Could a hormone drug slow Alzheimer's? LUCINDA trial tests idea

NCT ID NCT03649724

Ongoing Disease control Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether leuprolide (Eligard), a drug that lowers certain hormones, can slow memory and thinking decline in 180 women with mild Alzheimer's or mild cognitive impairment. All participants are already taking donepezil. The study compares leuprolide injections every 12 weeks against placebo for 48 weeks, measuring changes in memory tests and daily living skills.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: leuprolide (Eligard)
What this could lead to: If it works, this could point toward a new way to slow memory loss in women with early Alzheimer's.
What could go wrong: This is a small, early-phase trial with only 180 women. The drug may not improve thinking or daily function, and side effects from hormone suppression are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE MILD COGNITIVE IMPAIRMENT

Contacts and locations

Locations

University of Miami Miller School of Medicine

Boca Raton, Florida, 33433, United States
University of Wisconsin - Madison

Madison, Wisconsin, 53792, United States
Weill Medical College of Cornell University

New York, New York, 10021, United States

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