Can tracking brain changes over time unlock the secrets of frontotemporal dementia?

NCT ID NCT04363684

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This long-term study follows people with or at genetic risk for frontotemporal lobar degeneration (FTLD), a group of brain disorders that cause changes in behavior, language, and movement. Researchers will use brain scans, memory tests, and blood samples to measure how the disease progresses over time. The goal is to better understand FTLD and identify markers that could help develop future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could lead to better ways to diagnose and track frontotemporal lobar degeneration, and help design future treatments.
What could go wrong: This is an observational study, not a treatment trial, so it will not directly provide a cure or therapy. Results may take years to translate into clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis behavioral variant of frontotemporal dementia Corticobasal Degeneration corticobasal degeneration disorder frontotemporal dementia frontotemporal dementia with motor neuron disease Frontotemporal Lobar Degeneration GRN-related frontotemporal lobar degeneration with Tdp43 inclusions progressive non-fluent aphasia progressive supranuclear palsy semantic dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA (BVFTD) C9ORF72 CORTICOBASAL DEGENERATION (CBD) FRONTOTEMPORAL LOBAR DEGENERATION (FTLD) FTD WITH AMYOTROPHIC LATERAL SCLEROSIS (FTD/ALS) GRN RELATED FRONTOTEMPORAL DEMENTIA MAPT GENE MUTATION NONFLUENT VARIANT PRIMARY PROGRESSIVE APHASIA (NFVPPA) OLIGOSYMPTOMATIC PROGRESSIVE SUPRANUCLEAR PALSY OLIGOSYMPTOMATIC PSP (OPSP) PROGRESSIVE SUPRANUCLEAR PALSY(PSP) SEMANTIC VARIANT PRIMARY PROGRESSIVE APHASIA (SVPPA) TBK1 GENE MUTATION

Contacts and locations

Locations

Case Western Reserve Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
Cleveland Clinic Lou Ruvo Center for Brain Health
RECRUITING

Las Vegas, Nevada, 89106, United States
Columbia University
RECRUITING

New York, New York, 10032, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21287, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Mount Sinai
NOT_YET_RECRUITING

New York, New York, 10029, United States
NIH
RECRUITING

Bethesda, Maryland, 20814, United States
Nantz National Alzheimer Center Houston
RECRUITING

Houston, Texas, 77030, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
UT San Antonio Health Science Center
RECRUITING

San Antonio, Texas, 78229, United States
University of Alabama Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of British Columbia
RECRUITING

Vancouver, British Columbia, Canada
University of California San Francisco
RECRUITING

San Francisco, California, 91358, United States
University of California, Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of California, San Diego
RECRUITING

San Diego, California, 92093, United States
University of Colorado Denver
RECRUITING

Denver, Colorado, 80204, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of North Carolina, Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Toronto
RECRUITING

Toronto, Ontario, Canada
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
Vanderbilt University
RECRUITING

Nashville, Tennessee, 37235, United States
Washinton University in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

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