Fixing sleep may calm Alzheimer's-Related mood swings, study hints
NCT ID NCT04100057
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether improving sleep through cognitive behavioral therapy (CBT-I) can reduce neuropsychiatric symptoms like anxiety, depression, and agitation in 150 older adults with mild cognitive impairment or early Alzheimer's. Participants are randomly assigned to CBT-I or an active control group. The researchers will use brain scans and sleep tracking to understand how sleep affects emotion regulation in the brain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- What this could lead to
- If successful, this could show that treating insomnia helps ease anxiety, depression, and agitation in people at risk for Alzheimer's disease.
- What could go wrong
- This is a small, early-stage study focused on understanding brain mechanisms, not a treatment trial. Results may not lead to a new therapy or apply to all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Andrea Goldstein-Piekarski, PhD
Palo Alto, California, 94304, United States
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