Ultrasound zaps brain barrier in Parkinson's dementia – first safety results in
NCT ID NCT03608553
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a focused ultrasound device can safely and temporarily open the blood-brain barrier in 20 people with mild-to-moderate Parkinson's disease dementia. The goal was to see if the procedure is safe and feasible, not to treat the disease itself. Researchers monitored side effects using exams and brain scans.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MR-guided focused ultrasound (Exablate device)
What this could lead to
If successful, this approach could enable future treatments to reach the brain more effectively for Parkinson's dementia.
What could go wrong
This was a very small, early feasibility study with only 20 participants. It focused on safety, not on treating symptoms or slowing the disease. The procedure may carry risks like bleeding or swelling in the brain.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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HM Hospitales Puerta del Sur - CINAC
Móstoles, Madrid, 28938, Spain