Cure My Disease

Don't miss your cure!

 Log in / Sign up

6 months of exercise may boost memory in seniors at risk for Alzheimer's

NCT ID NCT03727360

Prevention Sponsor: University of Maryland, College Park Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether 6 months of moderate aerobic exercise could improve memory and brain health in older adults (ages 60-80) who are inactive but cognitively healthy. Some participants carried a gene (APOE-ε4) that raises Alzheimer's risk. They were randomly assigned to either moderate exercise or gentle stretching. The goal was to see if exercise could help protect the brain from future decline.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

124 people

The number who actually took part.

Started

Oct 2018

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 60 to 80 years old * Fluent in English * Willingness to make the time commitment to participate in the project, including randomization to treatments * Physically inactive (physical activity not more than 2 days per week for the past 6 months) * Physician consent to undergo an exercise stress test and engage in moderate intensity exercise * Determined to be safe for MRI Exclusion Criteria: * Neurological illnesses/conditions such as cerebral palsy, epi¬lepsy, brain tumor, chronic meningitis, multiple scle¬rosis, pernicious anemia, normal-pressure hydrocephalus, HIV infection, Parkinson's disease, and Huntington's disease * Untreated hypertension, glaucoma, and chronic obstructive pul¬monary disease * Untreated severe major depression * Substance abuse or dependence * Current use of psychoactive medications, except selective serotonin/norepinephrine reuptake inhibitor antidepressants * Use of acetylcholinesterase inhibitors (e.g., Aricept) * Unstable or severe cardiovascular disease or asthmatic condition * History of transient ischemic attack, cerebral ischemia, or clinically diagnosed stroke * Diagnosis of mild cognitive impairment or dementia, or objective evidence of cognitive impairment

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Healthy cognition are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Alzheimer disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy cognition

Contacts and locations

Locations

  • University of Maryland, Department of Kinesiology

    College Park, Maryland, 20742, United States