Cognitive disorder

This Phase 2 study tested ABvac40, a vaccine designed to help the immune system target and clear a protein called amyloid-beta 40, which builds up in the brains of people with Alzheimer's. The trial included 134 adults aged 55-80 with mild cognitive impairment or very mild Alzhei…

This study tests whether a small social robot named Tessa can help people with disabilities who have trouble planning and remembering daily tasks. Participants use the robot in their home, and researchers track how much professional caregiver support they need. The goal is to see…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This early-phase trial tests whether MIB-626, a drug that activates sirtuin-NAD pathways, can reach the brain and affect aging-related markers in people with mild Alzheimer's. 22 participants will take either MIB-626 or a placebo for 90 days. The study primarily checks if the dru…

This phase 3 trial tested whether giving preterm babies a drug called darbepoetin weekly could improve their brain development and reduce the need for blood transfusions. 650 infants born between 23 and 28 weeks of pregnancy were treated until they reached 35 weeks or went home. …

This study tests a 10-week nutrition program in 61 older adults (ages 55-85) from rural North Florida, some with mild cognitive impairment and some without. Participants follow either a Mediterranean diet or a modified Mediterranean-ketogenic diet. The goal is to see if the progr…

This early-phase trial tests whether a daily vitamin B3 supplement called nicotinamide riboside can improve brain energy and reduce stress in people with mild cognitive impairment or mild Alzheimer's disease. Fifty participants will take the supplement for 12 weeks while research…

This early-phase study tested the drug baricitinib in 17 people with Alzheimer's disease, ALS, or mild cognitive problems. The goal was to see if the drug reaches the brain and lowers inflammation linked to these diseases. Participants took baricitinib pills for 24 weeks, and res…

This phase 1 trial tests a single injection of TV-44749, an extended-release form of olanzapine, in Chinese adults with stable schizophrenia. The study aims to check safety, tolerability, and how the drug moves through the body. Participants receive one of three doses of the inje…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve memory, thinking, and daily function compared to a placebo over 24 weeks. Researchers also c…

This study tested a long-acting injectable (LAI) form of the drug lumateperone in 52 adults with stable schizophrenia or schizoaffective disorder. Participants received a single injection of one of several LAI formulations, along with oral capsules, to see how the drug behaves in…

This large Phase 3 trial tested whether the diabetes drug semaglutide, taken as a daily pill, can slow cognitive decline in people with early Alzheimer's disease. About 1,840 participants received either semaglutide or a placebo for up to 3 years and 4 months. The study measured …

This study tested the safety and tolerability of aripiprazole (Abilify) in 21 children and adolescents aged 10 to 17 with schizophrenia or mania. Participants took daily doses of 2 to 30 mg for 14 days. The main goals were to see how many could tolerate the highest dose without s…

This study tested the safety of a new drug called KarXT in 173 adults with schizophrenia. Researchers slowly increased the dose to see how well participants tolerated it and whether food affected the drug. The main goal was to track side effects, with secondary measures looking a…

This Phase 3 trial tested an investigational drug called SEP-363856 in 464 people with schizophrenia who were experiencing acute psychosis. Participants received either the drug or a placebo daily for up to 9 weeks. The study measured changes in symptoms like hallucinations and d…

This trial investigates whether a single 4 mg dose of the steroid dexamethasone, given intravenously before hip fracture surgery, can lower the risk and severity of postoperative delirium in adults aged 60 and older. Delirium is a sudden state of confusion that often occurs after…

This phase 2 trial investigates whether lenalidomide, a drug that calms inflammation, can slow cognitive decline in people with mild cognitive impairment due to Alzheimer's disease. Participants take lenalidomide or a placebo for up to 12 months, followed by a 6-month washout per…

This completed Phase 2 trial tested an oral drug called LY3372689 in 327 people with early symptomatic Alzheimer's disease. The goal was to see if the drug could safely slow down declines in thinking and daily living skills compared to a placebo. The study focused on participants…

This study tested the safety and effects of nilotinib, a cancer drug, in 43 people with Dementia with Lewy Bodies (DLB). DLB is a common type of dementia that shares features with Parkinson's and Alzheimer's. The goal was to see if nilotinib is safe and changes brain biomarkers, …

This study tested a weight-loss program called CoachToFit for 257 veterans with serious mental illness (like schizophrenia or bipolar disorder) who were obese. Participants used a smartphone app, an activity tracker, and a Bluetooth scale, and worked with a peer coach. The goal w…

This study tested whether a once-monthly injection of aripiprazole can help people with schizophrenia avoid a relapse of symptoms. Over 900 adults took part, first switching to oral aripiprazole, then receiving either the long-acting shot or another treatment for up to 38 weeks. …

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested whether adding slow, paced breathing exercises to computer-based brain training could improve thinking skills and slow dementia in older adults with mild cognitive impairment. Over 8 weeks, 113 participants either did both breathing and brain training, brain tra…

This study tested a long-acting injectable form of risperidone (Risperdal Consta) in 31 people with schizophrenia or schizoaffective disorder who were already receiving home-care treatment. Participants switched from their usual antipsychotic medication to receive a shot every tw…

This early-stage study tested whether multiple infusions of donor stem cells are safe for people with mild to moderate Alzheimer's disease. Six participants received the treatment and were monitored for serious side effects and changes in thinking skills. The goal was to check sa…

This study tested an investigational drug called SEP-363856 in 463 people with schizophrenia who were having severe symptoms. Participants received either the drug or a placebo for 6 weeks. The main goal was to see if the drug reduced symptoms like hallucinations and emotional wi…

This study tested a special team-based program called R-FACT for people with serious mental illness who are also involved with the criminal justice system. The program provides intensive, community-based support with close coordination between mental health and justice staff. Res…

This large Phase 3 study tested an experimental drug called remternetug in over 1,600 people with early symptoms of Alzheimer's disease. The main goal was to see if the drug could safely clear amyloid plaques from the brain, a hallmark of Alzheimer's. Participants received either…

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This study tested whether adding memantine, a drug used for Alzheimer's, to targeted cognitive training (brain exercises) could improve thinking and daily function in people with schizophrenia or schizoaffective disorder. 62 participants took either memantine or a placebo while c…

This study looked at whether changing antipsychotic medication can better control schizophrenia symptoms in people already taking these drugs. Researchers followed 219 adults with schizophrenia or schizoaffective disorder who still had symptoms despite treatment. The main measure…

This study tested three non-drug approaches—cognitive training, reminiscence therapy, and a personalized program—in 640 people with mild-to-moderate Alzheimer's. The goal was to see if these therapies could delay progression to severe dementia. Participants were followed for chan…

This study tested whether restoring proper chewing function through dental implants or braces could improve cognitive health in adults. Researchers enrolled 150 people with missing teeth or misaligned bites. They measured changes in brain activity, thinking skills, and mood. The …

This completed study looked at whether two different blood thinners—dabigatran (Pradaxa) and warfarin (Coumadin)—could help prevent memory loss and dementia in people over 65 with atrial fibrillation (an irregular heartbeat). A total of 101 participants were randomly assigned to …

This early-stage trial tested an experimental drug called SHR-1707 in 33 people with mild memory problems or mild Alzheimer's disease. The drug is an antibody given through a vein, designed to target and clear amyloid plaques in the brain. The main goal was to check safety and si…

This phase 3 trial tested KarXT, a combination of two drugs, as an add-on treatment for 396 adults with schizophrenia whose symptoms were not well controlled by their current medication. Over 6 weeks, researchers measured changes in symptom severity using a standard rating scale.…

This study tested a special tablet exercise program called KOKU-LITE, designed for people with dementia to help prevent falls and improve well-being. Sixty people with dementia and their carers took part to see if the program was easy to use and helpful. The goal was to see if th…

This study looked at 6 people with schizophrenia who were already taking a combination of two long-acting injectable medications: Abilify Maintena and Rexulti. Researchers tracked their symptoms and side effects over 6 months to see how well the combo worked in everyday life. The…

This study tested an online family education program delivered via a messaging app to help families of people with first-episode schizophrenia. The goal was to reduce negative emotions in family members and improve how consistently patients take their medication. 53 patients and …

This pilot study tested whether a short course of low-dose radiation to the brain could reduce amyloid plaques, a hallmark of Alzheimer's disease. Twenty people with early Alzheimer's and positive amyloid scans were enrolled. Half received radiation over 5 days, while the other h…

This completed phase 1 study tested whether taking choline, a dietary supplement, for 6 months could improve fat metabolism in the brain of people with the APOE4 gene, which raises Alzheimer's risk. Fifteen participants aged 55-80 took choline capsules twice daily. The main goal …

This study followed 24 people with metachromatic leukodystrophy (MLD), a rare and serious brain disease, who were already receiving an experimental drug called HGT-1110. The main goal was to check for side effects and immune reactions over a long period. Researchers wanted to see…

This study adapted a proven mouth care program for nursing homes to work in assisted living facilities for people with dementia. Nursing assistants were trained to provide daily mouth care and given supplies. The goal was to reduce harmful mouth bacteria that can lead to pneumoni…

This study tested whether personalized notifications from a Fitbit—about sleep, activity, and nutrition—could improve thinking skills and muscle mass in adults over 65. Over 350 older adults in Japan wore a Fitbit for 6 months and received automatic tips, while a control group go…

This study tested whether a probiotic supplement (Pediococcus acidilactici) could reduce metabolic problems like high cholesterol and blood sugar caused by antipsychotic drugs. 36 adults with first-episode psychosis or schizophrenia took the probiotic or a placebo alongside their…

This study looked at whether providing mental health care to people who inject drugs can improve their mental health and reduce their risk of getting HIV or hepatitis C. Over 500 participants in Haiphong, Vietnam, received free psychiatric consultations, medications, and support …

This completed Phase 2a study tested an oral drug called neflamapimod in 26 people with dementia with Lewy bodies. The main goal was to check safety and how the drug moves through the body over 24 weeks. Researchers also looked at changes in thinking and memory as a secondary mea…

This completed Phase 3 trial tested whether oral semaglutide (a drug used for diabetes and weight loss) can slow cognitive decline in 1840 people with early Alzheimer's disease. Participants received either semaglutide or a placebo daily for up to 3 years and 4 months. The study …

This trial tested a custom-made drug called nL-TARD-001 in one person with ALS caused by a specific genetic mutation in TARDBP. The drug is an antisense oligonucleotide designed to target the faulty gene. The study measured changes in muscle function, breathing, and thinking over…

This Phase 2 study tested a once-daily combination pill (polypill) in 121 adults aged 50–85 with very mild to severe Alzheimer's disease. Over 180 days, researchers measured changes in thinking, memory, and daily function using standard dementia scales. The goal was to estimate w…

This study tested a drug called TPN-101 in 42 people with ALS or frontotemporal dementia caused by a specific gene change (C9orf72). The main goal was to check if the drug is safe and tolerable over 48 weeks. Researchers also looked at how the drug moves in the body and whether i…

This study tested whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery can lower the risk of postoperative delirium—a state of confusion that can slow recovery. Researchers compared 130 patients who received either low tidal volume ventilation or n…

This study tested two long-acting injectable medications, aripiprazole and paliperidone, in 165 people who use stimulants and have psychosis. The goal was to see if these drugs could better manage psychosis and prevent progression to chronic schizophrenia compared to standard tre…

This study tested an experimental drug called METAZYM (a lab-made enzyme) in one child with late infantile metachromatic leukodystrophy (MLD) who had already received a stem cell transplant. The goal was to see if the enzyme could improve nerve function and reduce harmful buildup…

This study looked at whether a plant-based ketogenic diet combined with intermittent fasting (called Ketoflex 12/3) could slow the progression of early-to-mid stage Alzheimer's disease. Sixty participants followed the diet, and researchers measured changes in memory and thinking …

This completed trial tested a ketogenic diet (high-fat, low-carb) in 32 people with mild to moderate Alzheimer's disease. Participants followed the diet or a placebo for 26 weeks. Researchers measured changes in cognitive function using a standard test. The goal was to see if the…

This study tested whether a year of twice-weekly resistance training could protect brain health and thinking skills in 91 older adults with vascular cognitive impairment, a condition linked to small strokes. Participants were randomly assigned to either resistance training or a s…

This study tested a drug called donanemab (LY3002813) in 272 people with early symptoms of Alzheimer's disease. The goal was to see if the drug is safe and can slow down memory loss and daily functioning problems. Participants received either the drug or a placebo, and researcher…

This study tested whether a peer-led psycho-education program (where trained patients lead group sessions) helps adults with schizophrenia improve symptoms and daily functioning over two years. 342 participants were randomly assigned to peer-led groups, professional-led groups, o…

This study tested a monthly injection of olanzapine (TV-44749) in 675 adults with schizophrenia to see if it controls symptoms better than a placebo. Participants received up to 14 injections over about a year. The goal is to offer a long-acting option that may improve treatment …

This study tested whether adding structured supportive psychotherapy to the antipsychotic drug risperidone helps improve thinking and reduce inflammation in people with schizophrenia. Forty-six male patients were split into two groups: one received risperidone plus 12 therapy ses…

This study tested a gene therapy called OTL-200 in 10 children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. The treatment uses the child's own blood stem cells, modified to produce a missing enzyme, and aims to slow or stop disease progres…

This study tested whether a non-invasive brain stimulation method called tACS could reduce amyloid and tau proteins in people with mild to moderate Alzheimer's. Seventeen participants received daily sessions of tACS or a sham treatment for 2-4 weeks. The goal was to see if the st…

This study tested whether narrow dental implants work as well as standard-sized implants placed with bone regeneration in people with narrow jawbone in the back of the mouth. Thirty adults with a ridge width between 5 and 6.5 mm received either a 3.0 mm narrow implant or a 4.0 mm…

This study tested an experimental drug called lecanemab (BAN2401) in 856 people with early Alzheimer's disease, including those with mild cognitive impairment or mild dementia. Participants received different doses of the drug or a placebo every 2 or 4 weeks for 18 months. The go…

This study tested a gene therapy for children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. Five children aged 6 months to 5 years received injections of a harmless virus carrying a working copy of the ARSA gene directly into their brains. …

This study tested a tablet-based platform called Tenèpsia® for remote cognitive assessments in 250 healthy adults and people with cognitive impairment. The goal was to collect normal test scores and validate the digital tool for diagnosing neurocognitive disorders. If proven reli…

This study looked at whether a special brain scan called 18F-FDG PET can help doctors tell the difference between cognitive problems caused by psychiatric conditions versus neurodegenerative diseases like Alzheimer's. Researchers studied 20 adults with cognitive impairment who ha…

This study tested whether a special PET scan using florbetapir can help doctors figure out why some people develop memory and thinking problems after a stroke. The scan looks for amyloid plaques, a hallmark of Alzheimer's disease. Researchers studied 92 adults aged 40 to 80 who h…

This study checked if a Turkish version of the MoCA-B test can correctly tell the difference between healthy people, those with mild memory problems, and those with dementia. The test was given to 166 adults aged 50-100 with little or no schooling. The goal was to find the best c…

This study tested whether an artificial intelligence system could detect mild cognitive impairment and Alzheimer's disease by analyzing simple self-figure drawings. Over 3,400 older adults drew themselves on paper, and the AI learned to spot patterns linked to cognitive decline. …

This study tested a new digital tool that uses artificial intelligence to analyze a person's speech during three one-minute verbal fluency tests. The goal was to see if it could accurately detect mild cognitive impairment (MCI) or early dementia. The study involved 221 adults age…

This study tested an artificial intelligence platform that screens for cognitive dysfunction by analyzing eye movements. Over 1,500 participants, including people with various dementias and healthy individuals, took part. The AI aims to detect cognitive impairment and provide ref…

This study tested whether an automated speech analysis tool called AcceXible can help detect mild cognitive impairment or dementia early. Researchers analyzed speech patterns from 273 adults aged 55 and older, including healthy individuals and those with memory concerns. The goal…

This completed study looked at whether combining an online memory test with a blood test can help find Alzheimer's disease early in people 65 and older. Over 1,400 volunteers took part. The goal is to make early detection easier and faster, so treatment can start sooner.

This study tested a low-cost method to find undiagnosed dementia in primary care. Researchers used electronic health records to identify patients at risk. Over 1,200 adults without a prior dementia diagnosis took part. The goal was to see if this approach could increase new demen…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study tested whether giving mannitol, a substance that reduces brain swelling, could prevent delirium in older adults hospitalized for a heart attack. Fifty patients aged 65 and older with high inflammation levels were included. The goal was to see if mannitol could lower th…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tests whether a computer program called pronia.ai can help doctors identify young people at high risk for psychosis and offer them early, tailored treatment. Participants aged 16 to 40 with early warning signs will either receive standard care or the AI-guided approach…

This study tested whether a health belief model-based education program could improve knowledge about dementia and increase motivation to adopt healthy behaviors in adults aged 60 and older. 66 participants without dementia took part. The program aimed to help seniors understand …

This study tested whether mindfulness training can prevent relapse in people with psychosis. 152 participants who were in remission were randomly assigned to either mindfulness training or standard education. Researchers tracked them for 12 months to see who had a relapse.

This completed study tested a program called HomeStyles-2, which aims to help parents of children aged 6 to 11 create healthier home environments. The program focuses on improving diet, physical activity, and sleep habits to prevent obesity. Over 450 families participated, with s…

This study tested whether a structured lifestyle program—including diet, exercise, and cognitive training—can help prevent cognitive decline in older adults at risk for dementia. Over 1,000 participants aged 60-77 from 12 Latin American countries took part. The goal was to see if…

This study looked at whether 6 months of moderate aerobic exercise could improve memory and brain health in older adults (ages 60-80) who are inactive but cognitively healthy. Some participants carried a gene (APOE-ε4) that raises Alzheimer's risk. They were randomly assigned to …

This study tested whether an 8-week course led by a robot (Kebbi) could help prevent cognitive decline in 80 community-dwelling adults aged 65+ with mild cognitive impairment. The experimental group interacted with the robot in small groups, playing board games and learning, whil…

This study tested whether giving IV acetaminophen (Tylenol) every 6 hours during and after heart surgery could prevent delirium—sudden confusion—in patients aged 60 and older. Delirium is common after heart surgery and can lead to longer hospital stays and other problems. The tri…

This study tested a non-invasive brain stimulation technique called HD-tDCS in 269 people with mild cognitive impairment or early Alzheimer's. The goal was to see if different doses could improve brain connectivity and memory. Participants received the stimulation while researche…

This study tests whether a 6-week online self-help program can help people with psychotic disorders who hear voices at least once a week. The program combines metacognitive training and mindfulness techniques to reduce the frequency and distress of auditory hallucinations. Partic…

This pilot study tested whether adding structured supportive psychotherapy to the antipsychotic risperidone could improve cognitive function and reduce inflammation in 44 hospitalized adults with schizophrenia. Participants received either risperidone plus 12 weekly talk therapy …

This study tests whether time-restricted eating (fasting for 16 hours each day) can improve memory, thinking, and overall well-being in overweight adults aged 65 and older who are worried about their memory. Over 24 weeks, participants either follow the fasting plan or join a hea…

This study tests whether combining two sedatives, dexmedetomidine and esketamine, can lower the chance of delirium (sudden confusion) in older patients (60+) after surgery in the ICU. Delirium is common and can lead to worse outcomes. The trial will involve 100 participants and t…

This study looks at whether berberine, a natural compound, can improve cognitive problems like memory and attention in people with schizophrenia. One hundred adults aged 18-60 will take either berberine or a placebo pill for 12 weeks, in addition to their regular antipsychotic me…

This study looks at whether adding a physical activity education program to adapted exercise helps people with mild memory or thinking problems more than exercise alone. Thirty-four participants will be followed for six months to measure changes in activity level, thinking skills…

This study tested whether older adults with mild cognitive impairment or early Alzheimer's can use a tablet-based brain-training app at home. 52 participants played 12 different games for 8 minutes each, daily for two weeks. The goal was to see if the app was easy to use and acce…

This completed study tested whether taking a daily whey protein drink rich in phospholipids for 6 to 12 weeks could improve memory, mood, and overall wellbeing in healthy adults aged 25 to 49. 119 participants were randomly assigned to receive either the active supplement or a pl…

This study tests whether a special flickering light (40 Hz) can improve sleep and thinking in people with mild cognitive impairment or early Alzheimer's disease. Participants will sit under the light for one hour while researchers measure brain activity and memory. The goal is to…

This study tested whether giving electroacupuncture 30 minutes before major surgery could lower the chance of postoperative delirium (sudden confusion) in patients aged 65 to 90. Over 1,100 participants were randomly assigned to receive real or sham acupuncture. The goal was to s…

This study tested whether metformin, a drug used for diabetes, can improve cognitive problems in people with schizophrenia. 120 participants took either metformin or a placebo for 24 weeks. Researchers measured changes in thinking skills and brain scans to see if metformin helps.

This study tests whether the drug mevidalen can safely improve thinking, memory, and daily function in people with mild-to-moderate Alzheimer's disease. About 300 participants will receive either mevidalen or a placebo for 26 weeks. The main goal is to see if the drug eases sympt…

This study tested a program where a pharmacist worked with people living with dementia, their care partners, and their doctors to review and reduce unnecessary medications. The goal was to simplify medication routines and lower treatment burden. The study included 138 participant…

This study tests whether Snoezelen multisensory therapy — a calming, personalized experience using lights, sounds, textures, and scents — can reduce agitation, depression, and anxiety in older adults with dementia. Sixty participants with mild to moderate dementia will receive ei…

This study tests whether immersive virtual reality (VR) can safely help people with schizophrenia improve their thinking skills, reduce symptoms, and function better in daily life. Forty adults with schizophrenia or schizoaffective disorder will either receive VR-based cognitive …

This study looked at whether a weekly hour of adapted physical activity for 12 weeks could improve self-esteem and motivation in 17 older adults with mild to major cognitive disorders like Alzheimer's. Researchers measured changes in self-esteem, motivation, and apathy. The goal …

This study tests whether an 8-week choral singing program can improve the well-being of nursing home residents with dementia. Participants attend one 75-minute group singing session each week, plus a dress rehearsal and final concert. Researchers measure changes in stress hormone…

This study tested whether combining a gentle brain stimulation technique called tDCS with memory and thinking exercises could help people with early Alzheimer's. Twenty-two participants received either real or fake stimulation during 10 sessions of cognitive training. Researchers…

This study tested whether playing a gentle sound called 'pink noise' during deep sleep could strengthen memory in people with early Alzheimer's disease. Nineteen participants wore a special headband that delivered the noise on some nights and not on others. The goal was to see if…

This study tested a 12-week music therapy program for 76 care home residents with dementia or cognitive impairment. Residents received individual music therapy sessions, and staff were trained to use music techniques. The goal was to see if music therapy could reduce unmet care n…

This study tests whether adding a caregiver training program to a visual mapping assistive technology (MapHabit) improves daily life for people with Alzheimer's or dementia and reduces stress for their caregivers. Fifty patient-caregiver pairs will use either the technology alone…

This study tested a virtual reality (VR) program designed to stimulate thinking skills in 45 people with mild cognitive impairment. Participants used VR headsets to do tasks like virtual shopping and recipe sequencing over 8 sessions. The goal was to see if the VR program was eas…

This study tested whether low-intensity ultrasound waves aimed at a specific brain area could help reduce negative symptoms of schizophrenia, such as lack of motivation and social withdrawal. 78 adults with stable schizophrenia received either real or fake ultrasound over 20 days…

This study tested if immersive virtual reality (VR) can improve memory and thinking in people with Alzheimer's disease. 33 participants wore VR headsets to explore scenes from 1960s Burgos, Spain, designed to trigger personal memories. Researchers measured changes in cognitive te…

This study tested a non-invasive brain stimulation technique called rTMS, guided by each person's unique brain activity map, to see if it could improve thinking and memory in 46 people with mild Alzheimer's disease. Participants received either real or fake (placebo) stimulation …

This pilot study tested whether a gentle brain stimulation technique called HD-tDCS could improve memory and word recall in 27 older adults with mild cognitive impairment. Participants received either real or sham stimulation over 10 sessions across two weeks. The goal was to see…

This study tested a gentle brain stimulation technique (HD-tDCS) combined with computer-based memory exercises in 60 people with early Alzheimer's. The goal was to see if this combination could improve thinking and memory more than either treatment alone. Researchers also used br…

This study tested whether personalized magnetic brain stimulation (TMS) is safe and helpful for people with early Alzheimer's disease. Forty participants received either real or fake TMS to see if it could improve memory and thinking. The goal was to find a non-drug way to ease s…

This study tested two smartphone-based digital treatments alongside standard medication for people with schizophrenia who struggle with low motivation and lack of pleasure. Over 460 adults and teens took part for 16 weeks. The goal was to see if these apps could ease these tough …

This study tested a program based on Acceptance and Commitment Therapy (ACT) for 64 caregivers of people with mental disorders. The program aimed to help caregivers build psychological resilience, manage stress better, and feel less burdened. Results showed that those who took pa…

This study tested a prescription smartphone app called RiSolve for women with overactive bladder (OAB). The app provides an 8-week program of bladder training, pelvic floor exercises, and digital cognitive behavioral therapy. Researchers enrolled 46 women in Ireland to see if the…

This study tested whether a herbal supplement called Redormin 500 (made from valerian and hop extracts) can help people with occasional sleep problems think more clearly during the day and feel better overall. Forty healthy adults with mild sleep issues took either the supplement…

This study tests whether a smartphone app can help reduce negative symptoms of schizophrenia, such as lack of motivation and pleasure. It includes 73 adults and older teens who already completed a previous trial with the same app. Participants use the app for 16 weeks alongside t…

This Phase 3 trial tested a sublingual film containing dexmedetomidine (BXCL501) to quickly reduce agitation in 380 adults with schizophrenia or related disorders. Participants received either the drug or a placebo film, and researchers measured changes in agitation symptoms over…

This study tested a program to reduce anticholinergic medications (like benztropine) in 53 adults with schizophrenia, bipolar disorder, or other serious mental illnesses who had been taking these drugs for at least 6 months. The goal was to safely taper or stop these medications …

This study tested a safe, non-invasive brain stimulation technique called tACS in 26 people with mild cognitive impairment due to Alzheimer's. The goal was to see if a 40 Hz electrical current applied to the brain could improve memory. Participants completed memory tests before, …

This study looked at whether different lengths of light exposure can improve sleep, mood, and agitation in people with Alzheimer's disease. 135 participants were randomly assigned to receive 2 hours, 4 hours, or all-day morning light. The goal was to see which light schedule work…

This study tested a silent alarm system in intensive care units to see if it lowers noise, patient delirium, and staff burnout. Over 200 patients and healthcare workers took part, comparing four weeks with the silent system to four weeks without. The goal was to see if reducing a…

This study tested a sublingual film containing dexmedetomidine (BXCL501) to quickly calm agitation in 100 older adults with dementia. Participants received either the drug or a placebo, and researchers measured changes in agitation scores and side effects. The goal was to find a …

This study tested an online education program called 'Caregiving While Black' to help Black American caregivers feel more confident and less stressed while caring for a family member or friend with dementia. About 140 caregivers took part. The program focused on building skills a…

This pilot study tested a website tool called WeCareToFeedDysphagia designed to reduce feelings of burden in caregivers of people with Alzheimer's or related dementias who also have trouble swallowing. Eighty caregivers were split into two groups: one got access to the tool plus …

This study tested an online training program called CHATO for nursing home staff who care for people with Alzheimer's or other dementias. The training aimed to improve how staff communicate, which may reduce behavioral symptoms like agitation or rejection of care. Over 5,000 staf…

This study tested whether a 10-week virtual reality program could help people with schizophrenia stop smoking. 160 participants were split into a VR group or a no-treatment group. Researchers measured nicotine dependence, smoking behavior, and quality of life before and after the…

This study tested whether adding levetiracetam (a seizure medication) to standard antipsychotics helps people with early psychosis who still have symptoms. 65 participants took either the drug or a placebo for 12 weeks. The goal was to see if it reduces psychotic symptoms and pro…

This study tested whether adding virtual reality (VR) to standard computer-based cognitive training could improve memory, attention, and thinking skills in older adults with mild cognitive impairment. 70 participants completed a 12-week program of cognitive exercises, with one gr…

This completed trial tested whether personalized text messages could help 100 caregivers of people with Alzheimer's disease build a habit of walking at least 250 steps each hour. The 12-week program used goal setting, action planning, self-monitoring, and prompts to encourage reg…

This study looked at whether adding cognitive behavioral therapy (CBT) to standard medication (risperidone) could improve cognitive function in 42 adults with stable schizophrenia. Participants either received risperidone alone or risperidone plus 10 weekly CBT sessions. Research…

This study tested a brief, two-session therapy program for young adults (ages 18-35) who had recently started early psychosis services. The program, adapted from a US-based intervention called 'Just Do You,' aimed to improve treatment engagement and recovery by addressing barrier…

This study tested whether partnered rhythmic dance is safe and helpful for people with early Alzheimer's disease. 76 participants were randomly assigned to either dance classes or a walking program for 12 months. The goal was to see if dance improves the ability to think and move…

This study looked at 120 boys aged 4 months to 12 years having urogenital surgery. It compared an opioid-free caudal block (using bupivacaine) with an opioid-supplemented penile nerve block (using fentanyl) to see which provides better pain control and less post-surgery delirium.…

This small study tested whether using a rocking chair for an hour each day could help reduce agitation in elderly people with dementia. Twelve nursing home residents took part in daily rocking sessions for six weeks. Researchers measured changes in agitation, use of calming medic…

This completed trial tested whether a combination of physical activity (the Otago program) and cognitive training (using the CogniFit app) could improve sleep and quality of life in people over 65. Sixty-six participants were split into groups: one did the physical program, anoth…

This early-stage study tested an experimental drug, NMRA-323511, in healthy older adults and people with Alzheimer's disease who experience agitation. The goal was to see if the drug is safe and can reduce agitated behaviors like pacing or yelling. The study involved 87 participa…

This study tested whether adding acupuncture to standard care can slow down memory and thinking problems in people with mild Alzheimer's disease. Researchers compared real acupuncture to a fake (sham) procedure in 160 participants to see if the effects were real or just a placebo…

This study tested whether personalized text messages could help 100 caregivers of people with Alzheimer's disease develop a regular walking habit. Over 12 weeks, participants received texts with goal-setting, action plans, and reminders to walk at least 1,000 steps in a set hour …

This study tested whether rivastigmine can safely reverse delirium caused by poisoning from certain drugs like clozapine or tricyclic antidepressants. 100 patients at a poison center received rivastigmine, and doctors measured their consciousness and agitation levels. The goal wa…

This study tested a program called EnACT for family caregivers of people with dementia. The program uses group sessions where caregivers watch scenarios, practice responses, and reflect on their choices. The goal is to help caregivers feel more prepared and less stressed when dea…

This study tested whether a non-invasive brain stimulation technique called tDCS can reduce auditory hallucinations in people with psychotic disorders. Twenty-four participants received the stimulation while researchers measured changes in hallucination severity and brain activit…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested whether giving clonidine, a blood pressure medication, before electroconvulsive therapy (ECT) could reduce the confusion and agitation that often follows the procedure. ECT is effective for severe depression and bipolar disorder, but up to 65% of patients experi…

This study tested whether 20 hours of computer-based executive function training could improve thinking skills and reduce mental ups and downs in adults over 40 with HIV-related cognitive problems. About 119 participants were split into a training group and a no-contact control g…

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This study tested a new combination of two talk therapies for adults with eating disorders who are not underweight. Twenty participants were randomly assigned to either standard cognitive behavioral therapy (CBT-E) or a mix of CBT and metacognitive interpersonal therapy (CBT-F+MI…

This study tested whether a pain plan without strong opioids works as well as one with opioids for children after tonsil surgery. Sixty-two kids aged 3 to 17 were randomly assigned to get either morphine plus other drugs or a combo of dexmedetomidine, acetaminophen, and ketorolac…

This study looked at whether visits from therapy animals can improve mood, behavior, and quality of life for people with moderate to severe dementia living in nursing homes. Researchers observed 20 participants and compared animal visits to other activities. The goal was to see i…

This study tested whether adding Turkish music to a functional exercise program helps older adults with mild dementia more than exercise alone. Forty participants from a nursing home did exercises twice a week for 8 weeks, with half listening to music during the sessions. Researc…

This study tested whether the sedative dexmedetomidine can reduce how long non-intubated ICU patients experience agitated delirium. Researchers randomly gave 168 patients either dexmedetomidine or a placebo. The goal was to see if the drug shortens agitation and delirium, and red…

This Phase 2 trial tested whether AVP-786, a combination of two drugs, can reduce negative symptoms (like lack of emotion or motivation) in people with schizophrenia. 145 adults on stable antipsychotics received either AVP-786 or a placebo for 12 weeks. The study measured changes…

This study tested whether high doses of methylphenidate (Ritalin) could improve walking and attention in 69 people with advanced Parkinson's disease who still had severe gait problems despite standard treatments. Participants received either methylphenidate or a placebo for three…

This study tested whether a 6-session educational program could help people receiving electroconvulsive therapy (ECT) feel less stigma and anxiety about their mental health treatment. Sixty adult inpatients with conditions like depression or bipolar disorder took part. Those who …

This study tested a Dialectical Behavior Therapy skills training program for older adults (age 50+) who care for a family member with Alzheimer's disease or related dementias. The goal was to reduce suicidal thoughts and feelings. Nine caregivers participated, and the program foc…

This study tested whether combining balance exercises with mental tasks (like naming animals) can improve balance and mild memory problems in people with diabetic nerve damage. Fifty adults aged 50 and older with type 2 diabetes and mild cognitive issues took part in 24 sessions …

This study tested whether virtual music therapy can lower stress as well as live music therapy in older adults with memory problems. Thirty-two participants from assisted living facilities took part. Researchers measured stress through surveys, heart rate, and blood pressure befo…

This study tested a set of tablet games called VibrantMinds, designed to be easy and fun for older adults, including those with dementia. 26 participants aged 65+ with mild cognitive impairment played games like Whack-A-Mole and Word Search. Researchers measured changes in thinki…

This study tested whether adding ashwagandha extract to standard schizophrenia medication (risperidone) could reduce inflammation and improve symptoms. 80 male patients took part. Researchers measured changes in a blood marker for inflammation (IL-1β) and used a standard symptom …

This study tested whether a special type of lighting, called a tailored lighting intervention, could help people with mild to moderate Alzheimer's disease and type 2 diabetes sleep better and improve their metabolism. Sixty-one participants living in assisted living or nursing ho…

This study tested whether extra psychoeducational nursing sessions could improve quality of life, emotional well-being, and reduce anxiety in 120 adults receiving modified electroconvulsive therapy (ECT) for depression, bipolar disorder, or schizophrenia. Half the patients got th…

This study tested whether a socially assistive robot could reduce apathy in older adults with mild cognitive impairment or Alzheimer's disease living in long-term care. 142 participants were randomly assigned to either usual activities or usual activities plus robot-led sessions.…

This study tested a personalized approach to manage agitation in people with Alzheimer's disease living at home. A nurse worked with doctors and caregivers to create a custom care plan, using video calls and training. The goal was to reduce hospitalizations and ease caregiver str…

This pilot study tested whether adding virtual reality (VR) exercises to standard rehabilitation helps people who recently had a stroke recover their thinking skills and ability to do daily tasks. Thirty-six adults with acute stroke and mild cognitive impairment were assigned to …

This study tested whether tongue-strengthening exercises using a special device could improve swallowing in people with Alzheimer's disease and related dementias. 76 participants with mild to moderate dementia did exercises over 8 weeks. The goal was to reduce food or liquid goin…

This study tested whether a new drug called TAK-063 can help people with schizophrenia who are having a sudden worsening of symptoms. 164 adults took either the drug or a placebo for 6 weeks. The main goal was to see if symptoms improved using a standard rating scale. The study i…

This study tested whether a long-term light treatment could improve sleep and memory in 73 people with mild cognitive impairment or mild Alzheimer's disease living at home. Participants used a special light device, and researchers measured changes in thinking skills and sleep qua…

This study tested a software system that uses a humanoid robot to give cognitive and motor tests to people with early Alzheimer's or other mild to moderate dementia. The goal was to see if the robot could effectively administer tests like the Mini Mental State Exam (MMSE) and hel…

This study tested an experimental drug called neflamapimod in 159 people with dementia with Lewy bodies (DLB). The goal was to see if it could improve memory, problem-solving, and attention compared to a placebo. Participants took the drug or a dummy pill for a set period, and re…

This study tested a new drug called phenserine in 16 people with early or mild Alzheimer's disease. The goal was to see how it affects brain cell health and inflammation compared to the standard drug donepezil. Participants took the drug for 8 weeks and had regular checkups. The …

This study tested whether virtual peer support groups, co-led by a mental health clinician and a trained peer specialist, could help veterans with serious mental illness (like schizophrenia or bipolar with psychosis) feel more socially connected and less distressed. Twenty-eight …

This study tested a new behavioral program called SEMAT that teaches people with early-stage Alzheimer's or mild cognitive impairment how to use memory aids like calendars and reminders. The goal was to help them stay independent in daily life. 68 older adults took part, and rese…

This study tested a video game called 'Healing Town' to see if it could help people with stable schizophrenia take their medication more regularly. Twenty participants played the game, which uses stories and decisions to encourage adherence. The goal was to improve attitudes towa…

This early-stage study tested the safety of a new drug called MK-8189 (elpipodect) in 29 people with Alzheimer's disease who also had symptoms like agitation, aggression, or psychosis. The main goal was to see if the drug was safe and tolerable. Researchers monitored side effects…

This pilot study tested whether a single dose of a ketone drink could improve information processing and cognition in 28 people with schizophrenia or bipolar disorder. Participants drank either the ketone drink or a carbohydrate drink, then had brain wave tests, cognitive tasks, …

This study tested a new medicine called MK-8189 in 224 adults having an acute episode of schizophrenia. Participants received either MK-8189, a placebo (inactive pill), or an active control (risperidone) for 4 weeks. The main goal was to see if MK-8189 reduces schizophrenia sympt…

This early-stage study tested a new drug called MK-8189 (elpipodect) in 63 people with schizophrenia, including both younger and older adults, as well as healthy older volunteers. The main goal was to check the drug's safety and how the body processes it, not to cure the disease.…

This study tested a 12-week online program called Brain Health Together for older adults with mild cognitive decline. Participants joined live-streaming exercise and education classes, plus individual coaching, all from home. The goal was to see if the program could improve think…

This early-stage study tested the safety and how the body processes the drug brexpiprazole in 43 teenagers aged 13-17 with schizophrenia. Researchers monitored side effects and changes in vital signs over 17 days. The goal was to find a safe dose for future studies, not to measur…

This study tested whether giving a low-dose sedative called dexmedetomidine at night can prevent delirium (sudden confusion) in older adults after heart surgery. The trial involved 504 patients aged 60-89 who had heart surgery with a heart-lung machine. The drug was infused overn…

This early-stage study tested a new drug called MK-8189 (elpipodect) in 53 adults with schizophrenia or schizoaffective disorder. The main goal was to see if the drug is safe and tolerable when given in increasing doses. Researchers monitored side effects and how many people stop…

This study tested a new drug called MK-8189 (elpipodect) in 499 adults having an acute episode of schizophrenia. The goal was to see if it reduces symptoms like hallucinations and delusions better than a placebo. Participants received different doses of the drug, an active compar…

This study tested a program called Cuidando Juntos, designed to support Latino caregivers of people with dementia. The program includes eight modules on stress management, self-care, and handling difficult behaviors. Researchers wanted to see if the program was well received and …

This study tested a new medication called HS-10380 in 363 Chinese adults hospitalized with acute schizophrenia. The goal was to see if it reduces symptoms like hallucinations and delusions better than a placebo or an existing drug. Participants took the drug for 6 weeks, and doct…

This study tested whether a social robot named Kebbi could improve thinking, heart rate patterns, and emotional well-being in 136 older adults with mild dementia living in long-term care. Participants in the robot group spent 30 minutes with Kebbi three times a week for 12 weeks,…

This study tested a training program for people with mild to moderate Alzheimer's disease. The training used personal photos and videos to recreate familiar situations, aiming to improve orientation to time, place, and person. 126 participants were assigned to either the training…

This study tested whether playing interactive digital games in a group could improve mood, behavior, and thinking in 24 older adults with early to moderate dementia. Participants played games like Mahjong on a touch-sensitive table twice a week for 20 weeks. Researchers measured …

This study looked at whether adding ashwagandha, an herbal supplement, to standard schizophrenia medication (risperidone) could improve thinking and memory. 80 men with schizophrenia took either risperidone alone or risperidone plus ashwagandha for 8 weeks. Researchers measured c…

This study tested whether luteolin, a natural supplement found in celery and chamomile tea, can improve symptoms of schizophrenia. 85 adults with schizophrenia or schizoaffective disorder took either luteolin or a placebo for 12 weeks. Researchers measured changes in overall symp…

This study tested a ketogenic drink made from medium chain triglycerides (MCTs) in 43 people with Alzheimer's disease or a type of frontotemporal dementia. The goal was to see if it was safe and tolerable, and to measure ketone levels in the blood. It was a small, early-stage tri…

This completed study tested a structured music improvisation program for older adults with mild to moderate dementia and their caregivers. Seven participants took part in three-hour sessions led by professional musicians. The goal was to see if this non-drug approach could improv…

This pilot study tested whether combining a gentle brain stimulation technique called HD-tDCS with computer-based cognitive training is feasible for people with mild cognitive impairment (MCI). Eight participants completed 15 sessions over three months. The main goal was to see i…

This study tested whether a virtual reality program featuring nostalgic scenes from Taiwanese culture could improve mood, life satisfaction, and thinking skills in older adults with mild cognitive impairment or mild dementia. Sixty-four participants aged 65 and older were randoml…

This study tested whether adding cognitive behavioral therapy (CBT) to standard medication (risperidone) could reduce auditory hallucinations and inflammation in 50 people with schizophrenia. Participants either received CBT plus medication or medication alone. The goal was to se…

This study tested a web platform designed for people with mild cognitive impairment or mild to moderate dementia and their primary caregivers. The platform offers social networks, activities, and games to improve quality of life and help them stay in the community longer. Researc…

This study tested whether simple brain function measures can predict which Alzheimer's patients will respond to the drug memantine. 53 participants with mild-to-moderate Alzheimer's took memantine or placebo, then all received memantine for 24 weeks. The goal was to see if early …

This study tested a smartphone app designed to help unpaid caregivers of people with dementia reduce their stress and burden. 150 caregivers used the app for 8 weeks, and researchers measured changes in stress, anxiety, and depression. The app provides practical strategies based …

This study tested whether adding curcumin (the active compound in turmeric) to the standard medication risperidone could improve quality of life and reduce inflammation in people with schizophrenia. Forty-four men took part and were followed for 8 weeks. The goal was to see if cu…

This study tested whether a painless, non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve memory in people with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's disease. Researchers used MRI…

This completed phase 2 trial tested whether levetiracetam, a drug used for epilepsy, could reduce abnormal brain overactivity and improve cognitive function in 58 people with early Alzheimer's disease or mild cognitive impairment. Participants received either the drug or a placeb…

This study tested a web-based program called RELOAD-C designed to reduce loneliness in people caring for a family member or friend with Alzheimer's disease. The program uses short videos and online group discussions based on Meaning-Centered Psychotherapy to help caregivers find …

This study tested if a gentle, non-invasive brain stimulation device used at home can help improve memory and thinking in people with mild to moderate Alzheimer's disease. One hundred older adults used the device for 30 minutes a day, five times a week, for six months. The goal w…

This study tested whether a group reminiscence program—where people share and discuss past memories—is practical and helpful for adults hospitalized with schizophrenia. Thirty-eight participants took part in an 8-week program. Researchers measured changes in thinking, communicati…

This study tested a computer program called BrainWorks that uses fun games to train thinking skills like memory, attention, and problem-solving. 72 adults with bipolar disorder and psychosis played these games over several sessions. Researchers measured changes in cognitive abili…

This study tests whether high-frequency magnetic stimulation (rTMS) can reduce auditory hallucinations in people with schizophrenia. Unlike standard low-frequency treatment that takes 15 days, this approach uses 20 Hz stimulation over just 2 days, guided by brain scans for precis…

This study tested a new way to follow up with gynecologic cancer survivors. Instead of seeing a doctor every time, patients saw a nurse at every other visit and used a smartphone app to help manage their health. The goal was to see if this approach improved self-management skills…

This study tested whether adding a virtual reality experience to an online education program could help reduce stress and anxiety in people caring for a loved one with mild-to-moderate Alzheimer's disease. About 127 unpaid caregivers took part, with some receiving only the educat…

This study tested a type of brain stimulation called theta-burst TMS to see if it can safely improve negative symptoms (like lack of motivation) and thinking problems in people with schizophrenia. 76 adults with stable schizophrenia took part in a double-blind trial where some re…

This study tested an online platform called the Living Memory Home for Dementia Care Pairs (LMH-4-DCP). It helps people with dementia and their family caregivers share and record meaningful memories together. The goal was to see if using the platform could reduce feelings of grie…

This study tested whether repeated sessions of transcranial magnetic stimulation (TMS) could improve language in people with primary progressive aphasia (PPA), a condition that slowly damages language areas of the brain. Ten participants received both real and sham (fake) TMS ove…

This study tested a therapy called Cognitive Behavioral Therapy for Work Success (CBTw) in 294 veterans with serious mental illness (like depression, bipolar disorder, or PTSD) who were unemployed. The goal was to help them find and keep competitive jobs, which can improve their …

This pilot study tested whether combining exercise with a gentle brain stimulation technique called tDCS can improve memory in 60 older adults with mild cognitive impairment or Alzheimer's disease. Participants exercised and received either real or sham tDCS. The goal was to see …

This study tested two dietary supplements—a lipase enzyme blend and the same blend plus tributyrin—against a placebo in 90 healthy adults aged 30 to 79 who felt their memory wasn't as sharp as it used to be. Participants took capsules three times a day for 84 days and completed m…

This study tested a gentle bathing technique based on Basale Stimulation for people with moderate to severe dementia. The approach uses soft mittens, warm water, and careful movements to reduce distress and increase engagement during showers. Fifty participants were videotaped du…

This study tested whether a six-week sleep therapy program (CBT-I) could improve thinking and memory in older adults aged 60-85 with insomnia. Two hundred participants were randomly assigned to either CBT-I or a sleep education program. A small group also had brain scans to see i…

This study tested a sleep improvement program designed for both people with Alzheimer's disease and the family members who care for them. The program was tailored to address sleep problems in both the patient and caregiver at the same time. The goal was to see if this approach co…

This study looked at whether a 6-week mindfulness-based yoga program could improve psychological well-being and happiness in adults with schizophrenia. 91 participants from community mental health centers were randomly assigned to either the yoga program or their usual care. The …

This study looked at whether learning to play Go or Chess can improve thinking skills in people with mild cognitive impairment or subjective cognitive decline. 80 participants were split into groups that played Go, Chess, both, or neither for 12 weeks. The researchers measured ch…

This completed study tested whether wearing a special graphene cap that emits far-infrared heat could improve thinking and mood in older adults with mild cognitive decline or Alzheimer's. 126 participants were split into groups based on their cognitive level and received either t…

This study tested two types of mental exercises in 514 older adults with mild to moderate Alzheimer's disease. One group used a computer program with brain games, while the other used physical puzzles and memory cards. The goal was to see if these activities could improve thinkin…

This study tested whether playing a recording of a mother's voice to children as they wake up from anesthesia can reduce postoperative delirium. Eighty children having tonsil surgery took part. Half heard their mother's reassuring voice during recovery; the other half did not. Re…

This study tested whether a virtual group therapy program called Cognitive Stimulation Therapy (V-CST) could help slow cognitive decline in people with mild to moderate dementia. 133 participants were randomly assigned to either receive a referral for V-CST or continue with stand…

This study tested a video-based program called Tele-STELLA for family members caring for someone with moderate to late-stage Alzheimer's or related dementia. The program connects caregivers with a guide to find ways to manage upsetting behaviors. The goal was to see if it could r…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This study tested a virtual program called MASC (Mindful and Self-Compassionate Care) for caregivers of people with Alzheimer's or related dementias. The program teaches mindfulness, self-compassion, and behavioral management skills through six group sessions and home practice. T…

This small pilot study tested whether adding a horse to memory workshops could improve thinking, mood, and quality of life for people with mild to moderate dementia. Thirty-six older adults were split into three groups: traditional memory workshops, equine-assisted memory worksho…

This study tested whether two types of mild electrical brain stimulation (tDCS and tRNS) could improve memory and thinking in 36 people with schizophrenia. Participants received both types of stimulation on different days to compare effects. The goal was to see if these safe, non…

This study gave robotic pets (like the Joy for All™ cat or dog) to 106 older adults with mild-to-moderate dementia during their hospital stay. The goal was to see if the pets could lower delirium risk, reduce falls, and cut down on strong medications. Researchers compared these p…

This study tested whether taking royal jelly (a bee product) as a daily supplement for 4 weeks could improve memory and thinking in healthy adults aged 55-70. Researchers measured cognitive test scores and blood markers of inflammation. The goal was to see if royal jelly's anti-i…

This study tested whether a non-invasive magnetic brain stimulation technique called rTMS can reduce chronic low back pain. Thirty adults with long-lasting pain received multiple sessions of rTMS over the brain's motor cortex. Researchers measured pain changes using a standard pa…

This study tested a drug called CT1812 in 130 people with mild to moderate Dementia with Lewy Bodies. Over 6 months, researchers checked if the drug was safe and if it helped with thinking, sleep, or other symptoms. The goal was to see if it might ease the burden of this challeng…

This study tested whether tesamorelin, a drug already approved for belly fat in HIV, could improve memory and thinking in 73 older HIV patients with mild cognitive problems. Participants also used a text-messaging app to stay motivated. The trial measured changes in brain perform…

This study tested whether an eight-session expressive arts therapy program could increase hope in 50 hospitalized adults with schizophrenia. Participants in the therapy group showed significantly higher hope scores compared to those receiving standard care alone. The findings sug…

This study tested a 6-week Integrated Attention Training Program (IATP) in 120 older adults aged 60-90 who had both anxiety symptoms and subjective memory complaints. Participants were randomly assigned to either the attention training or a health education control group. The goa…

This study tested a device that gently stimulates a nerve in the ear to see if it can improve thinking, sleep, and inflammation in older adults with frailty. Eighty people over 60 received either the active stimulation or a sham version, along with standard physical therapy, for …

This study tested whether a gentle electrical current applied to the scalp (tDCS) can reduce symptoms of major depression, schizophrenia, OCD, generalized anxiety, and insomnia. 320 adults aged 16–65 received multiple sessions over weeks. Researchers measured symptom changes usin…

This study tested a web-based program called Diapason for family caregivers of people with Alzheimer's disease. The program provides information, relaxation techniques, and a forum to connect with other caregivers. Researchers measured stress levels in 49 caregivers over 6 months…

This study tested whether a smartphone app called FOCUS, along with coaching from trained clinicians, could help people with serious mental illnesses like schizophrenia and bipolar disorder. 191 participants used the app and received coaching over 12 weeks. Researchers measured c…

This study tested whether eating prebiotic-fortified bakery products (like bread and pastries) for several weeks could improve memory, mood, and reduce inflammation in healthy adults aged 60-75 who had mild memory complaints. 55 participants were randomly assigned to eat either t…

This study looked at whether nicergoline, a drug that improves blood flow in the brain, can help people with swallowing problems caused by stroke, Parkinson's disease, or dementia. 92 adults were given either a low or high dose for 12 weeks. The goal was to see if swallowing impr…

This study tested whether personalizing cognitive training based on a person's early auditory processing ability improves thinking and daily function in schizophrenia. 194 adults with schizophrenia or schizoaffective disorder were assigned to either a tailored program (Brain Basi…

This study looked at whether giving precise amounts of fluid during coronary artery bypass surgery can reduce the risk of postoperative cognitive dysfunction (POCD) — problems with memory, focus, and thinking that affect up to 70% of heart surgery patients. Researchers monitored …

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study looked at whether emergency department pharmacists can safely reduce the use of certain brain-active medications in people with dementia or mild cognitive impairment. Researchers worked with 300 participants to see if pharmacists could communicate medication changes to…

This study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling,…

This study looked at how schizophrenia affects physical activity, balance, muscle strength, and thinking skills. Researchers measured these abilities in 35 adults diagnosed with schizophrenia. The goal was to better understand the challenges patients face, which could help improv…

This study tests whether an 8-hour digital learning program using virtual reality (VR) and augmented reality (AR) can improve dementia care knowledge, attitudes, and teamwork among long-term care professionals. About 150 staff from 12 care institutions in Taiwan take part, with s…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study looked at how dopamine receptors in the brain work in people with schizophrenia compared to healthy volunteers. Researchers used special PET and MRI scans to measure two types of dopamine receptors. The goal was to better understand what causes schizophrenia, which cou…

This study is the first time Leucettinib-21 is being tested in humans. It aims to check the drug's safety and how the body processes it. The trial includes healthy volunteers and people with Down syndrome or Alzheimer's disease. No treatment benefit is expected at this early stag…

This study looks at whether certain antibiotics given before surgery are linked to postoperative delirium in adults over 65 having elective non-cardiac surgery. Researchers will track antibiotic use and check for delirium twice daily. The goal is to provide safety evidence to gui…

This study examines whether levels of a blood enzyme called α-N-acetylgalactosaminidase differ between people with schizoaffective disorder during acute episodes and those in remission, compared to healthy individuals. The goal is to better understand the biological processes beh…

This completed Phase 2 study tested whether a special PET scan using a tracer called UCB-J can measure synaptic density—the connections between brain cells—in people with Alzheimer's disease. Researchers scanned 100 participants across different stages, from healthy to dementia, …

This study followed 50 adults with a C9ORF72 gene mutation that can cause ALS or frontotemporal dementia. Over three years, researchers measured changes in strength, thinking, memory, and behavior using brain scans, spinal fluid tests, and other assessments. The goal was to under…

This completed study created the first international database of Datscan imaging values from 300 patients. The goal was to help doctors better diagnose Parkinson's disease and other neurodegenerative conditions by comparing brain scan results. Researchers hope this database will …

This study looked at whether doing short, frequent exercise sessions (called 'exercise snacks') is better for your mental health than doing longer, less frequent workouts. 180 healthy young adults were split into two groups: one did six 15-minute cycling sessions per week, the ot…

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This completed study looked at the experiences of 275 extended family members (like grandchildren, siblings, and nieces/nephews) who care for a person with dementia. Researchers interviewed caregivers about their daily tasks, stress, and use of support services. The goal is to us…

This study measured the activity of an enzyme called glucocerebrosidase in 236 people with and without Lewy body dementia. The goal was to see if lower enzyme activity could help identify patients who might benefit from treatments already used for Gaucher disease. The study did n…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This study surveys anesthesiologists to explore whether feelings of being a fraud (impostor phenomenon) are linked to everyday memory and attention lapses. Participants complete online questionnaires about impostor feelings, cognitive failures, anxiety, depression, sleep quality,…

This study tested a 6-week museum-based programme called 'Refresh and Reconnect!' for older adults with mild cognitive impairment or mild dementia. Participants took guided tours and joined artist-led activities like dance, art, or drama. Researchers measured changes in quality o…

This study looked for protein markers in the blood and saliva of 96 people with long-term traumatic brain injury (TBI). Researchers compared samples from blast injury and non-penetrating injury patients to find common changes. The goal is to better understand the lasting effects …

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study watched 60 adults getting electroconvulsive therapy (ECT) for severe depression to see if their need for anesthesia changed over multiple sessions. Researchers measured the dose of anesthetic used each time and how it related to seizure quality and recovery. No new tre…

This study looked at how menopause-related hormone changes affect brain function and Alzheimer's risk in 120 postmenopausal women aged 50-70. Researchers used memory tests and brain scans to see which women's brains coped well with hormone changes and which showed signs of future…

This study looked at whether regular physical activity can improve thinking and memory in middle-aged adults (40-65) who have a family history of Alzheimer's disease. About 180 participants were randomly assigned to an exercise program or a comparison group and were followed for …

This study looked at how people with schizophrenia process sounds and remember where information comes from. Researchers tested 50 participants (patients and healthy controls) using computer tasks. The goal was to understand if trouble telling sounds apart relates to difficulty d…

This study follows people with idiopathic normal pressure hydrocephalus (iNPH) who are already scheduled for shunt surgery. Researchers measure changes in thinking skills and frailty one year after the procedure to identify which patients are most likely to improve. The goal is t…

This study explores whether a special type of MRI called flow MRI can improve the diagnosis and management of normal pressure hydrocephalus, a condition where excess fluid builds up in the brain's cavities. Researchers will measure how cerebrospinal fluid and blood move through t…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This pilot study tested a community-based intervention for people with psychosis in Malawi, Nigeria, Sierra Leone, and Zimbabwe. The program includes peer support from someone who has experienced psychosis, case management, and help with daily activities like finding work or soci…

This study looked at whether opioid use disorder and non-fatal overdoses cause a harmful protein called tau to build up in the brain. Researchers used special PET/CT scans on 12 adults, including those with opioid use disorder and healthy volunteers. The goal was to understand lo…

This completed pilot study scanned the brains of 30 people who were hospitalized with COVID-19 and later reported memory, concentration, or organizational problems—often called 'brain fog.' Researchers used MRI and spectroscopy to look for changes in brain structure and chemistry…

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This study tested whether two light-based technologies, fNIRS and DCS, can safely measure brain activity in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome. 73 participants, including healthy volunteers, wore a cap with lights …

This study tested whether a special MRI scan of the wrist can detect amyloid deposits in people with systemic amyloidosis, a condition where abnormal proteins build up in organs. Researchers enrolled 128 adults, including patients with cardiac amyloidosis and healthy volunteers. …

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This pilot study tested whether wearable sensors can accurately measure apathy in people with frontotemporal dementia. Researchers monitored 14 participants' movements and behaviors in real-life situations. The goal was to see if technology could provide a more objective way to a…

This study tested whether a digital tool that scans electronic health records could help find older adults (65+) who might have undetected mild cognitive impairment or Alzheimer's disease. Over 3,400 patients from primary care clinics were identified as high-risk by the tool. Res…

This study looked at whether regular exercise can help slow down memory and thinking problems in older adults with early Alzheimer's disease and in healthy older adults. Researchers tested a program combining aerobic and strength exercises against stretching and balance exercises…

This pilot study tested whether a virtual reality reaction time test can help predict fall risk and cognitive decline in older adults with memory problems. Twenty participants aged 65 and older with cognitive impairment completed a VR task and standard tests. The goal was to see …

This study examined whether older adults with disrupted sleep or irregular daily rhythms show early brain changes linked to Alzheimer's disease. Researchers used wrist-worn activity monitors and brain MRI scans in 47 people over 65 without major memory problems. The goal was to s…

This completed study looked at how the brains of people with schizophrenia work when they are not taking antipsychotic medication. The goal was to tell apart the effects of the illness itself from the effects of the drugs. 648 participants stayed in a hospital and underwent brain…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tested a 4-session education program for people with early schizophrenia. The goal was to see if it helps patients feel more connected to their therapist, which is important for ongoing care. 21 hospitalized patients took part, and researchers measured changes in the p…

This study looked at 30 healthy older adults to see if changes in a small brain area called the locus coeruleus could be an early sign of Alzheimer's disease. Researchers used brain scans, sleep tests, and spinal fluid analysis to measure brain function, sleep quality, and attent…

This study tested a new way to improve mental health services for people with psychosis in Uganda. Instead of just doctors making decisions, people who have experienced psychosis were trained to help at home, in the community, and at clinics. The goal was to see if this approach …

This study looked at how people with schizophrenia perceive familiarity when looking at faces. Researchers showed 30 participants blended images of familiar and unfamiliar faces and asked them to press a button when they felt a sense of familiarity. The goal was to understand how…

This study looked at whether a partnered dance program (adapted tango) could improve inflammation, memory, and mood in African-American women who care for a family member with Alzheimer's disease. Fifty women between 45 and 65 years old took part. Researchers measured changes in …

This study tested whether a lifestyle program delivered through a smartphone app could help older adults (ages 60-77) at risk for dementia. 156 participants in four countries were split into two groups: one received a structured program with app support and in-person sessions, wh…

This study looked at whether a case management program called PartnerED could help reduce unnecessary hospital stays for people with Alzheimer's disease living in assisted living facilities. Researchers worked with care managers who gave emergency room doctors real-time informati…

This study tested whether a tool inside a patient portal could help people with mild memory problems discuss and document their future healthcare wishes. Researchers enrolled 300 older adults with cognitive impairment who had a patient portal account. The goal was to see if peopl…

This study looked at how common dementia and memory problems are in older Mexican Americans compared to non-Hispanic whites. Researchers tracked changes in thinking skills over time and also asked caregivers what help they need. The goal is to find better ways to support patients…

This study looked at whether a 15-minute meditation practice called Shoonya meditation can help people stay sharp after a night without sleep. Researchers compared regular meditators to people who nap regularly, measuring brain activity, heart rate, and cognitive performance. The…

This study tested a smartphone app called A4i designed to help people with schizophrenia manage their illness and stay connected with their care providers. 91 adults with schizophrenia or related disorders used the app for 6 months. The goal was to see if the app was practical an…

This study collected blood samples from over 2,200 people with Alzheimer's or other dementias, plus healthy volunteers, to search for genes linked to these diseases. Researchers aimed to identify new genetic causes and better understand how genes affect disease risk and progressi…

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This study looked at 170 older hospital patients with delirium (sudden confusion) to see which bed-exit alarm works better at preventing falls. One system uses pressure-sensitive mats, the other uses a contactless radar device. The goal was to find out which technology more relia…

This pilot study tested whether a single dose of an oral ketone supplement could increase blood flow and improve brain connectivity in 15 older adults with subjective or mild cognitive decline. Participants had one 2-hour session including MRI scans and cognitive tests. The goal …

This study used special brain scans (SPECT imaging) to look at two key brain chemicals—acetylcholine and dopamine—in people with dementia with Lewy bodies. Researchers aimed to see if differences in these chemicals could help diagnose the disease and identify subtypes. The study …

This study tested whether a gentle electrical current applied to the scalp (transcranial electrical stimulation) could help healthy adults perform a complex computer task faster and more accurately. Forty-four volunteers with advanced degrees completed a track-and-capture task wh…

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This study looked at brain scans of 304 retired farmers aged 65 and older living in rural France. None had memory complaints at the start. Researchers used MRI and PET scans to measure brain areas linked to Alzheimer's, like the hippocampus. The goal was to find very early imagin…

This study looked at how two different anesthesia methods—intravenous propofol versus inhaled sevoflurane gas—affect the brain's protective barrier and the risk of confusion after surgery in 154 older adults (age 60+). Researchers measured a protein in the blood that indicates br…

This study looked at whether a quick, painless eye scan can detect early signs of Alzheimer's disease. Researchers measured the thickness of the retina's nerve layer in 200 older adults, some with Alzheimer's and some without. The goal was to see if these eye changes could serve …

This completed trial tested an online tool called 'Safety in Dementia' that guides caregivers through decisions about firearm access for a person with dementia. 500 informal caregivers across the U.S. participated. The tool helps clarify options, risks, and personal values, aimin…

This study looked at how older adults with and without Alzheimer's disease move in time with music. Researchers wanted to understand if this rhythmic movement relates to emotional expression and communication. The study involved 240 participants and measured how accurately they t…

This completed Phase 1 study looked at whether obstructive sleep apnea (OSA) might contribute to Alzheimer's disease. Researchers studied 182 older adults aged 65-85 with and without OSA, using brain scans and breathing tests. The goal was to understand how sleep disruptions like…

This study looked at 128 children aged 2-18 who had ear, nose, or throat surgery. Researchers compared standard opioid-based anesthesia to opioid-free anesthesia to see if it reduced post-surgery agitation and delirium. The goal was to find a way to help children recover more cal…

This study tested whether a 20-minute session of gentle brain stimulation (tDCS) before an afternoon nap could improve sleep patterns linked to memory and thinking in healthy adults aged 60 and older. Twelve participants completed computer tasks, received either real or fake tDCS…

This study tested whether a short bout of running at different intensities could improve attention and emotional well-being in 120 university students aged 18-24. Participants completed 16-minute sessions of sitting quietly or running at light, moderate, or vigorous levels. Resea…

This early-stage trial tested the safety and tolerability of multiple doses of TAK-063 in 77 participants, including people with stable schizophrenia and healthy Japanese volunteers. Researchers monitored side effects, lab results, and vital signs over 7 days. The study does not …

This study used eye-tracking to see how people with Alzheimer's, Parkinson's, or frontotemporal dementia look at faces when trying to recognize emotions. Researchers compared their eye movements to healthy adults. The goal was to understand if different visual strategies explain …

This study observed 100 adults having planned heart surgery to see how many develop delirium (sudden confusion) and whether a standard risk score called EuroSCORE II could predict it. Researchers checked patients for delirium using a special test. The goal was to better understan…

This completed study looked at 344 frail older adults (70+) with memory issues to see how many have Alzheimer's-related brain changes. Participants had MRI and PET scans to detect amyloid plaques. The goal was to understand the link between frailty, memory loss, and Alzheimer's p…

This early-stage study tested a new drug called MK-8189 in 55 people, including healthy volunteers and those with schizophrenia. The main goal was to see if the drug is safe and how it behaves in the body. Researchers measured drug levels and side effects, but this study did not …

This study checks whether a questionnaire called SCREEN can accurately find nutrition risk in older adults (55+) who have mild cognitive impairment or dementia and live at home or in retirement homes. Researchers will compare SCREEN results to a dietitian's assessment and test if…

This completed study at Rutgers University looked at how the brain and body communicate in 30 people with conditions like autism, ADHD, Alzheimer's, and Parkinson's. Participants performed natural movements like walking and pointing while their brain, heart, and motion signals we…

This study tested two training programs (in-person and online) for staff in long-term care facilities in Minnesota. The goal was to improve care for LGBTQ+ residents with Alzheimer's or other dementias. Over 700 staff members participated, and researchers measured changes in poli…

This study looked at whether cochlear implants, which help restore hearing, can also improve thinking and memory in adults aged 65 and older with hearing loss. Researchers gave 37 participants a series of cognitive tests before surgery and again at 6 months, 12 months, and 5 year…

This study tested whether a device that measures pupil changes (automated pupillometry) can help assess pain in intensive care patients who are confused or delirious after surgery. Pain is hard to evaluate in these patients because they cannot communicate clearly. The study enrol…

This small study tested whether a nurse-led walking and sit-to-stand program is practical and liked by older adults with cognitive issues like dementia who are in transitional care after a hospital stay. Six people took part, and the researchers measured how many joined, stayed, …

This study tested a program called Promoting Positive Care Interactions (PPCI) in assisted living facilities. The goal was to see if it's feasible and acceptable to train staff—like nurses and housekeepers—to improve daily interactions with residents who have Alzheimer's or relat…

This study checked whether a high dose of the experimental drug MK-8189 (elpipodect) affects heart rhythm in people with schizophrenia. 107 participants received the drug, a placebo, and an active control in a crossover design. The main goal was to see if the drug causes a danger…

This study tested a program called Alianza Latina to improve dementia care for older Latinos. Researchers trained primary care doctors to better detect and treat dementia, and provided bilingual health navigators to help patients and their caregivers. The study involved 243 parti…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This early-stage study tested a new oral drug, SEP-380135, in 43 adults with schizophrenia or major depression (including bipolar disorder). The main goal was to check its safety and how the body processes it. Participants took multiple doses and were monitored for side effects, …

This study tested a training program for emergency department staff to better detect delirium—a sudden confusion—in older adults. Researchers trained nurses and doctors at three hospitals and checked if detection improved. About 3,000 patients were involved. The goal was to see i…

This completed study looked at 1,000 patients who had heart surgery and were then moved to the ICU. Researchers tracked whether high or low oxygen levels increased the chance of developing delirium, a state of confusion. The goal was to understand how oxygen management might affe…

This study looked at whether breathing extra oxygen (hyperbaric oxygen) helps healthy adults do multiple things at once, like paying attention while moving. Twenty-four healthy volunteers with at least 12 years of education took cognitive and motor tests in normal and high-oxygen…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This early-stage study tested whether a working memory training program is practical and acceptable for people aging with HIV. Researchers enrolled 100 participants aged 50-85, including those with and without HIV, to see if the training could improve memory and thinking skills. …

This study looked at families with at least two members who developed Alzheimer's before age 65. Researchers wanted to find new genes that cause the disease, beyond the three already known. They collected medical and genetic information from 150 people across 23 centers in France…

This study looked at 73 trauma patients in the ICU to see if brainwave (EEG) patterns could predict delirium before it happens. Researchers recorded brain activity over several days and used machine learning to find early warning signs. The goal is to help doctors spot brain prob…

This study looked at how older adults, including those with Alzheimer's or mild cognitive impairment, make decisions about where to live as they age. Researchers followed 293 participants to understand what factors—like memory, health knowledge, and support from family—influence …

This study followed 51 people with schizophrenia who were already stable on long-acting injectable antipsychotics. Over 48 weeks, researchers checked every 12 weeks whether patients stayed well or had a relapse. The goal was to see how often symptoms return when medication adhere…

This study tested whether wearing stroboscopic glasses during practice could improve cognitive skills in 34 adolescent male volleyball players. For eight weeks, the players wore the glasses for 10 minutes a day, two days a week, while training. Researchers measured changes in vis…

This study looked at whether self-compassion (being kind to yourself) is linked to better quality of life in older adults recently diagnosed with dementia. Researchers also checked if feeling threatened by dementia affects this relationship. 23 participants aged 65 and older, dia…

This completed study looked at over 11,000 adults in Trøndelag, Norway, to find out how many people have dementia and how many are undiagnosed. Researchers used standard tests to measure memory and thinking skills. The goal is to get a clearer picture of dementia rates across Nor…

This Norwegian study followed 169 elderly patients with depression for three years to see how they fared after specialist treatment. Researchers tracked whether depression returned or became chronic, and also checked for signs of dementia. The goal was to better understand the lo…

This completed study involved over 2,200 people diagnosed with or suspected of having frontotemporal dementia (FTD). Researchers collected blood samples to look for genetic changes linked to the disease. The goal was to find out how common these genetic causes are in people with …

This study tested a training program for home care workers who care for people with dementia. The program used realistic scenarios to help workers build empathy, feel more prepared, and improve their caregiving skills. 70 full-time home care workers took part, and the study measu…

This study tested a program called PorchLight Project, where trained senior companions helped families caring for someone with Alzheimer's or dementia. The goal was to connect families with community services and improve their interactions with doctors. Researchers measured thing…

This study looked at how well patients, their family members, and doctors agree when rating agitation episodes in people with bipolar disorder or schizophrenia. Thirty-three adults received a treatment called BXCL501, and researchers compared different questionnaires to see which…

This study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…

This completed study followed 509 children aged 3 to 18 who were taking risperidone or aripiprazole for conditions like schizophrenia or bipolar disorder. Researchers measured weight changes over up to 50 months to understand long-term risks. The goal was to provide better safety…

This completed observational study followed 168 pregnant or breastfeeding women with schizophrenia, psychosis, or mania who were already taking long-acting injectable antipsychotics. Researchers measured drug levels in the mother's blood, breastmilk, and the baby's blood to under…

This study tested whether a community health worker (CHW) can help people with dementia and their family caregivers after a hospital stay. The CHW provided education, care planning, and support through home visits and phone calls. The goal was to see if the program was feasible a…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This study looked at whether a special drink called ketone ester can improve brain energy use and thinking skills in healthy adults aged 55 and older who have metabolic syndrome. Participants took the drink or a placebo for 28 days and had brain scans and memory tests. The goal w…

This study looked at whether a protein called S100B in the blood can help predict memory problems or confusion after surgery. Researchers followed 137 adults having elective surgery, testing their blood and thinking skills before and after the operation. The goal was to see if S1…

This study tested how low (1 Hz) and high (20 Hz) frequency repetitive transcranial magnetic stimulation (rTMS) changes brain activity in 30 healthy adults. Participants received both types of stimulation in separate sessions, and their brain waves were measured before and after.…

This study tested a program called Patient Priorities Care in 178 people with dementia or mild cognitive impairment. Participants received a packet before their clinic visit and could talk with a trained facilitator about their personal healthcare goals. The study aimed to see if…

This study used brain imaging and memory tests to find early signs of Alzheimer's disease. Researchers followed 242 volunteers, including healthy young, middle-aged, and older adults, to track changes over time. The goal was to understand how the disease develops and identify mar…

This study tested a new version of NPT 2042 soft-gelatin capsules to see if it is absorbed better than the original version. Eight healthy adults took single doses of both formulations. The goal was to measure how the drug moves through the body, not to treat any disease.

This study looked at how people with Alzheimer's disease or a type of frontotemporal dementia remember personal events from their past. Researchers tested 39 participants using a detailed scale to see if memories were specific (like a single event in time and place) or more gener…

This study placed 15 healthy volunteers in a natural cave with no access to time cues for 40 days. Researchers measured how their sense of time, sleep cycles, stress levels, and group coordination changed. The goal was to understand how humans adapt to extreme isolation and time …

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This study followed 44 adults with a confirmed VCP gene mutation to learn how their disease (IBMPFD) naturally progresses over one year. Participants completed walking tests, strength assessments, and surveys about daily function and quality of life. The goal was to gather data t…

This study looked at sleep disturbances in people with Alzheimer's disease. Researchers tracked sleep diaries, activity levels, and behavior in 70 participants to understand how disrupted sleep relates to daily cycles and daytime alertness. The goal was to learn more about the li…

This completed study looked at how teenagers with autism or schizophrenia understand emotions, metaphors, and social situations compared to healthy teens. Researchers tested 60 participants using facial emotion recognition and other tasks. The goal was to find out if social diffi…

This study tested a program that screens older adults (60+) for memory and thinking problems after they leave the intensive care unit (ICU). The goal was to see if it's possible to identify issues like mild cognitive impairment or dementia early. 109 people took part, and the stu…

This completed study from the University of Hong Kong looked at 110 cannabis users aged 16-60 to see how their thinking skills change over time and if genes play a role. Participants took memory and thinking tests and gave blood for genetic analysis. The goal is to understand lon…

This study looked at 150 people with mild memory problems to see if a special MRI scan (pCASL) could give similar information to a standard PET scan. Participants had both scans, plus a spinal tap and yearly memory tests for three years. The goal was to see if the MRI could help …

This study tested whether an AI platform can detect mild cognitive impairment and early dementia by analyzing people's speech. Researchers compared language patterns from speaking tasks with standard memory and thinking tests in 196 older adults. The goal was to see if speech cha…

This study examined 186 people with Alzheimer's, Lewy body, frontotemporal, or corticobasal dementia, plus healthy controls, to see if subtle physical signs (like coordination or reflexes) differ between dementia types. Participants had simple exams and cognitive tests. The goal …

This study looked at a process called autophagy, which is how cells clean out damaged parts, in 82 women over 65 with osteoporosis. Some also had Alzheimer's disease. Researchers measured autophagy levels in bone cells from hip samples to see if poor cell cleanup links bone loss …

This study aimed to create a communication tool to help people with Alzheimer's or dementia and their caregivers discuss and plan for future medical care. Researchers worked with 38 participants to see if the tool improved their readiness to make advance care plans. The goal was …

This completed study looked at how people with Alzheimer's disease search for objects in realistic scenes and real-life settings. Researchers tracked eye movements in 48 participants to understand which attention and memory processes are impaired. The goal was to link visual expl…

This study tested whether a focused ultrasound device can safely and temporarily open the blood-brain barrier in 20 people with mild-to-moderate Parkinson's disease dementia. The goal was to see if the procedure is safe and feasible, not to treat the disease itself. Researchers m…

This study tested a special type of talk therapy (Cognitive Behavioral Suicide Prevention for psychosis) to see if it could help adults with schizophrenia who have had recent suicidal thoughts or behaviors. About 51 people took part, and the therapy was compared to usual care. Th…

This study tested whether sending text message reminders and support to young people with psychosis after an emergency room visit helps them attend their first early psychosis appointment. 186 participants were enrolled. The goal was to see if a low-cost, youth-friendly approach …

This study tested a program called NAVIGATE, which provides coordinated care for youth and young adults (ages 14-35) who have had a first episode of psychosis. The goal was to see if NAVIGATE helps improve recovery, reduce hospital stays, and lower healthcare costs compared to st…

This completed pilot study looked at 46 older adults with Alzheimer's disease to see if age-related hearing loss is linked to trouble finding words. Participants took a computer test to measure word-finding ability and answered a hearing questionnaire. The goal was to better unde…

This study tested whether a gentle electrical current applied to the scalp at 40 Hz can strengthen brain rhythms linked to memory in healthy adults aged 50-80. Thirty participants received the stimulation while performing a working memory task. The goal was to see if this approac…

This study tested whether combining two non-invasive brain stimulation techniques (tACS and iTBS) can enhance gamma brain waves and working memory in 30 healthy adults. The goal is to develop better stimulation protocols that could one day help people with Alzheimer's disease. Pa…

This study tested a new mobile app called iTEST that helps people with schizophrenia or schizoaffective disorder improve how accurately they judge their own performance on memory and emotion recognition tasks. 69 adults completed daily exercises on a smartphone for 16 weeks, gues…

This study looked at whether using EEG brain-wave monitoring during general anesthesia helps doctors give the right amount of medicine. The goal was to help patients wake up faster after surgery and reduce memory or thinking problems. About 100 adults having surgery took part. Re…

This completed observational study enrolled 1,141 participants with mild cognitive impairment or Alzheimer's disease. Researchers tracked changes in memory tests, brain scans, and other biomarkers over time. The goal was to improve how future clinical trials measure the disease, …

This study tested whether a daily multivitamin called Vitals+ improves health, mood, and thinking skills in healthy adults. Thirty-seven volunteers took either the multivitamin or a placebo for 3 months. Researchers measured blood vitamin levels, cognitive function, and gut healt…

This study tested a new version of a common memory test (MMSE) that is adapted for people in Réunion Island, especially those who cannot read or write well. Researchers compared the new test with the standard French version in 61 hospitalized older adults. The goal was to see if …

This study followed 37 people with a genetic risk for hereditary ATTR amyloidosis over five years. Researchers measured levels of misfolded proteins in the blood to see if they could detect the earliest signs of the disease. The goal is to develop a way to catch the condition bef…

This study tested whether a daily NAD+ supplement can improve thinking and reduce inflammation in healthy women aged 40 to 80. Participants took either NAD+ or a placebo for 4 weeks and completed computer tests and blood draws. The goal was to see if NAD+ affects memory, attentio…

This completed study measured levels of two substances (IGF-I and IGFBP-3) in the blood of 693 older adults: some with Alzheimer's disease, some with mild cognitive impairment, and some with normal memory. The goal was to see if these levels differ between groups and relate to th…

This study looked at how often brainstem problems occur in COVID-19 patients who are on a ventilator and deeply sedated in the ICU. Researchers checked brainstem reflexes using a simple scoring system, both during sedation and a few days after sedation stopped. The goal was to un…

This small pilot study explored whether advanced heart imaging can detect hidden strokes in people who have never had atrial fibrillation but are at high risk due to conditions like diabetes or heart failure. Researchers used brain MRIs to find silent, symptom-free strokes and li…

This study tested a telepresence robot called COVEALINK 2 that allows patients hospitalized for at least 2 months to remotely control a robot in their own home. Using a smartphone app, patients could move the robot around and talk with family and friends. The goal was to see how …

This study tested a social robot that leads activities like trivia and reminders for people with Alzheimer's or other dementias living in assisted living. Researchers wanted to see what makes it easy or hard to use the robot in daily care. 26 residents, family members, and staff …

This study looked at whether measuring the skin's electrical activity can warn of agitation or aggressive behavior in people with dementia. 21 patients from a dementia unit took part. The goal was to see if a warning signal appears before an outburst, which could help caregivers …

This study looked at whether bowel cleansing before colorectal surgery is linked to memory or thinking problems after the operation. Researchers measured certain brain-related proteins in the blood and gave thinking tests to 84 patients before and after surgery. The goal was to u…

This study tested whether a scale that measures personal and social performance can predict symptom improvement in people with schizophrenia. Over 700 participants taking paliperidone were followed for 12 weeks. Results showed that those with better social functioning scores were…

This study followed 404 older adults for 10 years after hip fracture surgery. Researchers checked whether early signs of Alzheimer's in spinal fluid or cognitive tests were linked to how long patients lived. The goal is to understand if hidden Alzheimer's changes affect long-term…