Could this pill slow Alzheimer's? new trial results are in
NCT ID NCT05063539
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 2 trial tested an oral drug called LY3372689 in 327 people with early symptomatic Alzheimer's disease. The goal was to see if the drug could safely slow down declines in thinking and daily living skills compared to a placebo. The study focused on participants with mild memory problems and specific brain scan findings.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LY3372689 (an oral drug)
What this could lead to
If successful, this drug could slow down memory loss and daily function decline in people with early Alzheimer's.
What could go wrong
This is a Phase 2 trial, so it's still early. The drug may not work better than placebo, and side effects are possible. Results are not yet published.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Abington Neurological Associates, Ltd.
Abington, Pennsylvania, 19001, United States
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Adams Clinical
Watertown, Massachusetts, 02472, United States
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Advanced Memory Research Institute of New Jersey
Toms River, New Jersey, 08755, United States
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Boston Center for Memory
Newton, Massachusetts, 02459, United States
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Box Hill Hospital
Box Hill, Victoria, 3128, Australia
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Brain Matters Research
Delray Beach, Florida, 33445, United States
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Brain Matters Research
Stuart, Florida, 34997, United States
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Bruyère Research Institute
Ottawa, Ontario, K1N 5C8, Canada
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Central Coast Neurosciences Research (Tumbi Umbi)
Central Coast, New South Wales, 2261, Australia
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Centrum Badan Klinicznych PI-House sp. z o.o.
Gdansk, Pomeranian Voivodeship, 80-546, Poland
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Centrum Medyczne Euromedis
Szczecin, West Pomeranian Voivodeship, 70-111, Poland
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Centrum Medyczne NEUROMED
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-163, Poland
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Centrum Medyczne NeuroProtect
Warsaw, Masovian Voivodeship, 01-684, Poland
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Centrum Medyczne SENIOR
Sopot, Pomeranian Voivodeship, 81-855, Poland
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Charter Research - Lady Lake
The Villages, Florida, 32162, United States
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ClinCloud - Viera
Melbourne, Florida, 32940, United States
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Clinique de la Mémoire de l'Outaouais
Ottawa, Ontario, K1Z 1G3, Canada
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Delmont Private Hospital
Glen Iris, Victoria, 3146, Australia
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Diamond Clinic
Krakow, Lesser Poland Voivodeship, 31-559, Poland
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Diex Recherche Sherbrooke Inc.
Sherbrooke, Quebec, J1L 0H8, Canada
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Donald S. Marks M.D., P.C.
Plymouth, Massachusetts, 02360, United States
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HammondCare
Malvern, Victoria, 3144, Australia
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HammondCare Greenwich Hospital
Sydney, New South Wales, 2065, Australia
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Himeji Central Hospital Affiliated Clinic
Himeji, Hyōgo, 672-8043, Japan
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Hope Clinical Research, Inc.
Canoga Park, California, 91303, United States
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Hornsby Ku-Ring-Gai Hospital
Sydney, New South Wales, 2077, Australia
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IMIC, Inc.
Miami, Florida, 33176, United States
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Institute for Neurodegenerative Disorders
New Haven, Connecticut, 06510, United States
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Irvine Clinical Research
Irvine, California, 92614, United States
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JEM Research Institute
Atlantis, Florida, 33462, United States
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Josephson Wallack Munshower Neurology, PC
Indianapolis, Indiana, 46256, United States
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K2 Medical Research
Maitland, Florida, 32751, United States
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KARA Institute for Neurological Diseases
Sydney, New South Wales, 2113, Australia
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Katayama Medical Clinic
Kurashiki, Okayama-ken, 710-0813, Japan
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Kerwin Medical Center
Dallas, Texas, 75231, United States
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Keystone Clinical Studies
Plymouth Meeting, Pennsylvania, 19462, United States
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Kikukawa Clinic
Nerima City, Tokyo, 179-0072, Japan
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Kobe City Medical Center General Hospital
Kobe, Hyōgo, 650-0047, Japan
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MedVadis Research Corporation
Waltham, Massachusetts, 02451, United States
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Memory Clinic Ochanomizu
Tokyo, 113-0034, Japan
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Memory Clinic Toride
Toride, Ibaraki, 302-0004, Japan
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Merritt Island Medical Research, LLC
Merritt Island, Florida, 32952, United States
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National Center for Geriatrics and Gerontology
Ōbu, Aichi-ken, 4748511, Japan
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Neuro-Pain Medical Center
Fresno, California, 93710, United States
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NeuroCentrix
Carlton, Victoria, 3053, Australia
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Neurology Offices of South Florida
Boca Raton, Florida, 33428, United States
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Neuropsychiatric Research Center of Southwest Florida
Fort Myers, Florida, 33912, United States
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Nozomi Memory Clinic
Mitaka-shi, Tokyo, 181-0013, Japan
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Nzoz Neuro-Kard Ilkowski i Partnerzy SPL
Poznan, Greater Poland Voivodeship, 61-853, Poland
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Oita University Hospital
Yufu, Oita Prefecture, 879-5593, Japan
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Ottawa Memory Clinic
Ottawa, Ontario, K1Z 1G3, Canada
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Podlaskie Centrum Psychogeriatrii
Bialystok, Podlaskie Voivodeship, 15-756, Poland
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Private Practice - Dr PL Morris
Southport, Queensland, 4215, Australia
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Renstar Medical Research
Ocala, Florida, 34470, United States
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Rhode Island Mood & Memory Research Institute
East Providence, Rhode Island, 02914, United States
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Sharp Mesa Vista Hospital
San Diego, California, 92123, United States
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St Vincent's Hospital
Sydney, New South Wales, 2010, Australia
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Suncoast Clinical Research, Inc.
New Port Richey, Florida, 34652, United States
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The Cognitive and Research Center of New Jersey
Springfield, New Jersey, 07081, United States
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The Memory Clinic
Bennington, Vermont, 05201-9810, United States
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The Queen Elizabeth Hospital
Woodville, South Australia, 5011, Australia
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The University of Texas Health Science Center at Houston
Houston, Texas, 77054, United States
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Toronto Memory Program
Toronto, Ontario, M3B 2S7, Canada
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University at Buffalo - UBMD Neurology
Buffalo, New York, 14203, United States
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VIN- Margarita Almeida El-Ramey
Pembroke Pines, Florida, 33026, United States
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VIN-Andrew Lerman
Miami, Florida, 33133, United States
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VIN-Julie Schwartzbard
Aventura, Florida, 33180, United States
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VIN-Victor Faradji
Miami, Florida, 33176, United States
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Wroclawskie Centrum Alzheimerowskie
Wroclaw, Lower Silesian Voivodeship, 53-203, Poland