Restless leg drug tested for rare disease in women

NCT ID NCT05003648

Ongoing Symptom relief Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study looks at whether pramipexole, a drug used for restless leg syndrome, can ease leg symptoms in women with X-linked adrenoleukodystrophy (ALD). About 24 women will take the drug or a placebo for two months. The goal is to see if it improves sleep, walking, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pramipexole
What this could lead to: If it works, this could point toward a treatment for restless leg syndrome in women with adrenoleukodystrophy, improving sleep and quality of life.
What could go wrong: This is a small, early-phase study with only 24 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adrenoleukodystrophy restless legs syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADRENOLEUKODYSTROPHY RESTLESS LEGS SYNDROME

Contacts and locations

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Locations

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
University Medical Center of Amsterdam

Amsterdam, Netherlands

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