Cognitive disorder

This phase 2 trial tests whether leuprolide (Eligard), a drug that lowers certain hormones, can slow memory and thinking decline in 180 women with mild Alzheimer's or mild cognitive impairment. All participants are already taking donepezil. The study compares leuprolide injection…

This study tested whether daily nicotine patches could improve memory and daily function in 348 people with mild cognitive impairment (MCI). Participants wore either a nicotine patch (up to 21 mg) or a placebo patch for two years. The goal was to see if nicotine, known to affect …

This phase 2 trial tests whether glycerol phenylbutyrate (GPB) can slow corticobasal syndrome (CBS), a rare and fast-progressing brain disease. 32 adults with CBS will receive either GPB or a placebo for 26 weeks. The main goal is to see if GPB lowers levels of a nerve damage mar…

Researchers are studying a once-weekly tablet form of brexpiprazole, an antipsychotic drug, in adults with schizophrenia. The trial follows about 247 participants for 52 weeks to see how well they tolerate the medicine and whether it remains safe over the long term. Everyone in t…

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

Researchers are testing whether hydralazine, a drug already approved for high blood pressure, can slow cognitive decline in people with early Alzheimer's disease. The trial will give 228 participants either hydralazine or a placebo for one year, alongside their usual Alzheimer's …

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This phase 2 trial tests whether a single dose of insulin given through the nose can change how the brain produces energy and improve thinking in people with psychotic disorders like schizophrenia, schizoaffective disorder, or bipolar disorder with psychosis. Researchers will com…

Researchers are testing an experimental drug called MK-2214, given by IV infusion, in adults with mild cognitive impairment or mild-to-moderate Alzheimer's disease. The trial aims to see whether the drug is safe and tolerable, and whether it reaches meaningful levels in the brain…

This trial tests whether combining cognitive behavioral therapy with social skills training helps young people with early-onset psychosis improve their symptoms and daily functioning. Participants receive either this combined therapy or a control program of psychoeducation and he…

This trial tests two online programs designed to improve thinking skills in people with schizophrenia. One program focuses on cognitive remediation, helping participants build learning strategies and confidence. The other, metacognitive training, targets how people interpret info…

This trial tests whether a specialized two-year early intervention service, called OPUS YOUNG, can improve daily and social functioning in adolescents aged 12-17 who have experienced a first episode of psychosis. Participants are randomly assigned to either OPUS YOUNG or standard…

This trial compares giving zoledronate, a yearly intravenous bone-strengthening drug, within 5 days of hip fracture surgery versus waiting 3 months. The goal is to see if early treatment is as safe and effective at reducing bone turnover and preventing future fractures. Participa…

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

The BEAT-AD study is testing whether a low-carb, high-fat ketogenic diet can improve thinking and memory in 120 adults with mild cognitive impairment, a precursor to Alzheimer's. Participants are randomly assigned to either a ketogenic diet or a low-fat diet for 16 weeks, with fo…

This study tests a new group program called Forging New Paths for adults with serious mental illness who have also been involved with the criminal justice system. The program combines cognitive behavioral therapy with social learning techniques to reduce aggression and help peopl…

This study tested a low dose of nilotinib, a drug used for leukemia, in 37 people with mild to moderate Alzheimer's disease. The goal was to see if the drug is safe and can reach the brain to affect proteins linked to Alzheimer's, like tau and amyloid. Participants took the drug …

This study tests a drug called SHP611, given as a spinal injection, in 36 children with late infantile metachromatic leukodystrophy (MLD), a rare and severe brain disease. The main goal is to see if the treatment helps children keep their ability to walk and move for as long as p…

This study tests a new drug called PRI-002 in 304 people with mild memory problems or early Alzheimer's. The drug aims to break apart harmful protein clumps in the brain that are linked to Alzheimer's. Researchers want to see if it is safe and can slow down memory and thinking de…

This trial tests a decision-making tool designed to help ICU staff decide when to use physical restraints. The tool uses objective measures of a patient's mental state and equipment needs, along with family involvement. The goal is to reduce the use of restraints and related inci…

This pilot study is testing whether adults with serious mental health issues like psychosis, anxiety, or depression can receive hospital-level care in their own homes. Researchers will see how many people are eligible and willing to try this approach. The goal is to offer a safe,…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This phase 3 trial tested whether giving preterm babies a drug called darbepoetin weekly could improve their brain development and reduce the need for blood transfusions. 650 infants born between 23 and 28 weeks of pregnancy were treated until they reached 35 weeks or went home. …

This early-phase study tested the drug baricitinib in 17 people with Alzheimer's disease, ALS, or mild cognitive problems. The goal was to see if the drug reaches the brain and lowers inflammation linked to these diseases. Participants took baricitinib pills for 24 weeks, and res…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve memory, thinking, and daily function compared to a placebo over 24 weeks. Researchers also c…

This large Phase 3 trial tested whether the diabetes drug semaglutide, taken as a daily pill, can slow cognitive decline in people with early Alzheimer's disease. About 1,840 participants received either semaglutide or a placebo for up to 3 years and 4 months. The study measured …

This phase 2 trial investigates whether lenalidomide, a drug that calms inflammation, can slow cognitive decline in people with mild cognitive impairment due to Alzheimer's disease. Participants take lenalidomide or a placebo for up to 12 months, followed by a 6-month washout per…

This study tested whether a once-monthly injection of aripiprazole can help people with schizophrenia avoid a relapse of symptoms. Over 900 adults took part, first switching to oral aripiprazole, then receiving either the long-acting shot or another treatment for up to 38 weeks. …

This study tested a special team-based program called R-FACT for people with serious mental illness who are also involved with the criminal justice system. The program provides intensive, community-based support with close coordination between mental health and justice staff. Res…

This study tested three non-drug approaches—cognitive training, reminiscence therapy, and a personalized program—in 640 people with mild-to-moderate Alzheimer's. The goal was to see if these therapies could delay progression to severe dementia. Participants were followed for chan…

This study tested whether restoring proper chewing function through dental implants or braces could improve cognitive health in adults. Researchers enrolled 150 people with missing teeth or misaligned bites. They measured changes in brain activity, thinking skills, and mood. The …

This completed study looked at whether two different blood thinners—dabigatran (Pradaxa) and warfarin (Coumadin)—could help prevent memory loss and dementia in people over 65 with atrial fibrillation (an irregular heartbeat). A total of 101 participants were randomly assigned to …

This phase 3 trial tested KarXT, a combination of two drugs, as an add-on treatment for 396 adults with schizophrenia whose symptoms were not well controlled by their current medication. Over 6 weeks, researchers measured changes in symptom severity using a standard rating scale.…

This study tested a special tablet exercise program called KOKU-LITE, designed for people with dementia to help prevent falls and improve well-being. Sixty people with dementia and their carers took part to see if the program was easy to use and helpful. The goal was to see if th…

This study looked at 6 people with schizophrenia who were already taking a combination of two long-acting injectable medications: Abilify Maintena and Rexulti. Researchers tracked their symptoms and side effects over 6 months to see how well the combo worked in everyday life. The…

This study tested whether personalized notifications from a Fitbit—about sleep, activity, and nutrition—could improve thinking skills and muscle mass in adults over 65. Over 350 older adults in Japan wore a Fitbit for 6 months and received automatic tips, while a control group go…

This study tested whether a probiotic supplement (Pediococcus acidilactici) could reduce metabolic problems like high cholesterol and blood sugar caused by antipsychotic drugs. 36 adults with first-episode psychosis or schizophrenia took the probiotic or a placebo alongside their…

This study looked at whether providing mental health care to people who inject drugs can improve their mental health and reduce their risk of getting HIV or hepatitis C. Over 500 participants in Haiphong, Vietnam, received free psychiatric consultations, medications, and support …

This study tested whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery can lower the risk of postoperative delirium—a state of confusion that can slow recovery. Researchers compared 130 patients who received either low tidal volume ventilation or n…

This study tested an experimental drug called METAZYM (a lab-made enzyme) in one child with late infantile metachromatic leukodystrophy (MLD) who had already received a stem cell transplant. The goal was to see if the enzyme could improve nerve function and reduce harmful buildup…

This completed trial tested a ketogenic diet (high-fat, low-carb) in 32 people with mild to moderate Alzheimer's disease. Participants followed the diet or a placebo for 26 weeks. Researchers measured changes in cognitive function using a standard test. The goal was to see if the…

This study tested a monthly injection of olanzapine (TV-44749) in 675 adults with schizophrenia to see if it controls symptoms better than a placebo. Participants received up to 14 injections over about a year. The goal is to offer a long-acting option that may improve treatment …

This study tested whether adding structured supportive psychotherapy to the antipsychotic drug risperidone helps improve thinking and reduce inflammation in people with schizophrenia. Forty-six male patients were split into two groups: one received risperidone plus 12 therapy ses…

This study tested a gene therapy for children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. Five children aged 6 months to 5 years received injections of a harmless virus carrying a working copy of the ARSA gene directly into their brains. …

This study tested whether a smartphone app designed for people with serious mental illness can help them quit smoking better than standard methods. Researchers enrolled 343 adults with conditions like bipolar disorder or schizophrenia who wanted to quit. Participants used either …

This completed study tested whether painting metal roofs with a special heat-reflecting coating can lower indoor temperatures and improve health in Niue, a Pacific island nation facing record heat. Researchers enrolled 288 adults living in single-story homes with metal roofs. The…

This study tested whether a personalized treatment plan—based on each person's test results—works better than standard care for people with mild cognitive impairment or early-stage dementia. 73 adults aged 45-76 took part, receiving either the tailored plan or usual care for 9 mo…

This trial tested a 9-month group program called Illness Management and Recovery (IMR) for 198 adults with schizophrenia or bipolar disorder. The program focused on helping participants set personal goals and manage their symptoms. Researchers measured changes in daily functionin…

This study tested whether eating one avocado and one cup of mango daily for 8 weeks could improve blood vessel health and thinking in 82 adults with pre-diabetes. Participants were randomly assigned to either a diet including these fruits or a matched control diet. Researchers me…

This study tested whether delivering coordinated specialty care (CSC) via telehealth works as well as standard in-person care for young people (ages 16–35) with early psychosis. Over 12 months, researchers tracked hospitalizations and engagement in 74 participants. The goal was t…

This study tested whether early cognitive training and rehabilitation can improve long-term thinking skills in older adults (65+) who experienced delirium during a hospital stay. 283 participants were randomly assigned to receive either the cognitive training program or usual car…

This study tested a new drug called KarXT in 202 Chinese adults hospitalized for schizophrenia. The goal was to see if KarXT could reduce symptoms like hallucinations and delusions better than a placebo over 5 weeks, followed by a 12-week period where everyone received the drug. …

This study tested whether a personalized crisis plan, called the SOS Plan, could reduce hospitalizations in people with schizophrenia or schizoaffective disorder. 124 patients worked with their doctors and loved ones to create a plan outlining what to do in a crisis. The goal was…

This study looked at how well Risperidone ISM works for people with schizophrenia who were hospitalized after a relapse. Researchers tracked 275 patients over 56 days to see if their symptoms improved and if they could better manage daily life. The treatment is given as an inject…

This study tested a remote, personalized program to help 36 adults with schizophrenia take their medication as prescribed. Participants were randomly assigned to the program or standard care. The goal was to see if the program was practical, well-liked, and improved medication ad…

This small pilot study tested daratumumab, a cancer drug, in 16 people with mild to moderate Alzheimer's. The goal was to see if it could improve thinking and memory. Participants received daratumumab injections under the skin. The study was open-label, meaning everyone knew they…

This study tested an experimental drug called ALZ-801 in 325 people with early Alzheimer's disease who carry two copies of the APOE4 gene, a strong risk factor. Participants received either the drug or a placebo for a year. Researchers measured changes in memory, thinking, and da…

This study is testing whether a set of memory and thinking tests, usually done in person, can be given remotely over a video call. Researchers will compare results from in-person and remote versions to see if they match. If it works, it could make dementia assessments easier for …

This study looked at whether a special brain scan called 18F-FDG PET can help doctors tell the difference between cognitive problems caused by psychiatric conditions versus neurodegenerative diseases like Alzheimer's. Researchers studied 20 adults with cognitive impairment who ha…

This study tested whether a special PET scan using florbetapir can help doctors figure out why some people develop memory and thinking problems after a stroke. The scan looks for amyloid plaques, a hallmark of Alzheimer's disease. Researchers studied 92 adults aged 40 to 80 who h…

This study checked if a Turkish version of the MoCA-B test can correctly tell the difference between healthy people, those with mild memory problems, and those with dementia. The test was given to 166 adults aged 50-100 with little or no schooling. The goal was to find the best c…

This study tested an artificial intelligence platform that screens for cognitive dysfunction by analyzing eye movements. Over 1,500 participants, including people with various dementias and healthy individuals, took part. The AI aims to detect cognitive impairment and provide ref…

This completed study looked at whether combining an online memory test with a blood test can help find Alzheimer's disease early in people 65 and older. Over 1,400 volunteers took part. The goal is to make early detection easier and faster, so treatment can start sooner.

This study tested a low-cost method to find undiagnosed dementia in primary care. Researchers used electronic health records to identify patients at risk. Over 1,200 adults without a prior dementia diagnosis took part. The goal was to see if this approach could increase new demen…

This study looked at whether measuring a protein called amyloid beta 1-40 in spinal fluid can help doctors diagnose Alzheimer's disease more accurately. Researchers collected spinal fluid from 204 people with memory problems. They want to see if adding this new measurement to exi…

This study looked at whether a blood test can accurately diagnose Alzheimer's disease, compared to the current standard of testing spinal fluid. Researchers measured specific proteins in the blood of 342 adults visiting memory clinics. The goal was to see if these blood markers c…

This study tested a new blood test that uses a microfluidic chip to detect Alzheimer's disease. Researchers collected blood and urine samples from 150 people, including those with Alzheimer's, other brain diseases, and healthy volunteers. The goal was to see if the test could acc…

This study is working on a blood test to help diagnose Alzheimer's disease. Researchers are measuring two specific markers in the blood of 200 people—some with Alzheimer's and some healthy—to see if these markers can reliably tell the difference. The goal is to create a simple, n…

This study looked at whether measuring certain proteins in the blood (amyloid peptides) can help diagnose Alzheimer's disease or predict its progression. Over 1,000 older adults with mild cognitive impairment or Alzheimer's were followed for two years. Researchers compared blood …

Older adults who have major reconstructive spine surgery often develop postoperative delirium, a sudden state of confusion that can lead to longer hospital stays and lasting cognitive problems. Poor pain control raises that risk, and opioids used for pain bring their own side eff…

This study involves 60 young people at high risk for psychosis. They receive a stepped series of psychological treatments, starting with the least intensive options like group support, and moving to more intensive therapy if needed. The goal is to prevent the development of psych…

Researchers are testing whether adjusting anesthesia depth with a bispectral index (BIS) brain monitor lowers the chance that children wake up confused and agitated after tonsil or adenoid removal. The trial includes 125 children aged 2 to 12 who are generally healthy and go home…

This early-stage trial tests a vaccine called AV-1959R, designed to prevent Alzheimer's disease by targeting a protein linked to the condition. Sixteen healthy adults aged 40-60 will receive three shots of the vaccine or a placebo over 14 weeks. Researchers will monitor for side …

Researchers are testing a school-based program that screens adolescents for anxiety, depression, and other mental health concerns, then offers stepped support. Students at eight schools in Spain complete regular mental health questionnaires. Based on their results, they receive d…

This trial tests whether solanezumab, an antibody that targets amyloid plaques in the brain, can slow the progression of memory problems in people who have no symptoms but show early signs of Alzheimer's-related brain changes. Participants are older adults with normal thinking an…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This study tests whether a nurse-led program combining lifestyle education and cognitive play-based training can reduce dementia risk among older adults living in residential care. About 134 residents from seven care homes in Cairo, Egypt, will receive either the intervention or …

This study tests whether a pharmacist-led program to stop certain medications (anticholinergics) can lower dementia risk in older adults. 344 participants aged 65+ who take these drugs will be followed for 2 years, comparing cognitive changes and quality of life between those who…

This pilot study tests whether giving insulin as a nasal spray can prevent delirium (sudden confusion) in adults aged 65 and older after complex heart surgery. About 30 participants will receive either the insulin spray or a placebo before and after surgery. The goal is to see if…

This trial tests a 12-week group program designed to help adults aged 65 and older address modifiable risk factors for dementia, such as high blood pressure and cognitive decline. Participants meet weekly for an hour to learn about brain health and practice evidence-based lifesty…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tests whether a computer program called pronia.ai can help doctors identify young people at high risk for psychosis and offer them early, tailored treatment. Participants aged 16 to 40 with early warning signs will either receive standard care or the AI-guided approach…

This completed study tested a program called HomeStyles-2, which aims to help parents of children aged 6 to 11 create healthier home environments. The program focuses on improving diet, physical activity, and sleep habits to prevent obesity. Over 450 families participated, with s…

This study tested whether a structured lifestyle program—including diet, exercise, and cognitive training—can help prevent cognitive decline in older adults at risk for dementia. Over 1,000 participants aged 60-77 from 12 Latin American countries took part. The goal was to see if…

This study tested whether giving IV acetaminophen (Tylenol) every 6 hours during and after heart surgery could prevent delirium—sudden confusion—in patients aged 60 and older. Delirium is common after heart surgery and can lead to longer hospital stays and other problems. The tri…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This study tested a 4-week program called Zinde Zihin ("Fit Mind") in 62 adults aged 65-80 living in nursing homes. The program included brain games, exercise, nutrition advice, and stress management. Researchers measured changes in Alzheimer's risk scores and found that the prog…

This study tested whether aromatherapy can prevent delirium (sudden confusion) in adults in the intensive care unit who are on breathing machines. 161 patients took part, and the approach used scented oils applied to the skin. The goal was to see if this simple, drug-free method …

This study tested whether lithium, a drug used for mood disorders, can prevent Alzheimer's dementia in older adults with mild cognitive impairment (MCI). 83 participants took either lithium or a placebo for a period, and researchers measured memory, thinking skills, and brain cha…

This study tested whether rivastigmine can safely reverse delirium caused by poisoning from certain drugs like clozapine or tricyclic antidepressants. 100 patients at a poison center received rivastigmine, and doctors measured their consciousness and agitation levels. The goal wa…

Researchers at Hebrew University of Jerusalem are testing a group program called Cog-Fun Ageing for older adults who feel their memory is worsening even though standard tests do not show it. The program involves 14 weekly group sessions led by occupational therapists, where parti…

This study tests if shining a special near-infrared light on the head and through the nose can improve memory and brain function in older adults at risk for Alzheimer's disease. The treatment, called photobiomodulation, is low-risk and aims to boost brain cell energy. 168 partici…

Researchers at Meiho University are studying whether applying an oral moisturizing gel changes the mix of bacteria in the mouths of older adults living in long-term care. The trial enrolls people aged 65 and older who have lived in a care facility for at least six months, includi…

This study compares two support programs for family and friends caring for Veterans with dementia after a hospital stay. One program, Hospital GamePlan4Care, offers a handbook, online training, and phone coaching tailored to the caregiver. The other provides general education and…

This study tested whether playing interactive digital games in a group could improve mood, behavior, and thinking in 24 older adults with early to moderate dementia. Participants played games like Mahjong on a touch-sensitive table twice a week for 20 weeks. Researchers measured …

This study tests whether a type of brain stimulation called cTBS can improve thinking and memory in people with schizophrenia. Forty participants will receive targeted stimulation to a brain network linked to daydreaming and self-focus. The goal is to see if this changes brain ac…

Researchers are testing whether the experimental drug LY2140023 (pomaglumetad methionil) reduces schizophrenia symptoms better than a placebo. The trial enrolls adults diagnosed with schizophrenia who stay in a hospital or clinic during the four-week study. Participants take the …

Researchers are testing whether an experimental drug, LY2140023, eases schizophrenia symptoms better than placebo in people who are acutely ill. The trial also compares it to risperidone, an approved antipsychotic. About 1,100 patients with schizophrenia join this phase 2 study. …

Researchers are testing whether a combination of water-based exercise and cognitive training can improve memory in veterans with amnestic mild cognitive impairment, a condition that often precedes dementia. Participants first complete six months of pool exercise three times a wee…

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

Researchers are testing whether memantine, a drug already used for Alzheimer's disease, can ease symptoms or slow decline in people with frontotemporal dementia. The trial enrolls adults aged 45 to 75 with mild to moderate FTD and compares memantine against a placebo over one yea…

Researchers at Tanta University are testing whether fractional CO2 laser can reduce skin amyloid deposits and itching in people with primary cutaneous amyloidosis. The trial enrolls 22 adults with confirmed disease who have not used other treatments for at least six months. Parti…

This completed trial tested a virtual program for people with Alzheimer's or related dementias and their caregivers. Nearly 1,000 participants received monthly video or phone visits from nurses or social workers over a year. The program focused on managing symptoms, reducing care…

This study tests a smartphone app called CT-155 designed to help people with schizophrenia manage negative symptoms like low motivation and reduced pleasure. About 262 adults with schizophrenia will use the app for 16 weeks, with an optional extension. Researchers will track symp…

This study tests whether Snoezelen multisensory therapy — a calming, personalized experience using lights, sounds, textures, and scents — can reduce agitation, depression, and anxiety in older adults with dementia. Sixty participants with mild to moderate dementia will receive ei…

This study looked at whether two specific diets—the ketogenic diet and the Therapeutic Lifestyles Changes diet—could improve thinking and memory in people with Alzheimer's disease. Researchers measured changes in cognitive test scores over three months in 84 adults aged 50 to 90 …

This pilot study tests whether a 10-week group program called Cog-Fun Aging helps older adults who worry about their memory. Participants learn about memory changes and practice strategies to manage daily challenges. Researchers compare those who take the program with those who d…

This study tested an experimental drug called neflamapimod in 159 people with dementia with Lewy bodies (DLB). The goal was to see if it could improve memory, problem-solving, and attention compared to a placebo. Participants took the drug or a dummy pill for a set period, and re…

This study tests whether an oral oil containing THC and CBD can reduce agitation in people with dementia who are eligible for hospice care. About 120 participants will receive either the active drug or a placebo for 12 weeks. The main goal is to see if agitation scores improve af…

This study tests whether giving a small amount of the sedative midazolam during anesthesia can lower the risk of delirium (sudden confusion) and anxiety in older adults after surgery. About 612 patients aged 65-85 having non-heart, non-brain surgery will be randomly assigned to r…

This pilot study tested a 6-session virtual program called MASC that teaches mindfulness, self-compassion, and behavior management skills to caregivers of people with Alzheimer's or related dementias. 82 caregivers participated to see if the program is feasible and acceptable. Th…

This early-stage trial tested a drug called MW151 in 27 adults with brain tumors who were receiving whole-brain radiation. The drug aims to reduce brain inflammation and prevent memory and thinking problems that often follow radiation. The study focused on safety, but also looked…

Researchers are testing whether a virtual-reality program called RC2S+ can be used remotely to help people with schizophrenia improve social cognition, such as recognizing emotions and understanding others' thoughts. The study enrolls 15 adults with schizophrenia or related psych…

This trial tests whether a smartphone app can help people with obesity take a more active role in their care around bariatric (weight-loss) surgery. The app helps users track diet and exercise, report problems, and organize medical documents, with a nurse available to connect the…

This study tests whether making music in a group can help people with schizophrenia who hear voices. Participants will be randomly assigned to one of four activities: creating and performing their own song, singing karaoke, listening to popular music, or curating playlists. The g…

This pilot study is testing the safety of fisetin, a natural compound found in fruits and vegetables, in 5 older adults with mild Alzheimer's or mild cognitive impairment. Participants will take fisetin daily for a period, and researchers will monitor for side effects. The goal i…

This pilot study tests a mobile app called Brain CareNotes designed to reduce the burden on unpaid caregivers of people with Alzheimer's or related dementias who live in rural areas. About 60 caregivers will use either the Brain CareNotes app or a basic education app for six mont…

This study tests an online program called SAGE LEAF that teaches positive emotion skills to family caregivers of people with dementia. Over 6 weeks, participants learn techniques like gratitude and mindfulness through short lessons and daily practice. The goal is to see if the pr…

This study tested an experimental drug called AXS-05 to see if it can safely reduce agitation in people with Alzheimer's disease. About 408 participants took either the drug or a placebo for several weeks. The goal was to measure changes in agitation using a standard rating scale…

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This trial tests whether adding virtual reality to cognitive behavioural therapy (CBT) can better reduce persecutory thoughts in people with schizophrenia spectrum disorders compared to traditional CBT alone. About 256 participants will receive either VR-assisted CBT or standard …

This study tests a mobile program called Compass for Care, designed to help people caring for a loved one with Alzheimer's or related dementias. The program delivers 12 weekly modules and tailored messages focusing on five self-care behaviors, such as taking time to recharge and …

This study tested a sublingual film containing dexmedetomidine (BXCL501) to quickly calm agitation in 100 older adults with dementia. Participants received either the drug or a placebo, and researchers measured changes in agitation scores and side effects. The goal was to find a …

This Phase 3 trial tested a sublingual film containing dexmedetomidine (BXCL501) to quickly reduce agitation in 380 adults with schizophrenia or related disorders. Participants received either the drug or a placebo film, and researchers measured changes in agitation symptoms over…

This study tests whether a gamified physical therapy software, called Yoomi, can help older hospital patients exercise safely in their beds. The goal is to see if this fun, interactive approach can preserve muscle strength and function during a hospital stay, reducing the need fo…

This study tests whether weekly live harp music sessions can reduce behavioral symptoms like agitation and anxiety in nursing home residents with moderate-to-severe dementia. Participants in memory care units will listen to a harp therapist play during the late afternoon, a time …

This study tests whether giving family caregivers of people with Alzheimer's or related dementias a tailored list of local resources – addressing needs like food, housing, and support services – can boost their confidence in caregiving. About 360 caregivers in specific Chicago zi…

This pilot study tested whether a gentle brain stimulation technique called HD-tDCS could improve memory and word recall in 27 older adults with mild cognitive impairment. Participants received either real or sham stimulation over 10 sessions across two weeks. The goal was to see…

This trial tests whether transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, can reduce auditory hallucinations in people with schizophrenia who haven't found relief from antipsychotic medications. Participants receive either real tDCS or a…

This study tests whether daily exposure to a flickering gamma light is safe and tolerable for people with Parkinson's disease who experience freezing of gait—a sudden inability to step forward. Researchers will monitor side effects and see if the light therapy reduces freezing ep…

This study tests whether adding electroconvulsive therapy (ECT) to usual care can safely reduce severe agitation in people with moderate to severe dementia, including Alzheimer's and other types. Fifty participants will receive ECT sessions with anesthesia, and researchers will m…

This trial tests whether shared virtual reality (VR) experiences can improve quality of life, mood, and family closeness for older adults with mild cognitive impairment or dementia who live in senior communities, and for their adult children who live far away. Participants will t…

This study tests whether an 8-week internet-based mindfulness program (iMBSR) can improve brain health in adults aged 50 and older who have subjective cognitive decline, a potential early sign of Alzheimer's disease. Sixty participants will be randomly assigned to either the mind…

This study tests whether playing a child's favorite music before and during ear tube surgery can reduce confusion and agitation when they wake up. Researchers will enroll 160 children ages 3 to 9. The goal is to see if personalized music makes recovery smoother and less distressi…

This study tested an online platform called the Living Memory Home for Dementia Care Pairs (LMH-4-DCP). It helps people with dementia and their family caregivers share and record meaningful memories together. The goal was to see if using the platform could reduce feelings of grie…

This study tested a silent alarm system in intensive care units to see if it lowers noise, patient delirium, and staff burnout. Over 200 patients and healthcare workers took part, comparing four weeks with the silent system to four weeks without. The goal was to see if reducing a…

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tests a structured nursing program called 'Conectando Corazones' (Connecting Hearts) designed to help family caregivers of older adults with dementia. The program includes six sessions over 12 hours, combining in-person meetings with independent work, to improve how ca…

This study tested whether adding virtual reality (VR) to standard computer-based cognitive training could improve memory, attention, and thinking skills in older adults with mild cognitive impairment. 70 participants completed a 12-week program of cognitive exercises, with one gr…

This study tests whether a 6-week online self-help program can help people with psychotic disorders who hear voices at least once a week. The program combines metacognitive training and mindfulness techniques to reduce the frequency and distress of auditory hallucinations. Partic…

This pilot study tested whether adding structured supportive psychotherapy to the antipsychotic risperidone could improve cognitive function and reduce inflammation in 44 hospitalized adults with schizophrenia. Participants received either risperidone plus 12 weekly talk therapy …

This study looks at whether adding a physical activity education program to adapted exercise helps people with mild memory or thinking problems more than exercise alone. Thirty-four participants will be followed for six months to measure changes in activity level, thinking skills…

This study tested a program where a pharmacist worked with people living with dementia, their care partners, and their doctors to review and reduce unnecessary medications. The goal was to simplify medication routines and lower treatment burden. The study included 138 participant…

This study looked at whether a weekly hour of adapted physical activity for 12 weeks could improve self-esteem and motivation in 17 older adults with mild to major cognitive disorders like Alzheimer's. Researchers measured changes in self-esteem, motivation, and apathy. The goal …

This study tests whether immersive virtual reality (VR) can safely help people with schizophrenia improve their thinking skills, reduce symptoms, and function better in daily life. Forty adults with schizophrenia or schizoaffective disorder will either receive VR-based cognitive …

This study tests whether an 8-week choral singing program can improve the well-being of nursing home residents with dementia. Participants attend one 75-minute group singing session each week, plus a dress rehearsal and final concert. Researchers measure changes in stress hormone…

This study tested whether combining a gentle brain stimulation technique called tDCS with memory and thinking exercises could help people with early Alzheimer's. Twenty-two participants received either real or fake stimulation during 10 sessions of cognitive training. Researchers…

This study tested whether playing a gentle sound called 'pink noise' during deep sleep could strengthen memory in people with early Alzheimer's disease. Nineteen participants wore a special headband that delivered the noise on some nights and not on others. The goal was to see if…

This study tested a virtual reality (VR) program designed to stimulate thinking skills in 45 people with mild cognitive impairment. Participants used VR headsets to do tasks like virtual shopping and recipe sequencing over 8 sessions. The goal was to see if the VR program was eas…

This study tested if immersive virtual reality (VR) can improve memory and thinking in people with Alzheimer's disease. 33 participants wore VR headsets to explore scenes from 1960s Burgos, Spain, designed to trigger personal memories. Researchers measured changes in cognitive te…

This study tested a gentle brain stimulation technique (HD-tDCS) combined with computer-based memory exercises in 60 people with early Alzheimer's. The goal was to see if this combination could improve thinking and memory more than either treatment alone. Researchers also used br…

This study tested whether personalized magnetic brain stimulation (TMS) is safe and helpful for people with early Alzheimer's disease. Forty participants received either real or fake TMS to see if it could improve memory and thinking. The goal was to find a non-drug way to ease s…

This study tested a program to reduce anticholinergic medications (like benztropine) in 53 adults with schizophrenia, bipolar disorder, or other serious mental illnesses who had been taking these drugs for at least 6 months. The goal was to safely taper or stop these medications …

This study tested a safe, non-invasive brain stimulation technique called tACS in 26 people with mild cognitive impairment due to Alzheimer's. The goal was to see if a 40 Hz electrical current applied to the brain could improve memory. Participants completed memory tests before, …

This study looked at whether adding cognitive behavioral therapy (CBT) to standard medication (risperidone) could improve cognitive function in 42 adults with stable schizophrenia. Participants either received risperidone alone or risperidone plus 10 weekly CBT sessions. Research…

This small study tested whether using a rocking chair for an hour each day could help reduce agitation in elderly people with dementia. Twelve nursing home residents took part in daily rocking sessions for six weeks. Researchers measured changes in agitation, use of calming medic…

This study tested a program called EnACT for family caregivers of people with dementia. The program uses group sessions where caregivers watch scenarios, practice responses, and reflect on their choices. The goal is to help caregivers feel more prepared and less stressed when dea…

This study tested whether giving clonidine, a blood pressure medication, before electroconvulsive therapy (ECT) could reduce the confusion and agitation that often follows the procedure. ECT is effective for severe depression and bipolar disorder, but up to 65% of patients experi…

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This study tested a new combination of two talk therapies for adults with eating disorders who are not underweight. Twenty participants were randomly assigned to either standard cognitive behavioral therapy (CBT-E) or a mix of CBT and metacognitive interpersonal therapy (CBT-F+MI…

This study looked at whether visits from therapy animals can improve mood, behavior, and quality of life for people with moderate to severe dementia living in nursing homes. Researchers observed 20 participants and compared animal visits to other activities. The goal was to see i…

This study tested whether the sedative dexmedetomidine can reduce how long non-intubated ICU patients experience agitated delirium. Researchers randomly gave 168 patients either dexmedetomidine or a placebo. The goal was to see if the drug shortens agitation and delirium, and red…

This study tested whether high doses of methylphenidate (Ritalin) could improve walking and attention in 69 people with advanced Parkinson's disease who still had severe gait problems despite standard treatments. Participants received either methylphenidate or a placebo for three…

This study tested whether a 6-session educational program could help people receiving electroconvulsive therapy (ECT) feel less stigma and anxiety about their mental health treatment. Sixty adult inpatients with conditions like depression or bipolar disorder took part. Those who …

This study tested whether adding ashwagandha extract to standard schizophrenia medication (risperidone) could reduce inflammation and improve symptoms. 80 male patients took part. Researchers measured changes in a blood marker for inflammation (IL-1β) and used a standard symptom …

This study tested a personalized approach to manage agitation in people with Alzheimer's disease living at home. A nurse worked with doctors and caregivers to create a custom care plan, using video calls and training. The goal was to reduce hospitalizations and ease caregiver str…

This pilot study tested whether adding virtual reality (VR) exercises to standard rehabilitation helps people who recently had a stroke recover their thinking skills and ability to do daily tasks. Thirty-six adults with acute stroke and mild cognitive impairment were assigned to …

This study tested a software system that uses a humanoid robot to give cognitive and motor tests to people with early Alzheimer's or other mild to moderate dementia. The goal was to see if the robot could effectively administer tests like the Mini Mental State Exam (MMSE) and hel…

This study tested a new drug called phenserine in 16 people with early or mild Alzheimer's disease. The goal was to see how it affects brain cell health and inflammation compared to the standard drug donepezil. Participants took the drug for 8 weeks and had regular checkups. The …

This study tested whether virtual peer support groups, co-led by a mental health clinician and a trained peer specialist, could help veterans with serious mental illness (like schizophrenia or bipolar with psychosis) feel more socially connected and less distressed. Twenty-eight …

This pilot study tested whether a single dose of a ketone drink could improve information processing and cognition in 28 people with schizophrenia or bipolar disorder. Participants drank either the ketone drink or a carbohydrate drink, then had brain wave tests, cognitive tasks, …

This study tested a program called Cuidando Juntos, designed to support Latino caregivers of people with dementia. The program includes eight modules on stress management, self-care, and handling difficult behaviors. Researchers wanted to see if the program was well received and …

This study looked at whether adding ashwagandha, an herbal supplement, to standard schizophrenia medication (risperidone) could improve thinking and memory. 80 men with schizophrenia took either risperidone alone or risperidone plus ashwagandha for 8 weeks. Researchers measured c…

This study tested a ketogenic drink made from medium chain triglycerides (MCTs) in 43 people with Alzheimer's disease or a type of frontotemporal dementia. The goal was to see if it was safe and tolerable, and to measure ketone levels in the blood. It was a small, early-stage tri…

This study tested whether adding cognitive behavioral therapy (CBT) to standard medication (risperidone) could reduce auditory hallucinations and inflammation in 50 people with schizophrenia. Participants either received CBT plus medication or medication alone. The goal was to se…

This study tested a web platform designed for people with mild cognitive impairment or mild to moderate dementia and their primary caregivers. The platform offers social networks, activities, and games to improve quality of life and help them stay in the community longer. Researc…

This study tested whether adding curcumin (the active compound in turmeric) to the standard medication risperidone could improve quality of life and reduce inflammation in people with schizophrenia. Forty-four men took part and were followed for 8 weeks. The goal was to see if cu…

This completed phase 2 trial tested whether levetiracetam, a drug used for epilepsy, could reduce abnormal brain overactivity and improve cognitive function in 58 people with early Alzheimer's disease or mild cognitive impairment. Participants received either the drug or a placeb…

This study tested if a gentle, non-invasive brain stimulation device used at home can help improve memory and thinking in people with mild to moderate Alzheimer's disease. One hundred older adults used the device for 30 minutes a day, five times a week, for six months. The goal w…

This study tested a computer program called BrainWorks that uses fun games to train thinking skills like memory, attention, and problem-solving. 72 adults with bipolar disorder and psychosis played these games over several sessions. Researchers measured changes in cognitive abili…

This study tests whether high-frequency magnetic stimulation (rTMS) can reduce auditory hallucinations in people with schizophrenia. Unlike standard low-frequency treatment that takes 15 days, this approach uses 20 Hz stimulation over just 2 days, guided by brain scans for precis…

This study tested a new way to follow up with gynecologic cancer survivors. Instead of seeing a doctor every time, patients saw a nurse at every other visit and used a smartphone app to help manage their health. The goal was to see if this approach improved self-management skills…

This study tested whether adding a virtual reality experience to an online education program could help reduce stress and anxiety in people caring for a loved one with mild-to-moderate Alzheimer's disease. About 127 unpaid caregivers took part, with some receiving only the educat…

This study tested a type of brain stimulation called theta-burst TMS to see if it can safely improve negative symptoms (like lack of motivation) and thinking problems in people with schizophrenia. 76 adults with stable schizophrenia took part in a double-blind trial where some re…

This study tested a therapy called Cognitive Behavioral Therapy for Work Success (CBTw) in 294 veterans with serious mental illness (like depression, bipolar disorder, or PTSD) who were unemployed. The goal was to help them find and keep competitive jobs, which can improve their …

This pilot study tested whether combining exercise with a gentle brain stimulation technique called tDCS can improve memory in 60 older adults with mild cognitive impairment or Alzheimer's disease. Participants exercised and received either real or sham tDCS. The goal was to see …

This study looked at whether a 6-week mindfulness-based yoga program could improve psychological well-being and happiness in adults with schizophrenia. 91 participants from community mental health centers were randomly assigned to either the yoga program or their usual care. The …

This study looked at whether learning to play Go or Chess can improve thinking skills in people with mild cognitive impairment or subjective cognitive decline. 80 participants were split into groups that played Go, Chess, both, or neither for 12 weeks. The researchers measured ch…

This study tested whether playing a recording of a mother's voice to children as they wake up from anesthesia can reduce postoperative delirium. Eighty children having tonsil surgery took part. Half heard their mother's reassuring voice during recovery; the other half did not. Re…

This study tested a video-based program called Tele-STELLA for family members caring for someone with moderate to late-stage Alzheimer's or related dementia. The program connects caregivers with a guide to find ways to manage upsetting behaviors. The goal was to see if it could r…

This study tested a virtual program called MASC (Mindful and Self-Compassionate Care) for caregivers of people with Alzheimer's or related dementias. The program teaches mindfulness, self-compassion, and behavioral management skills through six group sessions and home practice. T…

This small pilot study tested whether adding a horse to memory workshops could improve thinking, mood, and quality of life for people with mild to moderate dementia. Thirty-six older adults were split into three groups: traditional memory workshops, equine-assisted memory worksho…

This study tested whether a non-invasive magnetic brain stimulation technique called rTMS can reduce chronic low back pain. Thirty adults with long-lasting pain received multiple sessions of rTMS over the brain's motor cortex. Researchers measured pain changes using a standard pa…

This study tested a drug called CT1812 in 130 people with mild to moderate Dementia with Lewy Bodies. Over 6 months, researchers checked if the drug was safe and if it helped with thinking, sleep, or other symptoms. The goal was to see if it might ease the burden of this challeng…

This study tested whether an eight-session expressive arts therapy program could increase hope in 50 hospitalized adults with schizophrenia. Participants in the therapy group showed significantly higher hope scores compared to those receiving standard care alone. The findings sug…

This study tested whether a gentle electrical current applied to the scalp (tDCS) can reduce symptoms of major depression, schizophrenia, OCD, generalized anxiety, and insomnia. 320 adults aged 16–65 received multiple sessions over weeks. Researchers measured symptom changes usin…

This study tested whether forest therapy—mindful walking, sun bathing, hugging trees, and meditation—could improve symptoms and reduce inflammation in 80 adults with psychotic disorders. Half received forest therapy plus standard care for 8 weekly sessions; the other half receive…

This study tested whether guided meditation combined with binaural beats (special sound frequencies) could help reduce negative symptoms of schizophrenia, like low motivation and social withdrawal. Ninety inpatients were assigned to meditation alone or meditation with either alph…

This pilot study tested a telehealth program called C-SMART for people with primary brain tumors who have mild memory or thinking problems. The program combines cognitive rehabilitation with mindfulness training over 8 weekly sessions. Researchers enrolled 32 patients and caregiv…

This study tested whether giving intravenous guanfacine to critically ill patients with delirium in the ICU could improve their brain function. 46 adults on breathing machines or for shock were randomly assigned to receive guanfacine or a placebo. Researchers measured days withou…

This study tested three online wellness programs—Tai Chi, a gentle mindful movement class called PLIE, and health education—in 77 adults aged 55 and older with mild memory or cognitive difficulties. The goal was to see if these programs could improve thinking skills, physical fun…

This study tested whether wearing eye masks and earplugs at night for three nights could help prevent confusion (delirium) and reduce pain in children aged 6-12 in the pediatric intensive care unit (PICU). 74 children were randomly assigned to either wear the sleep aids or receiv…

This study tested a program called MEMORI Corps, where trained volunteers aged 55+ provide companionship and personalized activities to people with dementia living at home. The program was delivered virtually over 12 weeks. Researchers measured changes in mood, quality of life, a…

This study tested whether an Apple Watch paired with a special app and weekly health coaching could help dementia caregivers improve their sleep and mood. Twenty-one caregivers wore the watch to track their activity and sleep, and received personalized feedback and motivational c…

This study tested whether a digital program called Sleepio, which provides cognitive behavioural therapy for insomnia, could be used by people with mild cognitive impairment or mild dementia. Thirty participants were enrolled to see if the program was acceptable and easy to use. …

This study tested whether a procedure called a stellate ganglion block (SGB), given with standard medication, could improve thinking and memory in people with Alzheimer's disease. Forty participants were randomly assigned to receive either SGB plus standard drugs or standard drug…

This study tested a Danish support program called DemTool for family caregivers of people with dementia. The program included group sessions and educational materials to help caregivers cope and reduce stress. Researchers measured changes in caregiver distress and overall health …

This study tested a safe, noninvasive treatment for memory and word-finding problems in Gulf War veterans. 93 veterans received either real or fake (sham) brain stimulation over 10 sessions. The goal was to see if the stimulation improved their ability to recall words and speak m…

This study tested a program where home-care nurses were trained to support people with dementia in making their own everyday choices, with help from family caregivers. 12 people with dementia, 14 caregivers, and 33 nurses took part. Most found it helpful, but the program was time…

This study tested whether a sleep medication called suvorexant could improve sleep and reduce severe confusion (delirium) in adults 65 and older after non-cardiac surgery. 142 participants received either the drug or a placebo after their operation. The goal was to see if better …

This study tested a program called ABC ANSWERS for veterans with Alzheimer's disease or traumatic brain injury and their informal caregivers (family or friends). The program added extra support and education to regular primary care. Researchers measured changes in quality of life…

This study tested if a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve thinking and walking in people with Parkinson's disease. 41 participants received either real or fake rTMS sessions over two weeks. The results…

This study tested whether a non-invasive brain stimulation technique called rTMS, guided by MRI scans, could reduce severe hallucinations in people with schizophrenia who don't respond to medication. 85 participants received either MRI-guided or standard rTMS over 5 days. The goa…

This study tested a mobile app called SleepFix that provides digital behavioral therapy for insomnia in 128 older adults aged 50+ who also had mild memory concerns. Participants either used the app or received online sleep health education. The goal was to see if the app could re…

This pilot study tested a mobile app called iCanChange in 100 young adults (ages 18-35) with psychosis and cannabis use disorder. The app uses motivational interviewing and cognitive behavioral therapy techniques through short interactive modules. The main goal was to see if the …

This study tested a support program called TACSI for people caring for a family member with both traumatic brain injury and dementia. The program included coaching and education to help caregivers manage stress and improve communication. Researchers measured changes in caregiver …

This study tested whether a non-invasive brain stimulation technique called tDCS can help people with schizophrenia whose symptoms persist despite medication. 141 adults received either real or sham tDCS over 10 sessions. The goal was to see if active stimulation leads to a meani…

This study tested a special palliative care program for people with late-stage Alzheimer's or related dementias and their family caregivers. The program started during a hospital stay and included caregiver education and support to reduce hospital transfers and improve symptom co…

This study looked at whether a long-term exercise program can help people with dementia living in nursing homes keep their ability to do daily tasks like bathing and dressing. 140 participants were split into an exercise group and a social activity group. The goal was to see if e…

This study looked at the long-term safety and effectiveness of a drug called AXS-05 for treating agitation in people with Alzheimer's disease. A total of 456 participants who had already been in earlier studies took part. The goal was to see if the drug could safely reduce agitat…

This study tested whether an 8-week mindfulness program could reduce anxiety in 168 older adults who have memory concerns but normal cognitive test scores. Participants were randomly assigned to either mindfulness training or a health education program. The goal was to see if min…

This study tested whether giving oxytocin nasal spray before mindfulness-based group therapy could reduce negative symptoms (like lack of motivation or social withdrawal) in people with schizophrenia. 42 participants were randomly assigned to receive either oxytocin or a placebo …

This study tested a combination of brain monitoring and specific drugs during heart surgery to see if it could reduce confusion, pain, and blood pressure problems afterward. 70 older adults (60+) having heart bypass or valve surgery took part. The approach used EEG monitoring and…

This study tested a video-based program called STELLA-FTD to help family caregivers of people with frontotemporal dementia (FTD). Sixteen caregivers participated in the program, which aimed to reduce their stress and improve their quality of life. The approach used videoconferenc…

This study tested speech entrainment therapy (SET) in 80 people with non-fluent aphasia after a stroke. Participants practiced speaking along with an audio-visual computer program for 3, 4.5, or 6 weeks, or received no therapy. The goal was to find the best duration for lasting i…

This study tested whether a brief, personalized activity or care routine (called IPPI) is feasible for nursing home residents with dementia who also show signs of distress or depression. Care partners delivered two short sessions per week for six months. The goal was to see if th…

This study tested whether playing an immersive video game called Bandit the Dolphin could improve thinking and movement in adults who had a traumatic brain injury years ago. The game involves moving your arms to control a dolphin in an ocean environment, combining physical and me…

This completed study tested whether repetitive transcranial magnetic stimulation (rTMS) can improve memory and thinking in 32 veterans aged 55+ with mild cognitive impairment or dementia. Participants received either real rTMS or a sham (fake) treatment. The main goal was to see …

This study tested a cognitive training software called SUPERBRAIN DEX in 140 people aged 50–85 with mild cognitive impairment (MCI), a condition that can lead to dementia. Participants used the software for 15–30 minutes daily, while a control group received an educational bookle…

This study tested a new way of caring for people with Parkinson's disease. The goal was to help 214 participants achieve their personal goals and improve their quality of life. The approach involved proactive, integrated care and patient empowerment, compared to standard care.

This study tested whether repetitive transcranial magnetic stimulation (rTMS) can reduce certain core symptoms of schizophrenia, called first rank symptoms. Thirty-one patients received either real rTMS or a sham (fake) treatment over 10 sessions in 5 days. The goal was to see if…

This study tested whether computer-based visual exercises can help people with schizophrenia who have trouble with contrast sensitivity and organizing visual information. Researchers compared several training programs, including one called UltimEyes, in 79 participants. The goal …

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This study looked at whether adding a brain wave monitor (pEEG) to standard sedation checks helps reduce delirium and time on a breathing machine in ICU patients. Researchers followed 150 adults on ventilators who needed sedation. They compared those who got both the brain monito…

This study looks at whether falls and mobility problems can signal very early, preclinical Alzheimer's disease in older adults who are still cognitively normal. Researchers will follow 355 volunteers aged 65 and older, some with and some without biological signs of Alzheimer's, t…

This study tests whether wearable sensors and caregiver questionnaires can capture the behavioral signs of apathy in people with dementia during daily life. Patients with Alzheimer's or frontotemporal dementia and their caregivers wear a sensor bracelet for 28 days, while caregiv…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study tested whether two light-based technologies, fNIRS and DCS, can safely measure brain activity in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome. 73 participants, including healthy volunteers, wore a cap with lights …

Researchers are testing two ways to train VA primary care clinicians to hold goals of care conversations with veterans who have serious illnesses such as cancer, heart failure, or dementia. One approach gives clinicians written materials and online training. The other adds team f…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This study followed 50 adults with a C9ORF72 gene mutation that can cause ALS or frontotemporal dementia. Over three years, researchers measured changes in strength, thinking, memory, and behavior using brain scans, spinal fluid tests, and other assessments. The goal was to under…

This completed study looked at how the brains of people with schizophrenia work when they are not taking antipsychotic medication. The goal was to tell apart the effects of the illness itself from the effects of the drugs. 648 participants stayed in a hospital and underwent brain…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study tests whether offering a $25 gift card encourages older adults from diverse backgrounds to join an Alzheimer's prevention registry. Researchers will recruit 400 people aged 50+ at community events, comparing the gift card to a non-cash gift. The goal is to see if small…

Researchers at the University of California, San Francisco are studying how the brain processes rewards in people with early-onset schizophrenia, major depressive disorder, post-traumatic stress disorder, or gambling disorder, compared with healthy volunteers. Participants comple…

This study analyzed health records from over 400,000 adults who had heart surgery to see if the sedative dexmedetomidine helped prevent problems like confusion, kidney injury, or death within 30 days. Researchers compared patients who received the drug around surgery time to thos…

This study surveys Indonesian sports science undergraduates to understand how self-esteem, anxiety, sleep habits, and social media use relate to feelings of being a fraud (impostor phenomenon). Researchers aim to identify which psychological, behavioral, and structural factors mo…

Delirium is a common and serious problem for critically ill patients in intensive care units. Researchers at the Medical University of Graz are measuring light and noise levels in three ICUs to see whether these environmental factors are associated with the development of deliriu…

This study will measure levels of two proteins, LRFN5 and OLFM4, in the blood of 120 people—some with schizoaffective disorder and some healthy. Researchers want to see if these proteins are linked to symptoms, overall function, and inflammation. The goal is to better understand …

This study measures two blood proteins, LRFN5 and OLFM4, in people with methamphetamine use disorder, those with methamphetamine-induced psychosis, and healthy volunteers. Researchers want to see if these markers are linked to inflammation and symptom severity. The study involves…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study follows people with idiopathic normal pressure hydrocephalus (iNPH) who are already scheduled for shunt surgery. Researchers measure changes in thinking skills and frailty one year after the procedure to identify which patients are most likely to improve. The goal is t…

Researchers are testing whether a non-invasive brain stimulation technique called high-definition transcranial alternating current stimulation (HD-tACS) can change brain wave activity in people with schizophrenia who hear voices. The study compares patients with auditory hallucin…

This study tests whether an AI tool that uses electronic medical records can help predict and reduce delirium (sudden confusion) in older adults after major surgery. About 60 people aged 65 and older will take part. The goal is to see if giving doctors a delirium risk alert can l…

This trial tests whether xenon gas can help reveal how the brain loses and regains consciousness. Healthy volunteers aged 20 to 40 will breathe xenon at concentrations up to 60% for two hours. Researchers will measure the brain concentration of xenon at the moment consciousness i…

This pilot study tested whether a nurse-led community-based rehabilitation program is feasible and acceptable for people with psychosis in Blantyre, Malawi. Sixty adults with psychosis were randomly assigned to either usual care or the home-based program. The study focused on rec…

This study tested whether a tool inside a patient portal could help people with mild memory problems discuss and document their future healthcare wishes. Researchers enrolled 300 older adults with cognitive impairment who had a patient portal account. The goal was to see if peopl…

This study tested a new digital tool called CBTpro that uses artificial intelligence to help therapists improve their skills in cognitive behavioral therapy for psychosis (CBTp). Over 600 participants, including therapists and their clients with conditions like schizophrenia or b…

This study looks at whether teaching people in the hospital about their psychiatric medications helps them stick to their treatment and handle side effects. Researchers will work with 64 adults who have serious mental illnesses like schizophrenia or bipolar disorder. The goal is …

This study looked at whether regular physical activity can improve thinking and memory in middle-aged adults (40-65) who have a family history of Alzheimer's disease. About 180 participants were randomly assigned to an exercise program or a comparison group and were followed for …

This study follows people who have a 50% chance of inheriting a gene for spinocerebellar ataxia, a group of progressive brain disorders that affect movement and coordination. The goal is to identify the earliest clinical signs and biological markers that appear before the disease…

This study looks at whether people with mild memory problems change their health habits, make future plans, or join more research after learning about their Alzheimer's-related brain scan results. It includes 100 Black and White adults with amnestic mild cognitive impairment. The…

This study looks at whether a fast, automatic eye test can predict delirium (sudden confusion) in intensive care patients who need a breathing machine. Delirium is common and serious, but current screening methods take time and training. Researchers will measure pupil reactions i…

This study tested whether a digital tool that scans electronic health records could help find older adults (65+) who might have undetected mild cognitive impairment or Alzheimer's disease. Over 3,400 patients from primary care clinics were identified as high-risk by the tool. Res…

This study looks at whether trained community health workers can help Korean American elders with dementia and their caregivers. About 288 pairs (elder and caregiver) will either get the program or usual care. The goal is to see if the program improves access to medical services …

This pilot trial tests whether adding social contact — personal stories and interactions with people who have mental illness — to standard mental health training can reduce stigma among primary care workers in Nepal. About 88 healthcare providers and their patients will take part…

This study gathers information from memory clinics across France to track how many people have Alzheimer's disease, how it progresses, and what factors affect diagnosis and care. Researchers will analyze anonymous medical records from over 500 centers to spot trends in health and…

This study tested a special training and tool for home hospice nurses and social workers to help them better care for people with dementia and support their families. About 93 participants, including clinicians and family caregivers who are Black or White, took part. The goal was…

This study tested whether a special MRI scan of the wrist can detect amyloid deposits in people with systemic amyloidosis, a condition where abnormal proteins build up in organs. Researchers enrolled 128 adults, including patients with cardiac amyloidosis and healthy volunteers. …

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitor…

This study investigates whether levels of the hormone ghrelin in the blood differ between people with various types of dementia, including Alzheimer's disease and dementia with Lewy bodies. Researchers will collect blood samples from 85 participants over age 60, both fasting and …

This study tests whether personalized digital coaching helps people stick to brain-healthy habits like exercise, diet, and sleep. 120 adults at risk for cognitive decline will be assigned to generic education, a digital platform, or the platform plus health coaching. The goal is …

This study tests whether spending less time in bed for four weeks can deepen sleep and boost memory in adults aged 65-85 who have poor sleep and are at risk for Alzheimer's. Researchers will measure brain activity, memory, and blood markers. The goal is to see if a simple behavio…

This study looked at whether emergency department pharmacists can safely reduce the use of certain brain-active medications in people with dementia or mild cognitive impairment. Researchers worked with 300 participants to see if pharmacists could communicate medication changes to…

This study is the first time Leucettinib-21 is being tested in humans. It aims to check the drug's safety and how the body processes it. The trial includes healthy volunteers and people with Down syndrome or Alzheimer's disease. No treatment benefit is expected at this early stag…

This completed study created the first international database of Datscan imaging values from 300 patients. The goal was to help doctors better diagnose Parkinson's disease and other neurodegenerative conditions by comparing brain scan results. Researchers hope this database will …

This study looked at whether doing short, frequent exercise sessions (called 'exercise snacks') is better for your mental health than doing longer, less frequent workouts. 180 healthy young adults were split into two groups: one did six 15-minute cycling sessions per week, the ot…

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This study measured the activity of an enzyme called glucocerebrosidase in 236 people with and without Lewy body dementia. The goal was to see if lower enzyme activity could help identify patients who might benefit from treatments already used for Gaucher disease. The study did n…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This study tested a 6-week museum-based programme called 'Refresh and Reconnect!' for older adults with mild cognitive impairment or mild dementia. Participants took guided tours and joined artist-led activities like dance, art, or drama. Researchers measured changes in quality o…

This study looked for protein markers in the blood and saliva of 96 people with long-term traumatic brain injury (TBI). Researchers compared samples from blast injury and non-penetrating injury patients to find common changes. The goal is to better understand the lasting effects …

This study watched 60 adults getting electroconvulsive therapy (ECT) for severe depression to see if their need for anesthesia changed over multiple sessions. Researchers measured the dose of anesthetic used each time and how it related to seizure quality and recovery. No new tre…

This study looked at how menopause-related hormone changes affect brain function and Alzheimer's risk in 120 postmenopausal women aged 50-70. Researchers used memory tests and brain scans to see which women's brains coped well with hormone changes and which showed signs of future…

This study looked at how people with schizophrenia process sounds and remember where information comes from. Researchers tested 50 participants (patients and healthy controls) using computer tasks. The goal was to understand if trouble telling sounds apart relates to difficulty d…

This study explores whether a special type of MRI called flow MRI can improve the diagnosis and management of normal pressure hydrocephalus, a condition where excess fluid builds up in the brain's cavities. Researchers will measure how cerebrospinal fluid and blood move through t…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This pilot study tested a community-based intervention for people with psychosis in Malawi, Nigeria, Sierra Leone, and Zimbabwe. The program includes peer support from someone who has experienced psychosis, case management, and help with daily activities like finding work or soci…

This completed pilot study scanned the brains of 30 people who were hospitalized with COVID-19 and later reported memory, concentration, or organizational problems—often called 'brain fog.' Researchers used MRI and spectroscopy to look for changes in brain structure and chemistry…

This pilot study tested whether wearable sensors can accurately measure apathy in people with frontotemporal dementia. Researchers monitored 14 participants' movements and behaviors in real-life situations. The goal was to see if technology could provide a more objective way to a…

This study looked at whether regular exercise can help slow down memory and thinking problems in older adults with early Alzheimer's disease and in healthy older adults. Researchers tested a program combining aerobic and strength exercises against stretching and balance exercises…

This pilot study tested whether a virtual reality reaction time test can help predict fall risk and cognitive decline in older adults with memory problems. Twenty participants aged 65 and older with cognitive impairment completed a VR task and standard tests. The goal was to see …

This study examined whether older adults with disrupted sleep or irregular daily rhythms show early brain changes linked to Alzheimer's disease. Researchers used wrist-worn activity monitors and brain MRI scans in 47 people over 65 without major memory problems. The goal was to s…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tested a 4-session education program for people with early schizophrenia. The goal was to see if it helps patients feel more connected to their therapist, which is important for ongoing care. 21 hospitalized patients took part, and researchers measured changes in the p…

This study tested a new way to improve mental health services for people with psychosis in Uganda. Instead of just doctors making decisions, people who have experienced psychosis were trained to help at home, in the community, and at clinics. The goal was to see if this approach …

This study tested whether a lifestyle program delivered through a smartphone app could help older adults (ages 60-77) at risk for dementia. 156 participants in four countries were split into two groups: one received a structured program with app support and in-person sessions, wh…

This study looked at how common dementia and memory problems are in older Mexican Americans compared to non-Hispanic whites. Researchers tracked changes in thinking skills over time and also asked caregivers what help they need. The goal is to find better ways to support patients…

This study looked at whether a 15-minute meditation practice called Shoonya meditation can help people stay sharp after a night without sleep. Researchers compared regular meditators to people who nap regularly, measuring brain activity, heart rate, and cognitive performance. The…

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This study looked at 170 older hospital patients with delirium (sudden confusion) to see which bed-exit alarm works better at preventing falls. One system uses pressure-sensitive mats, the other uses a contactless radar device. The goal was to find out which technology more relia…

This study used special brain scans (SPECT imaging) to look at two key brain chemicals—acetylcholine and dopamine—in people with dementia with Lewy bodies. Researchers aimed to see if differences in these chemicals could help diagnose the disease and identify subtypes. The study …

This study tested whether a gentle electrical current applied to the scalp (transcranial electrical stimulation) could help healthy adults perform a complex computer task faster and more accurately. Forty-four volunteers with advanced degrees completed a track-and-capture task wh…

This study looked at brain scans of 304 retired farmers aged 65 and older living in rural France. None had memory complaints at the start. Researchers used MRI and PET scans to measure brain areas linked to Alzheimer's, like the hippocampus. The goal was to find very early imagin…

This study looked at whether a quick, painless eye scan can detect early signs of Alzheimer's disease. Researchers measured the thickness of the retina's nerve layer in 200 older adults, some with Alzheimer's and some without. The goal was to see if these eye changes could serve …

This study looked at how older adults with and without Alzheimer's disease move in time with music. Researchers wanted to understand if this rhythmic movement relates to emotional expression and communication. The study involved 240 participants and measured how accurately they t…

This study tested whether a short bout of running at different intensities could improve attention and emotional well-being in 120 university students aged 18-24. Participants completed 16-minute sessions of sitting quietly or running at light, moderate, or vigorous levels. Resea…

This study used eye-tracking to see how people with Alzheimer's, Parkinson's, or frontotemporal dementia look at faces when trying to recognize emotions. Researchers compared their eye movements to healthy adults. The goal was to understand if different visual strategies explain …

This completed study looked at 344 frail older adults (70+) with memory issues to see how many have Alzheimer's-related brain changes. Participants had MRI and PET scans to detect amyloid plaques. The goal was to understand the link between frailty, memory loss, and Alzheimer's p…

This study checks whether a questionnaire called SCREEN can accurately find nutrition risk in older adults (55+) who have mild cognitive impairment or dementia and live at home or in retirement homes. Researchers will compare SCREEN results to a dietitian's assessment and test if…

This study tested two training programs (in-person and online) for staff in long-term care facilities in Minnesota. The goal was to improve care for LGBTQ+ residents with Alzheimer's or other dementias. Over 700 staff members participated, and researchers measured changes in poli…

This small study tested whether a nurse-led walking and sit-to-stand program is practical and liked by older adults with cognitive issues like dementia who are in transitional care after a hospital stay. Six people took part, and the researchers measured how many joined, stayed, …

This study checked whether a high dose of the experimental drug MK-8189 (elpipodect) affects heart rhythm in people with schizophrenia. 107 participants received the drug, a placebo, and an active control in a crossover design. The main goal was to see if the drug causes a danger…

This study tested a training program for emergency department staff to better detect delirium—a sudden confusion—in older adults. Researchers trained nurses and doctors at three hospitals and checked if detection improved. About 3,000 patients were involved. The goal was to see i…

This study looked at families with at least two members who developed Alzheimer's before age 65. Researchers wanted to find new genes that cause the disease, beyond the three already known. They collected medical and genetic information from 150 people across 23 centers in France…

This study looked at how older adults, including those with Alzheimer's or mild cognitive impairment, make decisions about where to live as they age. Researchers followed 293 participants to understand what factors—like memory, health knowledge, and support from family—influence …

This Norwegian study followed 169 elderly patients with depression for three years to see how they fared after specialist treatment. Researchers tracked whether depression returned or became chronic, and also checked for signs of dementia. The goal was to better understand the lo…

This completed study involved over 2,200 people diagnosed with or suspected of having frontotemporal dementia (FTD). Researchers collected blood samples to look for genetic changes linked to the disease. The goal was to find out how common these genetic causes are in people with …

This study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…

This completed study followed 509 children aged 3 to 18 who were taking risperidone or aripiprazole for conditions like schizophrenia or bipolar disorder. Researchers measured weight changes over up to 50 months to understand long-term risks. The goal was to provide better safety…

This completed observational study followed 168 pregnant or breastfeeding women with schizophrenia, psychosis, or mania who were already taking long-acting injectable antipsychotics. Researchers measured drug levels in the mother's blood, breastmilk, and the baby's blood to under…

This study tested whether a community health worker (CHW) can help people with dementia and their family caregivers after a hospital stay. The CHW provided education, care planning, and support through home visits and phone calls. The goal was to see if the program was feasible a…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This study tested how low (1 Hz) and high (20 Hz) frequency repetitive transcranial magnetic stimulation (rTMS) changes brain activity in 30 healthy adults. Participants received both types of stimulation in separate sessions, and their brain waves were measured before and after.…

This study tested a program called Patient Priorities Care in 178 people with dementia or mild cognitive impairment. Participants received a packet before their clinic visit and could talk with a trained facilitator about their personal healthcare goals. The study aimed to see if…

This study used brain imaging and memory tests to find early signs of Alzheimer's disease. Researchers followed 242 volunteers, including healthy young, middle-aged, and older adults, to track changes over time. The goal was to understand how the disease develops and identify mar…

This study looked at how people with Alzheimer's disease or a type of frontotemporal dementia remember personal events from their past. Researchers tested 39 participants using a detailed scale to see if memories were specific (like a single event in time and place) or more gener…

This study placed 15 healthy volunteers in a natural cave with no access to time cues for 40 days. Researchers measured how their sense of time, sleep cycles, stress levels, and group coordination changed. The goal was to understand how humans adapt to extreme isolation and time …

This completed study from the University of Hong Kong looked at 110 cannabis users aged 16-60 to see how their thinking skills change over time and if genes play a role. Participants took memory and thinking tests and gave blood for genetic analysis. The goal is to understand lon…

This study looked at 150 people with mild memory problems to see if a special MRI scan (pCASL) could give similar information to a standard PET scan. Participants had both scans, plus a spinal tap and yearly memory tests for three years. The goal was to see if the MRI could help …

This study examined 186 people with Alzheimer's, Lewy body, frontotemporal, or corticobasal dementia, plus healthy controls, to see if subtle physical signs (like coordination or reflexes) differ between dementia types. Participants had simple exams and cognitive tests. The goal …

This study looked at a process called autophagy, which is how cells clean out damaged parts, in 82 women over 65 with osteoporosis. Some also had Alzheimer's disease. Researchers measured autophagy levels in bone cells from hip samples to see if poor cell cleanup links bone loss …

This completed study looked at how people with Alzheimer's disease search for objects in realistic scenes and real-life settings. Researchers tracked eye movements in 48 participants to understand which attention and memory processes are impaired. The goal was to link visual expl…

This study tested a program called NAVIGATE, which provides coordinated care for youth and young adults (ages 14-35) who have had a first episode of psychosis. The goal was to see if NAVIGATE helps improve recovery, reduce hospital stays, and lower healthcare costs compared to st…

This completed pilot study looked at 46 older adults with Alzheimer's disease to see if age-related hearing loss is linked to trouble finding words. Participants took a computer test to measure word-finding ability and answered a hearing questionnaire. The goal was to better unde…

This study tested a new mobile app called iTEST that helps people with schizophrenia or schizoaffective disorder improve how accurately they judge their own performance on memory and emotion recognition tasks. 69 adults completed daily exercises on a smartphone for 16 weeks, gues…

This completed observational study enrolled 1,141 participants with mild cognitive impairment or Alzheimer's disease. Researchers tracked changes in memory tests, brain scans, and other biomarkers over time. The goal was to improve how future clinical trials measure the disease, …

This study tested whether a daily multivitamin called Vitals+ improves health, mood, and thinking skills in healthy adults. Thirty-seven volunteers took either the multivitamin or a placebo for 3 months. Researchers measured blood vitamin levels, cognitive function, and gut healt…

This study tested a new version of a common memory test (MMSE) that is adapted for people in Réunion Island, especially those who cannot read or write well. Researchers compared the new test with the standard French version in 61 hospitalized older adults. The goal was to see if …

This study followed 37 people with a genetic risk for hereditary ATTR amyloidosis over five years. Researchers measured levels of misfolded proteins in the blood to see if they could detect the earliest signs of the disease. The goal is to develop a way to catch the condition bef…

This study looked at how often brainstem problems occur in COVID-19 patients who are on a ventilator and deeply sedated in the ICU. Researchers checked brainstem reflexes using a simple scoring system, both during sedation and a few days after sedation stopped. The goal was to un…

This study tested a telepresence robot called COVEALINK 2 that allows patients hospitalized for at least 2 months to remotely control a robot in their own home. Using a smartphone app, patients could move the robot around and talk with family and friends. The goal was to see how …

This study looked at 77 people with Alzheimer's or frontotemporal dementia to understand why some lose awareness of their condition (anosognosia). Researchers used EEG and brain scans to measure how the brain responds to mistakes and emotional signals. The goal is to find brain m…

This study collected blood and DNA samples from 26 people with early-onset Alzheimer's disease and their close family members. Researchers analyzed the samples to find genetic changes and biomarkers that could help doctors diagnose, treat, and monitor the disease in the future. T…

This study looked at how a supplement called N-acetylcysteine (NAC) affects brain chemicals and thinking in 88 adults with schizophrenia or related disorders. Participants took tryptophan to raise a brain chemical called kynurenic acid, then had cognitive tests and brain scans. T…

This study looked at whether a single dose of a ketone supplement can improve blood flow to the brain and thinking skills in young adults. Twenty healthy people aged 18-35 took either a low dose, high dose, or a placebo drink. Researchers measured brain blood flow and memory perf…

This study looked at the dental health of 110 adults with schizophrenia in Côte d'Or, France. Participants received a mouth exam, a blood test for vitamin C levels, and answered a 30-minute questionnaire about their dental care and eating habits. The goal was to understand their …

This pilot study tested an automated phone system called 'My Coach Connect' for people with chronic mental illness. Participants called in twice a week to answer questions about how they were doing. The goal was to see if the system was easy to use and helpful for both patients a…

This study tested a new questionnaire to measure how people with schizophrenia perceive their own oral health. Researchers enrolled 59 patients who completed surveys about their oral health and quality of life. The goal is to create a reliable tool to guide better dental preventi…

This study looked at whether certain gene variations (ABCB1) make it harder for the brain to clear a protein called amyloid beta, which is linked to Alzheimer's disease. Researchers compared 510 people with and without Alzheimer's to see if these gene changes are more common in t…

This study looked at whether a 30-minute walk outside in a green area helps people recover from mental tiredness and stress better than walking on a treadmill indoors. 80 healthy young adults were split into two groups: one walked outdoors in nature, the other walked indoors in a…

This study looked at how caregivers' beliefs and attitudes might help or get in the way of teaching patients with schizophrenia to manage their own health. Researchers interviewed 21 medical and paramedical staff in France, both those who had given such education and those who ha…

This study tested a training program to help emergency department nurses better detect delirium in older adults. Delirium, a sudden confusion, affects up to 20% of older ER patients and is often missed. The program trained nurse champions through workshops and telehealth sessions…

This study looked at the gut microbiome (the bacteria living in the digestive tract) of 44 people with mild cognitive impairment, early Alzheimer's, or healthy memory. Researchers wanted to see if lifestyle changes could alter the gut microbiome and whether those changes might be…

This study looked at whether continuously measuring oxygen levels in the brain during heart bypass surgery can reduce memory and thinking problems after the operation. 326 older adults (age 60+) having planned heart surgery took part. Researchers compared standard care to care gu…

This study looked at whether people with mild cognitive impairment or Alzheimer's-type dementia can understand and decide about receiving their PET scan results for amyloid and tau proteins. Researchers educated 152 participants and their care partners, then assessed their abilit…

This study looked at 676 children in Swedish pediatric intensive care units (PICUs) to find out how often delirium occurs and what factors increase the risk. Delirium is a sudden change in mental state causing confusion or trouble paying attention. The researchers used a simple s…

This completed study looked for chemical markers in blood and urine that could help detect Alzheimer's disease early. Researchers analyzed samples from 95 people with mild cognitive impairment or Alzheimer's, comparing them to healthy older adults. The goal was to find biomarkers…

This study tested a program called InVEST that provides one-on-one support for young people aged 12 to 22 who are at high risk for psychosis. The goal was to see if the program helps them do better at work or school. The study had two parts: first a small test with 8 people to se…

This study tested a program where a care coordinator helps people with Alzheimer's and their caregivers manage doctor visits, medications, and support. Over 2,000 people took part to see if this approach reduces emergency room visits and delays nursing home stays. The goal was to…

This study tested whether an online platform can effectively share Alzheimer's gene and biomarker test results with 681 participants, compared to a video call with a healthcare provider. The goal was to see if the self-guided method causes similar levels of anxiety, distress, and…

This pilot study tested a new online program called the Brain Health Support Program (BHSP) designed to teach people about dementia and how to lower their risk through lifestyle changes like diet, exercise, and social connection. Twenty adults with mild memory concerns or a famil…

This study tested whether showing videos about care options to hospitalized patients aged 65 and older, or those with dementia, helps them make better advance care plans. Over 11,000 patients took part at two hospitals. The goal was to see if these video discussions lead to more …

This study tested whether daily paced breathing combined with brain training games could improve attention, memory, and reduce Alzheimer's-related markers in healthy adults aged 50-70. Participants did brain training and paced breathing at home for 10 weeks, and provided blood an…

This study tested a two-step process to improve care for older adults in the emergency department. First, quick screening tests for fall risk, delirium, and frailty were used. Patients with concerning results were then placed in an observation unit for a full team assessment by g…

This study gathered test results from 1,300 healthy adults aged 50 and older to create a reference database for a quick, tablet-based brain function test called BrainCheck. The goal was to establish normal score ranges and check if the test gives consistent results over time. No …

This study looked at whether doing memory and thinking tests over a video call at home works as well as doing them in person for people with suspected Alzheimer's disease. 116 older adults (ages 60-90) with mild memory problems took part. The goal was to see if video assessments …

This study tested a program called Collaborative Decision Skills Training (CDST) to help veterans with serious mental illness (like schizophrenia or major depression with psychosis) work more closely with their doctors in making treatment decisions. The program involved eight wee…

This study reviewed medical records of 274 adults who had emergency surgery for a torn aorta (aortic dissection). Researchers looked at how often patients had brain complications like stroke or coma after surgery and whether those complications led to longer stays in the intensiv…

This study worked with 23 adults aged 50 and older who have memory concerns to design online mindfulness and lifestyle education programs. Participants joined focus groups to share their views on healthy living and web-based interventions. Their feedback will help shape future cl…

This study tested a program where trained peer providers help young people with early psychosis reduce or stop using alcohol and drugs. 113 participants from coordinated specialty care teams took part. The goal was to see if the program could be delivered as planned and whether i…

This study looked at cells from 21 people with BPAN, a rare brain disease caused by a gene mutation. Researchers wanted to see if the cells have trouble handling stress, which might explain why brain cells die. No treatment was given; the goal was simply to learn more about the d…

This study looked at 51 adults who had COVID-19 2 to 12 months earlier and still had brain fog or other thinking problems. Researchers checked if the virus was still hiding in the nose's smell center. They compared these patients to a control group to see if lingering virus is li…

This completed study followed 229 stroke survivors over time to understand what factors might lead to dementia or cognitive problems after a stroke. Researchers looked at medical history, brain scans, and medications. The goal was to identify clues that could help predict and pos…

This study tested a program called APPROACHES in nearly 500 nursing homes across the U.S. The program trained staff to better discuss and document care preferences for residents with Alzheimer's or related dementias. The goal was to see if this approach could reduce unwanted hosp…

This completed study tested whether a daily fermented soy powder (Q CAN PLUS) could improve thinking skills, immune function, and response to the flu shot in healthy adults aged 65 and older. 62 participants took either the soy supplement or a placebo for 16 weeks. Researchers me…

This completed study involved 100 adults aged 50-80 who gave blood samples weekly for 9 weeks. Researchers measured a protein called pTau-217, which is linked to Alzheimer's disease. The goal was to see how much this biomarker naturally fluctuates from week to week, which could h…

This study looked at whether thinning of the retina (the back part of the eye) can be a sign of Alzheimer's disease. Researchers compared eye scans from 55 people with Alzheimer's, Lewy body disease, and healthy volunteers. The goal was to see if measuring retinal layers could he…

This study tested whether a home-based web program combining exercise, brain games, and nutrition advice is practical and well-liked by older adults. 120 participants aged 60+ with mild memory concerns used the program for several months. The goal was to see if they would stick w…

This completed study looked for genetic and environmental factors that increase the risk of developing Parkinson's disease. Researchers compared DNA and lifestyle data from over 2,200 people, including Parkinson's patients, people with related brain diseases, and healthy voluntee…

This study looked at driving skills in 60 people over age 70 with early-stage Alzheimer's disease (MMSE score 24 or higher) and compared them to healthy older drivers. The goal was to identify common driving mistakes and suggest adaptive measures or technology to help them drive …

This study exposed 40 healthy, non-smoking adults to diesel exhaust and clean air to see how pollution affects the olfactory system (the part of the nose that detects smells). Researchers took biopsies from the nose and tested thinking and smell abilities. The goal is to understa…

This study used powerful MRI scans to track how a rare genetic disease called metachromatic leukodystrophy (MLD) damages the brain's white matter in young children. Researchers studied 29 children aged 1 to 6 years with MLD, along with a control group, to better understand how th…

This study tested a special PET scan tracer (F-18 AV 1451) to see how much tau protein builds up in the brains of 81 people with primary progressive aphasia or frontotemporal dementia. Researchers compared these scans to those of healthy controls to find unique patterns for each …

This study looked at 134 adults with chronic sinusitis to see if sleep problems and daytime tiredness predict declines in thinking skills and daily functioning. Participants filled out questionnaires about their symptoms and quality of life. The goal was to better understand how …

This study measured inflammation markers and brain activity in 20 older adults during elective surgery. Researchers wanted to see if these factors could be early signs of Alzheimer's disease. The study is complete and aimed at understanding, not treating, the disease.

This study adapted a Canadian safety checklist for use in France to help caregivers assess accident risks for elderly people with dementia living at home. Researchers worked with 116 caregivers to test the checklist's reliability. The goal is to give healthcare providers a simple…

This study tested a program to support families right after a dementia diagnosis. 82 caregivers from Iowa took part. The program provided education and help connecting to community services. The goal was to reduce caregiver burden and improve knowledge of available support.

This study looked at how giving people information about their genetic risk for Alzheimer's disease affects them emotionally and behaviorally. It involved 374 Latino adults aged 40-64 in New York City who did not have Alzheimer's. Some participants learned their risk based only o…

This completed study from the University of East Anglia looked at how gut bacteria break down certain plant compounds (flavan-3-ols) in people with different versions of the APOE gene, which is linked to Alzheimer's risk. 49 healthy adults donated stool and saliva samples. The go…

This completed study looked at 40 people with spinocerebellar ataxia types 2 and 7, a rare brain disease that affects movement. Researchers used MRI scans and lumbar punctures over one year to track changes in the brain and body. The goal was to find reliable markers that could b…

This completed study followed 6,000 adults who had COVID-19 symptoms and were tested for the virus. Participants completed online surveys every 3 months for 18 months to track long-term health issues like fatigue, brain fog, and heart problems. The goal was to better understand t…

This pilot study tested whether remote smartphone tests of thinking, memory, and motor function can identify older adults who may be vulnerable to cognitive problems after spine surgery. 34 participants completed the tests before surgery, and researchers tracked who developed pos…

This study looked at how sleep apnea might make brain problems worse after surgery. Researchers enrolled 32 adults with moderate-to-severe sleep apnea who were scheduled for surgery. They used brain scans and memory tests before surgery, two days after, and six months later to tr…

This study tested a nutrition training program for home care workers to help people with dementia eat better at home. Researchers worked with 139 participants, including people with dementia, their families, and care staff, to see if the program was practical and acceptable. The …

This completed study looked at how often thinking, memory, and behavior problems happen after a stroke. Researchers tested over 1600 people, including stroke patients and healthy volunteers, using a French version of a standard cognitive battery. The goal was to better understand…