MLD drug safety tracked for years in extension study

NCT ID NCT01887938

First seen Jan 10, 2026 · Last updated May 17, 2026 · Updated 16 times

Summary

This study checked the long-term safety of a drug called HGT-1110 in 24 people with metachromatic leukodystrophy (MLD), a rare nerve disease. All participants had already received the drug in an earlier study. Researchers monitored side effects and immune responses over many years to see if the treatment remained safe.

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Contacts and locations

Locations

  • CHR Orleans - Hopital La Source

    Orléans, 45067, France

  • CHU de Nantes

    Nantes, 44093, France

  • Center for Pediatric Clinical Studies (CPCS)

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Detska Interni Klinika, Lf Mu A Fn Brno

    Brno, 61300, Czechia

  • Hopital Femme Mere Enfant

    Bron, 69 677, France

  • Hopital Gui de Chauliac - CHRU de Montpellier

    Montpellier, 34000, France

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, 90035-003, Brazil

  • Hôpital de Bicêtre

    Le Kremlin-Bicêtre, Île-de-France Region, 94275, France

  • Kitakyushu Municipal Yahata Hospital

    Fukuoka, 805-8534, Japan

  • Klinikum Oldenburg

    Oldenburg, 26133, Germany

  • Kurashiki Central Hospital

    Okayama Prefecture, 710-8602, Japan

  • Marien-Hospital Wesel gGmbh

    Wesel, 46483, Germany

  • Osaka University Hospital

    Osaka, 565-0871, Japan

  • Rigshospitalet

    Copenhagen, 2100, Denmark

  • The Children's Hospital at Westmead

    Westmead, 2145, Australia

Conditions

Explore the condition pages connected to this study.