Cedars-sinai Medical Center

This study tests whether fisetin, a natural compound found in fruits and vegetables, can improve lung function in older adults. Researchers will give fisetin or a placebo to 40 people aged 60 and older, including both former smokers and never-smokers. The goal is to see if fiseti…

This study tests whether early referral to a cardio-oncology specialist can lower heart risks in prostate cancer patients receiving long-term hormone therapy (ARPI). About 80 men with high-risk or advanced prostate cancer and additional heart risk factors will be assigned to eith…

This study will use advanced imaging to check for blood clots or other problems in 3000 people with artificial aortic heart valves. Those found to have clots will receive the blood thinner warfarin for three months, then be re-imaged to see if the clots have resolved. The goal is…

This study tests whether a ketogenic (high-fat, low-carb) diet can help people with newly diagnosed glioblastoma, an aggressive brain cancer, live longer. About 170 adults will be randomly assigned to either a ketogenic diet or standard dietary guidance, while all receive standar…

This study tests whether adding the drug ivonescimab to standard chemotherapy before surgery can improve outcomes for people with early-stage triple-negative breast cancer. About 34 participants will receive the combination every three weeks for six cycles, then undergo surgery. …

This study tests whether intensive cholesterol-lowering therapy can increase cancer-fighting immune cells in the prostate. About 140 men with prostate cancer who are under active surveillance will take a cholesterol-lowering drug for 3 to 6 months before a planned biopsy. The goa…

This study tests a stem cell transplant for people aged 13-28 with severe Crohn's disease that hasn't responded to other treatments. Doctors take the patient's own blood stem cells, then use high-dose therapy to wipe out overactive immune cells before returning the stem cells. Th…

This study compares two ways to help people with overweight or obesity lose weight: avoiding tempting situations (AVOID) or practicing self-control when faced with cravings (RESIST). About 500 adults will be followed for 12 months to see which approach works better for weight los…

This phase 2 trial tests seliciclib, an oral drug, in 13 adults with Cushing disease. The goal is to see if 4 weeks of treatment can lower high cortisol levels to normal or reduce them by at least half. Researchers will also monitor safety and check for changes in tumor size and …

This study is testing a new urine test that aims to predict whether bladder cancer patients will respond well to a standard treatment called BCG. Currently, about half of patients do not respond to BCG, leading to extra treatments or bladder removal. The test looks for specific m…

This study is testing a new urine test that looks for specific proteins to detect bladder cancer in people who have microscopic blood in their urine (not visible to the naked eye). The goal is to see if this simple, non-invasive test can accurately identify cancer, potentially re…

This study is testing a new urine test that might find returning bladder cancer earlier and more accurately than current urine tests. The goal is to see if this test can reduce the need for cystoscopy, a procedure where a tiny camera is inserted into the bladder. About 300 adults…

This study tests whether a dye called pafolacianine (CYTALUX™) can make cancer cells glow under near-infrared light during surgery. Fifteen adults with gastric, esophageal, or appendiceal cancer will receive the dye before standard surgery. Surgeons will use a special camera to l…

This study tests whether daily 15-minute virtual reality sessions with calming nature scenes and meditation can prevent delirium in high-risk ICU patients. About 822 adults in the surgical ICU at Cedars-Sinai will either get standard care or standard care plus VR for up to 5 days…

This study tests whether a low dose of oral ketamine can safely help with anxiety in people with pancreatic cancer. Twenty participants will receive both ketamine and a placebo at different times to compare effects. The main goal is to see if such a study is even possible, not to…

This study tests whether wearing a plastic finger splint at night for 6 weeks, right after a cortisone injection, helps trigger finger heal better than the injection alone. Researchers will track pain, finger locking, and daily function in 146 adults over 12 weeks. The goal is to…

This pilot study tests whether the VirtuaCare platform, a digital home exercise program, can help people with shoulder injuries do their rehab more consistently and with fewer clinic visits. Twenty adults prescribed physical therapy for shoulder conditions will use the platform a…

This study tests whether providing medically tailored meals and shakes for 12 days after orthopaedic trauma surgery can improve healing and reduce wound complications. Researchers will track metabolic markers and wound issues in 75 patients over one year. The goal is to see if be…

This study tests a program that gives people with diabetes a continuous glucose monitor (CGM) when they leave the hospital. The goal is to see if it makes patients more satisfied and improves their quality of life. About 37 adults with Type 1 or Type 2 diabetes who use insulin wi…

This study tests whether a new nasal spray system that delivers fluticasone deeper into the nose can relieve Eustachian tube dysfunction (ETD) — a condition causing ear pressure, popping, and muffled hearing. About 80 adults with chronic ETD will receive either the active spray o…

This study tests whether using a navigation system during balloon sinus dilation improves success rates for people with chronic maxillary sinusitis. Fifty adults who have not had prior sinus surgery will be randomly assigned to receive either standard balloon dilation or navigati…

This pilot study tests whether simvastatin, a common cholesterol medication, can improve quality of life in adults with recurrent acute or chronic pancreatitis. Researchers will enroll 90 participants to check if the drug is feasible and acceptable. The goal is to see if it helps…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve quality of life in people with digestive tract cancers. 360 participants will be split into three groups: one using a skills-based VR program, one using distracting VR videos, and a contr…

This study tests a one-time educational session called Proactive Costs of Care, designed to help gynecologic cancer patients and their caregivers manage the financial side of treatment. A trained lay educator reviews health insurance, employment options, and community support usi…

This study helps pregnant individuals who used assisted reproductive technology (like IVF) and their support partner build a strong coparenting relationship. Participants attend 9 free online sessions and complete surveys and at-home blood tests to measure stress and inflammation…

This study tests whether smelling lavender essential oil during awake ear, nose, and throat procedures can lower anxiety and pain. About 184 adults will be randomly assigned to receive either lavender aromatherapy or a placebo (odorless liquid). Participants will rate their anxie…

This study looks at whether eating only during certain hours of the day can reduce side effects from cancer treatment and improve mood and behavior. About 175 adults with colorectal or breast cancer will follow a time-restricted eating plan while receiving standard therapy. Resea…

This study tests whether shining a special light on the forehead (photobiomodulation) can improve thinking and memory in 45 people with mild cognitive impairment or mild dementia due to Alzheimer's disease. Participants will receive the light treatment and take cognitive tests an…

This early-phase trial tests whether paricalcitol, a vitamin D analog, can improve quality of life in adults with chronic pancreatitis. Researchers will enroll 24 participants to take either the drug or a placebo for 12 months. The main goal is to see if the study is feasible and…

This study tests whether a combination of zinc and nicotinamide riboside can help people with idiopathic pulmonary fibrosis (IPF) feel better and breathe easier. Sixty participants will take the supplements or a placebo twice a day for 24 weeks, all from home with remote check-in…

This study compares different nerve block techniques to manage pain after gender-affirming surgery in transgender adults. The goal is to find which method reduces pain and opioid use while minimizing side effects like nausea and urinary problems. Researchers will track pain level…

This study tests an online decision aid called Protect Your Colon™ that helps people aged 45-75 choose a colorectal cancer screening test. Participants will use the tool or get usual care, and researchers will see if the tool increases screening completion within 6 months. The go…

This study compares two treatments for a common heart valve problem in people over 60: a less invasive catheter-based repair versus open-heart surgery. Researchers will track which approach leads to better long-term outcomes, including survival, heart function, and quality of lif…

This study follows 216 people with very small papillary thyroid cancers (1.5 cm or smaller) to see what happens when they choose active surveillance—regular checkups instead of immediate surgery. The goal is to learn how often these cancers grow and whether observation is a safe …

This study follows 1,250 people with pituitary tumors to learn what predicts tumor return or ongoing disease. Researchers will track survival and other health markers over time. No new treatment is given—the goal is simply to gather information that may improve future care.

This study examines fat tissue from older adults to see how exercise, diet, or senolytic drugs affect cell health and metabolism. Researchers will take small fat samples and use advanced genetic analysis to map cell types and signs of aging. The goal is to better understand how l…

This study tests a new capillary catheter designed to collect fluid from the small intestine during endoscopy. Inspired by how plants draw water, the device aims to be faster and less prone to contamination than the standard catheter. Researchers will compare the two devices in 4…

This pilot study tests whether adding hands-on nutrition demonstrations to the standard Diabetes Prevention Program (DPP) helps recruit and keep participants engaged. Twenty adults with prediabetes from two community health centers in Los Angeles will take part. The main goal is …

This study tests whether giving doctors and patients a report generated by artificial intelligence can improve how well risks and benefits of prostate cancer treatments are discussed. About 283 men with newly diagnosed prostate cancer and their doctors will be randomly assigned t…

This study looks at how two different catheters used to treat atrial fibrillation (a type of irregular heartbeat) affect the temperature of the esophagus (the tube connecting the mouth to the stomach) and the risk of injury to it. About 30 adults with paroxysmal atrial fibrillati…