Could a natural compound in food help aging hearts?

NCT ID NCT06186102

Completed Disease control Sponsor: University of Aarhus Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 4 times

Summary

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a period. Researchers will measure changes in heart mass, muscle mass, inflammation, and exercise capacity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Spermidine (a dietary supplement)

What this could lead to

If it works, this could point toward a simple supplement to help elderly heart patients maintain heart and muscle function.

What could go wrong

This is a small, early-phase trial (180 people) testing a supplement, not a drug. Results may not lead to a proven treatment, and benefits may be modest or absent.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome cardiovascular disorder Cognition Disorders cognitive disorder Cognitive Dysfunction coronary artery disorder diabetes mellitus Feeding Behavior heart disorder hypertensive disorder hypertensive heart disease Inflammation inflammatory disease Insulin Resistance metabolic syndrome X myocardial infarction myocardial ischemia Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASES COGNITION DISORDER COGNITIVE IMPAIRMENT DIABETES MELLITUS (TYPE 2) DIASTOLIC DYSFUNCTION DIETARY HABITS HYPERTENSION HYPERTENSIVE HEART DISEASE INFLAMMATION ISCHEMIC HEART DISEASE METABOLIC SYNDROME MYOCARDIAL INFARCTION OBESITY QUALITY OF LIFE

Contacts and locations

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Locations

Aarhus University Hospital

Aarhus, Jutland, 8200, Denmark