Fixing sleep may calm Alzheimer's-Related mood swings, study hints
NCT ID NCT04100057
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether improving sleep through cognitive behavioral therapy (CBT-I) can reduce neuropsychiatric symptoms like anxiety, depression, and agitation in 150 older adults with mild cognitive impairment or early Alzheimer's. Participants are randomly assigned to CBT-I or an active control group. The researchers will use brain scans and sleep tracking to understand how sleep affects emotion regulation in the brain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cognitive Behavioral Therapy for Insomnia (CBT-I)
What this could lead to
If successful, this could show that treating insomnia helps ease anxiety, depression, and agitation in people at risk for Alzheimer's disease.
What could go wrong
This is a small, early-stage study focused on understanding brain mechanisms, not a treatment trial. Results may not lead to a new therapy or apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Andrea Goldstein-Piekarski, PhD
Palo Alto, California, 94304, United States