Cedars-sinai Medical Center

This study tests whether hearts from donors who died from circulatory death (DCD) are as safe for transplant as hearts from brain-dead donors (DBD). About 40 adult heart transplant recipients will receive either a DCD or DBD heart. The goal is to see if using DCD hearts can safel…

This study tests whether a combination of high-dose statins, blood pressure medications (ACE inhibitors or ARBs), and low-dose aspirin can reduce the risk of death, heart attack, stroke, or hospitalization in women who have chest pain or shortness of breath but no major blockages…

This study tests a less intense version of standard chemo-radiation for people with HPV-positive throat cancer who have had robotic surgery to remove visible tumors. The goal is to see if the milder treatment works just as well as the standard dose but causes fewer side effects. …

This study tests whether having a pharmacist review medications and counsel patients before and after hospital discharge can reduce return trips to the hospital or ER within 30 days. Over 6,400 older adults (55+) taking many medications or high-risk drugs are taking part. The pha…

This study looks at whether terazosin, a drug usually used for high blood pressure, can slow the progression of Parkinson's disease. Researchers are tracking changes in heart and brain scans of 15 people who are either in early stages or at high risk for Parkinson's. The goal is …

This phase 2 trial tests whether carvedilol, a drug usually used for heart conditions, can slow the loss of dopamine transporters in the brain and delay Parkinson's symptoms. It follows 15 people with REM sleep behavior disorder and other early Parkinson's risk factors over three…

This early-stage study tests whether atezolizumab, a drug used for cancer, is safe for people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing problems. About 24 adults aged 50 and older with confirmed IPF will receive the drug. Research…

This study tests whether adding Thymoglobulin to standard anti-rejection drugs helps prevent complications after a first heart transplant. About 60 adults will receive either standard therapy alone or standard therapy plus five days of Thymoglobulin. Researchers will check for si…

This study is testing a new urine test that looks for specific markers of bladder cancer. The goal is to see if this simple, non-invasive test can accurately detect bladder cancer in 450 people who have blood in their urine, potentially reducing the need for a more invasive camer…

This study is testing a new urine test to detect bladder cancer early in people at high risk, such as smokers over 50. Researchers will check how accurate the test is and use the data to build a risk calculator. The goal is to offer a non-invasive way to catch the disease sooner.

This study tests whether a new type of MRI called 6D-MRI can predict how well pancreatic cancer patients respond to chemotherapy. Researchers will scan 36 patients before and during treatment to see if the MRI can spot signs of tumor activity and help guide surgery decisions. The…

This study compares two methods of giving the pain medicine EXPAREL during knee replacement surgery. About 40 adults will receive the medicine either as a targeted block or as local infiltration. Participants will report their pain levels and any extra pain medicines they need. T…

This study looks at whether women aged 65 and older with early-stage, estrogen-positive breast cancer can safely have a lumpectomy without also removing and testing nearby lymph nodes (sentinel node biopsy). The goal is to see if skipping this extra step leads to cancer coming ba…

This early-phase study tests giving a precise dose of radiation to brain tumors before surgical removal, rather than after. The goal is to protect healthy brain tissue and possibly eliminate the need for additional radiation after surgery. About 25 adults with brain metastases (t…

This study tests a 6-week supervised exercise program for people with pancreatic cancer. Participants will do aerobic and resistance training three times a week, plus home exercise tracked by a FitBit. The goal is to see if the program is feasible and safe, not to cure the cancer…

This early-stage trial is testing whether injecting donated fat tissue into the small joints of the hand can reduce pain and improve movement in people with hand osteoarthritis. About 34 adults with joint pain and X-ray evidence of arthritis will receive the injection under local…

This study looks at how the brain learns from past experiences and uses that knowledge in new situations. Researchers will monitor brain activity in 114 adults with hard-to-treat epilepsy who are already undergoing brain monitoring. The goal is to understand the process of abstra…

This study tests whether a culturally tailored mobile health program can improve mental health and pregnancy outcomes in Black pregnant women. Half of the 150 participants will receive the program, which builds communication and self-advocacy skills and provides support. The goal…

This study tests a program to help older adults (65+) safely reduce unnecessary medications that may cause harm. Researchers will use a risk-prediction tool to identify high-risk participants and then guide their doctors to deprescribe. The goal is to see if this approach is prac…

This study looks at whether terazosin, a drug used for high blood pressure, can change heart nerve activity in people at high risk for Parkinson's disease. Researchers are studying 15 adults with REM sleep behavior disorder (a strong early sign of Parkinson's) to see if the drug …

This study looks at how the brain learns, remembers, and makes decisions. Researchers will record brain activity from 200 epilepsy patients who already have electrodes implanted for medical monitoring. Participants perform simple computer tasks while their brain signals are measu…

This study tests a new high-density microelectrode designed to record activity from individual brain cells and groups of cells. Ten Parkinson's patients already scheduled for deep brain stimulation surgery will have the electrode used during their procedure. The main goals are to…

This study looks at whether a special heart MRI can find problems in the small arteries of women who have chest pain but no major blockages. About 375 women will get both a standard angiogram and a cardiac MRI to compare results. The goal is to see if the MRI can detect hidden he…