New schizophrenia drug shows promise in major trial

NCT ID NCT04072354

Completed Disease control Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an investigational drug called SEP-363856 in 463 people with schizophrenia who were having severe symptoms. Participants received either the drug or a placebo for 6 weeks. The main goal was to see if the drug reduced symptoms like hallucinations and emotional withdrawal better than a placebo.

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Conditions

The condition(s) this trial relates to.

schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

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Locations

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Little Rock, Arkansas, 72211, United States
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Anaheim, California, 92805, United States
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Bellflower, California, 90706, United States
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Lemon Grove, California, 91945, United States
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Long Beach, California, 90807, United States
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Montclair, California, 91763, United States
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Pico Rivera, California, 90660, United States
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San Diego, California, 92103, United States
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Hollywood, Florida, 33021, United States
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Hollywood, Florida, 33024, United States
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Miami Springs, Florida, 33166, United States
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Atlanta, Georgia, 30318, United States
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Atlanta, Georgia, 30331, United States
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Decatur, Georgia, 30030, United States
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Gaithersburg, Maryland, 20877, United States
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Flowood, Mississippi, 39232, United States
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Dayton, Ohio, 45417, United States
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Austin, Texas, 78754, United States
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Pazardzhik, 4400, Bulgaria
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Pleven, 5800, Bulgaria
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Sofia, 1202, Bulgaria
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Sofia, 1431, Bulgaria
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Veliko Tarnovo, 5000, Bulgaria
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Vratsa, 3000, Bulgaria
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Bello, Antioquia, 051053, Colombia
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Bogotá, 111166, Colombia
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Bogotá, Colombia
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Chelyabinsk, 454087, Russia
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Moscow, 107076, Russia
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Nizniy Novgorod, 603155, Russia
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Petrozavodsk, 186131, Russia
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Saint Petersburg, 092019, Russia
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Saint Petersburg, 192019, Russia
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Samara, 443016, Russia
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Saratov, 410028, Russia
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Belgrade, 11000, Serbia
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Gornja Toponica, 18202, Serbia
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Kovin, 26220, Serbia
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Kragujevac, 34000, Serbia
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Niš, 18000, Serbia
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Novi Kneževac, 23330, Serbia
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Novi Sad, 21000, Serbia
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Vršac, 26300, Serbia
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Ivano-Frankivsk, 76011, Ukraine
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Kropyvnytskyi, 25491, Ukraine
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Kyiv, 02192, Ukraine
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Kyiv, 04080, Ukraine
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Lviv, 79021, Ukraine
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Odesa, 65006, Ukraine
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Odesa, 67513, Ukraine
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Poltava, 36013, Ukraine
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Smila, 20708, Ukraine
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Vinnytsia, 21005, Ukraine