Fasting-Mimicking diet tested to protect aging brains

NCT ID NCT06682767

Not yet recruiting Disease control Sponsor: Cedars-Sinai Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a special low-calorie, plant-based diet taken for 5 days each month can safely improve blood flow to the brain in middle-aged adults who carry the APOE4 gene, which raises Alzheimer's risk. Forty participants aged 45-65 will be randomly assigned to either the fasting-mimicking diet or standard dietary guidance for six months. The main goals are to check safety and see if the diet affects brain blood flow measured by MRI.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fasting-mimicking diet (FMD)
What this could lead to: If it works, this could point toward a simple dietary approach to support brain health and potentially lower Alzheimer's risk in people with the APOE4 gene.
What could go wrong: This is a very small, early feasibility study with only 40 participants. It is not designed to prove the diet prevents or treats Alzheimer's, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Alzheimer disease 2

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APOE 4 CEREBRAL BLOOD FLOW

Contacts and locations

Locations

Cedars Sinai Medical Center

Los Angeles, California, 90048, United States

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Other studies related to the condition(s) this trial covers.