Could a Vitamin-Like supplement ward off Alzheimer's in High-Risk individuals?
NCT ID NCT05880849
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed phase 1 study tested whether taking choline, a dietary supplement, for 6 months could improve fat metabolism in the brain of people with the APOE4 gene, which raises Alzheimer's risk. Fifteen participants aged 55-80 took choline capsules twice daily. The main goal was to check safety and see if choline changes certain fat-related markers in spinal fluid. This early trial focuses on biological effects, not on preventing or treating Alzheimer's symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
choline (a dietary supplement)
What this could lead to
If it works, this could point toward a simple dietary supplement to help delay or prevent Alzheimer's in people with the APOE4 gene.
What could go wrong
This is a very early, small phase 1 trial with only 15 people. It mainly checks safety and biological changes, not whether choline actually prevents Alzheimer's. The results may not lead to a proven treatment.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The University of Texas Health Science Center at Houston (UTHealth)
Houston, Texas, 77054, United States