Could a drug for addiction help restless legs sufferers?
NCT ID NCT04145674
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether d-methadone, a drug related to methadone, can ease symptoms of moderate to very severe restless legs syndrome (RLS). About 50 adults with RLS will take either d-methadone or a placebo daily for 30 days. The goal is to see if it reduces leg discomfort and improves sleep, which are major problems for people with RLS.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
d-methadone (esmethadone, dextromethadone, REL-1017)
What this could lead to
If it works, this could point toward a new treatment option for restless legs syndrome that improves sleep and quality of life.
What could go wrong
This is a small, early-phase trial with only 50 participants. The study is currently suspended, and it's unknown if d-methadone will prove effective or safe for this condition.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Pain in Restless Legs Syndrome Study | NCT07679087
- Epidural Injection for Restless Legs in Spinal S NCT07637643
- THRIVE Study: Long-Term RLS Device Safety & Effe NCT06076499
- Botulinum Toxin for Restless Legs Syndrome – NCT00949806
- Ecopipam for RLS Augmentation – NCT03218969
- Dry Needling for Restless Legs Syndrome | NCT05860751
Contacts and locations
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Locations
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Neurologie / Schlaflabor Kantonsspital Graubünden
Chur, 7000, Switzerland
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Schlaf-Wach-Epilepsie Zentrum, Inselspital
Bern, Switzerland
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Sleep Center, IRCCS San Raffaele
Milan, Italy
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Sleep Center, Neurocenter of Southern Switzerland
Lugano, 6900, Switzerland