Brain zapping study seeks to unlock rTMS secrets

NCT ID NCT01466439

Completed Knowledge-focused Sponsor: University Hospital, Caen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested how low (1 Hz) and high (20 Hz) frequency repetitive transcranial magnetic stimulation (rTMS) changes brain activity in 30 healthy adults. Participants received both types of stimulation in separate sessions, and their brain waves were measured before and after. The goal was to see if different frequencies have opposite effects on brain inhibition and facilitation, which could help explain how rTMS works for conditions like depression and schizophrenia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: repetitive transcranial magnetic stimulation (rTMS)
What this could lead to: If successful, this could help explain how rTMS works in the brain, potentially improving its use for depression and schizophrenia.
What could go wrong: This is a small, early-phase study in healthy volunteers, not patients. Results may not directly translate to clinical benefits or apply to real-world treatment.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION SCHIZOPHRENIA

Contacts and locations

Locations

Caen University Hospital, department of psychiatry and explorations fonctionnelles neurologiques

Caen, France

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