Wrist MRI may spot hidden amyloid clumps without needles

NCT ID NCT05150353

Completed Knowledge-focused Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study tested whether a special MRI scan of the wrist can detect amyloid deposits in people with systemic amyloidosis, a condition where abnormal proteins build up in organs. Researchers enrolled 128 adults, including patients with cardiac amyloidosis and healthy volunteers. The goal was to see if MRI mapping could non-invasively identify amyloid in the wrist, potentially offering a simpler way to diagnose the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a non-invasive way to detect amyloid deposits in the wrist, potentially aiding earlier diagnosis of systemic amyloidosis.
What could go wrong: This is an observational study, not a treatment trial. The MRI technique may not be accurate enough for routine use, and results may not apply to all types of amyloidosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

AL amyloidosis Alzheimer disease amyloidosis Immunoglobulin Light-chain Amyloidosis primary systemic amyloidosis wild type ATTR amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYLOID SYSTEMIC AMYLOIDOSIS

Contacts and locations

Locations

Hôpital Privé Paul d'Egine

Champigny-sur-Marne, 94500, France

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