Restless legs syndrome

This study is testing whether a simple test called the suggested immobilization test (SIT), along with heart rate monitoring, can help doctors diagnose restless legs syndrome (RLS) more accurately. Currently, RLS is diagnosed based on symptoms, which can be tricky. The study will…

This study tests a wearable device that uses mild nerve stimulation to reduce symptoms of restless legs syndrome (RLS). Twenty adults with RLS will use the device at bedtime to see if it decreases nighttime awakenings and improves symptom severity. The goal is to find a safe, non…

This study tests whether adding lower-body strength training to static stretching helps pregnant women with restless legs syndrome (RLS) feel better. Thirty pregnant women with RLS will be split into two groups: one does only stretching, the other does stretching plus strength ex…

This study tests whether aerobic exercises or muscle relaxation exercises can help pregnant women with restless leg syndrome sleep better, feel less tired, and have less pain. Forty pregnant women in their second or third trimester will do one of the two exercise types for 8 week…

This pilot study will test whether cannabis oil is safe and feasible for treating restless legs syndrome (RLS). Thirty adults with moderate-to-severe RLS will receive either cannabis oil (with a 5:1 ratio of CBD to THC) or a placebo for 8 weeks. Researchers will track side effect…

This study looks at whether dipyridamole, a drug usually used for heart conditions, can reduce the uncomfortable urge to move the legs in people with kidney failure who are on dialysis. About 80 adults will take the drug three times a day for 12 weeks. Researchers will measure ch…

This early-stage study is testing a new calcium channel modulator to see if it can ease symptoms of Restless Legs Syndrome (RLS). About 20 adults with moderate-to-severe RLS will take the drug twice a day for 12 weeks. Researchers will measure changes in symptom severity and watc…

This study tests a small, non-invasive device that stimulates a nerve in the leg to see if it can safely ease Restless Legs Syndrome (RLS) during pregnancy. Fifteen pregnant women between 21 and 26 weeks will use the device for 30-minute sessions over 8 weeks. Researchers will ch…

This study compares myofascial release (a type of massage) and cupping therapy to see which better improves quality of life in people with restless leg syndrome and knee osteoarthritis. 54 adults aged 40-70 with moderate to severe knee arthritis will receive 12 sessions over 4 we…

This study tests whether gentle electrical stimulation of the chest and leg muscles can improve lung function and reduce restless leg symptoms in people with COPD. Sixty participants will receive either real or placebo stimulation alongside standard pulmonary rehab. The main goal…

This study looks at how spinal cord stimulators affect nerve signals and symptoms in people with Restless Leg Syndrome (RLS). Researchers will measure brain and nerve activity using EEG, EMG, and other tests while the stimulator is on or off. The study includes 50 participants, s…

This study tests whether using a smartphone to answer quick surveys several times a day is a practical way to track restless legs syndrome (RLS) symptoms in real time. Researchers will enroll 62 adults with RLS to use a study phone for 14 days. The goal is to see if patients find…

This study looks at whether people with Restless Legs Syndrome (also called Willis-Ekbom disease) have overactive nerve signals that could raise their risk for high blood pressure and heart disease. Researchers will measure heart nerve activity using a special scan, along with bl…

This study looks at how the brain processes internal body signals in people with Restless Legs Syndrome (RLS). Researchers will use MRI scans and daily smartphone surveys to track brain activity and symptom changes over two weeks. The goal is to understand why the urge to move oc…

This study tracks gene changes in people with Restless Legs Syndrome who take dopamine agonists for different lengths of time. Researchers will collect nasal swabs from 50 participants—some new to the drugs, others on them for 6+ months—to see how key genes change. The goal is to…