Cedars-sinai Medical Center

This study tests whether a stem cell transplant using the patient's own cells can 'reset' the immune system in teens and young adults (ages 13-28) with severe Crohn's disease that hasn't responded to other treatments. The approach removes overactive immune cells and replaces them…

This study tests whether a strict ketogenic diet, compared to standard dietary advice, can improve survival in 170 adults newly diagnosed with glioblastoma, a serious brain cancer. All participants continue standard treatments like chemotherapy and radiation. The diet lasts 18 we…

This study tests an oral drug called seliciclib in 13 adults with Cushing disease, a condition where a pituitary tumor causes high cortisol levels. The goal is to see if 4 weeks of treatment can lower cortisol to normal or reduce it by at least half. The drug aims to control the …

This study tests whether adding the drug ivonescimab to standard chemotherapy before surgery can improve outcomes for people with early-stage triple-negative breast cancer. About 34 participants will receive the combination every three weeks for six cycles, then undergo surgery. …

This study tests whether aggressively lowering cholesterol with a common FDA-approved drug (Vytorin or ezetimibe) can increase cancer-fighting immune cells inside the prostate. It involves 140 men with prostate cancer who are under active surveillance and planning a biopsy in 3-6…

This study compares two ways to help people with overweight or obesity lose weight and eat healthier. One approach focuses on avoiding tempting situations (AVOID), while the other trains the brain to resist impulses (RESIST). About 500 adults will be followed for 12 months to see…

This study aims to see if a new urine test can accurately detect bladder cancer recurrence in 300 people with a history of the disease. Currently, patients need a camera inserted into the bladder (cystoscopy) to check for cancer return. If successful, this simple urine test could…

This study is testing a new urine test that looks for signs of bladder cancer in people who have tiny amounts of blood in their urine (microscopic hematuria). The goal is to see if the test can accurately detect bladder cancer without needing a cystoscopy, which is an invasive pr…

This study is testing a new urine test to see if it can predict which bladder cancer patients will respond well to a standard treatment called BCG. Currently, about half of patients do not respond to BCG, leading to more treatments or surgery. The goal is to use this test to help…

This study tests whether a dye called CYTALUX™, given before surgery, can help surgeons see cancer tissue in real time using a special camera. It includes 15 adults with stomach, esophagus, or appendix cancer who are already scheduled for surgery. The goal is to improve how compl…

This study tests whether daily 15-minute virtual reality sessions with calming nature scenes and meditation can prevent delirium in high-risk ICU patients. About 822 adults in the surgical ICU at Cedars-Sinai will either get standard care or standard care plus VR. The goal is to …

This study looks at whether adding hands-on cooking and nutrition lessons can help people at risk for prediabetes stick with a diabetes prevention program. About 20 adults in Los Angeles will take part. The goal is to see if this approach is practical and helpful for keeping part…

This study tests whether using a navigation system (like GPS) during a balloon sinus procedure improves success rates for people with chronic sinusitis. About 50 adults who need sinus surgery will be enrolled. The goal is to see if navigation helps the doctor place the balloon mo…

This study aims to help pregnant individuals who used assisted reproductive technology (ART) build a strong coparenting bond with a support person. Participants will attend 9 virtual sessions and complete surveys and at-home blood tests to measure stress and inflammation. The goa…

This study tests a one-time, 30-minute educational session with a trained educator to help gynecologic cancer patients and their caregivers manage the costs of care. The goal is to see if the program is practical and can boost confidence in handling financial issues while reducin…

This pilot study is testing whether simvastatin, a widely used cholesterol medication, can improve quality of life for adults with recurrent acute or chronic pancreatitis. Researchers will enroll 90 participants to see if the drug is practical and well-tolerated, and whether it h…

This study tests whether taking zinc and nicotinamide riboside (a form of vitamin B3) for 24 weeks can improve symptoms and quality of life in people with idiopathic pulmonary fibrosis (IPF), a chronic lung disease. About 60 participants will take the supplements or a placebo fro…

This early-stage study is testing whether a low dose of oral ketamine can safely reduce anxiety in people with pancreatic cancer who are currently on or recently finished cancer treatment. About 20 participants will receive both ketamine and a placebo at different times to compar…

This study tests whether a digital platform called VirtuaCare can help people with shoulder problems do their exercises at home instead of going to the clinic as often. Researchers want to see if using the app leads to better recovery and fewer in-person visits. The study involve…

This study looks at whether a 12-day program of delivered meals and shakes can improve recovery and nutrition after orthopaedic trauma surgery. About 75 adults who live in certain Los Angeles zip codes will receive meals at home and have their blood tested at 2 and 6 weeks after …

This study tests whether a special discharge program for continuous glucose monitors (CGMs) can improve satisfaction and quality of life in adults with diabetes who use insulin. About 37 participants will complete surveys before and after using the device. The goal is to see if b…

This study tests whether smelling lavender during awake ear, nose, and throat procedures can lower anxiety and pain. About 184 adults will be randomly given either lavender scent or an odorless placebo during their procedure. Participants will fill out short questionnaires before…

This study tests whether using virtual reality (VR) can reduce severe belly pain in people with digestive tract cancers. 360 participants will be split into three groups: one using skills-based VR, one using distraction VR, and a sham control group. Researchers will track pain, a…

This study tests if limiting when you eat (time-restricted eating) can reduce side effects from cancer treatment, improve mood, and even affect tumor biology. Researchers will enroll 175 adults with rectal or breast cancer who are receiving treatment. Participants will follow a s…

This study compares different pain treatment options for transgender people after gender-affirming surgery. The goal is to find which methods work best to control pain while reducing the need for opioids and their side effects. Researchers will track pain levels, opioid use, and …

This early-stage study tests whether paricalcitol, a vitamin D-like drug, can improve quality of life in 24 adults with chronic pancreatitis. Participants take the drug or a placebo for 12 months while reporting pain and overall health. The goal is to see if the treatment is prac…

This study tests a new nasal spray device that delivers fluticasone deeper into the nose to treat chronic Eustachian tube dysfunction, a condition causing ear pressure, popping, and muffled hearing. About 80 adults with symptoms lasting over 3 months will receive either the activ…

This study tests whether shining a special light on the forehead (photobiomodulation) can improve thinking skills in people with mild memory problems or early Alzheimer's disease. About 45 adults aged 55 to 89 will receive the light treatment weekly and take cognitive tests. Rese…

This study looks at whether wearing a splint at night after a cortisone injection can improve pain and hand function for people with trigger finger. About 146 adults will be split into two groups: one gets the injection plus a night splint, the other gets only the injection. The …

This study looks at how two different catheters used to treat atrial fibrillation (an irregular heartbeat) affect the temperature of the esophagus (the tube connecting the mouth to the stomach) and the risk of injury. About 30 adults with paroxysmal atrial fibrillation will be en…

This study follows 1,250 people with pituitary tumors over time to see what factors predict the tumor coming back or staying active. Researchers will track survival and use medical records to gather data. No new treatments are given—the goal is simply to learn more about the dise…

This study compares a new capillary-action catheter to the standard tool for collecting fluid from the small intestine during upper endoscopy. 46 adults undergoing endoscopy will be split into two groups to see which method collects more fluid in less time. The goal is to improve…

This study looks at whether it is safe to monitor very small thyroid cancers (1.5 cm or smaller) instead of removing them right away. About 216 people with papillary thyroid microcarcinoma will be followed over time to see how often the disease progresses. The goal is to learn wh…

This study looks at fat tissue from older adults to see how cells change with age and obesity. Researchers will take small fat samples and use advanced genetic tools to map different cell types. Some older participants will also try lifestyle changes or a drug that targets aging …

This study tests a decision aid called Protect Your Colon™ to see if it helps people aged 45-75 who are due for colorectal cancer screening choose and complete a screening test. Half the participants will use the tool, and the other half will get usual care. The goal is to see if…

This study tests whether giving doctors AI-powered feedback on how they discuss treatment risks helps men with prostate cancer make better decisions. About 259 men and 24 doctors will take part. Doctors in the experimental group receive a report within 72 hours of each visit, gra…