Biggest ALS gene study aims to unlock disease secrets

NCT ID NCT02327845

Ongoing Knowledge-focused Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at people with ALS and similar diseases like frontotemporal dementia and hereditary spastic paraplegia. Researchers want to understand how genes affect the disease and find biological markers (biomarkers) to help develop future treatments. About 708 participants, including family members, will provide data over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for AMYOTROPHIC LATERAL SCLEROSIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis frontotemporal dementia hereditary spastic paraplegia inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2 lateral sclerosis motor neuron disorder progressive muscular atrophy spinal muscular atrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS FRONTOTEMPORAL DEMENTIA HEREDITARY SPASTIC PARAPLEGIA MULTISYSTEM PROTEINOPATHY PRIMARY LATERAL SCLEROSIS PROGRESSIVE MUSCULAR ATROPHY

Contacts and locations

Locations

California Pacific Medical Center (CPMC)

San Francisco, California, 94115, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Eberhard Karls University of Tübingen

Tübingen, Germany
Kansas University Medical Center (KUMC)

Kansas City, Kansas, 66160, United States
Stanford University

Palo Alto, California, 94304, United States
Twin Cities ALS Research Consortium

Minneapolis, Minnesota, 55415, United States
University of California San Diego (UCSD)

San Diego, California, 92093, United States
University of Cape Town

Cape Town, South Africa
University of Iowa

Iowa City, Iowa, 52242, United States
University of Miami

Miami, Florida, 33136, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Texas Health Science Center San Antonio (UTHSCSA)

San Antonio, Texas, 78229, United States
University of Texas Southwestern (UTSW)

Dallas, Texas, 75390, United States
University of Virginia (UVA)

Charlottesville, Virginia, 22908, United States
Wake Forest University

Winston-Salem, North Carolina, 27157, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.