Massive Alzheimer's study aims to sharpen diagnosis and trial design
NCT ID NCT02854033
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed observational study enrolled 1,141 participants with mild cognitive impairment or Alzheimer's disease. Researchers tracked changes in memory tests, brain scans, and other biomarkers over time. The goal was to improve how future clinical trials measure the disease, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could help researchers design better Alzheimer's treatments by identifying reliable ways to measure disease progression.
What could go wrong
This is an observational study, not a treatment trial. It may not directly lead to new therapies, and findings might not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Albany Medical College
Albany, New York, 12208, United States
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Banner Alzheimer's Institute
Phoenix, Arizona, 85006, United States
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Banner Sun Health Research Institute
Sun City, Arizona, 85351, United States
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Barrow Neurological Institute
Phoenix, Arizona, 85013, United States
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Boston University School of Medicine
Boston, Massachusetts, 21182307, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 21155804, United States
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Butler Hospital Memory and Aging Program
Providence, Rhode Island, 02906, United States
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Case Western Reserve University
Beachwood, Ohio, 441224312, United States
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Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, Nevada, 891060100, United States
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Columbia University
New York, New York, 10032, United States
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Dent Neurologic Institute
Buffalo, New York, 142261727, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Emory University
Atlanta, Georgia, 30322, United States
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Georgetown University
Washington D.C., District of Columbia, 200072145, United States
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Houston Methodist
Houston, Texas, 77030, United States
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Howard University
Washington D.C., District of Columbia, 200600001, United States
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Indiana University
Indianapolis, Indiana, 46202, United States
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Jewish General Hospital Memory Clinic
Montreal, Quebec, H3T 1E2, Canada
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Johns Hopkins University
Baltimore, Maryland, 212242764, United States
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Long Beach VA Neuropsychiatric Research Program
Long Beach, California, 90822, United States
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Mayo Clinic, Jacksonville
Jacksonville, Florida, 32224, United States
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Mayo Clinic, Rochester
Rochester, Minnesota, 559050001, United States
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Mount Sinai School of Medicine
New York, New York, 100296552, United States
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Nathan Kline Institute for Psychiatric Research
Orangeburg, New York, 109621159, United States
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New York University Medical Center
New York, New York, 100166055, United States
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Northwestern University
Chicago, Illinois, 606113010, United States
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Ohio State University
Columbus, Ohio, 43210, United States
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Oregon Health & Science University
Portland, Oregon, 972393011, United States
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Parkwood Institute
London, Ontario, N6C 0A7, Canada
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Ralph H. Johnson VA Health Care System
Charleston, South Carolina, 29401, United States
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Rhode Island Hospital
Providence, Rhode Island, 02903, United States
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Rush University Medical Center
Chicago, Illinois, 606123806, United States
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St. Joseph's Health Center - Cognitive Neurology
London, Ontario, N6C 4R3, Canada
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Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5, Canada
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University of Alabama, Birmingham
Birmingham, Alabama, 35294, United States
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University of British Columbia, Clinic for AD & Related
Vancouver, British Columbia, V6T1Z3, Canada
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University of California, Davis
Walnut Creek, California, 945985900, United States
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University of California, Irvine
Irvine, California, 92697, United States
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University of California, Los Angeles
Los Angeles, California, 90095, United States
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University of California, San Diego
La Jolla, California, 920371707, United States
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University of California, San Francisco
San Francisco, California, 94158, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Kansas
Fairway, Kansas, 66205, United States
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University of Kentucky
Lexington, Kentucky, 405042681, United States
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University of Michigan, Ann Arbor
Ann Arbor, Michigan, 481052967, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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University of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
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University of Rochester
Rochester, New York, 14620, United States
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University of South Florida - Health Byrd Alzheimer Institute
Tampa, Florida, 336134808, United States
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University of Southern California
Los Angeles, California, 900335310, United States
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University of Texas, Southwestern MC at Dallas
Dallas, Texas, 75390, United States
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University of Wisconsin
Madison, Wisconsin, 537920001, United States
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VA Palo Alto HSC / Stanford School of Medicine
Palo Alto, California, 94304, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37212, United States
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
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Washington University, St. Louis
St Louis, Missouri, 631082215, United States
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Wien Center for Clinical Research
Miami Beach, Florida, 331402877, United States
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Yale University School of Medicine
New Haven, Connecticut, 65103330, United States