New study sheds light on antipsychotic safety during pregnancy and breastfeeding

NCT ID NCT05766007

Completed Knowledge-focused Sponsor: University of Liverpool Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed observational study followed 168 pregnant or breastfeeding women with schizophrenia, psychosis, or mania who were already taking long-acting injectable antipsychotics. Researchers measured drug levels in the mother's blood, breastmilk, and the baby's blood to understand how pregnancy affects drug exposure. The goal is to help healthcare providers make informed decisions about using these medications during pregnancy and while breastfeeding.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: long-acting injectable antipsychotics (Risperidone, Paliperidone palmitate, Fluphenazine decanoate, Flupenthixol decanoate, Zuclopenthixol decanoate)
What this could lead to: If successful, this study could help doctors better understand how to safely use long-acting antipsychotics in pregnant and breastfeeding women, improving care for both mother and baby.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test new therapies. Results may not apply to all women or all antipsychotics, and the small sample size limits how much we can conclude.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Breast Feeding Mania psychotic disorder Psychotic Disorders schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIPSYCHOTIC AGENTS BREASTFEEDING DRUG EXPOSURE IN UTERO DRUG EXPOSURE VIA BREAST MILK MANIA PREGNANCY PSYCHOSIS SCHIZOPHRENIA

Contacts and locations

Locations

Federal Medical Centre

Makurdi, Benue State, Nigeria
Federal Neuropsychiatric Hospital

Kaduna, Kaduna State, Nigeria
Federal Neuropsychiatric Hospital

Yaba, Lagos, Nigeria
Neuropsychiatric Hospital

Abeokuta, Ogun State, Nigeria
Neuropsychiatric Specialist Hospital

Akure, Ondo State, Nigeria
Obafemi Awolowo University Teaching Hospital

Ile-Ife, Osun State, Nigeria

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