Could a Vitamin-Like supplement ward off Alzheimer's in High-Risk individuals?
NCT ID NCT05880849
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed phase 1 study tested whether taking choline, a dietary supplement, for 6 months could improve fat metabolism in the brain of people with the APOE4 gene, which raises Alzheimer's risk. Fifteen participants aged 55-80 took choline capsules twice daily. The main goal was to check safety and see if choline changes certain fat-related markers in spinal fluid. This early trial focuses on biological effects, not on preventing or treating Alzheimer's symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- choline (a dietary supplement)
- What this could lead to
- If it works, this could point toward a simple dietary supplement to help delay or prevent Alzheimer's in people with the APOE4 gene.
- What could go wrong
- This is a very early, small phase 1 trial with only 15 people. It mainly checks safety and biological changes, not whether choline actually prevents Alzheimer's. The results may not lead to a proven treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The University of Texas Health Science Center at Houston (UTHealth)
Houston, Texas, 77054, United States
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