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Restless legs syndrome

MONDO:0005391

A condition that occurs while resting or lying in bed; it is characterized by an irresistible urgency to move the legs to obtain relief from a strange and uncomfortable sensation in the legs.

Also known as: RLS, WED, restless leg syndrome

38 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Nervous system disorder (217) Human disease (14) Disease by body system or component (0)

Trials to join now! 15 Not yet recruiting 10 Not yet finished but already full! 4 Completed 8 Terminated 1

Can a restless legs drug ease opioid withdrawal?

Symptom relief Terminated

This study tested whether pramipexole (Mirapex), a drug for restless legs syndrome, could also reduce symptoms of opioid withdrawal in people with opioid use disorder. The trial planned to enroll 75 adults but was terminated early. Researchers measured changes in restless legs se…

Phase: PHASE2, PHASE3 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief

Last updated Jun 27, 2026 07:51 UTC