Ketone drink shows promise for brain disorders in small study

NCT ID NCT06426134

Completed Symptom relief Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether a single dose of a ketone drink could improve information processing and cognition in 28 people with schizophrenia or bipolar disorder. Participants drank either the ketone drink or a carbohydrate drink, then had brain wave tests, cognitive tasks, and mood ratings. The study also looked at metabolism, inflammation, and circadian rhythm over five days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketone drink (delta G Ketones)
What this could lead to: If it works, this could point toward a dietary supplement that helps with thinking and mood in schizophrenia and bipolar disorder.
What could go wrong: This is a very small pilot study with only 28 people, so results may not apply widely. It only tested a single dose, not long-term effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Bipolar and Related Disorders bipolar disorder major depressive disorder Mania psychotic disorder Psychotic Disorders schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

Amsterdam UMC, dept. Psychiatry

Amsterdam, North Holland, 1105 AZ, Netherlands

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Other studies related to the condition(s) this trial covers.