Natural compound berberine takes on Schizophrenia's hidden symptoms

This study tests whether berberine, a natural compound, can safely improve negative symptoms of schizophrenia—like low motivation and emotion—that current medications often miss. Researchers will give berberine or a placebo to 120 Han Chinese adults with stable schizophrenia and track changes in symptoms, gut bacteria, and inflammation. The goal is to find a new way to ease these challenging symptoms and improve daily life.