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Restless legs syndrome
MONDO:0005391A condition that occurs while resting or lying in bed; it is characterized by an irresistible urgency to move the legs to obtain relief from a strange and uncomfortable sensation in the legs.
Also known as: RLS, WED, restless leg syndrome
38 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Restless leg drug tested for rare disease in women
Symptom relief OngoingThis study looks at whether pramipexole, a drug used for restless leg syndrome, can ease leg symptoms in women with X-linked adrenoleukodystrophy (ALD). About 24 women will take the drug or a placebo for two months. The goal is to see if it improves sleep, walking, and quality of…
Phase: PHASE4 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jul 03, 2026 00:00 UTC
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New device offers Drug-Free hope for restless legs sufferers
Symptom relief OngoingThis study is checking the long-term safety and effectiveness of a device called the Noctrix TOMAC System for people with restless legs syndrome. The device uses mild nerve stimulation to calm leg discomfort. Researchers are following 325 patients for one year to see if symptoms …
Sponsor: Noctrix Health, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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Could a drug for addiction help restless legs sufferers?
Symptom relief TerminatedThis phase 2 trial tests whether d-methadone, a drug related to methadone, can ease symptoms of moderate to very severe restless legs syndrome (RLS). About 50 adults with RLS will take either d-methadone or a placebo daily for 30 days. The goal is to see if it reduces leg discomf…
Phase: PHASE2 • Sponsor: Mauro Manconi • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Vibrating device may calm restless legs during dialysis
Symptom relief OngoingThis study tests whether a simple vibration device applied to the calf muscles can reduce the severity of restless legs syndrome and improve sleep quality in people undergoing hemodialysis. Seventy participants will receive vibration therapy for 10 minutes, twice a week for one m…
Phase: NA • Sponsor: Amjed Abdulabbas Shraida • Aim: Symptom relief
Last updated Jun 26, 2026 13:57 UTC