ISCHEMIC HEART DISEASE

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This early-phase study tested whether a single infusion of donor stem cells could help repair damaged blood vessels in 26 adults with type 2 diabetes and symptomatic heart disease. Researchers measured blood vessel function and looked for signs of repair in the lab. The goal was …

This study tested a program to help veterans with heart disease or rheumatic conditions take their medications as prescribed. Over 5,000 participants received reminders via text or phone calls, with extra support if needed. The goal was to improve medication adherence and reduce …

This study compared two medications, levosimendan and adrenaline, given during heart bypass surgery to patients with weak hearts (ejection fraction 30-40%). Sixty adults aged 18-65 having elective surgery were included. The goal was to see which drug better supports heart functio…

This study looked at 121 people with heart disease who were getting a stent. Researchers checked if they also had a silent H. pylori stomach infection and whether treating that infection reduced stomach symptoms or bleeding. The goal was to see if eradicating the bug helps patien…

This study looked at 556 people with coronary artery disease to confirm that the Orsiro drug-eluting stent is safe and effective in everyday use. The stent releases sirolimus to prevent artery re-narrowing. Researchers tracked how many patients had heart-related death, heart atta…

This study tested a program to help people with heart disease, stroke, or heart failure in India. The program used non-physician health workers, text messages about healthy living, and a computer tool to help doctors make decisions. 410 adults took part to see if the program impr…

This study tracked 161 patients with coronary artery disease who were treated with the Essential Pro device in routine hospital practice. The goal was to confirm the device's safety and performance, such as freedom from heart attack or repeat procedures. Results support its conti…

This study looked at 1,424 veterans at high risk for heart problems who had major surgery. It compared two approaches to blood transfusion: a liberal strategy (transfusing when hemoglobin drops below 10) versus a restrictive strategy (transfusing only when hemoglobin drops below …

This study tested whether video education using deepfake technology—where an AI replicates the patient's own doctor's voice—could improve blood pressure monitoring and medication adherence in 218 adults with both ischemic heart disease and hypertension. Participants were randomly…

This early-phase trial tested a gene therapy called VM202RY in 9 people with ischemic heart disease who had incomplete revascularization after bypass surgery. The therapy was injected directly into heart muscle areas that still had poor blood flow. The main goal was to check safe…

This study tested a 'no-touch' method for taking veins from the leg during heart bypass surgery, compared to the usual technique. Over 900 patients were followed for two years to see if the no-touch method kept the vein grafts open better. The goal is to improve long-term success…

This study tested whether a new MRI technique using artificial intelligence (deep learning) can accurately measure heart function while patients breathe normally, instead of holding their breath. The standard method requires repeated breath-holds, which can be hard for people wit…

This study tests whether watching an augmented reality (AR) educational video on a tablet can lower anxiety in people about to undergo cardiac catheterization, a common heart procedure. Participants in the experimental group view the AR video in addition to receiving standard pap…

This study compares two types of nerve blocks (ESPB and SPSIPB) to manage pain after heart bypass surgery. About 60 adults aged 18-80 having planned bypass surgery will take part. The goal is to see which block reduces the need for painkillers and improves comfort after surgery.

This study tested problem-solving therapy (PST) for adults with type 2 diabetes or heart disease who also have poor mental well-being. PST is a structured talk therapy where patients list their problems, weigh solutions, and take action. The trial involved 147 patients in general…

This study tested whether a home-based breathing exercise program, guided by video calls, can improve quality of life, heart and lung function, and mood in 104 adults with ischemic heart disease. Participants did either a combined inspiratory and expiratory muscle training, inspi…

This study tested a 6-week program called Heart Up! that uses text messages and social support to help adults with heart disease become more physically active and feel less hopeless. About 224 patients who had a heart attack or related procedure took part. The program aimed to im…

This study tested whether interactive physical therapy (using computer-based balance and strength exercises) could help frail older adults recover better after open heart surgery. 153 participants aged 65 and older were assigned to either multicomponent training or computer-based…

This study looked at 150 patients who had a heart attack 12 to 36 hours earlier. Researchers wanted to see if opening the blocked artery right away was better than waiting a few days. They used MRI scans to measure heart muscle damage and function.

This study checked if certain blood markers can predict serious heart events like heart attack or death within a year after a stent procedure. Researchers measured two types of cells related to blood vessel health in 170 adults scheduled for a stent. The goal was to see if these …

This study tested whether an augmented reality (AR) tool, accessed via a QR code on a smartphone, could help heart patients better understand their discharge instructions. 303 adults hospitalized for heart attack, heart failure, atrial fibrillation, or pacemaker implantation took…

This completed study examined blood samples from 40 adults to see if high levels of lipoprotein (a), a type of cholesterol, are linked to fewer or different blood vessel repair cells. Participants with high Lp(a) were compared to those with normal levels. The goal was to better u…

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This study looked at whether using a thin, 7-French sheath through a small artery in the wrist is safe and effective for opening blocked heart arteries. 100 adults with heart disease took part. The goal was to see if this approach causes fewer bleeding or artery problems while st…

This study tested new MRI methods to detect bleeding inside the heart muscle after a heart attack. Researchers studied 14 patients to see if these scans could better identify damage that raises the risk of heart failure. The goal was to improve imaging, not to test a treatment.

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…