Can a restless legs drug ease opioid withdrawal?

NCT ID NCT04759703

Terminated Symptom relief Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether pramipexole (Mirapex), a drug for restless legs syndrome, could also reduce symptoms of opioid withdrawal in people with opioid use disorder. The trial planned to enroll 75 adults but was terminated early. Researchers measured changes in restless legs severity and withdrawal scores after two weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pramipexole (Mirapex)
What this could lead to: If it worked, this could point toward a way to reduce restless legs and withdrawal symptoms, helping people stay in treatment for opioid use disorder.
What could go wrong: This was a small pilot study that was terminated early, so results are limited. It is unclear if pramipexole is effective or safe for this use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence restless legs syndrome sleep disorder sleep-wake disorder substance withdrawal syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID WITHDRAWAL OPIOID-USE DISORDER RESTLESS LEGS SYNDROME SLEEP DISORDER

Contacts and locations

Locations

Gavin Foundation Clinical Stabilization Services

Quincy, Massachusetts, 02170, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

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