New study aims to cut opioid use in transgender surgery recovery

NCT ID NCT04979338

Recruiting now Symptom relief Sponsor: Cedars-Sinai Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study compares different nerve block techniques to manage pain after gender-affirming surgery in transgender adults. The goal is to find which method reduces pain and opioid use while minimizing side effects like nausea and urinary problems. Researchers will track pain levels, opioid consumption, and recovery quality in 640 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bupivacaine with epinephrine (nerve blocks)
What this could lead to: If successful, this could establish a standard for safer, more effective pain control after gender-affirming surgeries, reducing opioid use and side effects.
What could go wrong: This is a Phase 3 trial, but it compares existing techniques, so no new drug is being tested. Results may not apply to all surgery types or hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia Gender Dysphoria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENDER DYSPHORIA

Contacts and locations

Locations

Cedars-Sinai Medical Center - North and South Towers
RECRUITING

Los Angeles, California, 90048, United States

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