Cannabis oil put to the test for restless legs in First-Ever controlled trial

NCT ID NCT06863740

Recruiting now Symptom relief Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This pilot study will test whether cannabis oil is safe and feasible for treating restless legs syndrome (RLS). Thirty adults with moderate-to-severe RLS will receive either cannabis oil (with a 5:1 ratio of CBD to THC) or a placebo for 8 weeks. Researchers will track side effects, study completion rates, and changes in sleep and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cannabis oil (CBD:THC 5:1)
What this could lead to: If it works, this could point toward a new treatment option for restless legs syndrome that may improve sleep and quality of life.
What could go wrong: This is a very small, early pilot study focused on safety and feasibility, not effectiveness. It may not show clear benefits, and results may not apply to everyone with RLS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

restless legs syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESTLESS LEG SYNDROME (RLS)

Contacts and locations

Locations

Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N3M5, Canada
University Health Network
RECRUITING

Toronto, Ontario, M5G 2C4, Canada

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