New study sheds light on antipsychotic safety during pregnancy and breastfeeding
NCT ID NCT05766007
First seen Feb 19, 2026 · Last updated Jun 23, 2026 · Updated 25 times
Summary
This completed observational study followed 168 pregnant or breastfeeding women with schizophrenia, psychosis, or mania who were already taking long-acting injectable antipsychotics. Researchers measured drug levels in the mother's blood, breastmilk, and the baby's blood to understand how pregnancy affects drug exposure. The goal is to help healthcare providers make informed decisions about using these medications during pregnancy and while breastfeeding.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Federal Medical Centre
Makurdi, Benue State, Nigeria
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Federal Neuropsychiatric Hospital
Kaduna, Kaduna State, Nigeria
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Federal Neuropsychiatric Hospital
Yaba, Lagos, Nigeria
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Neuropsychiatric Hospital
Abeokuta, Ogun State, Nigeria
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Neuropsychiatric Specialist Hospital
Akure, Ondo State, Nigeria
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Obafemi Awolowo University Teaching Hospital
Ile-Ife, Osun State, Nigeria
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
long-acting injectable antipsychotics (Risperidone, Paliperidone palmitate, Fluphenazine decanoate, Flupenthixol decanoate, Zuclopenthixol decanoate)
What this could lead to
If successful, this study could help doctors better understand how to safely use long-acting antipsychotics in pregnant and breastfeeding women, improving care for both mother and baby.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test new therapies. Results may not apply to all women or all antipsychotics, and the small sample size limits how much we can conclude.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.