ISCHEMIC HEART DISEASE

This study is checking how well a new drug-coated stent (Coroflex ISAR NEO) works in people with coronary artery disease. Researchers will follow 3,000 patients who get the stent during a routine procedure to see if it keeps arteries open safely. The goal is to confirm the stent …

This trial is testing whether a higher dose of adenosine, a drug used during cardiac MRI to stress the heart, improves blood flow imaging compared to the standard dose. The study includes 180 adults with suspected or known coronary artery disease or heart failure. By comparing th…

This study tests a new type of stent (a small mesh tube) for people with heart disease who also take blood thinners. These patients have a high risk of bleeding when they also need anti-clotting drugs after stent placement. The new stent is designed to allow a shorter course of a…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time. It is designed for people with long blockages in their heart arteries. The goal is to see if the stent is safe and works well at keeping arteries open for up to 12 months. About 100 pa…

This study tests whether using a computer simulation (virtual stenting) before placing stents in heart arteries can lead to better outcomes than the usual method guided by X-ray images alone. About 1,472 adults with coronary artery disease will be randomly assigned to either the …

This study is testing a long version of the Ultimaster Nagomi stent in people with long blockages in their heart arteries. About 1,039 participants will receive the stent and be followed for one year to see if it works well and stays safe. The goal is to see if one long stent can…

This study tests whether using HEPA air filters at home can slow the progression of heart disease in adults aged 65-84 who have a history of ischemic heart disease. Over 112 participants in Los Angeles will use real or sham filters for several months, and researchers will measure…

This study tests a new medicine called ADR-002K in 50 people with heart failure caused by blocked heart arteries who are scheduled for bypass surgery. The goal is to see if the drug can prevent heart-related events and improve heart function over two years. Participants must have…

This study looks at two ways to treat a fast, dangerous heart rhythm called ventricular tachycardia in people with coronary artery disease and relatively good heart function. One treatment uses a catheter to burn the tiny area causing the problem (radiofrequency ablation), and th…

This study tests whether stem cells from umbilical cords can safely improve heart function in people with heart failure due to blocked arteries. Sixty participants will receive either one or two doses of stem cells or a placebo through an IV. The main goal is to see if the heart'…

This study follows 100 people with coronary artery disease who have already been treated with the Essential Pro device. Researchers want to confirm the device is safe and works as intended, meeting new European safety rules. The main goal is to see if the device prevents serious …

This study compares two approaches for people with a completely blocked heart artery (chronic total occlusion) that is causing reduced blood flow to the heart muscle. One group will receive a stent to open the blockage, while the other will take medications only. The goal is to s…

This study is tracking 508 patients with multivessel coronary artery disease who received the SUPRAFLEX CRUZ stent during routine care. Researchers are monitoring for heart-related events like heart attacks, repeat procedures, and heart function over 12 months. The goal is to con…

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The program starts in the hospital and continues at home, helping patients build skills and motivation to do cardiac rehab…

This study is testing whether taking a statin (atorvastatin) together with an SGLT2 inhibitor (dapagliflozin) helps people with ischemic heart failure. Researchers will measure cholesterol levels and other lab tests in 90 participants. The goal is to see if the combination works …

This study tests an artificial intelligence program that analyzes heart rhythm data from a small, wearable patch to estimate how well the heart pumps blood. Researchers will compare the AI's results to standard ultrasound in 2,000 adults. If accurate, this could offer a simpler, …

This study tests whether artificial intelligence can help doctors interpret echocardiograms (heart ultrasounds) more accurately and quickly. Researchers at Mayo Clinic will deploy AI algorithms to flag signs of genetic cardiomyopathy, ischemic heart disease, and cardiac amyloidos…

This study tests whether adding extra support—like booster sessions and a website—to an 8-week telephone mindfulness program can better reduce stress, anxiety, and depression in people with heart disease or risk factors. Researchers will compare different program options in 160 a…

This study looks at whether giving a carbohydrate drink before coronary artery bypass surgery can improve insulin sensitivity and recovery in people with type 2 diabetes. About 50 participants will be enrolled. The goal is to see if this simple step can reduce complications and s…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study looks at whether a common heart procedure (using the wrist artery) can damage nerves in the hand. Researchers will check 400 patients for signs of carpal tunnel syndrome or other nerve problems. The goal is to understand the risks better, not to test a new treatment.

This study follows 2000 adults with suspected heart artery disease who undergo special imaging and pressure measurements during a heart catheterization. Researchers want to see which test results best predict future heart problems like heart attacks or the need for another proced…

This study tests a special MRI that can show how heart cells process energy in people with ischemic heart disease. About 15 adults with chronic heart failure will get this scan along with standard tests. The goal is to see if this new method can tell healthy from damaged heart ti…

This study tests a dynamic coronary roadmap system that helps doctors guide a pressure wire into narrowed heart arteries. 226 patients with ischemic heart disease will be randomly assigned to have the procedure with or without the roadmap. The main goal is to see if the roadmap r…

This study looks at whether a follow-up CT scan of the heart's arteries (coronary CT angiography) one year after stent placement can reduce major heart problems like heart attacks or death compared to usual care. It will enroll 3,500 high-risk patients who have had stents placed …

This study is testing a mobile app called GeriKit to gather more information about older adults (75+) with ischemic heart disease. Researchers want to see if the app helps them better understand patients' health and outcomes, like hospital readmission or quality of life. About 15…