Could a new drug slow lewy body dementia? phase 2 trial begins

NCT ID NCT07589595

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This phase 2 trial tests whether donanemab, an antibody given by IV, can slow worsening of thinking and daily function in people with early cognitive decline and Lewy body dementia. The study enrolls 350 participants who also have signs of two brain proteins (amyloid and alpha-synuclein). Each person will be followed for 1.5 years, comparing donanemab to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: donanemab
What this could lead to: If successful, this could point toward a treatment that slows cognitive and functional decline in people with early Lewy body dementia.
What could go wrong: This is a phase 2 trial with only 350 participants, so results may not confirm effectiveness. Donanemab also carries risks like brain swelling or bleeding, and the trial requires confirmation of specific brain proteins, which may limit who can benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease amyloidosis brain disorder Cognition Disorders cognitive disorder Cognitive Dysfunction Lewy body dementia Lewy Body Disease nervous system disorder neurodegenerative disease synucleinopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYLOID COGNITIVE DYSFUNCTION LEWY BODY DISEASE SYNUCLEINOPATHIES

Contacts and locations

Locations

Axiom Brain Health LLC
RECRUITING

Tampa, Florida, 33609, United States
BRP-Kendal Lakes
NOT_YET_RECRUITING

Miami, Florida, 33175, United States
Brain Matters Research
RECRUITING

Delray Beach, Florida, 33445, United States
CenExel Rocky Mountain Clinical Research
NOT_YET_RECRUITING

Englewood, Colorado, 80113, United States
Central Texas Neurology Consultants
RECRUITING

Round Rock, Texas, 78681, United States
Chang Gung Medical Foundation-Linkou Branch
NOT_YET_RECRUITING

Taoyuan, 333, Taiwan
Charter Research - Orlando
RECRUITING

Orlando, Florida, 32803, United States
Citizens Memorial Hospital District
RECRUITING

Bolivar, Missouri, 65613, United States
Conquest Research
RECRUITING

Winter Park, Florida, 32789, United States
EvergreenHealth
NOT_YET_RECRUITING

Kirkland, Washington, 98034, United States
Ewha Womans University Mokdong Hospital
NOT_YET_RECRUITING

Seoul, 07985, South Korea
Gadolin Research
RECRUITING

Beaumont, Texas, 77702, United States
Gangnam Severance Hospital, Yonsei University Health System
NOT_YET_RECRUITING

Gangnam-gu, 06273, South Korea
Hanyang University Seoul Hospital
NOT_YET_RECRUITING

Seoul, 04763, South Korea
Headlands Eastern MA LLC
RECRUITING

Plymouth, Massachusetts, 02360, United States
HonorHealth Research Institute
NOT_YET_RECRUITING

Scottsdale, Arizona, 85251, United States
Houston Methodist Hospital
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Hyogo Prefectural Harima-Himeji General Medical Center
NOT_YET_RECRUITING

Himeji, 670-8560, Japan
Inage Neurology and Memory Clinic
NOT_YET_RECRUITING

Inage, 263-0043, Japan
Indiana University Health Neuroscience Center
RECRUITING

Indianapolis, Indiana, 46202, United States
Inha University Hospital
NOT_YET_RECRUITING

Incheon, 22332, South Korea
Irvine Clinical Research
RECRUITING

Irvine, California, 92614, United States
JEM Research Institute
RECRUITING

Atlantis, Florida, 33462, United States
Juntendo Tokyo Koto Geriatric Medical Center
NOT_YET_RECRUITING

Kōtoku, 136-0075, Japan
K2 Medical Research - Foxborough
RECRUITING

Foxborough, Massachusetts, 02035, United States
K2 Medical Research ORLANDO
RECRUITING

Maitland, Florida, 32751, United States
Katayama Medical Clinic
RECRUITING

Kurashiki, 710-0813, Japan
Kerwin Medical Center
RECRUITING

Dallas, Texas, 75231, United States
Ki Health Partners, LLc, dba New England Institute for Clinical Research
NOT_YET_RECRUITING

Stamford, Connecticut, 06905, United States
Kobe University Hospital
NOT_YET_RECRUITING

Kobe, 650-0017, Japan
Konkuk University Medical Center
NOT_YET_RECRUITING

Seoul, 05030, South Korea
Massachusetts General Hospital - Charlestown
NOT_YET_RECRUITING

Charlestown, Massachusetts, 02129, United States
Mayo Clinic in Florida
NOT_YET_RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic in Rochester, Minnesota
NOT_YET_RECRUITING

Rochester, Minnesota, 55905, United States
Memory Clinic Ochanomizu
NOT_YET_RECRUITING

Bunkyō City, 113-0034, Japan
Memory Clinic Toride
NOT_YET_RECRUITING

Toride, 302-0004, Japan
Nagoya Ekisaikai Hospital
NOT_YET_RECRUITING

Nagoya, 454-8502, Japan
Nagoya University Hospital
NOT_YET_RECRUITING

Nagoya, 466-8560, Japan
National Center for Geriatrics and Gerontology
NOT_YET_RECRUITING

Ōbu, 474-8511, Japan
National Cheng Kung University Hospital
NOT_YET_RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
NOT_YET_RECRUITING

Taipei, 10002, Taiwan
Neurology Center of New England
NOT_YET_RECRUITING

Foxborough, Massachusetts, 02035, United States
Neuropsychiatric Research Center of Southwest Florida
RECRUITING

Fort Myers, Florida, 33912, United States
New Taipei Municipal TuCheng Hospital
NOT_YET_RECRUITING

New Taipei City, 236, Taiwan
Nippon Medical School Musashi Kosugi Hospital
NOT_YET_RECRUITING

Kawasaki, 211-8533, Japan
Norman Fixel Institute for Neurological Diseases (FIND)
NOT_YET_RECRUITING

Gainesville, Florida, 32608, United States
Oita University Hospital
NOT_YET_RECRUITING

Yufu, 879-5593, Japan
Oregon Health and Science University
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
Palm Beach Neurology
RECRUITING

West Palm Beach, Florida, 33407, United States
Pennsylvania Hospital
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Profound Research LLC
RECRUITING

Carlsbad, California, 92011, United States
QUEST Research Institute
RECRUITING

Farmington Hills, Michigan, 48334, United States
Re:Cognition Health
RECRUITING

Fairfax, Virginia, 22031, United States
Renstar Medical Research
RECRUITING

Ocala, Florida, 34471, United States
Shonan Keiiku Hospital
NOT_YET_RECRUITING

Fujisawa, 252-0816, Japan
St. Marianna University Hospital
NOT_YET_RECRUITING

Kawasaki, 216-8511, Japan
Stanford Neuroscience Health Center
NOT_YET_RECRUITING

Palo Alto, California, 94304, United States
Struthers Parkinson's Center
NOT_YET_RECRUITING

Golden Valley, Minnesota, 55427, United States
Summit Headlands
RECRUITING

Portland, Oregon, 97210, United States
Tachikawa Hospital
NOT_YET_RECRUITING

Tachikawa, 190-8531, Japan
Taipei Medical University Shuang Ho Hospital
NOT_YET_RECRUITING

New Taipei City, 235, Taiwan
Taipei Veterans General Hospital
NOT_YET_RECRUITING

Taipei, 11217, Taiwan
The University of Kansas - Clinical Research Center
NOT_YET_RECRUITING

Fairway, Kansas, 66205, United States
The University of Osaka Hospital
NOT_YET_RECRUITING

Suita, 565-0871, Japan
The University of Texas Health Science Center
NOT_YET_RECRUITING

San Antonio, Texas, 78229, United States
The University of Texas Health Science Center at Houston
NOT_YET_RECRUITING

Houston, Texas, 77054, United States
Tokyo Metropolitan Institute for Geriatrics and Gerontology
NOT_YET_RECRUITING

tabashi City, 173-0015, Japan
TrialSphere Corp
RECRUITING

Chandler, Arizona, 85286, United States
UCSD - Altman Clinical and Translational Research Institute (ACTRI)
NOT_YET_RECRUITING

La Jolla, California, 92037, United States
VIN - Aventura
RECRUITING

Aventura, Florida, 33180, United States
Yokohama Minami Kyosai Hospital
NOT_YET_RECRUITING

Yokohama, 236-0037, Japan

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