New hope for HIV-Related depression: which drug works better?

NCT ID NCT06705478

Terminated Symptom relief Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study compares two drugs, pramipexole and escitalopram, to treat major depression in people with HIV. Some participants also have mild memory or thinking problems. The goal is to see which medication is safer and more effective at easing depression symptoms. About 186 adults will take part.

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Conditions

The condition(s) this trial relates to.

cognitive disorder HIV infectious disease major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV MAJOR DEPRESSIVE DISORDER MILD NEUROCOGNITIVE DISORDER

Contacts and locations

Locations

Alabama CRS

Birmingham, Alabama, 35222, United States
Barranco CRS

Lima, 15063, Peru
Blantyre CRS

Blantyre, 265, Malawi
Byramjee Jeejeebhoy Medical College (BJMC) CRS

Pune, Maharashtra, 411001, India
Case CRS

Cleveland, Ohio, 44106, United States
Chapel Hill CRS

Chapel Hill, North Carolina, 27599-7215, United States
Chiang Mai University HIV Treatment (CMU HIV Treatment) CRS

Chiang Mai, 50200, Thailand
Cincinnati CRS

Cincinnati, Ohio, 45267-0405, United States
Columbia Physicians & Surgeons (P&S) CRS

New York, New York, 10032, United States
De La Salle Medical and Health Sciences Institute - Angelo King Medical Research Center (DLSMHSI-AKMRC)

Dasmariñas, Cavite, 4114, Philippines
Durban International CRS

Mount Edgecombe, 4302, South Africa
Gaborone CRS

Gaborone, Botswana
Greensboro CRS

Greensboro, North Carolina, 27401-1020, United States
Hanoi Medical University (HMU)

Hanoi, 10000, Vietnam
Harbor University of California, Los Angeles Center CRS

Torrance, California, 90502, United States
Houston Advancing Research Team CRS

Houston, Texas, 77030, United States
Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS

Rio de Janeiro, 21040-900, Brazil
Instituto de Pesquisas em AIDS do Rio Grande do Sul - IPARGS CRS

Porto Alegre, Rio Grande do Sul, 91350-180, Brazil
Joint Clinical Research Centre (JCRC)/Kampala CRS

Kampala, Uganda
Kenya Medical Research Institute/Walter Reed Project Clinical Research Center (KEMRI/WRP) CRS

Kericho, Rift Valley, 20200, Kenya
Massachusetts General Hospital CRS (MGH CRS)

Boston, Massachusetts, 02114, United States
Milton Park CRS

Milton Park, Harare, Zimbabwe
Moi University Clinical Research Center (MUCRC) CRS

Eldoret, Rift Valley, 30100, Kenya
New Jersey Medical School Clinical Research Center CRS (Site ID 31786)

Newark, New Jersey, 07103, United States
Northwestern University CRS

Chicago, Illinois, 60611, United States
Nutrición-Mexico CRS

Mexico City, Tlalpan, 14080, Mexico
Ohio State University CRS

Columbus, Ohio, 43210, United States
Penn Therapeutics CRS

Philadelphia, Pennsylvania, 19104, United States
Thai Red Cross AIDS Research Centre (TRC-ARC) CRS

Pathum Wan, Bangkok, 10330, Thailand
The Ponce de Leon Center CRS

Atlanta, Georgia, 30308-2012, United States
UCSD Antiviral Research Center CRS

San Diego, California, 92103, United States
University of California, Los Angeles CARE Center CRS

Los Angeles, California, 90035, United States
University of California, San Francisco HIV/AIDS CRS

San Francisco, California, 94110, United States
University of Colorado Hospital CRS

Aurora, Colorado, 80045, United States
University of Pittsburgh CRS

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester Adult HIV Therapeutic Strategies Network CRS

Rochester, New York, 14642, United States
Vanderbilt Therapeutics (VT) CRS

Nashville, Tennessee, 37204, United States
Washington University Therapeutics (WT) CRS

St Louis, Missouri, 63110-1010, United States
Weill Cornell Chelsea CRS

New York, New York, 10010, United States
Weill Cornell Uptown CRS

New York, New York, 10065, United States
Whitman-Walker Institute, Inc. CRS

Washington D.C., District of Columbia, 20009, United States

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