Could an Immune-Modulating drug slow early Alzheimer's?
NCT ID NCT04032626
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial investigates whether lenalidomide, a drug that calms inflammation, can slow cognitive decline in people with mild cognitive impairment due to Alzheimer's disease. Participants take lenalidomide or a placebo for up to 12 months, followed by a 6-month washout period. The study measures changes in memory, daily function, and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lenalidomide
What this could lead to
If successful, this could point toward a new way to treat early Alzheimer's by calming inflammation in the brain and body.
What could go wrong
This is a small, early-phase trial with only 15 participants, so results may not apply widely. Lenalidomide can cause blood-related side effects, and the drug may not improve cognition.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cleveland Clinic Lou Ruvo Center for Brain health
Las Vegas, Nevada, 89103, United States
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St. Joseph's Hospital and Medical Center
Phoenix, Arizona, 85013, United States