New pill formulation tested for better absorption in healthy volunteers

NCT ID NCT07222878

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new version of NPT 2042 soft-gelatin capsules to see if it is absorbed better than the original version. Eight healthy adults took single doses of both formulations. The goal was to measure how the drug moves through the body, not to treat any disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

8 people

The number who actually took part.

Started

Sep 2025

Finished

Nov 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Males and females between 19 and 65 years of age, inclusive. * Body mass index (BMI) of 18 to 35 kg/m2, inclusive, using the following formula: weight (kg)/\[height (m)\] * A minimum body weight of 50 kg for males and 45 kg for females. * All females must have a negative serum pregnancy test at Screening and a negative serum pregnancy test upon admission to the clinical research center. * Females must be of non-child-bearing potential. * Male participants with female partners of reproductive potential must agree to protocol specifications. Exclusion Criteria: * Clinically significant acute illness within 2 weeks prior to Day -1. * Presence of active or recurring clinically significant cardiovascular, pulmonary, renal, endocrine, hepatic, neurologic, psychiatric, immunologic, hematologic, gastrointestinal, or metabolic disease requiring medical treatment. * Presence of an active malignancy or a malignancy of any type within the past 5 years, other than squamous cell or basal cell carcinoma of the skin. * Clinically significant acute or chronic infection or known inflammatory condition. * Personal or family history of long QT syndrome. * History or evidence of adverse symptoms associated with phlebotomy or blood donation * History of clinically significant orthostatic hypotension or any vasovagal syncope. * Plans for surgery or other medical procedures during the study. * Clinically significant past or current medical or surgical history that could interfere with treatment. * Participation in an investigational drug or device study within 30 days or five half-lives, whichever is longer \[90 days for biologics\], prior to dosing. * Presence of clinically significant illness or abnormality on physical examination. * Presence of clinically significant ECG abnormality at Screening, including any QT interval corrected for heart rate (QTc) using Fridericia formula (QTcF) ≥470 msec. * Ongoing liver disease or unexplained liver function test (LFT) elevations, defined as alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), or alkaline phosphatase (ALP) greater than the upper limit of normal (ULN). * Any other clinically significant laboratory results, as judged by the investigator. * History or presence of clinically significant hypersensitivity (e.g. systemic or cutaneous) as judged by the investigator to NPT 2042. * History of substance abuse or current use of any drugs of abuse. * Blood donation of \>500 mL or more within 56 days prior to Day -1. * Any other reason that, in the opinion of the investigator, would render the participant unsuitable for study enrollment.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Celerion

    Lincoln, Nebraska, 68502, United States

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