Brain zaps may boost memory in those at risk for Alzheimer's
NCT ID NCT04583215
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a non-invasive brain stimulation technique called paired associative stimulation (PAS) can improve memory and thinking in 150 older adults with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. Participants receive daily sessions of TMS combined with nerve stimulation over 10 days. The goal is to enhance brain plasticity in the frontal lobes and potentially slow cognitive decline.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Paired Associative Stimulation (PAS) using Transcranial Magnetic Stimulation (TMS) and Peripheral Nerve Stimulation (PNS)
- What this could lead to
- If it works, this could offer a non-drug way to improve memory and thinking in people with mild cognitive impairment and possibly delay Alzheimer's.
- What could go wrong
- This is an early-stage study with 150 participants, so results may not apply to everyone. The treatment is experimental and may not provide lasting benefits.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre for Addiction and Mental Health
Toronto, Ontario, M6J 1H4, Canada
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