it is valid and reliable. The goal is to giv…

This observational study will enroll 100,000 people over age 45 to track early signs of Alzheimer's and Parkinson's using smartphone-based tests, genetic data, and brain scans. Researchers aim to develop better ways to identify who is at risk before symptoms worsen. Participants …

This study follows 567 ICU survivors to see how their brain function changes over up to 12 years. Researchers will use brain scans, spinal fluid tests, and brain donations to find out why some people develop dementia after critical illness. The goal is to learn the causes of post…

This study aimed to see how common delirium is in children in the pediatric intensive care unit (PICU) by using a French version of a screening tool called the Cornell Assessment of Pediatric Delirium (CAPD). The plan was to check each child twice a day during their stay. However…

The ALOHA study is a community-based research project for adults aged 50 and older in the Washington, D.C., Maryland, and Virginia area. Over five years, participants receive annual health assessments—including physical and cognitive tests—and get a personalized 'Health Passport'…

This study looks at what happens when healthy older adults learn their personal five-year risk of developing Alzheimer's dementia. Researchers are giving 450 participants their risk estimates at different times and tracking changes in mood, thinking, and distress. The goal is to …

This study uses health records from about 100,000 people in Israel to see if past viral infections (like Epstein-Barr, COVID-19, or herpes) increase the risk of developing mental illnesses such as depression, anxiety, bipolar disorder, or schizophrenia. It also looks at whether i…

This study follows 110 people with brain metastases who are receiving either focused or whole-brain radiation. Researchers use advanced MRI scans and memory tests before treatment and for two years after to see if the scans can predict thinking and memory problems. The goal is to…

This study uses a portable 48-hour EEG monitor to check for hidden seizures in people with early-onset Alzheimer's disease (ages 40-64). Researchers want to learn how common seizures and epilepsy are in this group. The study involves 20 participants and is purely observational, m…

This study looks at whether it's possible to track memory and thinking changes in adults aged 65 and older who are starting a new type of cancer treatment called immune checkpoint inhibitors. Thirty participants will take simple memory and concentration tests every six weeks for …

This study aims to test a risk assessment screening and a caregiver coaching program to prevent elder abuse in people with dementia. Researchers will compare caregivers who receive the screening and coaching to those who do not, looking at stress, depression, and anxiety. The goa…

This long-term study uses yearly brain scans, genetic tests, and thinking/memory assessments to track changes in nearly 1,800 people with various dementias (like Alzheimer's and vascular dementia) and over 140 healthy older adults. The goal is to better diagnose, monitor, and eve…

This study is testing a new, low-cost eye scanner to see if it can take clear pictures of the retina, the light-sensitive layer at the back of the eye. Researchers will compare images from this device with those from a standard, expensive scanner. They will also measure the thick…

This study looks at how certain hormone therapies for advanced prostate cancer might affect memory, thinking, and brain structure. Researchers will use brain scans and thinking tests in 100 men to track changes over time. The goal is to understand which patients are more likely t…

This study was designed to measure body temperature patterns in people with first-episode psychosis compared to healthy individuals. Researchers wanted to see if temperature differences relate to psychotic symptoms. However, the study was withdrawn before enrolling any participan…

This study was designed to see if a tracking system called Care Companion could help family caregivers of people with dementia who are at risk of wandering. The study was withdrawn before any participants were enrolled, so no results are available. It would have asked caregivers …

This study is analyzing blood samples from 1,799 people with Alzheimer's, dementia, depression, bipolar disorder, schizophrenia, or Parkinson's disease. Researchers want to see if certain substances in the blood can help doctors diagnose and manage these conditions more accuratel…

This study is a registry that collects information from about 2,000 people with mild cognitive impairment or Alzheimer's disease. Researchers will track how the disease progresses and how treatments work in real-world settings. The goal is to better understand Alzheimer's and imp…

This study tests whether a phone app called StudyU can help people with heart failure reach their recommended beta blocker dose. Five adults aged 65 and older with heart failure will use the app to track their medication. The goal is to see if the app is practical and acceptable …

This study aims to improve how doctors communicate with patients facing serious illnesses like cancer, heart failure, COPD, or dementia. Researchers will give doctors detailed feedback on their conversations about goals of care. The goal is to help patients receive care that matc…

This study uses a noninvasive brain stimulation technique called TMS, combined with brain scans, to understand working memory problems in people with early psychosis. Twenty participants will receive both active and placebo TMS to see how it affects brain activity and memory perf…

This study looks at how focused ultrasound (sound waves) aimed at the cerebellum changes brain activity and thinking in 20 healthy adults aged 18 to 40. Participants do thinking tasks after real or fake ultrasound. The goal is to learn how the cerebellum affects brain function, n…

This study looks at whether doing brain-training exercises in the morning or the afternoon helps older adults (60+) recover thinking skills after a stay in the intensive care unit. Forty participants will either train in the morning, in the late afternoon/evening, or receive usua…

This study follows 826 ICU survivors to understand why some develop long-term thinking and memory problems. Researchers will look at factors like delirium and sedative use during the ICU stay. The goal is to find modifiable risks that could lead to better prevention and recovery …

This study looks at why over half of ICU patients develop severe muscle weakness that can last for months or years. Researchers will use muscle biopsies, ultrasound, and strength tests on 50 critically ill adults to find better ways to diagnose and track this condition. The goal …

This study aimed to see if an online lesson could improve people's knowledge and healthy habits for preventing dementia. It planned to enroll Canadians aged 16 and older without dementia, giving some the prevention lesson and others a different topic. However, the study was withd…

This study looks at whether a supplement made from black rice extract can increase levels of BDNF, a protein important for memory and mood. Researchers will give 12 healthy adults either the supplement or a placebo and measure BDNF in their blood. The goal is to see if this natur…

This study is collecting DNA, brain scans, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. The goal is to better understand the physical and genetic factors behind these conditions, whi…

This study will test whether it's possible to create a registry for people with Alzheimer's who are receiving lecanemab infusions, along with their care partners. Researchers want to see if they can collect information on quality of life and caregiver burden in a real-world clini…

This study aims to build a research group of 100 people with neurological diseases like stroke, Parkinson's, epilepsy, or dementia. Researchers will use overnight sleep tests and questionnaires to measure sleep patterns, breathing, and heart rate during sleep. The goal is to bett…

This study examines whether self-awareness—knowing your own strengths and limits—can predict fall risk in older adults and rehab patients. About 100 participants aged 60-85 will complete cognitive tests, questionnaires, and walking assessments with wearable sensors. The goal is t…

This study follows 400 people with schizophrenia who took part in an earlier clinical trial. Researchers want to see how their health and daily lives change over 3 to 10 years. The goal is to learn what factors affect hospital stays and social functioning, without offering any ne…

This study is testing whether wearable sensors can reliably monitor movement problems in people with progressive supranuclear palsy (PSP) and related frontotemporal disorders. About 60 participants will wear pendant-like devices for 12 months to track their activity. The goal is …

This study looks at how a specific brain chemical pathway (tryptophan-kynurenine) relates to thinking and memory problems in people with schizophrenia. Researchers will measure blood levels of these chemicals and assess cognitive function in 200 participants, including healthy vo…

This study follows 156 people experiencing their first episode of psychosis who have never taken antipsychotic medication. Participants receive standard treatment with risperidone or aripiprazole and undergo brain scans four times over 32 weeks. The goal is to identify brain diff…

This study looks at whether a fast, automatic eye test can predict delirium (sudden confusion) in intensive care patients who need a breathing machine. Delirium is common and serious, but current screening methods take time and training. Researchers will measure pupil reactions i…

The Brain Health Registry is an online project that collects information about memory, mood, sleep, diet, and exercise from adults over 18. Participants also take simple cognitive tests online. The goal is to build a large database to speed up research into brain diseases like Al…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study looks at whether people with mild memory problems change their health habits, make future plans, or join more research after learning about their Alzheimer's-related brain scan results. It includes 100 Black and White adults with amnestic mild cognitive impairment. The…

This study looks at whether brain wave patterns recorded during and after electroconvulsive therapy (ECT) can predict how much depression symptoms improve. About 31 adults with treatment-resistant depression will have their brain activity measured with a wearable EEG device. The …

This study will collect brain scans from over 10,000 healthy people in China to create standard brain charts. These charts will show what a normal brain looks like at different ages. Doctors can then compare a patient's brain scan to these charts to help diagnose diseases like mu…

This study uses a special brain scan to measure amyloid protein buildup in 800 people already enrolled in an Alzheimer's research center. The goal is to understand when amyloid starts accumulating and how fast it builds up, which could reveal a window for early treatment. Partici…

This early-stage trial is testing how eating food changes the way the body absorbs a new experimental drug called LY03020. The drug is being developed for schizophrenia and psychosis related to Alzheimer's disease. Sixteen healthy volunteers will take the drug once with food and …

This study monitors indoor air quality in 500 French schoolchildren's classrooms, measuring pollutants like chemicals, allergens, and microbes. Researchers will track asthma and allergy symptoms using questionnaires and lung function tests. The goal is to understand how combinati…

The PorchLight Project tests whether training senior volunteers can improve care for people with memory loss or Alzheimer's disease. Over 340 volunteers and clients in Minnesota are taking part. The training includes online modules, a course, and monthly check-ins. Researchers wi…

This study measures brain activity and chemical levels in people with epilepsy who already have electrodes implanted for medical reasons. Participants play simple computer games while their brain signals are recorded. The goal is to learn how the brain works during thinking and e…

This study planned to see if using a special blood test (PrecivityAD2) could help doctors diagnose Alzheimer's disease or other dementias more quickly. It was designed for veterans and people in other closed healthcare systems who had memory problems. However, the study was withd…

This study looks at brain tissue and lab-grown nerve cells from people with schizophrenia, depression, bipolar disorder, frontotemporal dementia, and Alzheimer's. Researchers want to find out how problems with synapses—the connections between brain cells—differ in these condition…

This program aims to enroll up to 500,000 people aged 50-90 in the U.S. who are interested in Alzheimer's research. Participants provide basic health information and consent to genetic testing (APOE) without receiving their results. Their genetic profile is then used to match the…

This study was designed to observe how doctors choose medications for people with schizophrenia who have committed violent crimes. It planned to track changes in symptoms and aggressive behavior over time. However, the study was withdrawn before enrolling any participants, so no …

This study was designed to track stress in real time by measuring things like heart rate, sweat, and temperature, along with how people feel. It planned to include both healthy volunteers and people with psychiatric disorders to find better ways to diagnose stress-related problem…

This study looks at whether trained community health workers can help Korean American elders with dementia and their caregivers. About 288 pairs (elder and caregiver) will either get the program or usual care. The goal is to see if the program improves access to medical services …

This study looks at how weight-loss (bariatric) surgery might change memory and thinking skills in people with obesity who also have cognitive decline. Researchers will test memory and thinking before and after surgery in up to 9,500 participants. The goal is to understand if los…

This study looks at whether a virtual reality (VR) education program can improve how nursing students in Indonesia think and feel about people with dementia. About 200 students will take part in a single 100-minute class that includes VR experiences, lectures, and discussions. Th…

This study uses a safe, painless eye scan called OCT to look at support cells (glia) in the retina, which is part of the brain. Researchers want to see if these cells work differently in people with early signs of Alzheimer's compared to those without. If they find a difference, …

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve how the brain's vestibular network works, which may help with walking and navigation. Sixty older adults with memory concerns will receive either real or fake stimulation during three 20-mi…

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…

This study interviews 6 healthcare support workers in a hospital to understand how they handle distressed behavior in people with dementia. The goal is to learn from their experiences and identify what training might help them better support patients. It is an observational study…

This study looks at how cancer treatment and multiple rounds of anesthesia affect thinking skills, emotions, and quality of life in people who survived retinoblastoma (a rare eye cancer) or were at risk for it. Researchers will test memory, attention, and other brain functions in…

This study uses a special brain scan called Tau PET to look at a protein linked to Alzheimer's disease in healthy older African Americans. Researchers want to learn how this protein builds up and relates to memory changes over time. The goal is to better understand early signs of…

This study follows 130 older adults with mild to moderate Alzheimer's for up to 5 years to see if frailty (weakness, slow walking, exhaustion, weight loss, low activity) leads to faster loss of daily living skills. Participants are tested at the start and after one year, with lon…

This study follows 1,800 adults with reduced kidney function (not on dialysis) to see how nutrition and lifestyle affect their health. Researchers will track changes in kidney function, heart health, bone health, and thinking skills over time. The goal is to find better ways to m…

This study is testing whether simple blood tests can accurately diagnose dementia in everyday clinic settings. Over 3,000 people aged 45 and older with memory problems will give blood samples and answer questionnaires. Researchers will check how reliable and acceptable these bloo…

This study tests whether a scenario-driven virtual reality game can improve nursing students' attitudes and knowledge about dementia. 200 Indonesian nursing students will be assigned to different combinations of VR and classroom education. The goal is to see if interactive VR hel…

This study looks at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. Participants have mild memory concerns or are at risk for cognitive decline.…

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions over time, using brain scans and genetic tests to see how the diseases progress. T…

This study uses special brain scans (tau PET) to see how anti-amyloid immunotherapy affects tau protein buildup in people with mild Alzheimer's disease. About 135 participants will get two tau PET scans—one before starting treatment and another 12-18 months after finishing it. Th…

This study follows over 1,000 children aged 0-21 who are getting stem cell transplants. Researchers will check for delirium twice a day during their hospital stay. The goal is to learn how often delirium happens, what raises the risk, and how it affects recovery. This information…