Cognitive disorder

This early-stage study tests a new vaccine called DUVAX in 24 healthy adults aged 40-65. The vaccine aims to train the immune system to attack two proteins linked to Alzheimer's disease. The main goal is to check safety and see if the vaccine produces a protective immune response…

This trial investigates whether a surgical procedure that connects lymph vessels in the neck to veins, combined with the standard drug donepezil, can slow cognitive decline in people with moderate Alzheimer's disease. The surgery aims to improve drainage of waste from the brain, …

This phase 2 trial tests whether ublituximab, an immune-modulating drug, can reduce symptoms in people with treatment-resistant schizophrenia. Participants receive the drug by IV infusion, and researchers measure changes in symptom scores over time. The goal is to see if targetin…

This study tests whether a daily dose of tricaprilin, a type of fat that may provide energy to brain cells, can improve memory, thinking, and daily function in people with mild-to-moderate Alzheimer's disease. About 535 participants will receive either tricaprilin or a placebo fo…

This study tests a smartphone-based digital training program designed to improve working memory in people with schizophrenia or related disorders. Participants use the app to practice cognitive exercises, and researchers measure changes in memory and mental health. The goal is to…

This study tests whether a daily 240 mg dose of Ginkgo biloba extract can change certain blood markers linked to Alzheimer's disease in people with mild cognitive impairment. Over 6 months, 120 participants will be randomly assigned to receive either Ginkgo biloba or a placebo. T…

About one in four older adults experiences confusion (delirium) after cardiac surgery, which can lead to longer hospital stays and higher risks. This pilot study tests whether using a brain-monitoring device to personalize blood pressure during surgery can help prevent delirium. …

This study compares two types of cognitive-based balance training for people with Parkinson's disease: one using virtual reality (VR) and the other combining balance exercises with mental tasks like counting. Thirty-four participants aged 40-80 will do 16 sessions over 8 weeks. R…

This study tests a one-time microsurgery that connects lymphatic vessels in the neck to veins, aiming to improve drainage of waste proteins from the brain. Fifty-nine people with severe Alzheimer's will receive the surgery plus standard medication. Researchers will measure change…

This study tests a program that combines executive function training (like planning and problem-solving) with cognitive behavioral social skills training for adults aged 60 and older who have schizophrenia or schizoaffective disorder. Participants attend 42 sessions that teach pr…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests a surgical procedure called deep cervical lymphovenous anastomosis (LVA) for people with moderate Alzheimer's disease. The surgery aims to improve the brain's ability to clear waste proteins, like amyloid-beta, which are linked to Alzheimer's. Researchers will co…

This study tests a single intravenous dose of an experimental drug called CGB3002 in healthy adults aged 18 to 55. The main goal is to see if the drug is safe and how the body processes it. This is a first step toward possibly developing a treatment for Alzheimer's disease.

This study tests a new nasal spray treatment for frontotemporal dementia (FTD), a brain disease that changes personality and language. The spray contains tiny particles from umbilical cord stem cells that may protect brain cells and reduce harmful protein buildup. About 33 adults…

This pilot study will test whether deep brain stimulation (DBS) can help people with schizophrenia who still hear voices and have delusions despite trying multiple medications. Fifteen adults will have electrodes placed in a brain region linked to schizophrenia symptoms. The goal…

This Phase 3 trial tests whether a daily injection of GV1001 can slow cognitive decline in 750 people with moderate-to-severe Alzheimer's. Participants will receive either the drug or a placebo for 24 weeks. Researchers will measure changes in thinking, memory, and daily function…

This study compares dapagliflozin and metformin for managing weight gain caused by antipsychotic medications. About 110 adults aged 16 and older will take one of the drugs plus lifestyle advice for 26 weeks. The goal is to see which drug works better and is safer for weight contr…

This study tests an oral medication called Gut-X-001 in 120 people with Alzheimer's disease. The goal is to see if it can improve thinking, daily living skills, and brain health. Participants will receive the drug or a placebo for 6 months, with an option to continue for another …

This study tests whether MLC901 (NeuroAiD™II) can improve thinking and memory in people with mild to moderate Alzheimer's disease. About 350 adults aged 50 and older will receive either the study drug or a placebo for several months. Researchers will measure changes in cognitive …

This early-stage trial tests whether lithium orotate, a form of the mineral lithium, is safe and reaches the brain in people with early Alzheimer's. Forty adults with confirmed Alzheimer's will take either the supplement or a placebo for 9 weeks. Researchers will measure lithium …

This study tests a brain implant called deep brain stimulation (DBS) to help six adults with severe aggression that hasn't improved with medication or other therapies. Participants have either autism or schizophrenia and live in locked psychiatric units. The implant targets a bra…

This study tests a drug called mivelsiran in 58 adults with Down syndrome who have early-stage Alzheimer's. Participants receive either the drug or a placebo via injection into the spine every few months for two years. The goal is to see if the drug can reduce brain changes linke…

This early study tests a new drug called SIPI6398 in 9 people (healthy volunteers and schizophrenia patients). Researchers use brain scans to see how much of the drug reaches brain receptors linked to schizophrenia. The goal is to find the right dose and check safety, not yet to …

The EMBRACE trial will test whether a 12-month program combining Mediterranean diet advice, cognitive and language training, physical activity, and financial/digital literacy can help older adults at risk of cognitive decline. 120 participants will be randomly assigned to the pro…

This study tests a drug called mirikizumab, which is already approved for other conditions, in people with schizophrenia who have a specific immune marker (AGA IgG antibodies). The goal is to see if it can improve negative symptoms like lack of motivation and pleasure, as well as…

This study tests a drug called TML-6 in 210 people with early Alzheimer's disease. Over 52 weeks, researchers will compare those taking TML-6 to those on a placebo to see if the drug can slow or stop memory and thinking problems. The goal is to find a treatment that helps people …

This study tests whether carefully reducing antipsychotic medication in stable schizophrenia patients can improve their daily functioning compared to staying on the same dose. Researchers will group 288 adults aged 18–60 by their specific psychosis type and randomly assign them t…

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This study tests if special reflective roof coatings can lower indoor temperatures and improve health in Fiji. About 800 households will receive either a cool roof or usual care. Researchers will measure heart rate, blood sugar, depression, and other heat-related symptoms to see …

This early-phase trial will test whether a special form of resveratrol (JOTROL) is safe and tolerable for people with Parkinson's disease. About 30 participants will receive either a low dose, high dose, or placebo daily for three months. The study will also measure how the drug …

This early-stage study tests whether a focused ultrasound can safely and temporarily open the brain's protective barrier in people with early Alzheimer's disease. The goal is to see if this helps clear harmful amyloid and tau proteins that build up in the brain. Six participants …

This study tests whether a personalized program of exercise, diet, sleep support, social activities, and a weight-loss drug (semaglutide) can improve mental functioning in 140 adults with depression, bipolar disorder, or schizophrenia. Participants are randomly assigned to the pe…

This early-stage study tests whether a nasal spray containing particles from neural stem cells is safe for people with moderate-to-severe early-onset Alzheimer's. Nine participants aged 50-75 will receive different dosing schedules over 28 days. The main goal is to check for side…

This study is testing the long-term safety of a new medication called LB-102 for adults with stable schizophrenia. About 900 participants will take the drug for 52 weeks to see what side effects occur. The goal is to make sure the drug is safe enough for ongoing use to control sc…

This study tests whether donanemab, given as an IV infusion every 4 weeks, can safely lower amyloid plaques in the brains of 60 adults aged 35–50 with Down syndrome. Participants receive either donanemab or a placebo for 12 months, followed by a 12-month extension where everyone …

This study tests whether tracking smartphone activity and offering extra support from peer specialists can help veterans with serious mental illness avoid emergency room visits and hospital stays. About 400 veterans who are at high risk will take part. The goal is to catch early …

This study tests an experimental pill called RP902 in 360 people with mild cognitive impairment caused by Alzheimer's disease. Participants will take the drug or a placebo for 48 weeks to see if it slows memory decline. The trial is conducted at about 50 sites in China and may ex…

This pilot study tests whether a noninvasive ultrasound device can safely help clear waste from the brain in people at risk for Alzheimer's. Fifteen adults with signs of amyloid buildup will receive either real or sham ultrasound sessions over four weeks. The main goal is to chec…

This early-stage study tests a new drug called 8M2D for the first time in people. The goal is to see if it is safe and tolerable in healthy adults and in people with early Alzheimer's disease. Researchers will also check if 8M2D can lower amyloid beta, a protein linked to Alzheim…

This study tests whether low-dose radiation to the whole brain can slow down Alzheimer's disease in people with early-onset symptoms. Fifty participants will be randomly assigned to receive either the radiation treatment or a sham procedure. Researchers will track changes in memo…

This small pilot study will test a pharmacist-led program to control high blood pressure and cholesterol in 10 people aged 50-75 who carry the APOE ε4 gene, a major risk factor for Alzheimer's. Participants will take specific medications for six months to see if managing these he…

This study tests a vaccine called AADvac1 in 146 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and thinking. The vaccine aims to target a protein linked to the disease and slow its progression. Participants will receive injections o…

This Phase 2 trial tests whether the drug LM11A-31 can slow the progression of Progressive Supranuclear Palsy (PSP), a rare brain disorder that affects movement and balance. About 147 people with early-stage PSP will receive either the drug or a placebo twice daily for several mo…

This study tests whether lecanemab, a drug that clears amyloid plaques in Alzheimer's disease, can also help people with Parkinson's disease who have amyloid buildup in their brains. About 60 adults aged 50-90 with mild cognitive impairment or early dementia will receive lecanema…

This Phase 2 trial tests whether umbilical cord stem cells can safely improve movement and coordination in people with spinocerebellar ataxia (types 1, 2, 3, and 6). Forty-five participants will receive the cells through an IV and a spinal injection. The main goal is to see if sy…

This study compares a new injectable form of aripiprazole (SYH9096) to the approved drug Abilify Maintena® in 116 adults with stable schizophrenia. Participants receive five injections of each version, one month apart, to see if the new version reaches similar drug levels in the …

This study tests whether a non-invasive brain stimulation technique called rTMS can improve symptoms of Alzheimer's disease by regulating the 'gut-brain axis'—the link between gut bacteria and the brain. Researchers will treat 200 Alzheimer's patients with either real or sham rTM…

This study tests a vaccine called AADvac1, which targets tau tangles in the brain, a hallmark of Alzheimer's. It will be given alone or with another drug (donanemab) to 450 adults aged 50-80 with very early Alzheimer's. The goal is to see if this approach can reduce tau buildup a…

This study tests whether drugs that target tau protein, alone or with donanemab, can reduce tau buildup and slow memory decline in people aged 50-80 with early Alzheimer's. Participants will receive treatment for 30 months and undergo brain scans and cognitive tests. The goal is …

This study tests a smartphone app called StrokeApp designed to support people after a stroke or mini-stroke. The app provides educational content, medication reminders, and tools to track health. Researchers will compare quality of life and other health measures between 500 patie…

This study will test whether a lower dose of the drug lecanemab works as well as the standard dose for people with early Alzheimer's disease. Researchers will compare brain scans, memory tests, and blood markers in 140 participants over 18 months. The goal is to find the most eff…

This Phase 1 trial tests a single injection of QLH2405 in 68 healthy volunteers and people with mild Alzheimer's or mild cognitive impairment. The main goal is to check safety and how the body processes the drug. It is too early to know if QLH2405 will help treat Alzheimer's.

This study tests whether a drug called DAOIB, which boosts brain signaling, combined with omega-3 fatty acids can improve thinking and daily life in people with early Alzheimer's or mild cognitive impairment. 140 participants will receive either the combo or a placebo for 24 week…

This early-stage trial is testing a long-acting injectable form of the drug cariprazine, called AX251, in 48 adults with stable schizophrenia. The study aims to see how the drug moves through the body and whether it is safe when given as a single shot at different doses. If resul…

This trial tests whether a 'link work' intervention can help people with severe mental health difficulties attend routine dental appointments. 480 participants will be assigned to either the link worker support plus usual care, or usual care alone. The study measures whether they…

This study will test whether providing acute hospital care at home, instead of in a traditional hospital, can help people with moderate to severe dementia spend more days at home after an acute illness. Researchers will randomly assign 200 participants to either receive home-base…

This early-stage trial tests whether stem cells and their exosomes (tiny particles that help cells communicate) can safely improve movement in people with spinocerebellar ataxia, a condition that affects coordination and balance. Ninety participants will receive the treatment thr…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This study will screen 600 adults aged 55 and older in U.S. communities to find early signs of mild cognitive impairment (MCI). Participants will receive a combination of stem cell therapy, a wearable brain-computer interface device, and wellness coaching to see if these treatmen…

This early-stage trial tests whether a minimally invasive neck surgery, called lymphaticovenular anastomosis (LVA), is safe for people with Alzheimer's disease. The surgery connects tiny lymph vessels in the neck to nearby veins, creating a detour to help the brain drain harmful …

This study looks at whether an online education and support program can help people with schizophrenia or bipolar disorder stick to their medication plans. Researchers will compare digital questionnaires with pharmacy records to measure adherence. About 1,640 adults in Spain will…

This study looks at whether extra education from a pharmacist can help people aged 18-60 who are starting a new antipsychotic medication for conditions like schizophrenia or bipolar disorder. The goal is to see if this support reduces weight gain and other metabolic side effects.…

This study tests whether a natural compound from soy, called genistein, can slow down memory and thinking problems in people with mild cognitive impairment (MCI), often an early sign of Alzheimer's disease. About 150 adults over 50 with MCI will take either genistein or a placebo…

This study tests a home-based dual-task training program for people with Parkinson's disease who have mild cognitive impairment and are at high risk for dementia. Participants will cycle on a stationary bike while playing brain-training games on a tablet, three times a week for 3…

This study tests whether a digital platform called mindLAMP can help community health workers in India deliver better care for people with schizophrenia. About 240 adults with schizophrenia and at least one physical health risk (like diabetes or high blood pressure) will take par…

This study tests whether a special low-calorie, plant-based diet taken for 5 days each month can safely improve blood flow to the brain in middle-aged adults who carry the APOE4 gene, which raises Alzheimer's risk. Forty participants aged 45-65 will be randomly assigned to either…

This study tests whether a supervised 12-week resistance training programme can prevent harmful weight gain and improve physical health in people recently diagnosed with first-episode psychosis who are starting antipsychotic medication. Forty participants will be randomly assigne…

This early-stage trial tests whether repeated injections of a patient's own fat-derived stem cells into the brain are safe for people with mild to moderate Alzheimer's. Nine participants who previously received a single dose will now get up to six injections every two months. Res…

This study tests whether deep brain stimulation (DBS) — a device that sends electrical pulses to specific brain areas — can help people with schizophrenia that hasn't improved with medication. Ten adults aged 18-55 will have electrodes implanted in two brain regions and receive d…

This study tests whether adding cannabidiol (CBD) to the standard drug clozapine helps people with treatment-resistant psychosis. 250 participants will receive either CBD or a placebo for 12 weeks. Researchers will measure symptom changes and check safety.

This study tests a group psychoeducation program for people with schizophrenia to help them manage relapse and improve functional recovery. Sixty participants will be split into two groups: one receives the program (four 60-minute sessions) and the other does not. Researchers wil…

This Phase 1 trial tests a new drug called AK152 in healthy volunteers and people with Alzheimer's disease. The main goal is to check if it is safe and tolerable, and to see how the body processes it. The study is small and early-stage, so it will not prove whether the drug works…

This Phase 3 trial tests whether a daily supplement called tributyrin can slow cognitive decline in people with mild Alzheimer's disease. Over 12 weeks, 156 participants will take either tributyrin or a placebo. Researchers will measure changes in memory, thinking, gut bacteria, …

This study tests a talking therapy called the Cannabis Clinic for Psychosis (CCP) to help people with first-episode psychosis reduce or stop cannabis use. The therapy includes motivational interviewing and cognitive behavioral therapy in weekly sessions over 12 weeks. Researchers…

This Phase 3 trial tests whether masitinib, a drug that targets immune cells in the brain, can slow cognitive decline in 600 people with mild Alzheimer's. Participants take masitinib or a placebo alongside standard Alzheimer's medications. The study lasts 24 weeks and measures ch…

This Phase 2 trial tests whether repeated injections of a patient's own fat-derived stem cells into the brain can slow the progression of mild to moderate Alzheimer's disease. 115 participants will receive either the stem cells or a placebo every two months for a total of six dos…

This study tests whether oral semaglutide, a drug used for diabetes, is safe and can slow Alzheimer's disease. Sixty people with mild Alzheimer's will take the drug for one year. Researchers will check for side effects and use brain scans to see if the drug protects brain cells.

This study tests whether switching from daily oral antipsychotics to a monthly injection of paliperidone palmitate helps people with schizophrenia control symptoms and improve social function. Researchers will enroll 120 adults aged 18-65 who are stable on oral meds. Participants…

This study tests a new device that uses mild electrical currents on the brain and virtual reality exercises to help people in the early stages of Alzheimer's disease. Researchers want to see if this approach can improve memory, thinking, and sense of smell. The study will involve…

This small pilot study tests whether bromocriptine, a drug used for Parkinson's, can safely improve blood sugar problems in people with schizophrenia who have prediabetes from antipsychotic medications. Fifteen adults will take bromocriptine for 6 weeks, with researchers monitori…

This study tests a smartphone app called PRIMI that helps migrant women eat healthier and be more active after having a baby. The trial will include 200 women who recently gave birth and will use the app for six months. Researchers will measure diet quality and physical activity …

This phase 2 trial will test whether a nasal spray called NeuroEPO can help maintain thinking and memory in people with mild to moderate Alzheimer's disease. About 90 adults aged 50 and older will receive either NeuroEPO or a placebo three times a week for one year. Researchers w…

This study tests whether tadalafil, a drug typically used for erectile dysfunction, is safe and can help people with early Alzheimer's or mild cognitive impairment. Over one year, 244 participants will take either tadalafil or a placebo. Researchers will check for side effects an…

This study tests a new drug called NS101 in 15 people with semantic variant primary progressive aphasia (svPPA), a rare type of frontotemporal dementia that affects language and memory. The drug is an antibody designed to help repair connections between brain cells. The main goal…

This study will test the safety and effectiveness of paliperidone extended-release tablets in 505 adults with schizophrenia in Bangladesh. Participants will take the medication once daily for 12 weeks, with doses adjusted as needed. Researchers will measure changes in symptoms us…

This study will test the antibody drug lecanemab in 120 people with mild cognitive impairment or mild-to-moderate Alzheimer's disease. Using PET scans to measure amyloid and tau proteins in the brain, researchers hope to identify which patients are most likely to benefit from tre…

This study tests a French questionnaire designed to identify spatial orientation problems in people with Alzheimer's disease. Researchers will ask 330 participants—including Alzheimer's patients, their caregivers, and healthy older adults—to fill out the questionnaire. The goal i…

This study tests whether a non-invasive brain ultrasound, combined with machine learning, can help distinguish people with schizophrenia from healthy individuals. Researchers will scan 200 adults (100 with schizophrenia, 100 without) and measure specific brain features. The goal …

This study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This study tests a wearable insole and ankle device that measures walking patterns to detect early cognitive decline in older adults. Researchers will collect gait data from 150 participants—some healthy, some with mild cognitive impairment or dementia—first in a lab and then dur…

This study will test a wearable headband called Somfit that measures brain activity during sleep in people with early or no Alzheimer's symptoms. Researchers want to see if it works as well as a full lab sleep test. If it does, it could make it easier to track sleep changes linke…

This early-phase trial will test a new radioactive tracer called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The tracer targets a brain protein called MAO-B and is used with PET scans to see if it can help diagnose these conditions. Th…

This study tests a special PET probe that targets a protein called DDR2, which is linked to lung scarring in interstitial lung disease. Researchers will scan 50 patients to see if the probe can accurately detect the disease and also check for related cognitive problems. The goal …

This study tests a faster way to diagnose Alzheimer's disease using blood tests, spinal taps, and brain scans. It involves 200 people aged 50-90 with mild memory problems. The goal is to see if a nurse-led screening tool can help get a diagnosis in months instead of over a year.

This study will check if a blood test can find signs of Alzheimer's disease in people with early memory concerns. Researchers will test 1,000 adults aged 55 and older in primary care. The goal is to see if blood markers for amyloid and tau proteins match those found in spinal flu…

This study will check if a Greek version of the Montreal Cognitive Assessment (MoCA) test is reliable for spotting early memory problems. Researchers will enroll 250 Greek-speaking adults aged 55-85, including some with mild cognitive impairment or dementia. The goal is to give d…

This study will test if combining digital technology (analyzing how people walk, their facial expressions, and speech) with blood markers can better screen for early Alzheimer's disease in community adults aged 50 and older. The goal is to create a more efficient screening method…

This study looks at whether simple eye-tracking tests and brain scans can detect very early signs of Alzheimer's disease in 100 healthy older adults. Half of the participants carry a genetic risk factor (APOE4). The goal is to find biomarkers that could lead to earlier diagnosis,…

This study tests a new, non-invasive eye scan that uses artificial intelligence to look for changes linked to Alzheimer's disease. Researchers will compare the scan results with blood tests in 200 UAE adults who have mild memory problems. The goal is to see if this quick, painles…

This study will test whether measuring a specific abnormal protein (alpha-synuclein) in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Researchers will collect samples and perform cognitive tests on 286 older adults with suspected …

This study tests a 12-week remote program for adults aged 60-75 at risk of cognitive decline. The program includes aerobic exercise, cognitive training, and education on healthy aging, all delivered through a website. Researchers will measure whether the program improves memory, …

This pilot study will test whether teaching people aged 50 to 75 how to cook healthy meals can reduce their risk of type 2 diabetes and dementia. Forty participants at higher risk will either attend weekly cooking classes with at-home practice or receive nutrition handouts. The s…

This study tests a one-year lifestyle program designed to help people with traumatic brain injury lose weight and prevent diabetes. The program includes 22 sessions over a year, focusing on healthy eating and physical activity. Researchers will track weight, blood pressure, and b…

This study tests whether a year-long virtual lifestyle coaching program—focusing on diet, sleep, and activity—can lower Alzheimer's-related blood markers in 1,200 adults aged 60-80 who carry a genetic risk. Participants wear an Oura ring for tracking and provide blood samples. Th…

This study tests a new approach to prevent delirium (sudden confusion) in intensive care patients. It uses an artificial intelligence system to help nurses make better care decisions and virtual reality to keep patients mentally active. The goal is to reduce the risk of long-term…

This study tests whether an AI-powered digital coach called BLAZE can help adults aged 40 and older improve their brain health. Participants will receive personalized tips and support through WhatsApp to reduce risk factors for dementia. The study will compare their progress to t…

This study tests an 8-week program called KINDER, designed to help family caregivers of people with dementia reduce psychological elder abuse and improve the quality of care. The program includes group discussions over Zoom and a self-paced workbook. Researchers will enroll 260 c…

This study tests whether a 12-week high-velocity resistance training program can improve brain blood flow and thinking skills in adults aged 60 to 79 who are at higher risk for Alzheimer's disease. Participants will be randomly assigned to either the exercise program or their usu…

This study tests whether the drug HT-4253 can lower Alzheimer's risk in people aged 50-75 who carry the APOE4 gene and have high levels of amyloid in their blood. The 112 participants will receive either the drug or a placebo for 48 weeks. The main goal is to see if the drug can …

This pilot study tests whether giving insulin as a nasal spray can prevent delirium (sudden confusion) in adults aged 65 and older after complex heart surgery. About 30 participants will receive either the insulin spray or a placebo before and after surgery. The goal is to see if…

This study tests whether a structured program of nutrition advice, physical exercise, brain games, social activities, and health monitoring can improve brain health in adults aged 60 and older who are at risk for memory problems. About 80 participants will either follow the full …

This study tests whether a 5-session group mindfulness program can reduce distress and prevent psychosis in 270 young people (ages 18-30) at ultra-high risk. Participants will either receive the mindfulness training plus usual care, or usual care alone. The goal is to see if mind…

This study tests whether giving lorazepam, a sedative, can prevent delirium in intensive care patients who are at high risk due to heavy alcohol use. Researchers will use a blood test (Anttila-Index) to identify these patients. The trial involves 260 adults admitted to the ICU, w…

This pilot study tests whether a personalized lifestyle program combining workshops, remote coaching, and a smartphone app can help adults aged 55-75 at risk for dementia adopt healthier habits. 300 participants will either receive tailored guidance or standard advice. The main g…

This study tests a new approach to prevent delirium (sudden confusion) in patients with a type of stroke called subarachnoid hemorrhage who are in the intensive care unit. The program combines standard medical care with basic body awareness therapy and video-based communication. …

This study will test whether a personalized smartphone app can help prevent anxiety and depression in adults who do not currently have these conditions. About 2,595 people in Spain and Chile will use either a highly interactive app (Pandora-1), a simpler educational app (Pandora-…

This study tests whether a personalized smartphone app can prevent depression and anxiety in adults who do not currently have these conditions. Over 9,000 participants in Spain will use the app, which creates a custom plan with activities like exercise, sleep improvement, and pro…

This Phase 2 trial will test whether taking a daily probiotic supplement for six months is safe and practical for people with early Alzheimer's or those at risk. Researchers will enroll 40 participants aged 60 and older. The study does not test whether the probiotic improves memo…

This study tests two simple activities—volunteering inside the assisted living community or joining a current events discussion group—to see if they can reduce apathy in residents with mild to moderate memory problems. About 200 people aged 55 and older will take part for 6 month…

This study investigates whether playing 3D motion-sensing games (using Kinect and Google Cardboard) can improve motor control, thinking skills, and quality of life in people with mild to moderate Alzheimer's disease. Participants play specially designed games for 30 minutes a day…

This study will test a mobile app designed to help people with schizophrenia or those at high risk for psychosis recognize and change biased thinking patterns. One hundred participants will use the app and report on their mood and negative symptoms. The goal is to see if this sim…

This study tests whether three months of flicker stimulation (using near-infrared light or visual occlusion glasses) can improve thinking, movement, and mood in healthy older adults and those with subjective cognitive decline. Sixty participants aged 65-89 will be assigned to dif…

This study tests a special device that monitors sleep without any physical contact, designed for people with Alzheimer's or related dementias living in long-term care facilities. About 100 residents will use the device for four weeks. Researchers want to see if sharing sleep data…

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation can reduce negative symptoms (like lack of emotion or motivation) and cognitive problems in people with schizophrenia. 62 participants will receive either real or sham sti…

This study tests whether using a brain monitor (EEG) during laparoscopic surgery helps patients wake up faster, have less pain, and avoid confusion. 136 adults having elective abdominal surgery will be randomly assigned to groups with or without the monitor, in different surgical…

This study will test whether smartphone sensors can detect when someone with early psychosis is feeling anxious or depressed and then offer a short mindfulness or psychoeducation exercise. Ten adults aged 18–50 with early psychosis and mild mood symptoms will use the app for 10 w…

This study tests whether a handheld robot that guides meditation with touch and voice can improve sleep quality in older adults with mild memory concerns. 100 participants will either use the robot or a standard meditation app for daily sessions. The goal is to see if the robot h…

This study tests a special helmet that shines near-infrared light on the brain (called transcranial photobiomodulation) in 40 people with Lewy body dementia. Participants use the helmet twice daily for 6 months. Researchers will check thinking skills, symptoms, and quality of lif…

This study tests a 12-week online program designed to improve mood and motivation in people with schizophrenia or early psychosis. Participants complete 20-30 minute weekly sessions. Researchers will measure changes in symptoms and goal-directed behavior before and after the prog…

This study tests whether a mobile app that trains specific brain waves can improve working memory in adults with schizophrenia or schizoaffective disorder. Thirty participants will use the app at home twice a week for 12 weeks. Half get real neurofeedback, half get a placebo vers…

This study looks at whether moderate-intensity aerobic calisthenics, like the Jiamusi Happy Dance Steps, can improve thinking skills and walking speed in rural older adults with motoric cognitive risk syndrome (MCR), a condition that raises dementia risk. Over 12 weeks, 106 parti…

This study tests whether 8 weekly group sessions of Acceptance and Commitment Therapy (ACT), led by a nurse, can help people with schizophrenia improve social thinking, emotion control, and mental flexibility. 64 participants will be split into two groups: one gets ACT plus usual…

This study explores whether a virtual reality mindfulness meditation program is practical and well-liked by older adults with mild to moderate cognitive impairment living in long-term care homes. About 36 participants will try up to 8 VR sessions over 4 weeks, and researchers wil…

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over sever…

This study tests whether an 8-session training program based on Acceptance and Commitment Therapy (ACT) can help caregivers of schizophrenia patients feel less burdened, express emotions more healthily, and become more psychologically flexible. About 60 caregivers will be randoml…

This study tests whether a daily supplement of sulforaphane, a compound found in broccoli sprouts, can improve negative symptoms (like lack of motivation) and thinking problems in people with schizophrenia. Sixty participants aged 12 to 45 who are stable on antipsychotic medicati…

This study tests whether giving magnesium before surgery can reduce emergence delirium—a state of confusion and agitation—in children aged 4 to 7 after adenotonsillectomy. Half the children receive magnesium by mouth before surgery, half receive it through an IV during surgery, a…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests whether wearing eye masks and/or earplugs at night can improve sleep quality and reduce delirium in 128 patients recovering from coronary artery bypass surgery. Participants will be randomly assigned to use these aids on the first three nights after surgery. Rese…

This study tests whether a six-week program of automated text or email messages can help reduce stress and burden for people caring for a loved one with dementia. Twenty care partners who previously took part in an observational study will receive educational tips, stress managem…

This study aims to reduce unwanted loneliness and improve the daily experience of family caregivers for people with Alzheimer's disease. Researchers will test a combination of music therapy and health education with 50 caregivers. The goal is to see if these activities can help c…

This study tests a new, non-invasive brain stimulation method called time interference stimulation (TIS) to see if it can improve thinking and memory problems in people with schizophrenia. Fifty adults aged 18-50 with schizophrenia will receive either real TIS or a fake (sham) tr…

This study will test whether using a virtual reality (VR) headset for cognitive and physical exercises is practical and well-liked by people with mild cognitive impairment. Ten participants will do three supervised VR sessions per week for six weeks. The goal is to see if they ca…

This study will test whether silkworm pupa powder, taken daily for 12 weeks, can improve memory, daily living skills, and frailty in 100 people with mild-to-moderate Alzheimer's disease. Participants will take the powder twice a day and visit the clinic every 4 weeks for tests in…

This study tests whether gentle ultrasound waves aimed at the brain can help with memory and thinking problems in people with schizophrenia. 140 adults with stable schizophrenia will receive either real or fake ultrasound sessions over 20 days. Researchers will check if memory an…

This study will test whether giving children a local anesthetic (numbing medicine) in their gums before dental work under general anesthesia helps them wake up more calmly and with less pain. Eighty children aged 7 to 12 will be randomly assigned to receive the numbing shot or no…

This study tests a personalized brain stimulation technique called HD-tACS to help people with schizophrenia better combine information from their senses. The treatment is tailored to each patient's brain activity and targets areas involved in sensory binding. The trial will incl…

This study compares two brain-training programs for adults with ME/CFS who experience brain fog. Both programs include computer games and a mild nerve stimulation device, but one focuses on processing speed and daily tasks while the other emphasizes relaxation and healthy habits.…

This study tests whether a tailored online support group (VOCALE LBD) can reduce depression in family caregivers of people with Lewy body dementia (LBD). LBD caregivers often face high stress and depression rates. The 8-week program brings small groups together online to discuss …

This pilot study tests whether simple bedroom changes and sleep tips can improve sleep for older adults (65+) who live alone, have memory concerns, and struggle with insomnia. Over 8 weeks, researchers will visit participants' homes to adjust the bedroom environment and provide s…

This study looks at whether improving sleep can help memory and thinking in older adults with mild memory problems and sleep issues. Fifty participants aged 60-85 will receive either talk therapy for insomnia or gentle sound stimulation during sleep. Researchers will track change…

This study tests a drug called N-acetyl-L-leucine for people aged 4 and older with CACNA1A gene disorders, which can cause coordination problems, dizziness, and migraines. About 60 participants will receive either the drug or a placebo, then switch, to see if it improves movement…

This study tests a new therapy that combines face-to-face sessions with virtual reality (VR) to help people with psychosis manage their emotions. Participants will practice emotion regulation skills in realistic VR scenarios with live coaching from a therapist. Fifteen people wit…

This study compares opioid-free anesthesia to standard opioid-based anesthesia in 400 adults having elective heart surgery. The goal is to see if avoiding opioids can reduce both short-term and long-term pain, while also lowering side effects like delirium and nausea. Patients wi…

This study tests whether listening to music (Taiwan-localized or classical) combined with mindful breathing can reduce delirium, pain, and anxiety in ICU patients. Fifty-one adults at risk for delirium will receive the intervention twice daily for five days. Researchers will meas…

This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive eit…

This study tests whether using a special brain monitor (BIS) to guide sedation can reduce the amount of sedative drugs given to adults in the ICU after heart surgery. About 144 participants will be randomly assigned to either BIS-guided sedation or standard care. The goal is to s…

This study tests whether a personalized virtual reality program that uses sights, sounds, smells, and tastes can reduce apathy in older adults with cognitive impairment living in nursing homes. Ten participants will attend weekly sessions for six weeks, reliving meaningful memori…

This study tests whether a 45-minute session of viewing visual illusions with a partner can improve social cognition in people with psychotic disorders. Social cognition is the ability to understand what others think or feel. Sixty participants will be guided through illusion box…

This study tests whether an AI-powered chatbot can help adults aged 65 and older start and stick with a personalized exercise program. Researchers will measure changes in cognitive function, like memory and attention, over 24 weeks. Ninety participants will either get the chatbot…

This early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…

This study tests a smartphone app called NST-SPARK that uses augmented reality games to help people with schizophrenia who struggle with low motivation, lack of pleasure, and social withdrawal. About 30 adults with these symptoms will use the app for 12 weeks. The goal is to see …

This study tests whether a non-invasive brain training technique called gamma EEG neurofeedback can improve working memory in adults with schizophrenia or schizoaffective disorder. About 104 participants will be randomly assigned to receive either real neurofeedback (learning to …

This study tests whether two food supplements—one made from olive leaf extract and another combining olive leaf with mullein extract—can help maintain memory and thinking skills in older adults with mild cognitive impairment. About 99 participants aged 60–85 will take either one …

This study tests whether an artificial intelligence (AI)-guided sleep program is practical and well-liked by adults aged 60 and older who have both insomnia and mild memory concerns. Researchers will enroll 60 participants to check how many people join, stick with the program, an…

This study tests whether minocycline, an antibiotic that reduces brain inflammation, can safely prevent or reverse memory and thinking problems in adults with sickle cell disease. About 30 participants will take either a low dose, high dose, or placebo for one year. Researchers w…

This study tests whether adding low-dose ketamine to standard sedatives helps critically ill patients on breathing machines recover faster and spend more days alive at home. About 640 adults who need unplanned ventilation and sedation will receive either ketamine or a placebo for…

This study tests whether a new medicine, Xanomeline/Trospium (also called KarXT), can improve thinking and memory in adults with schizophrenia. Unlike standard antipsychotics, this drug targets a different brain system and may help with cognitive symptoms. Researchers will follow…

This study tests whether a self-paced online program called WeACT can help family caregivers of people with dementia feel better mentally and emotionally. About 40 adult caregivers with mild to moderate depression will use the program for six weeks. Researchers will check if care…

This study tests whether a stellate ganglion block (a nerve injection) can reduce delirium (sudden confusion) and improve sleep-wake cycles in intensive care patients aged 65 and older. Delirium is common in the ICU and linked to worse outcomes. The trial will compare 130 patient…

This study tests whether combining two types of non-invasive brain stimulation (tDCS and TMS) can improve memory, thinking, and movement in people who have had a stroke. Twenty-four participants will receive either real or fake (sham) stimulation daily for one week. Researchers w…

This study tests whether a gentle, non-invasive electrical brain stimulation (tACS) can improve working memory in people who have memory problems after a stroke. 24 participants will receive either real or fake stimulation for 40 minutes a day for 5 days, alongside cognitive ther…

This study tests whether a virtual cognitive behavioral therapy for insomnia (CBT-I) program, called REPAIR Sleep, can improve sleep and emotional well-being in people with dementia and their live-in caregivers. Over 5 weekly video sessions, participants learn techniques like set…

This study tests a personalized, non-invasive brain stimulation device for 10 people with mild cognitive impairment (MCI). The device uses AI to tailor electrical stimulation to each person's brain patterns while they do memory exercises. The goal is to see if this approach can i…

This study tests whether a short, telephone-delivered insomnia treatment (BBTI) can improve sleep and cognitive function in 214 older adults with HIV, compared to a mindfulness approach (BMT). Participants will complete four weekly phone sessions and attend in-person visits for s…

This study looks at whether a well-formulated ketogenic diet can reduce pain and improve thinking in adults with osteoarthritis and mild cognitive impairment. Ten participants will follow a supervised low-carb, high-fat diet for a period, with before-and-after tests for pain, phy…

This study tests whether using brain wave (EEG) monitoring to guide anesthesia during surgery can reduce postoperative delirium—a common side effect in older adults that can lead to lasting memory problems. Researchers will train anesthesia providers to interpret EEG data and adj…

This study tests whether intensive music therapy can improve thinking skills like memory, attention, and decision-making in people recovering from a stroke. It will include 36 adults in Malaysia who had a stroke within the last 3 months and have mild to moderate cognitive problem…

This study looks at whether virtual art therapy can help 62 patients in the coronary intensive care unit (ICU) feel less angry, anxious, and confused. Patients will use a tablet or screen to create art, and researchers will measure changes in vital signs, delirium risk, and menta…

This study tests a smartphone app called Senyo Health for people with bipolar disorder who also struggle with alcohol or drug use. The app offers therapy, rewards for healthy behaviors, and weekly check-ins with a care manager. The goal is to see if the app is easy to use and hel…

This study tests a group program called Veteran Voices and Visions (VVV) for veterans with psychosis who hear voices. The program, led by a peer specialist and a clinician, aims to reduce distress and help veterans feel a sense of belonging. 160 veterans will be randomly assigned…

This pilot study will test whether a non-invasive brain stimulation device called rTMS can improve cognitive function in adults aged 50 to 90 with mild to moderate memory problems. Eighty participants will receive six sessions of targeted magnetic pulses over three weeks. Researc…

This study tests whether dexmedetomidine, a sedative, can lower the chance of delirium (sudden confusion) in children who need a breathing machine in the ICU. About 266 children aged 1 month to 17 years will be randomly assigned to receive either dexmedetomidine or the standard d…

This study tests whether phenobarbital, an older sedative, can safely calm agitated delirium in ICU patients as well as standard antipsychotics. About 150 adults with hyperactive delirium will receive either phenobarbital or usual care. Researchers will compare how long patients …

This study tests whether combining breathing exercises with progressive muscle relaxation can reduce shortness of breath, anxiety, and delirium in patients recovering from heart surgery. 116 adults will be randomly assigned to either receive these techniques plus standard care, o…

This study tests whether taking creatine supplements before surgery can help protect thinking, memory, and attention in older adults. Creatine is widely used for muscle performance, but may also support brain health. Researchers will give creatine to 80 older adults scheduled for…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests whether a non-invasive brain stimulation technique called TMS can shorten the duration of delirium (sudden confusion) that often occurs after heart surgery in people aged 50 and older. Half of the 144 participants will receive real TMS, and half will receive a sh…

This study tests whether playing gentle sounds during deep sleep can improve memory and reduce Alzheimer's-related proteins in people with mild cognitive impairment (MCI). About 114 participants, including those with MCI and healthy older adults, will have their sleep monitored a…

This study tests whether a medication called dexmedetomidine can help patients in the intensive care unit (ICU) sleep more restfully. Good sleep is important for recovery, but ICU conditions often disrupt it. About 50 adult ICU patients will either receive the medication or a pla…

This study tests whether a mobile app or virtual reality program that teaches mindfulness and breathing exercises can lower stress, burnout, and improve sleep and thinking in nurses who work rotating shifts. 300 nurses will be split into four groups: one gets health education onl…

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study looks at whether a supplement called Alpha Brain can help healthy adults think more clearly, stay alert, and feel better when they haven't had enough sleep. About 34 people will take the supplement or a placebo in random order, with no one knowing which they got. The g…

This study tests a shared decision-making tool for antipsychotic medications in 120 young adults (ages 18-30) with early psychosis. The goal is to see if the tool helps patients feel more involved in their care and more likely to stick with treatment. Participants will use the de…

This study looks at whether eating pecans every day for three months can improve memory, mood, and brain function in people aged 50 and older with mild cognitive impairment. Sixty participants will be randomly assigned to eat either pecans or pretzels as a snack. Researchers will…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study tests whether giving home health aides extra training on dementia care can reduce troubling behaviors in older adults with dementia or mild cognitive impairment and improve quality of life for both patients and their care partners. About 120 patient-care partner pairs …

This study tests a portable exercise bike that clamps to hospital beds, allowing patients to pedal their arms and legs while lying down. The goal is to see if using the bike for at least 15 minutes a day can help prevent muscle loss, weakness, and other problems like blood clots …

This study tests whether a smartphone app called utmbHealthyBrain is easy for older adults and their caregivers to use. The app includes drawing, Tai-Chi, meditation, and a sharing feature to help with emotions, movement, and social connection. Forty pairs of adults aged 50+ and …

This study will test if guided nature-based therapy, like forest bathing and gardening, can improve the wellbeing of elderly patients with dementia and patients recovering from stroke or brain injury. Researchers will measure changes in agitation, mood, and quality of life in 1,6…

This pilot study will test whether bright light therapy can help reduce behavioral and psychological symptoms like agitation in people with dementia. Researchers plan to enroll 70 adults on inpatient units at Mayo Clinic. Participants will receive 60-minute sessions of light ther…

This early-phase pilot study will test whether a nasal spray containing exosomes from human dental stem cells is safe and feasible for people with treatment-resistant schizophrenia who have persistent negative symptoms like social withdrawal and lack of emotion. Fifteen long-term…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This early study tests if a gentle brain stimulation technique called time interference stimulation (TIS) can help with thinking and memory problems in people with schizophrenia. Ten adults aged 18-50 will receive TIS twice a day for two weeks. Researchers will measure changes in…

This study tests whether a 6-month program of reciting Chinese classics can improve memory in people aged 60+ who feel their memory is slipping. Sixty participants will be split into two groups: one does the recitation training, the other does not. Researchers will use brain scan…

This early-stage trial will test whether terazosin, a drug currently used for high blood pressure and enlarged prostate, is safe and tolerable for people with dementia with Lewy bodies. Forty participants will receive either terazosin or a placebo for 15 weeks. The study focuses …

This pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …

This study tests whether making weekly action plans for physical activity helps inactive older adults (60+) become more active and improve their memory and thinking. 148 participants will wear Fitbits for 9 months and complete brain games on their phones. Researchers compare thre…

This study will test whether an 8-week hatha yoga program is practical and helpful for adults hospitalized with schizophrenia. The goal is to see if yoga can improve mindfulness and how patients recall memories. Thirty-six stable patients will participate in group yoga sessions l…

This study tests whether two dietary supplements can help adults who are poor sleepers improve their sleep quality, thinking skills, and stress levels. Over 28 days, 68 participants will take either an active supplement or a placebo. Researchers will measure sleep efficiency, gut…

This study compares two types of brain stimulation—accelerated theta burst and high-frequency TMS—against a sham (fake) treatment to see if they can improve cognitive problems like memory and attention in people with treatment-resistant schizophrenia. Ninety adults on clozapine w…

This study tests whether shining red and near-infrared light on the forehead, inside the nose, and on the neck can improve memory and mood in older adults who feel their thinking is slipping. Eighty participants will use a light device at home twice daily for five weeks. Research…

This study tests a personalized method using non-drug therapies (like music or activities) to reduce behavioral issues such as agitation and wandering in elderly people living in care homes. Researchers will compare this new approach to the usual care methods. The goal is to see …

This study tests a gentle, non-invasive brain stimulation technique called so-tDCS in 80 older adults who have mild memory and sleep complaints. Participants will receive either real or sham stimulation over 4 weeks. Researchers will track changes in memory, sleep quality, and br…

This study will test whether 8 weeks of improvisation music therapy can improve mood and lower stress for people with mild Alzheimer's disease and their care partners. About 40 older adults and their caregivers will attend music sessions and fill out questionnaires before and aft…

This study tests a new text messaging program called CAPTURE for caregivers of people with dementia after an emergency department visit. The program sends up to two tailored texts per day for 30 days, covering topics like symptom monitoring, caregiver well-being, and community re…

This study tests whether dronabinol, a synthetic form of THC (the active ingredient in cannabis), can safely reduce agitation in people with Alzheimer's disease. About 140 adults aged 50 to 90 with Alzheimer's-related agitation will receive either dronabinol or a placebo for 12 w…

This study tests two different supervised exercise programs in 350 adults aged 60 and older in Angola. One program includes strength, balance, and coordination exercises, while the other focuses on basic strengthening and daily activities. Both are done three times a week for 12 …

This study looks at whether a 12-week strengthening exercise program can improve muscle strength, muscle mass, and cognitive function in people with compensated liver cirrhosis. Twenty participants will be randomly assigned to either face-to-face or home-based exercise sessions t…

This early-stage study will test whether an injection of gastrodin, a compound from a traditional Chinese herb, is safe and tolerable in 54 healthy adults. Researchers will also measure how the drug moves through the body. If successful, this could lead to larger studies in patie…

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve memory, attention, and multitasking in veterans with mild traumatic brain injury and PTSD. Forty-six veterans will receive either real or …

This study tests whether aerobic exercise, alone or with a gentle brain stimulation technique called tDCS, can improve thinking and memory in people with treatment-resistant schizophrenia. About 160 participants will be assigned to exercise, tDCS plus exercise, or a control group…

This study tests whether a sleep medication called lemborexant can help older adults in the intensive care unit (ICU) sleep better and reduce their risk of delirium, a state of sudden confusion. The trial will involve 100 patients aged 65 and older who are in the surgical ICU. Pa…

This study tests whether a medicine called dexmedetomidine can reduce pain and prevent confusion (delirium) in adults after brain surgery. Sixty people having planned brain tumor removal will receive either the drug or a placebo during surgery. The goal is to see if it lowers pai…

This study tests an experimental drug called LY03020 in 160 adults with schizophrenia who are currently having severe symptoms (acute psychosis). Half will get the drug and half a placebo, and neither the patients nor the doctors will know who gets what. The main goal is to see i…

This study tests whether a supplement called pyrroloquinoline quinone (PQQ) can help reduce negative symptoms (like lack of motivation) and improve thinking skills in people with chronic schizophrenia. About 70 adults will receive either PQQ or a placebo for 8 weeks, and research…

This study tests whether a non-invasive device that delivers mild electrical pulses to the ear (taVNS) can prevent confusion and restlessness when children wake up from anesthesia after tonsillectomy. 120 children aged 3-8 will be randomly assigned to receive either real taVNS or…

This study tests whether a 10-week program combining strength exercises with muscle relaxation techniques can reduce frailty, anxiety, and burden in people caring for a loved one with Alzheimer's. About 62 caregivers will be randomly assigned to either the combined program or rel…

This study tests a program called FPCI-AL that helps staff in assisted living communities interact more positively with residents who have dementia. Researchers will work with staff for several months to improve care interactions. The goal is to reduce residents' behavioral sympt…

This study tests whether a type of talk therapy called narrative exposure therapy (NET) is practical and helpful for people with psychosis who have experienced trauma. One participant will receive NET sessions and complete questionnaires about their symptoms and experiences. The …

This trial tests whether cabergoline, a drug that lowers the hormone prolactin, is safe for people with schizophrenia who have high prolactin levels due to antipsychotic medication. About 146 adults will receive either cabergoline or a placebo for 12 weeks, and researchers will c…

This pilot study will test a digital platform called the Dementia Journey Companion (DJC) that helps people with dementia and their caregivers plan future care. Researchers will enroll 150 participants with mild to moderate dementia living at home or in care facilities. The study…

This study will test whether eating 1.5 cups of mango every day for 12 weeks can improve immune function and thinking skills in healthy young adults aged 18 to 30. Researchers will measure changes in immune cells, inflammation, and cognitive test scores. The goal is to see if thi…

This early-phase study tests whether brivaracetam, a seizure medication, can calm overactive brain areas and improve thinking in 25 adults aged 45–70 with mild Alzheimer's or mild cognitive impairment. Participants will have brain activity monitored via scalp and depth electrodes…

This study tests whether an app called Health enSuite Caregivers can reduce distress in people caring for someone with moderate dementia. The app offers personalized tips on self-care, communication, and time management. Researchers will enroll 400 caregivers to see if using the …

This early study tests whether a device that delivers synchronized 40 Hz light and sound (called GENUS) is safe and feasible for people with schizophrenia. The goal is to see if this at-home stimulation can improve brain rhythms, thinking, and symptoms that current medications do…

This study aims to see if peer support can help pregnant and postpartum veterans who have serious mental illness. Researchers will develop a program where trained peer specialists offer support, then test it with 24 veterans to see if it is helpful and practical. The goal is to i…

This study tests whether a special type of speech training using five musical tones can help people with aphasia (trouble speaking) after a stroke. Researchers will enroll 120 adults who had a stroke and have non-fluent aphasia. Participants will receive either five-tone therapy …

This study tests whether adding cannabidiol (CBD) to standard antipsychotic medication can improve symptoms in people experiencing their first episode of psychosis who haven't responded well to initial treatment. About 250 participants aged 16-40 will receive either CBD or a plac…

This study tests a new digital education program called CARE-Dem for people caring for a loved one with dementia. The program includes videos, fact sheets, and activities to help caregivers understand dementia, communicate better, and find support. Researchers want to see if the …

This study tests whether playing interactive games with a social robot can improve thinking skills, mood, and quality of life in older adults with mild cognitive impairment or dementia. Researchers will randomly assign 80 participants to either 12 weeks of robot game sessions or …

This study tests whether an AI-powered smart electric vehicle can help people with Parkinson's disease or dementia improve their walking and reduce falls. The vehicle monitors gait, gives real-time feedback, and adapts to the user. Researchers will enroll 120 participants aged 50…

This study tests a 15-session group therapy program for people with schizophrenia who still hear voices despite medication. The program combines several proven strategies to help reduce how often the voices occur and how much distress they cause. Researchers will compare the ther…

This study tests whether prucalopride, a drug used for gut issues, can improve thinking and memory in people with schizophrenia. About 34 adults will take the drug for 4 weeks while staying on their usual medications. Researchers will measure changes in memory, attention, and pro…

This small study will test if a culturally-adapted form of cognitive-behavioural therapy (CBT) is practical, acceptable, and safe for Black Sub-Saharan African and Caribbean people who experience psychosis. Six participants will attend up to 16 therapy sessions and complete quest…

This study compares two sedatives, remimazolam and midazolam, to see which one causes less confusion (delirium) after heart valve surgery in people aged 65 and older. Delirium affects up to 70% of older heart surgery patients and can lead to longer hospital stays and memory probl…

This study explores whether drinking beetroot juice twice a day is practical and acceptable for people with mild-to-moderate Alzheimer's disease. Thirty participants will take the juice for one week, with help from a caregiver, to see if they can stick with it and if it causes an…

This study tests whether a smartphone app that guides patients through acupressure can reduce fatigue, itching, and improve sleep in people on hemodialysis. About 70 adults who have been on dialysis for at least three months will be randomly assigned to use the app daily for four…

This study tests a program where specially trained nurses work with families caring for a person with dementia. The nurses help identify and address unmet needs, and a mobile app gives caregivers direct access to experts and memory clinics. The goal is to see if this support help…

This study tests a virtual reality program designed to help family caregivers of people with dementia find a better balance in their lives. Researchers will enroll 60 caregivers to see if the VR experience reduces stress and improves quality of life. The goal is to ease the emoti…

This study tests whether a computer-based stepping game, called Smart±step, can help older adults with mild cognitive impairment (MCI) improve their balance, thinking, and quality of life while reducing their risk of falling. About 70 participants will use the game, which combine…

This study tests whether using a special blend of essential oils at home can improve mood and behavior in people with mild cognitive impairment or early dementia. It also looks at whether this simple, pleasant treatment can reduce stress for their caregivers. Two hundred patients…

This study tests whether a gentle electrical current applied to the scalp (called tACS) can improve memory and thinking in people with mild Alzheimer's disease. Researchers will compare real stimulation to a sham (fake) version in 160 participants. The goal is to see if this safe…

This study tests whether adding an experimental drug (X/T+X-EC) to standard Alzheimer's treatment (lecanemab) is safe and tolerable. About 60 adults with Alzheimer's will receive either the drug or a placebo for 24 weeks. The main goal is to check for side effects, not to measure…

This study will test whether different amounts of computerized brain training can improve thinking and memory in older adults with mild cognitive impairment. About 234 people aged 60 and older will be assigned to one of several training schedules over 12 weeks. Researchers will t…

This study tests whether laser acupuncture—using a pen-like device that shines light on specific points on the body—can improve behavioral and psychological symptoms in people with dementia. Sixty participants will receive either real or sham laser treatment three times a week fo…

This study tests whether a device that sends magnetic pulses to nerves (peripheral magnetic stimulation) can reduce symptoms and improve daily function in older adults with schizophrenia. Forty participants aged 60 and older will be split into groups receiving either active or sh…

This study will test if art therapy sessions can lower anxiety and disease severity in 48 adults hospitalized in a psychiatry ward. Participants will be randomly assigned to receive art therapy plus standard care or standard care alone. The goal is to see if creative expression c…

This study tests a care management checklist designed to guide end-of-life care and hospice transitions for people with advanced dementia and their care partners. Researchers will work with a home healthcare agency to see if the checklist is feasible, acceptable, and usable. The …

This early-phase study will test whether shining near-infrared light on the head each day can help people with mild to moderate Alzheimer's disease. Forty participants will receive 30-minute light sessions six times a week for 96 weeks. Researchers will measure changes in thinkin…

This study compares standard metacognitive training (MCT) with a personalized version (P-MCT) for people with schizophrenia spectrum disorder. The goal is to see which approach better improves daily functioning and reduces symptoms. Fifty-one adults with stable psychosis will tak…

This study compares an AI-powered orientation program to one given by human nurses for patients in the intensive care unit (ICU). The goal is to see if the AI program helps patients have more days without delirium, lowers anxiety and depression, and shortens their hospital stay. …

This study tests whether doing physical exercises (like walking and balancing) at the same time as mental tasks (like math or memory games) can improve thinking skills in people with mild Alzheimer's disease. Sixty older adults will be randomly assigned to either this dual-task t…

This study tests whether art therapy—like painting, clay modeling, and collage—can improve thinking and hand skills in people with mild to moderate Alzheimer's disease. Fifty adults aged 60 and older will be split into two groups: one does art therapy twice a week for 8 weeks, th…

This study tests whether listening to music at home can improve the quality of life and reduce burnout in people caring for a loved one with Alzheimer's. Ninety caregiver-patient pairs will be split into groups, with some listening to music or podcasts three times a week for 12 w…

This study tests whether an AI-powered app that guides chewing exercises can improve oral hygiene, chewing, and swallowing in people with schizophrenia. 100 participants from two hospitals will be randomly assigned to use the app before meals or receive standard care. The goal is…

This pilot study investigates whether exercising together or separately influences brain function, cognitive performance, mood, and parent-child connection in mother-child pairs. Mothers and their children (ages 4-12) will complete two fitness sessions—one together and one in sep…

This study tests whether a non-invasive electrical brain stimulation technique called TES-TI can temporarily alter sleep spindles—brain rhythms often reduced in schizophrenia. Researchers will apply the stimulation during sleep in 20 people (half with schizophrenia spectrum disor…

This study investigates how pomegranate dietary supplements influence gut bacteria and inflammation in people with alcohol use disorder and alcohol-related liver disease. Researchers will measure levels of beneficial gut metabolites called urolithins and inflammatory markers in b…

This study will test whether wearable sensors can accurately monitor movement problems in people with progressive supranuclear palsy (PSP) and dementia with Lewy bodies (DLB). About 60 participants will wear small sensors on their chest, ankles, and wrists while doing simple task…

This study will examine whether certain RNA molecules in the blood are different in people with psychiatric disorders like schizophrenia, depression, bipolar disorder, OCD, and panic disorder. Researchers will compare these molecules in patients who are not currently on medicatio…

This study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…

The AHEAD study is testing whether artificial intelligence can help detect early signs of Alzheimer's disease in people who feel their memory is slipping but still test normal. Researchers will use brain scans, eye tests, and blood markers to identify those at highest risk. High-…

This study will analyze the complete DNA of 1,500 people in Manitoba—some with schizophrenia and some without—to find genetic differences linked to the illness. Researchers will also look at how genes affect medication response and side effects. The goal is to better understand s…

This study from Stanford University will look at how people react when they learn their Lewy Body Disease biomarker test results. Researchers will interview and survey 40 participants, both with and without symptoms, to measure distress and other responses over time. The goal is …

This study looks at better ways to screen caregivers of people with dementia for depression and connect them to online treatment. About 15 adult caregivers who show mild depression symptoms will test a new app. The goal is to see if the approach is easy to use and helps more peop…

This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular even…

This study will test an Italian version of a questionnaire called the dynamic Neurocognitive Adaptation (dNA) scale in 265 older adults, including those with normal aging, mild memory complaints, or dementia. The goal is to see if higher scores on the scale—reflecting more engage…

This study explores whether using physical actions, imagined movements, or videos can improve memory in people with early-stage Alzheimer's disease. Researchers will compare recall in 80 older adults (some with Alzheimer's, some healthy) after they watch videos of daily activitie…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study will follow 500 people with severe aortic stenosis who need a heart valve replacement. Researchers want to see if a dedicated Heart Valve Unit—a team of heart specialists working together—can reduce confusion, delirium, and memory problems that sometimes happen after t…

This study tests a group program for older adults living in the community who feel their memory is slipping. The program includes social activities, brain games, physical exercise, healthy eating advice, and emotional support. Researchers will measure memory, thinking, and mood o…

This study will test a new mobile mental health app designed to help people with schizophrenia or schizoaffective disorder stick to their medication routine. Researchers will enroll 50 adults who are in remission and see if using the app is practical and well-liked. The goal is t…

This study tests whether a 12-week blended training program can improve dementia knowledge and skills among primary healthcare providers in China. About 240 workers from community health centers will be randomly assigned to either the training or self-study materials. Researchers…

This study follows 120 malnourished adults undergoing major abdominal or pelvic cancer surgery to see how their gut function, nutrition, and risk of confusion (delirium) change in the first week after surgery. Researchers will also check if giving a natural chemical called seroto…

This study will adapt and test an online communication training program called CHATO for nursing home staff who care for people with dementia. The goal is to improve how staff interact with residents, which may reduce behavioral symptoms like agitation or rejection of care. Resea…

This study tests whether an AI-powered smartphone app can accurately measure walking patterns compared to a high-tech motion-capture system. Forty healthy adults will walk with a phone in their pocket while being recorded by cameras. The goal is to see if phones can reliably trac…

This study looks at whether a single dose of modafinil or D-serine can improve decision-making and thinking in people who have had psychosis for less than five years. Twenty-four participants will play computer brain games and have brain scans before and after taking the drugs. T…

This study uses a special full-body PET scan to look for activated T cells (a type of immune cell) in the brain and body of people with Alzheimer's disease. Ten participants with Alzheimer's and some healthy volunteers will get the scan to compare results. The goal is to better u…

This observational study will enroll 200 people—100 with Parkinson's disease, 50 with related conditions, and 50 healthy controls—to find molecular markers in blood, urine, and stool that can distinguish Parkinson's from atypical parkinsonism. Participants provide samples and und…

This study will follow over 3,000 older adults for three years to see how age-related hearing loss is connected to dementia. Researchers will use hearing tests, cognitive assessments, and blood markers to build a 'Hearing Health Clock' and early screening tools. The goal is to be…

This study follows 285 older adults with Alzheimer's or mild cognitive impairment to learn how they make decisions about aging in place or moving to long-term care. Researchers will track planning and preferences over time. No treatment or intervention is being tested.

This study looks at how the brain works when people make decisions. Researchers will work with 30 adult epilepsy patients who already have electrodes in their brains for medical reasons. While patients play a simple decision-making game, the team will track their brain activity, …

This study looks at whether waking up more slowly from anesthesia can help people recover better after lower-leg or foot surgery. Researchers will compare two groups of adults to see if a longer wake-up improves clear thinking, reduces pain, and shortens time in the recovery room…

This study will test a digital platform called MEVA that measures cognitive wellness in healthy adults aged 55 to 75. Participants will complete activities and questionnaires to see how reliable and easy the platform is. The goal is to understand if the tool works well for older …

This study reviews records from 1,000 healthy adults who completed 60 sessions of hyperbaric oxygen therapy (HBOT). Researchers will compare exercise test results and thinking skills before and after treatment to see if there are any changes. The goal is to understand how HBOT mi…

This study watches 210 older adults (60+) having heart surgery to see if the anesthesia drug remimazolam affects their thinking and memory afterward. Participants answer questionnaires about confusion and mental function. The goal is to learn, not to test a new treatment.

This study checks if a Turkish version of the Physical Activity Enjoyment Scale (PACES-8) works well for adults aged 65 and older who have mild cognitive impairment. Researchers will ask 100 participants to take a 15-minute walk and then fill out the scale. They will also retest …

This study tests a short program in the emergency department for people with dementia who have fallen. The program includes the patient and their caregiver and aims to reduce future fall-related ER visits. About 700 participants will be split into two groups: one gets the new pro…

This early-stage study is testing a new drug called KR23248 in 66 healthy adults aged 18 to 45. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo. This study does not aim to treat any disease but to…

This study follows 600 offenders with both mental illness and substance abuse in Italy and California over three years. Researchers will compare community-based care in Italy with high-security hospitals in the US to see which model leads to better outcomes, like reduced violence…

This study watches brain activity in 300 adults during high-risk surgeries like heart or spine operations. Researchers use special monitors to track brain waves and pressure, linking them to patient outcomes. The goal is to understand why some people develop confusion or brain in…

This study will create and test new ways to measure how thinking (neurocognitive load) affects arm and hand performance in athletes and healthy adults aged 18-40. Researchers will compare results from physical tests done with and without a mental challenge (reacting to lights) to…

This study tests an online training program called DERA for community health workers. The goal is to see if it improves their knowledge about dementia, reduces stigma, and boosts their confidence in helping people with dementia. About 100 community health workers will take the tr…

This pilot study will test whether over-the-counter (OTC) hearing aids are practical and acceptable for older adults with mild-to-moderate hearing loss who are at risk for dementia. Forty participants aged 50 and older will either use the hearing aids right away or wait three mon…

This study looks at why some older people experience confusion or memory problems after major surgery. Researchers will test 40 patients aged 70 and older before and after colorectal or urological surgery. They will use memory tests and blood samples to see if they can link chang…

This study will test if wearable sensors can effectively monitor symptoms and daily function in people with frontotemporal dementia (FTD). Sixty adults with FTD will wear pendant and wrist sensors for two weeks at a time, every six months over two years. The goal is to develop di…

This study watches 250 children aged 2 to 8 who are having urogenital surgery. Researchers want to see if the time they fast (no food or drink) before the operation changes how much pain or confusion they feel afterward. The goal is to learn if shorter fasting times could help ki…

This pilot study will compare the Clubhouse Model—a structured, community-based program where members work together to run the clubhouse—to standard outpatient care for adults with schizophrenia. Researchers will measure changes in thinking, daily functioning, and brain activity …

This study tests whether wearable sensors and computerized voice and thinking tests can reliably track symptoms in people with frontotemporal dementia (FTD). Twenty participants will wear sensors and complete assessments at home over 12 months. The goal is to develop digital biom…

This study tests a new way to monitor muscle activity during electroconvulsive therapy (ECT) for depression, bipolar disorder, or schizophrenia. It compares a standard arm tourniquet method with a newer, potentially less painful technique. The goal is to see if the new method wor…

This study will see if an AI chatbot app is practical and acceptable for family caregivers of people with traumatic brain injury, dementia, or Huntington disease. About 60 caregivers will use the app for 8 weeks, focusing on physical and mental health. They will complete surveys …

This study looks at how doing mental tasks—like naming objects or remembering words—changes the way people with Parkinson's disease walk. Researchers will compare 30 people with Parkinson's to healthy adults of the same age and sex. The goal is to find out which type of thinking …

This study looks at whether a drug called fampridine, which blocks potassium channels in the brain, can improve working memory in people with cocaine use disorder. Forty chronic cocaine users will receive either the drug or a placebo and then take memory tests. The goal is to und…

This study tests a program called Improving Dementia Care (IDC) to help primary care doctors identify dementia in patients who have memory concerns but no prior diagnosis. About 80 adults with mild cognitive issues will take part. The goal is to see if the program leads to more d…

This study tests a group program to help veterans with serious mental illness feel more comfortable and confident working with their doctors and therapists. About 119 veterans from three VA centers will take part. The goal is to see if the program improves teamwork between vetera…

This study will use brain scans (PET/MRI) to see how the drug Cobenfy affects dopamine in the brains of 12 people with schizophrenia. Participants will take one of three doses of Cobenfy for 5 weeks and get a brain scan before and after treatment. The goal is to understand how th…

This study will check if levels of Alzheimer's-related substances in the blood differ among the main ethnic groups living in central Barcelona. Researchers will also look at how age, income, education, and health conditions affect these levels. The goal is to identify barriers to…

This study aims to develop and test advanced MRI methods to study kidney disease, including in patients with chronic kidney disease, those on dialysis, and kidney transplant recipients. Researchers will also use brain MRI to explore links between kidney function and cognitive pro…

This study uses brain scans to examine dopamine, a key brain chemical, in 115 people aged 18-30 who are at high risk for psychosis. Participants will have PET and MRI scans and be followed for up to two years to see if they develop psychosis. The goal is to understand where and w…

This study tracks 120 adults having heart surgery to see if continuous monitoring of blood pressure and brain oxygen levels can predict problems like confusion, memory loss, or kidney injury afterward. Researchers will measure how long and how severely these levels drop during su…

This study will test whether educational sessions can improve health literacy and attitudes toward medication in 34 adults hospitalized with schizophrenia or related disorders. Participants will receive pamphlets and watch videos about their condition, then complete questionnaire…

This observational study will use a non-invasive brain-computer interface and artificial intelligence to detect and record brain activity in terminally ill patients immediately after clinical death. Researchers aim to capture organized neurocognitive signals, such as gamma waves,…

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study aims to find out how many hospitalized patients in Iraq are malnourished, a problem that can lead to more complications and longer stays. Researchers will screen 300 adults in two hospitals using standard tools to identify those at risk. The goal is to gather data to i…

This study will follow 120 people with schizophrenia who use cannabis, using mobile phone surveys and thinking tasks to track symptoms in real time. The goal is to understand how cannabis may both worsen positive symptoms (like hallucinations) and reduce negative symptoms (like l…

This study looks at how personal traits like anxiety, self-esteem, and perfectionism influence the ability to adapt in people with alcohol use disorder. Thirty participants will complete a computer task and questionnaires in one 45-minute session. No medication or treatment is in…

This study aims to create a version of the Mini-Mental State Examination (MMSE) that works better for people in Reunion Island. The current French version has questions that don't fit local culture. Researchers will test 400 people aged 60-89, both healthy and those with Alzheime…

This study will test whether a mobile app called MI MOM can improve pregnancy and postpartum health for 500 pregnant women on Medicaid. One group uses the app and gets text messages with health tips, videos, and optional support from a community health worker. The other group rec…

This study will follow 10 people aged 6 to 75 with chronic traumatic brain injury who choose to get MUSE stem cell therapy outside the U.S. Researchers will not give any treatment but will track safety, brain function, and quality of life for 12 months. The goal is to gather real…

This study will follow 90 people hospitalized with methamphetamine-induced psychotic disorder, comparing those who have also used cannabis in their lifetime to those who have not. Researchers will assess psychiatric symptoms, insight, addiction severity, and sleep quality weekly …

This study will give 180 healthy adults a daily probiotic supplement (Lactobacillus plantarum) for 1 or 6 months. Researchers will collect blood and stool samples and run online cognitive tests to see if the supplement changes gut bacteria, blood markers, or thinking skills. The …

This study will test a simple score to predict which patients may become confused (delirium) after planned heart surgery. About 100 adults will be checked before surgery using memory, orientation, and frailty tests. The goal is to identify high-risk patients early so doctors can …

This study will measure levels of two proteins, LRFN5 and OLFM4, in the blood of 120 people—some with schizoaffective disorder and some healthy. Researchers want to see if these proteins are linked to symptoms, overall function, and inflammation. The goal is to better understand …

This early-stage trial will give 8 healthy men a single dose of a radioactive-labeled experimental drug called SEP-380135, which is being developed for schizophrenia. The goal is to track how the drug is absorbed, broken down, and eliminated from the body. This study does not tes…

This study tests a new monitor (Ceribell) to see if it can help doctors spot delirium in ICU patients sooner than standard checks. About 100 adults in the ICU will take part. The goal is to see if earlier detection leads to better treatment decisions.

This research looks at how brain networks relate to thinking and memory problems in people with schizophrenia, bipolar disorder, or major depression. The goal is to use brain imaging to better assess cognitive issues, improve diagnosis, and predict how well treatments might work.…

This study will test whether advanced MRI scans and blood tests can predict how well Alzheimer's patients respond to antibody drugs like lecanemab and donanemab. Researchers aim to create personalized models that show when amyloid plaques have been cleared from the brain, potenti…

This study aims to understand how walking patterns, body composition, and a blood protein called BDNF differ between older adults with mild cognitive impairment and healthy older adults. Researchers will measure gait, handgrip strength, and cognitive function in 60 participants a…

This study will follow 1,000 older adults from under-resourced communities who have early memory concerns or mild cognitive impairment. Participants will be monitored through phone or video visits, with data collected on thinking skills, brain scans, and blood samples. The goal i…

This study tests a new AI method to generate a type of brain scan (FDG PET) from another scan (amyloid PET) and an MRI, without needing an extra injection or scan. Researchers will use data from 35 Alzheimer's patients who already had both scans. If it works, it could reduce radi…

This study tests whether watching digital stories can help older adults in rural Vietnam learn about Alzheimer's and related dementias and encourage early diagnosis. Researchers will work with 100 older adults and their caregivers to see if this approach is feasible and improves …

This study looks at 48 teenagers with autism who were checked for psychotic symptoms 10 years ago. Researchers want to see how their mental health and daily functioning are now. They will compare those who had early signs of psychosis with those who did not, using interviews and …

This observational study will follow 100 children in Denmark who receive a stem cell transplant for blood cancer or other serious blood disorders. Researchers will test their thinking skills, physical abilities, and daily activity before the transplant and for one year after. The…

This observational study will follow 50 children aged 5 to 8 with non-progressive congenital ataxia, a rare condition that affects movement and coordination. Researchers will use detailed exams, brain scans, and genetic testing to better understand the disorder and its impact on …

This study watches real conversations between healthcare staff and people with dementia after hip fracture surgery. The goal is to find which words and phrases work best to encourage patients to stand or walk early. Researchers will record up to 50 care sessions on hospital wards…

This study will follow 5,160 pregnant women in France who have HIV, hepatitis B, hepatitis C, or an arbovirus infection (like Zika or dengue), along with their children, for up to 7 years. Researchers want to learn how these viruses and their treatments affect pregnancy, the moth…

This study aims to find out how reliable the DiaMem memory test is when taken multiple times. Researchers will have 30 adults aged 60 or older take memory tests once a day for 6 days. The goal is to see if scores stay consistent, which would help doctors better assess memory prob…

This study will collect health data from 250 Taiwanese adults aged 40 and older to understand how aging affects the brain, sleep, and thinking skills. Participants will undergo brain scans and wear activity monitors, and answer sleep questionnaires. The goal is to build a compreh…

This study tests whether an AI-powered app called HeartBot II can improve women's awareness of heart attack symptoms. About 200 women will be randomly assigned to use the app right away or wait 12 weeks. Participants complete surveys about their knowledge and confidence in recogn…

This study looks at how mental state, emotional eating, and sleep quality together influence the risk of metabolic syndrome (a cluster of conditions like high blood pressure and blood sugar) in people with schizophrenia or bipolar disorder. Researchers will measure these factors …

This study will look at how getting only 3 hours of sleep (instead of 8) affects blood sugar, blood vessel stiffness, and thinking skills in healthy adults aged 20-45. Researchers will also test if regular exercise can help protect against these negative effects. The goal is to b…

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study looks at whether teaching East Asian American adults about alcohol flushing and offering them a genetic test for it is practical and helpful. About 100 people who flush when they drink or have a family history of flushing will take part. Half will get education only, a…

This study will test if wearable devices like smartwatches and rings can detect early signs of mild cognitive impairment and Alzheimer's disease in 150 adults aged 65 and older. Participants will wear the devices for 30 days while researchers collect data on activity, sleep, and …

This study is testing a digital toolkit that uses AI and wearable sensors to assess pain and distress in people with mild to moderate dementia. The goal is to see if the toolkit is easy to use and accurate. If it works, it could help caregivers better understand and respond to th…

This study looks at how general anesthesia affects certain brain chemicals and thinking skills. Researchers will compare 160 adults having gallbladder surgery: those who have never had anesthesia before and those who have had it multiple times. The goal is to understand if repeat…

This study tests whether a short virtual reality experience can reduce stigma toward people with schizophrenia among healthcare workers and students. Participants will watch two VR videos that simulate hallucinations and paranoid thoughts, then researchers measure changes in atti…

This study looks at whether teaching people in the hospital about their psychiatric medications helps them stick to their treatment and handle side effects. Researchers will work with 64 adults who have serious mental illnesses like schizophrenia or bipolar disorder. The goal is …

This study will follow 2,800 adults aged 55 and older in China for many years to understand how aging affects the brain and thinking skills. Researchers will collect information on diet, lifestyle, medical history, brain scans, and gut bacteria. The goal is to learn what helps pe…

This study looks at whether eye movement patterns can help detect early cognitive problems in people over 65. Researchers will use special glasses to track eye movements while participants perform visual tasks. The goal is to find a simple, non-invasive way to screen for mild cog…

This study will follow 2,500 elderly people in Hong Kong for 2-3 years to find early signs of Alzheimer's disease. Researchers will use blood tests, brain scans, and memory assessments to see if a simple blood test can detect the disease before symptoms get worse. The goal is to …

This study looks at 45 adults with migraine and a small hole in the heart (PFO). Researchers will use brain scans and thinking tests to see if closing the hole changes brain activity, mood, and migraine symptoms over a year. The goal is to understand the link between PFO and migr…

Delirium is common in hospital intensive care units (ICUs) and can be hard to diagnose. This study will use non-contact cameras to analyze patients' facial micro-expressions and other biological signals. By combining this data with machine learning, researchers aim to build a mod…

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study looks at how people with a first episode of psychosis tell their life stories and whether that relates to their well-being and recovery. Researchers will compare 96 participants—those with early psychosis, those with chronic psychosis, and healthy controls—using questi…

This study will check how common thinking and memory problems are in people who have had their first stroke. Researchers will evaluate 400 adults aged 18 to 60 within three months of their stroke. The goal is to better understand the impact of stroke on the brain, not to test a n…

This study tests whether artificial intelligence can analyze video recordings of ICU patients to predict dangerous events like pulling out breathing tubes or becoming severely agitated. About 300 patients will have a small camera above their bed that records movements and sleep p…

This study will put 56 healthy adults aged 25-60 through 27 hours of sleep deprivation and alcohol consumption (to a 0.08% BAC) in a lab over 110 hours. Researchers will measure how these stressors affect thinking, movement, and brain scans. The goal is to better predict and mana…

This study looks at whether certain blood markers can predict delirium (sudden confusion) in older adults with heart failure. Researchers will compare two markers: one for inflammation (SII) and one for blood sugar and fat levels (TyG). They aim to find a simple way to identify h…

This study tests whether an AI model (ChatGPT-5) can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults admitted to the ICU will be randomly assigned to standard care or care where the AI provides diagnostic and trea…

This study tests whether low-intensity focused ultrasound can temporarily alter brain activity in 80 healthy adults. Participants receive MRI and CT scans, then ultrasound to the brain, followed by fMRI to measure changes in thinking and resting brain signals. The goal is to unde…

This study tests whether a computer-based virtual trainer can improve how new home care workers talk to people with dementia. Researchers will measure changes in workers' knowledge, communication skills, and empathy. The goal is to see if this training method helps caregivers pro…

This study tests whether a mild electrical pulse to the ear (called taVNS) can temporarily improve thinking skills like attention and memory in healthy adults aged 18-30. Each of the 60 participants will receive both the real stimulation and a fake (sham) version in separate sess…

This study will follow 300 older adults (70+) who have mild cognitive impairment (MCI) for one year to see if feeling lonely makes them more likely to develop dementia. Researchers will track who progresses from MCI to dementia and compare loneliness levels. The goal is to unders…

This study looks at how caring for a family member with Alzheimer's disease affects caregivers' daily lives, emotions, and sense of balance. Researchers will interview and survey 66 caregivers, some who are still caring for a loved one and some who have experienced the loss of th…

This study investigates how insulin delivered through the nose changes dopamine signaling and energy use in the brains of people with first-episode psychosis. Researchers will compare brain scans and chemical levels in 46 participants (patients and healthy volunteers) after recei…

This study will use combined PET and MRI scans to measure how the brain uses glucose and oxygen in healthy adults and people with Alzheimer's disease. Researchers want to see if a commercially available ketone drink can improve brain energy metabolism. The study involves 17 parti…

This Stanford study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve memory formation in healthy older adults (ages 65-80) compared to younger adults (ages 18-30). The stimulation is given during learning tasks, and researchers will also l…

This study will follow 200 adults in Egypt who have psychosis to compare two conditions: schizophrenia and psychosis caused by methamphetamine use. Researchers will assess symptoms, treatment response, and recovery over three months. The goal is to improve diagnosis and understan…

This study is developing and testing a screening tool for primary care doctors to spot signs of neglect in older adults with dementia, along with a mobile app called SIRENS that provides caregivers with expert-reviewed information and goal-setting features. The current phase will…

This study aims to create a decision aid to help people with dementia, their caregivers, and doctors talk through medication options together. Researchers will test the tool with 100 patients, caregivers, and clinicians to see if it reduces confusion and improves shared decision-…

This study tests a program designed to reduce stigma around dementia in rural Kenya. Researchers will train local health workers to lead group sessions that teach about dementia, correct myths, and build empathy through videos and discussions. The goal is to see if this approach …

This study is developing and testing a program called Cannabis Conversation Skills for Families (CCSF) that teaches family members communication skills to encourage their young adult loved one with first episode psychosis to reduce cannabis use. The program includes education abo…

This pilot study tests whether a 6-week digital health literacy program delivered through face-to-face sessions and WhatsApp activities can help older adults in Singapore improve their digital health skills and support brain function. Researchers will compare 140 participants age…

This study will follow 175 children and young adults who had a bone marrow transplant before age 18. Researchers will test their thinking, memory, and attention skills, and check for links to physical health issues like metabolism and fitness. The goal is to find early warning si…