Brain scans may unlock why antipsychotics work for some, not others
NCT ID NCT03442101
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study follows 156 people experiencing their first episode of psychosis who have never taken antipsychotic medication. Participants receive standard treatment with risperidone or aripiprazole and undergo brain scans four times over 32 weeks. The goal is to identify brain differences that predict who will respond well to treatment, which could lead to more personalized care and new therapies for those who don't improve.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
risperidone and aripiprazole (antipsychotic medications)
What this could lead to
If successful, this could help doctors predict which patients will respond to standard antipsychotics and point toward new treatments for those who don't.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly improve care. The findings may not apply to all patients with psychosis.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sparks Center
Birmingham, Alabama, 35294, United States