Alzheimer's polypill shows promise in early trial

NCT ID NCT06597058

Completed Disease control Sponsor: Noah Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 study tested a once-daily combination pill (polypill) in 121 adults aged 50–85 with very mild to severe Alzheimer's disease. Over 180 days, researchers measured changes in thinking, memory, and daily function using standard dementia scales. The goal was to estimate whether the polypill could slow decline compared to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a combination of multiple drugs in a single once-daily tablet (polypill)
What this could lead to: If this polypill shows benefit, it could point toward a new way to slow cognitive decline in Alzheimer's disease.
What could go wrong: This is an early Phase 2 study with only 121 participants, so results may not be conclusive. The polypill's effects are still uncertain, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Amnesia Cognitive Dysfunction dementia Nerve Degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE

Contacts and locations

Locations

Accel Research Sites (Noah Clinical Site 019)

DeLand, Florida, 32720, United States
Best Choice Medical and Research Service (Noah Clinical Site 025)

Pembroke Pines, Florida, 33024, United States
Boston Clinical Trials (Noah Clinical Site 006)

Boston, Massachusetts, 02131, United States
Carolina Research Center, Inc. (Noah Clinical Site 009)

Shelby, North Carolina, 28150, United States
Denali Health Plant City, LLC (Noah Clinical Site 024)

Plant City, Florida, 33563, United States
Health Awareness (Noah Clinical Site 020)

Jupiter, Florida, 33458, United States
IMA Clinical Research (Noah Clinical Site 004)

Albuquerque, New Mexico, 87109, United States
International Medical Investigational Centers (Noah Clinical Site 001)

Palmetto Bay, Florida, 33176, United States
Life Well Research Center (Noah Clinical Site 008)

Miami, Florida, 33134, United States
Marvel Clinical Research (Noah Clinical Site 010)

Huntington Beach, California, 92647, United States
Miami Jewish Health (Noah Clinical Site 023)

Miami, Florida, 33137, United States
Neurology Associates of Ormond Beach (Noah Clinical Site 015)

Ormond Beach, Florida, 32174, United States
Olympus Clinical Research (Noah Clinical Site 014)

Katy, Texas, 77450, United States
Regenerate Primary Medical Research (Noah Clinical Site 003)

Miami, Florida, 33134, United States
Scottsdale Clinical Trials (Noah Clinical Site 017)

Scottsdale, Arizona, 85260, United States
Tekton Research (Noah Clinical Site 002)

Yukon, Oklahoma, 73099, United States

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