Restless legs syndrome

This study tests whether burst spinal cord stimulation (a type of nerve stimulation) can reduce symptoms of severe restless leg syndrome (RLS) that hasn't responded to standard treatments. Fifteen adults with severe RLS will receive both real stimulation and a sham (fake) treatme…

This study tests whether daily iron supplements can improve restless sleep and ADHD symptoms in 70 children with ADHD who have low iron levels. Participants will take either iron or a placebo for 3 months, and their sleep and attention will be measured using motion-sensing leg ba…

This study at Mayo Clinic will test if dry needling with electrical stimulation can improve sleep and reduce symptoms in people with restless legs syndrome. Twenty adults aged 18-75 with a clinical diagnosis will receive two weekly sessions targeting leg muscles. Researchers will…

This study tests a noninvasive device that stimulates a nerve in the leg to help people with restless legs syndrome who have developed complications from their usual medication. About 50 adults will use the device at home for 8 weeks. Researchers will measure changes in symptom s…

This study tests a drug-free approach for restless leg syndrome (RLS) in people with type 2 diabetes. 42 adults aged 50-65 will receive either vibration, near-infrared light, or both, plus stretching, for 4 weeks. Researchers will measure changes in pain, sleep quality, and RLS s…

This study tests whether a relaxation method called autogenic training can help people on hemodialysis who suffer from restless leg syndrome, poor sleep, and fatigue. About 54 adults aged 45-55 will practice guided relaxation exercises for 8 weeks. Researchers will measure change…

This study tests whether a high-CBD cannabis extract is safe and helps relieve symptoms in people with moderate to severe restless legs syndrome (RLS). About 60 adults aged 18-79 will receive either the CBD extract or a placebo for several weeks. Researchers will track side effec…

This study will test whether a 16-week Pilates exercise program can reduce restless leg syndrome, improve physical function, and boost self-perception in 100 older adults (65+) who are on maintenance hemodialysis. Participants will do supervised resistance exercises two to three …

This study surveys 1,000 adults with Restless Legs Syndrome (RLS) to find out how often pain is part of their symptoms and how it affects their daily lives. Participants fill out an online questionnaire about their medical history, sleep, pain, and quality of life. The goal is to…

This observational study looks at whether people with restless legs syndrome (RLS) have different gut bacteria compared to healthy individuals. Researchers will collect stool and blood samples from 100 adults to find specific bacteria and molecules that may affect iron metabolism…